Amino acid dipepetide frequency for Shimia aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.866AlaAla: 14.866 ± 0.149	1.099AlaCys: 1.099 ± 0.03	6.522AlaAsp: 6.522 ± 0.071	7.903AlaGlu: 7.903 ± 0.086	4.295AlaPhe: 4.295 ± 0.063	9.642AlaGly: 9.642 ± 0.103	2.436AlaHis: 2.436 ± 0.045	5.897AlaIle: 5.897 ± 0.075	3.938AlaLys: 3.938 ± 0.056	13.095AlaLeu: 13.095 ± 0.126	3.771AlaMet: 3.771 ± 0.054	2.844AlaAsn: 2.844 ± 0.052	5.572AlaPro: 5.572 ± 0.078	4.273AlaGln: 4.273 ± 0.063	8.488AlaArg: 8.488 ± 0.1	5.387AlaSer: 5.387 ± 0.068	5.648AlaThr: 5.648 ± 0.07	8.042AlaVal: 8.042 ± 0.095	1.358AlaTrp: 1.358 ± 0.039	2.584AlaTyr: 2.584 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.096CysAla: 1.096 ± 0.029	0.12CysCys: 0.12 ± 0.01	0.673CysAsp: 0.673 ± 0.02	0.479CysGlu: 0.479 ± 0.02	0.357CysPhe: 0.357 ± 0.016	0.955CysGly: 0.955 ± 0.028	0.309CysHis: 0.309 ± 0.019	0.419CysIle: 0.419 ± 0.018	0.25CysLys: 0.25 ± 0.014	0.851CysLeu: 0.851 ± 0.028	0.199CysMet: 0.199 ± 0.012	0.253CysAsn: 0.253 ± 0.016	0.533CysPro: 0.533 ± 0.021	0.249CysGln: 0.249 ± 0.015	0.537CysArg: 0.537 ± 0.021	0.473CysSer: 0.473 ± 0.021	0.438CysThr: 0.438 ± 0.022	0.619CysVal: 0.619 ± 0.023	0.115CysTrp: 0.115 ± 0.011	0.225CysTyr: 0.225 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.168AspAla: 7.168 ± 0.079	0.54AspCys: 0.54 ± 0.019	3.329AspAsp: 3.329 ± 0.059	3.603AspGlu: 3.603 ± 0.058	2.382AspPhe: 2.382 ± 0.051	5.436AspGly: 5.436 ± 0.077	1.411AspHis: 1.411 ± 0.035	3.3AspIle: 3.3 ± 0.051	1.985AspLys: 1.985 ± 0.044	6.281AspLeu: 6.281 ± 0.071	1.922AspMet: 1.922 ± 0.035	1.389AspAsn: 1.389 ± 0.032	3.523AspPro: 3.523 ± 0.052	1.974AspGln: 1.974 ± 0.036	3.954AspArg: 3.954 ± 0.064	2.196AspSer: 2.196 ± 0.039	3.154AspThr: 3.154 ± 0.054	4.586AspVal: 4.586 ± 0.062	1.14AspTrp: 1.14 ± 0.025	1.603AspTyr: 1.603 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.871GluAla: 7.871 ± 0.107	0.408GluCys: 0.408 ± 0.017	3.635GluAsp: 3.635 ± 0.057	3.993GluGlu: 3.993 ± 0.072	1.94GluPhe: 1.94 ± 0.04	4.868GluGly: 4.868 ± 0.074	1.266GluHis: 1.266 ± 0.031	3.84GluIle: 3.84 ± 0.055	2.504GluLys: 2.504 ± 0.055	5.337GluLeu: 5.337 ± 0.067	2.015GluMet: 2.015 ± 0.043	2.014GluAsn: 2.014 ± 0.039	2.422GluPro: 2.422 ± 0.05	2.105GluGln: 2.105 ± 0.042	4.32GluArg: 4.32 ± 0.063	2.402GluSer: 2.402 ± 0.052	4.075GluThr: 4.075 ± 0.063	4.296GluVal: 4.296 ± 0.059	0.746GluTrp: 0.746 ± 0.024	1.185GluTyr: 1.185 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.427PheAla: 4.427 ± 0.063	0.459PheCys: 0.459 ± 0.02	2.938PheAsp: 2.938 ± 0.046	2.492PheGlu: 2.492 ± 0.051	1.555PhePhe: 1.555 ± 0.043	3.823PheGly: 3.823 ± 0.062	0.785PheHis: 0.785 ± 0.026	1.621PheIle: 1.621 ± 0.038	1.023PheLys: 1.023 ± 0.028	3.637PheLeu: 3.637 ± 0.061	0.899PheMet: 0.899 ± 0.025	1.074PheAsn: 1.074 ± 0.029	1.607PhePro: 1.607 ± 0.035	1.087PheGln: 1.087 ± 0.027	2.213PheArg: 2.213 ± 0.046	2.268PheSer: 2.268 ± 0.05	2.03PheThr: 2.03 ± 0.042	2.825PheVal: 2.825 ± 0.053	0.611PheTrp: 0.611 ± 0.023	0.966PheTyr: 0.966 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.607GlyAla: 9.607 ± 0.093	0.864GlyCys: 0.864 ± 0.029	4.899GlyAsp: 4.899 ± 0.07	4.813GlyGlu: 4.813 ± 0.072	3.753GlyPhe: 3.753 ± 0.061	7.312GlyGly: 7.312 ± 0.112	1.988GlyHis: 1.988 ± 0.047	4.437GlyIle: 4.437 ± 0.062	3.406GlyLys: 3.406 ± 0.059	8.856GlyLeu: 8.856 ± 0.087	2.741GlyMet: 2.741 ± 0.05	2.296GlyAsn: 2.296 ± 0.066	3.573GlyPro: 3.573 ± 0.064	3.074GlyGln: 3.074 ± 0.05	5.394GlyArg: 5.394 ± 0.066	3.938GlySer: 3.938 ± 0.066	4.544GlyThr: 4.544 ± 0.065	6.6GlyVal: 6.6 ± 0.076	1.504GlyTrp: 1.504 ± 0.037	2.454GlyTyr: 2.454 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.335HisAla: 2.335 ± 0.042	0.26HisCys: 0.26 ± 0.013	1.305HisAsp: 1.305 ± 0.035	1.141HisGlu: 1.141 ± 0.034	0.892HisPhe: 0.892 ± 0.027	2.059HisGly: 2.059 ± 0.04	0.611HisHis: 0.611 ± 0.024	1.04HisIle: 1.04 ± 0.029	0.64HisLys: 0.64 ± 0.023	2.226HisLeu: 2.226 ± 0.048	0.628HisMet: 0.628 ± 0.024	0.507HisAsn: 0.507 ± 0.021	1.423HisPro: 1.423 ± 0.033	0.608HisGln: 0.608 ± 0.021	1.357HisArg: 1.357 ± 0.036	1.022HisSer: 1.022 ± 0.032	0.885HisThr: 0.885 ± 0.029	1.684HisVal: 1.684 ± 0.037	0.409HisTrp: 0.409 ± 0.018	0.567HisTyr: 0.567 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.642IleAla: 6.642 ± 0.081	0.615IleCys: 0.615 ± 0.023	3.43IleAsp: 3.43 ± 0.055	3.522IleGlu: 3.522 ± 0.053	1.742IlePhe: 1.742 ± 0.045	4.82IleGly: 4.82 ± 0.062	0.989IleHis: 0.989 ± 0.027	2.208IleIle: 2.208 ± 0.047	1.62IleLys: 1.62 ± 0.036	4.88IleLeu: 4.88 ± 0.066	1.116IleMet: 1.116 ± 0.03	1.498IleAsn: 1.498 ± 0.035	2.378IlePro: 2.378 ± 0.053	1.23IleGln: 1.23 ± 0.033	3.158IleArg: 3.158 ± 0.05	3.053IleSer: 3.053 ± 0.056	2.966IleThr: 2.966 ± 0.051	3.882IleVal: 3.882 ± 0.062	0.722IleTrp: 0.722 ± 0.024	1.138IleTyr: 1.138 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.312LysAla: 4.312 ± 0.064	0.204LysCys: 0.204 ± 0.012	1.948LysAsp: 1.948 ± 0.042	1.788LysGlu: 1.788 ± 0.045	1.039LysPhe: 1.039 ± 0.033	3.02LysGly: 3.02 ± 0.055	0.746LysHis: 0.746 ± 0.023	1.725LysIle: 1.725 ± 0.042	1.404LysLys: 1.404 ± 0.04	3.272LysLeu: 3.272 ± 0.054	0.973LysMet: 0.973 ± 0.03	0.979LysAsn: 0.979 ± 0.027	2.032LysPro: 2.032 ± 0.043	1.004LysGln: 1.004 ± 0.034	2.436LysArg: 2.436 ± 0.045	1.916LysSer: 1.916 ± 0.042	2.105LysThr: 2.105 ± 0.043	2.554LysVal: 2.554 ± 0.046	0.471LysTrp: 0.471 ± 0.021	0.758LysTyr: 0.758 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.87LeuAla: 11.87 ± 0.115	0.964LeuCys: 0.964 ± 0.029	5.981LeuAsp: 5.981 ± 0.07	5.823LeuGlu: 5.823 ± 0.08	3.73LeuPhe: 3.73 ± 0.068	8.326LeuGly: 8.326 ± 0.091	1.917LeuHis: 1.917 ± 0.042	5.161LeuIle: 5.161 ± 0.069	3.588LeuLys: 3.588 ± 0.06	8.725LeuLeu: 8.725 ± 0.111	2.791LeuMet: 2.791 ± 0.046	2.866LeuAsn: 2.866 ± 0.05	5.369LeuPro: 5.369 ± 0.069	2.84LeuGln: 2.84 ± 0.049	6.753LeuArg: 6.753 ± 0.077	6.597LeuSer: 6.597 ± 0.072	5.615LeuThr: 5.615 ± 0.065	6.861LeuVal: 6.861 ± 0.077	1.286LeuTrp: 1.286 ± 0.037	1.924LeuTyr: 1.924 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.576MetAla: 3.576 ± 0.052	0.201MetCys: 0.201 ± 0.012	1.584MetAsp: 1.584 ± 0.039	1.505MetGlu: 1.505 ± 0.035	0.937MetPhe: 0.937 ± 0.028	2.374MetGly: 2.374 ± 0.046	0.562MetHis: 0.562 ± 0.018	1.622MetIle: 1.622 ± 0.036	1.162MetLys: 1.162 ± 0.031	2.634MetLeu: 2.634 ± 0.044	0.807MetMet: 0.807 ± 0.024	0.868MetAsn: 0.868 ± 0.026	1.58MetPro: 1.58 ± 0.036	1.042MetGln: 1.042 ± 0.031	2.031MetArg: 2.031 ± 0.039	1.956MetSer: 1.956 ± 0.041	2.033MetThr: 2.033 ± 0.045	1.961MetVal: 1.961 ± 0.042	0.277MetTrp: 0.277 ± 0.016	0.385MetTyr: 0.385 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.45AsnAla: 3.45 ± 0.059	0.288AsnCys: 0.288 ± 0.013	1.561AsnAsp: 1.561 ± 0.053	1.355AsnGlu: 1.355 ± 0.033	0.956AsnPhe: 0.956 ± 0.032	2.629AsnGly: 2.629 ± 0.05	0.593AsnHis: 0.593 ± 0.021	1.419AsnIle: 1.419 ± 0.034	0.817AsnLys: 0.817 ± 0.026	2.619AsnLeu: 2.619 ± 0.043	0.766AsnMet: 0.766 ± 0.025	0.764AsnAsn: 0.764 ± 0.024	1.938AsnPro: 1.938 ± 0.041	0.787AsnGln: 0.787 ± 0.026	1.811AsnArg: 1.811 ± 0.038	1.238AsnSer: 1.238 ± 0.032	1.516AsnThr: 1.516 ± 0.035	1.957AsnVal: 1.957 ± 0.042	0.489AsnTrp: 0.489 ± 0.019	0.664AsnTyr: 0.664 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.02ProAla: 5.02 ± 0.08	0.37ProCys: 0.37 ± 0.017	3.879ProAsp: 3.879 ± 0.053	4.313ProGlu: 4.313 ± 0.068	1.964ProPhe: 1.964 ± 0.036	4.339ProGly: 4.339 ± 0.063	1.095ProHis: 1.095 ± 0.028	2.29ProIle: 2.29 ± 0.043	1.868ProLys: 1.868 ± 0.044	4.423ProLeu: 4.423 ± 0.067	1.418ProMet: 1.418 ± 0.032	1.464ProAsn: 1.464 ± 0.036	2.116ProPro: 2.116 ± 0.053	1.531ProGln: 1.531 ± 0.035	2.705ProArg: 2.705 ± 0.052	2.492ProSer: 2.492 ± 0.042	2.431ProThr: 2.431 ± 0.048	4.307ProVal: 4.307 ± 0.064	0.675ProTrp: 0.675 ± 0.022	1.18ProTyr: 1.18 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.886GlnAla: 3.886 ± 0.061	0.253GlnCys: 0.253 ± 0.016	1.778GlnAsp: 1.778 ± 0.04	1.743GlnGlu: 1.743 ± 0.041	1.188GlnPhe: 1.188 ± 0.031	2.65GlnGly: 2.65 ± 0.046	0.613GlnHis: 0.613 ± 0.023	1.865GlnIle: 1.865 ± 0.035	1.192GlnLys: 1.192 ± 0.033	2.867GlnLeu: 2.867 ± 0.051	1.091GlnMet: 1.091 ± 0.037	0.95GlnAsn: 0.95 ± 0.031	1.475GlnPro: 1.475 ± 0.035	1.071GlnGln: 1.071 ± 0.033	2.134GlnArg: 2.134 ± 0.045	1.834GlnSer: 1.834 ± 0.04	1.797GlnThr: 1.797 ± 0.038	2.345GlnVal: 2.345 ± 0.047	0.389GlnTrp: 0.389 ± 0.019	0.655GlnTyr: 0.655 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.788ArgAla: 7.788 ± 0.091	0.477ArgCys: 0.477 ± 0.019	4.29ArgAsp: 4.29 ± 0.056	4.011ArgGlu: 4.011 ± 0.06	2.713ArgPhe: 2.713 ± 0.047	4.52ArgGly: 4.52 ± 0.064	1.528ArgHis: 1.528 ± 0.035	3.688ArgIle: 3.688 ± 0.054	2.556ArgLys: 2.556 ± 0.047	7.012ArgLeu: 7.012 ± 0.086	2.022ArgMet: 2.022 ± 0.035	1.887ArgAsn: 1.887 ± 0.041	3.065ArgPro: 3.065 ± 0.051	2.263ArgGln: 2.263 ± 0.039	4.737ArgArg: 4.737 ± 0.077	3.109ArgSer: 3.109 ± 0.051	2.861ArgThr: 2.861 ± 0.049	4.666ArgVal: 4.666 ± 0.061	0.948ArgTrp: 0.948 ± 0.028	1.597ArgTyr: 1.597 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.432SerAla: 5.432 ± 0.07	0.439SerCys: 0.439 ± 0.019	3.347SerAsp: 3.347 ± 0.048	3.167SerGlu: 3.167 ± 0.056	2.296SerPhe: 2.296 ± 0.043	5.438SerGly: 5.438 ± 0.072	1.135SerHis: 1.135 ± 0.033	2.464SerIle: 2.464 ± 0.05	1.682SerLys: 1.682 ± 0.037	4.938SerLeu: 4.938 ± 0.072	1.41SerMet: 1.41 ± 0.038	1.494SerAsn: 1.494 ± 0.04	2.459SerPro: 2.459 ± 0.048	1.6SerGln: 1.6 ± 0.036	3.178SerArg: 3.178 ± 0.054	2.438SerSer: 2.438 ± 0.046	2.56SerThr: 2.56 ± 0.048	3.887SerVal: 3.887 ± 0.057	0.669SerTrp: 0.669 ± 0.02	1.28SerTyr: 1.28 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.727ThrAla: 5.727 ± 0.066	0.518ThrCys: 0.518 ± 0.025	3.042ThrAsp: 3.042 ± 0.053	2.846ThrGlu: 2.846 ± 0.042	2.023ThrPhe: 2.023 ± 0.039	5.117ThrGly: 5.117 ± 0.065	1.229ThrHis: 1.229 ± 0.031	2.69ThrIle: 2.69 ± 0.046	1.621ThrLys: 1.621 ± 0.038	5.926ThrLeu: 5.926 ± 0.07	1.34ThrMet: 1.34 ± 0.027	1.353ThrAsn: 1.353 ± 0.032	3.463ThrPro: 3.463 ± 0.055	1.571ThrGln: 1.571 ± 0.039	3.55ThrArg: 3.55 ± 0.051	2.735ThrSer: 2.735 ± 0.054	2.779ThrThr: 2.779 ± 0.056	4.187ThrVal: 4.187 ± 0.062	0.687ThrTrp: 0.687 ± 0.025	1.329ThrTyr: 1.329 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.631ValAla: 8.631 ± 0.102	0.667ValCys: 0.667 ± 0.024	4.308ValAsp: 4.308 ± 0.063	4.65ValGlu: 4.65 ± 0.065	3.025ValPhe: 3.025 ± 0.051	5.502ValGly: 5.502 ± 0.071	1.451ValHis: 1.451 ± 0.031	4.295ValIle: 4.295 ± 0.06	2.267ValLys: 2.267 ± 0.047	7.539ValLeu: 7.539 ± 0.094	2.229ValMet: 2.229 ± 0.044	2.034ValAsn: 2.034 ± 0.04	3.543ValPro: 3.543 ± 0.05	2.165ValGln: 2.165 ± 0.039	4.309ValArg: 4.309 ± 0.064	4.287ValSer: 4.287 ± 0.061	4.406ValThr: 4.406 ± 0.064	5.713ValVal: 5.713 ± 0.085	1.021ValTrp: 1.021 ± 0.03	1.529ValTyr: 1.529 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.442TrpAla: 1.442 ± 0.036	0.138TrpCys: 0.138 ± 0.011	0.777TrpAsp: 0.777 ± 0.023	0.692TrpGlu: 0.692 ± 0.023	0.559TrpPhe: 0.559 ± 0.023	1.076TrpGly: 1.076 ± 0.026	0.368TrpHis: 0.368 ± 0.019	0.727TrpIle: 0.727 ± 0.024	0.524TrpLys: 0.524 ± 0.02	1.546TrpLeu: 1.546 ± 0.035	0.447TrpMet: 0.447 ± 0.02	0.47TrpAsn: 0.47 ± 0.019	0.712TrpPro: 0.712 ± 0.027	0.596TrpGln: 0.596 ± 0.022	1.095TrpArg: 1.095 ± 0.035	0.772TrpSer: 0.772 ± 0.025	0.727TrpThr: 0.727 ± 0.024	0.949TrpVal: 0.949 ± 0.029	0.211TrpTrp: 0.211 ± 0.013	0.309TrpTyr: 0.309 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.515TyrAla: 2.515 ± 0.042	0.265TyrCys: 0.265 ± 0.016	1.65TyrAsp: 1.65 ± 0.04	1.405TyrGlu: 1.405 ± 0.035	0.994TyrPhe: 0.994 ± 0.03	2.146TyrGly: 2.146 ± 0.047	0.567TyrHis: 0.567 ± 0.02	0.901TyrIle: 0.901 ± 0.027	0.638TyrLys: 0.638 ± 0.024	2.324TyrLeu: 2.324 ± 0.043	0.512TyrMet: 0.512 ± 0.019	0.611TyrAsn: 0.611 ± 0.026	1.099TyrPro: 1.099 ± 0.026	0.707TyrGln: 0.707 ± 0.026	1.577TyrArg: 1.577 ± 0.038	1.2TyrSer: 1.2 ± 0.034	1.163TyrThr: 1.163 ± 0.033	1.649TyrVal: 1.649 ± 0.038	0.407TyrTrp: 0.407 ± 0.018	0.607TyrTyr: 0.607 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4052 proteins (1267422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---