Amino acid dipepetide frequency for Lentibacter virus vB_LenP_ICBM3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.975AlaAla: 13.975 ± 4.437
0.319AlaCys: 0.319 ± 0.187
7.028AlaAsp: 7.028 ± 1.078
6.389AlaGlu: 6.389 ± 0.779
2.715AlaPhe: 2.715 ± 0.408
8.146AlaGly: 8.146 ± 1.361
0.799AlaHis: 0.799 ± 0.245
4.153AlaIle: 4.153 ± 0.756
5.67AlaLys: 5.67 ± 0.656
8.465AlaLeu: 8.465 ± 1.187
2.236AlaMet: 2.236 ± 0.421
2.955AlaAsn: 2.955 ± 0.504
2.236AlaPro: 2.236 ± 0.271
3.913AlaGln: 3.913 ± 0.672
3.993AlaArg: 3.993 ± 0.703
7.427AlaSer: 7.427 ± 2.235
7.187AlaThr: 7.187 ± 1.746
6.149AlaVal: 6.149 ± 0.984
1.517AlaTrp: 1.517 ± 0.408
3.753AlaTyr: 3.753 ± 0.476
0.0AlaXaa: 0.0 ± 0.0
Cys
0.559CysAla: 0.559 ± 0.225
0.08CysCys: 0.08 ± 0.086
0.16CysAsp: 0.16 ± 0.108
0.24CysGlu: 0.24 ± 0.159
0.16CysPhe: 0.16 ± 0.164
0.399CysGly: 0.399 ± 0.257
0.24CysHis: 0.24 ± 0.135
0.16CysIle: 0.16 ± 0.139
0.958CysLys: 0.958 ± 0.342
0.719CysLeu: 0.719 ± 0.266
0.24CysMet: 0.24 ± 0.138
0.479CysAsn: 0.479 ± 0.214
0.399CysPro: 0.399 ± 0.194
0.319CysGln: 0.319 ± 0.166
0.319CysArg: 0.319 ± 0.154
0.479CysSer: 0.479 ± 0.207
0.319CysThr: 0.319 ± 0.186
0.399CysVal: 0.399 ± 0.17
0.08CysTrp: 0.08 ± 0.085
0.399CysTyr: 0.399 ± 0.186
0.0CysXaa: 0.0 ± 0.0
Asp
6.309AspAla: 6.309 ± 0.672
0.479AspCys: 0.479 ± 0.276
3.035AspAsp: 3.035 ± 0.458
3.913AspGlu: 3.913 ± 0.558
2.875AspPhe: 2.875 ± 0.473
5.191AspGly: 5.191 ± 0.711
1.358AspHis: 1.358 ± 0.401
4.472AspIle: 4.472 ± 0.51
2.955AspLys: 2.955 ± 0.525
5.351AspLeu: 5.351 ± 0.722
1.278AspMet: 1.278 ± 0.354
2.715AspAsn: 2.715 ± 0.471
3.833AspPro: 3.833 ± 0.539
1.517AspGln: 1.517 ± 0.274
2.635AspArg: 2.635 ± 0.477
3.674AspSer: 3.674 ± 0.527
5.271AspThr: 5.271 ± 0.505
4.712AspVal: 4.712 ± 0.532
0.958AspTrp: 0.958 ± 0.368
2.236AspTyr: 2.236 ± 0.473
0.0AspXaa: 0.0 ± 0.0
Glu
7.667GluAla: 7.667 ± 0.721
0.399GluCys: 0.399 ± 0.184
5.111GluAsp: 5.111 ± 0.792
4.712GluGlu: 4.712 ± 0.675
3.115GluPhe: 3.115 ± 0.379
4.792GluGly: 4.792 ± 0.625
0.799GluHis: 0.799 ± 0.192
4.153GluIle: 4.153 ± 0.573
3.354GluLys: 3.354 ± 0.508
5.67GluLeu: 5.67 ± 0.697
1.917GluMet: 1.917 ± 0.395
2.875GluAsn: 2.875 ± 0.459
1.517GluPro: 1.517 ± 0.332
2.476GluGln: 2.476 ± 0.486
3.594GluArg: 3.594 ± 0.597
2.556GluSer: 2.556 ± 0.423
5.75GluThr: 5.75 ± 1.601
4.233GluVal: 4.233 ± 0.7
1.198GluTrp: 1.198 ± 0.351
2.556GluTyr: 2.556 ± 0.443
0.0GluXaa: 0.0 ± 0.0
Phe
2.156PheAla: 2.156 ± 0.546
0.16PheCys: 0.16 ± 0.11
2.955PheAsp: 2.955 ± 0.497
2.476PheGlu: 2.476 ± 0.421
1.038PhePhe: 1.038 ± 0.252
2.795PheGly: 2.795 ± 0.571
0.878PheHis: 0.878 ± 0.231
2.316PheIle: 2.316 ± 0.468
2.875PheLys: 2.875 ± 0.386
2.316PheLeu: 2.316 ± 0.338
1.278PheMet: 1.278 ± 0.294
2.476PheAsn: 2.476 ± 0.35
1.038PhePro: 1.038 ± 0.277
0.958PheGln: 0.958 ± 0.391
1.358PheArg: 1.358 ± 0.429
2.955PheSer: 2.955 ± 0.588
2.156PheThr: 2.156 ± 0.472
2.156PheVal: 2.156 ± 0.42
0.799PheTrp: 0.799 ± 0.239
1.597PheTyr: 1.597 ± 0.471
0.0PheXaa: 0.0 ± 0.0
Gly
5.989GlyAla: 5.989 ± 0.97
0.479GlyCys: 0.479 ± 0.214
3.594GlyAsp: 3.594 ± 0.461
4.472GlyGlu: 4.472 ± 0.629
3.115GlyPhe: 3.115 ± 0.418
10.462GlyGly: 10.462 ± 4.519
1.198GlyHis: 1.198 ± 0.394
2.556GlyIle: 2.556 ± 0.462
5.031GlyLys: 5.031 ± 0.536
6.069GlyLeu: 6.069 ± 0.936
2.076GlyMet: 2.076 ± 0.357
3.514GlyAsn: 3.514 ± 0.699
1.517GlyPro: 1.517 ± 0.306
2.556GlyGln: 2.556 ± 0.358
3.993GlyArg: 3.993 ± 0.554
6.069GlySer: 6.069 ± 1.015
6.628GlyThr: 6.628 ± 0.844
5.111GlyVal: 5.111 ± 0.674
1.358GlyTrp: 1.358 ± 0.33
2.795GlyTyr: 2.795 ± 0.523
0.0GlyXaa: 0.0 ± 0.0
His
1.038HisAla: 1.038 ± 0.294
0.16HisCys: 0.16 ± 0.135
0.559HisAsp: 0.559 ± 0.256
0.958HisGlu: 0.958 ± 0.322
0.479HisPhe: 0.479 ± 0.21
0.878HisGly: 0.878 ± 0.244
0.08HisHis: 0.08 ± 0.079
0.958HisIle: 0.958 ± 0.34
1.517HisLys: 1.517 ± 0.303
1.837HisLeu: 1.837 ± 0.376
0.639HisMet: 0.639 ± 0.23
0.559HisAsn: 0.559 ± 0.187
0.639HisPro: 0.639 ± 0.345
0.719HisGln: 0.719 ± 0.329
0.799HisArg: 0.799 ± 0.278
0.719HisSer: 0.719 ± 0.165
0.479HisThr: 0.479 ± 0.186
1.278HisVal: 1.278 ± 0.335
0.16HisTrp: 0.16 ± 0.111
0.479HisTyr: 0.479 ± 0.167
0.0HisXaa: 0.0 ± 0.0
Ile
4.632IleAla: 4.632 ± 0.711
0.479IleCys: 0.479 ± 0.166
4.153IleAsp: 4.153 ± 0.457
2.955IleGlu: 2.955 ± 0.459
1.358IlePhe: 1.358 ± 0.36
3.274IleGly: 3.274 ± 0.52
0.559IleHis: 0.559 ± 0.233
2.236IleIle: 2.236 ± 0.402
2.955IleLys: 2.955 ± 0.54
3.753IleLeu: 3.753 ± 0.638
1.278IleMet: 1.278 ± 0.29
2.076IleAsn: 2.076 ± 0.414
1.996IlePro: 1.996 ± 0.539
1.597IleGln: 1.597 ± 0.469
2.396IleArg: 2.396 ± 0.419
3.753IleSer: 3.753 ± 0.519
3.035IleThr: 3.035 ± 0.472
3.194IleVal: 3.194 ± 0.451
0.319IleTrp: 0.319 ± 0.16
2.396IleTyr: 2.396 ± 0.494
0.0IleXaa: 0.0 ± 0.0
Lys
5.83LysAla: 5.83 ± 1.175
0.08LysCys: 0.08 ± 0.097
3.753LysAsp: 3.753 ± 0.541
5.111LysGlu: 5.111 ± 0.801
2.076LysPhe: 2.076 ± 0.479
3.594LysGly: 3.594 ± 0.63
0.799LysHis: 0.799 ± 0.337
3.115LysIle: 3.115 ± 0.508
3.913LysLys: 3.913 ± 0.571
5.191LysLeu: 5.191 ± 0.64
1.677LysMet: 1.677 ± 0.342
1.837LysAsn: 1.837 ± 0.497
2.556LysPro: 2.556 ± 0.503
3.035LysGln: 3.035 ± 0.601
3.594LysArg: 3.594 ± 0.678
3.674LysSer: 3.674 ± 0.638
3.993LysThr: 3.993 ± 0.683
3.753LysVal: 3.753 ± 0.449
0.559LysTrp: 0.559 ± 0.221
1.757LysTyr: 1.757 ± 0.378
0.0LysXaa: 0.0 ± 0.0
Leu
8.066LeuAla: 8.066 ± 0.946
0.719LeuCys: 0.719 ± 0.254
6.548LeuAsp: 6.548 ± 0.78
5.59LeuGlu: 5.59 ± 0.881
3.035LeuPhe: 3.035 ± 0.609
6.548LeuGly: 6.548 ± 0.663
1.198LeuHis: 1.198 ± 0.301
2.795LeuIle: 2.795 ± 0.554
5.271LeuLys: 5.271 ± 0.69
5.59LeuLeu: 5.59 ± 0.649
1.837LeuMet: 1.837 ± 0.292
5.191LeuAsn: 5.191 ± 0.488
2.795LeuPro: 2.795 ± 0.673
2.715LeuGln: 2.715 ± 0.431
3.833LeuArg: 3.833 ± 0.508
6.149LeuSer: 6.149 ± 0.708
5.191LeuThr: 5.191 ± 0.592
4.233LeuVal: 4.233 ± 0.625
1.038LeuTrp: 1.038 ± 0.324
2.156LeuTyr: 2.156 ± 0.444
0.0LeuXaa: 0.0 ± 0.0
Met
3.115MetAla: 3.115 ± 0.451
0.319MetCys: 0.319 ± 0.172
1.437MetAsp: 1.437 ± 0.356
1.996MetGlu: 1.996 ± 0.393
0.719MetPhe: 0.719 ± 0.233
2.556MetGly: 2.556 ± 0.48
0.319MetHis: 0.319 ± 0.157
0.799MetIle: 0.799 ± 0.266
2.076MetLys: 2.076 ± 0.338
2.236MetLeu: 2.236 ± 0.436
0.719MetMet: 0.719 ± 0.225
0.958MetAsn: 0.958 ± 0.28
0.559MetPro: 0.559 ± 0.196
1.038MetGln: 1.038 ± 0.341
1.118MetArg: 1.118 ± 0.271
2.396MetSer: 2.396 ± 0.442
1.996MetThr: 1.996 ± 0.36
1.038MetVal: 1.038 ± 0.278
0.16MetTrp: 0.16 ± 0.12
0.559MetTyr: 0.559 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
4.073AsnAla: 4.073 ± 1.374
0.799AsnCys: 0.799 ± 0.274
2.875AsnAsp: 2.875 ± 0.419
2.156AsnGlu: 2.156 ± 0.388
1.437AsnPhe: 1.437 ± 0.426
3.434AsnGly: 3.434 ± 0.551
0.24AsnHis: 0.24 ± 0.118
3.194AsnIle: 3.194 ± 0.46
2.396AsnLys: 2.396 ± 0.535
3.674AsnLeu: 3.674 ± 0.579
1.437AsnMet: 1.437 ± 0.401
3.115AsnAsn: 3.115 ± 0.578
2.316AsnPro: 2.316 ± 0.362
0.958AsnGln: 0.958 ± 0.262
2.156AsnArg: 2.156 ± 0.402
2.476AsnSer: 2.476 ± 0.432
3.115AsnThr: 3.115 ± 0.501
3.274AsnVal: 3.274 ± 0.628
0.24AsnTrp: 0.24 ± 0.137
2.396AsnTyr: 2.396 ± 0.479
0.0AsnXaa: 0.0 ± 0.0
Pro
3.354ProAla: 3.354 ± 0.498
0.399ProCys: 0.399 ± 0.173
2.316ProAsp: 2.316 ± 0.453
2.875ProGlu: 2.875 ± 0.511
1.597ProPhe: 1.597 ± 0.383
0.16ProGly: 0.16 ± 0.102
0.479ProHis: 0.479 ± 0.202
1.996ProIle: 1.996 ± 0.344
1.917ProLys: 1.917 ± 0.44
2.156ProLeu: 2.156 ± 0.394
1.278ProMet: 1.278 ± 0.284
1.677ProAsn: 1.677 ± 0.286
0.719ProPro: 0.719 ± 0.303
1.677ProGln: 1.677 ± 0.337
1.278ProArg: 1.278 ± 0.357
3.753ProSer: 3.753 ± 0.486
2.795ProThr: 2.795 ± 0.395
2.396ProVal: 2.396 ± 0.356
0.319ProTrp: 0.319 ± 0.162
1.118ProTyr: 1.118 ± 0.247
0.0ProXaa: 0.0 ± 0.0
Gln
4.073GlnAla: 4.073 ± 0.747
0.16GlnCys: 0.16 ± 0.109
1.677GlnAsp: 1.677 ± 0.389
2.556GlnGlu: 2.556 ± 0.438
0.958GlnPhe: 0.958 ± 0.274
2.556GlnGly: 2.556 ± 0.371
0.958GlnHis: 0.958 ± 0.334
1.757GlnIle: 1.757 ± 0.432
2.556GlnLys: 2.556 ± 0.34
2.955GlnLeu: 2.955 ± 0.437
1.198GlnMet: 1.198 ± 0.267
1.517GlnAsn: 1.517 ± 0.494
1.038GlnPro: 1.038 ± 0.276
1.517GlnGln: 1.517 ± 0.337
1.837GlnArg: 1.837 ± 0.431
1.996GlnSer: 1.996 ± 0.343
2.316GlnThr: 2.316 ± 0.425
2.875GlnVal: 2.875 ± 0.518
0.24GlnTrp: 0.24 ± 0.125
0.958GlnTyr: 0.958 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
3.674ArgAla: 3.674 ± 0.661
0.399ArgCys: 0.399 ± 0.218
3.674ArgAsp: 3.674 ± 0.483
2.875ArgGlu: 2.875 ± 0.544
1.278ArgPhe: 1.278 ± 0.317
3.753ArgGly: 3.753 ± 0.61
1.198ArgHis: 1.198 ± 0.285
2.795ArgIle: 2.795 ± 0.54
2.955ArgLys: 2.955 ± 0.569
4.153ArgLeu: 4.153 ± 0.673
1.278ArgMet: 1.278 ± 0.249
2.156ArgAsn: 2.156 ± 0.42
0.958ArgPro: 0.958 ± 0.274
2.076ArgGln: 2.076 ± 0.441
1.837ArgArg: 1.837 ± 0.655
2.875ArgSer: 2.875 ± 0.437
1.677ArgThr: 1.677 ± 0.311
3.354ArgVal: 3.354 ± 0.545
0.958ArgTrp: 0.958 ± 0.27
1.917ArgTyr: 1.917 ± 0.366
0.0ArgXaa: 0.0 ± 0.0
Ser
6.069SerAla: 6.069 ± 1.188
0.559SerCys: 0.559 ± 0.222
4.233SerAsp: 4.233 ± 0.633
5.271SerGlu: 5.271 ± 1.561
3.194SerPhe: 3.194 ± 0.491
5.75SerGly: 5.75 ± 0.918
1.118SerHis: 1.118 ± 0.281
2.556SerIle: 2.556 ± 0.389
3.594SerLys: 3.594 ± 0.7
5.111SerLeu: 5.111 ± 0.742
1.278SerMet: 1.278 ± 0.288
3.354SerAsn: 3.354 ± 0.397
3.035SerPro: 3.035 ± 0.631
2.236SerGln: 2.236 ± 0.448
2.156SerArg: 2.156 ± 0.438
5.031SerSer: 5.031 ± 0.671
4.632SerThr: 4.632 ± 1.11
5.191SerVal: 5.191 ± 0.637
1.517SerTrp: 1.517 ± 0.265
2.635SerTyr: 2.635 ± 0.449
0.0SerXaa: 0.0 ± 0.0
Thr
7.667ThrAla: 7.667 ± 1.512
0.24ThrCys: 0.24 ± 0.134
3.993ThrAsp: 3.993 ± 0.56
4.552ThrGlu: 4.552 ± 0.527
2.715ThrPhe: 2.715 ± 0.652
5.83ThrGly: 5.83 ± 1.006
1.437ThrHis: 1.437 ± 0.336
2.236ThrIle: 2.236 ± 0.383
3.514ThrLys: 3.514 ± 0.651
5.191ThrLeu: 5.191 ± 0.859
1.757ThrMet: 1.757 ± 0.404
3.035ThrAsn: 3.035 ± 1.148
2.715ThrPro: 2.715 ± 0.387
2.476ThrGln: 2.476 ± 0.391
3.514ThrArg: 3.514 ± 0.563
5.191ThrSer: 5.191 ± 1.016
4.632ThrThr: 4.632 ± 0.819
4.871ThrVal: 4.871 ± 0.728
1.358ThrTrp: 1.358 ± 0.453
2.316ThrTyr: 2.316 ± 0.55
0.0ThrXaa: 0.0 ± 0.0
Val
6.628ValAla: 6.628 ± 0.676
0.479ValCys: 0.479 ± 0.196
4.392ValAsp: 4.392 ± 0.701
5.271ValGlu: 5.271 ± 0.74
2.715ValPhe: 2.715 ± 0.536
4.792ValGly: 4.792 ± 0.583
0.719ValHis: 0.719 ± 0.273
3.674ValIle: 3.674 ± 0.658
3.274ValLys: 3.274 ± 0.599
5.59ValLeu: 5.59 ± 0.66
1.278ValMet: 1.278 ± 0.306
3.115ValAsn: 3.115 ± 0.729
2.715ValPro: 2.715 ± 0.513
1.917ValGln: 1.917 ± 0.451
2.635ValArg: 2.635 ± 0.487
4.632ValSer: 4.632 ± 0.735
4.712ValThr: 4.712 ± 0.542
5.031ValVal: 5.031 ± 0.734
0.958ValTrp: 0.958 ± 0.285
1.837ValTyr: 1.837 ± 0.417
0.0ValXaa: 0.0 ± 0.0
Trp
1.358TrpAla: 1.358 ± 0.266
0.0TrpCys: 0.0 ± 0.0
0.719TrpAsp: 0.719 ± 0.195
1.278TrpGlu: 1.278 ± 0.369
0.878TrpPhe: 0.878 ± 0.248
0.958TrpGly: 0.958 ± 0.364
0.16TrpHis: 0.16 ± 0.108
0.639TrpIle: 0.639 ± 0.281
1.038TrpLys: 1.038 ± 0.386
1.198TrpLeu: 1.198 ± 0.354
0.24TrpMet: 0.24 ± 0.124
0.799TrpAsn: 0.799 ± 0.228
0.559TrpPro: 0.559 ± 0.241
0.479TrpGln: 0.479 ± 0.19
0.719TrpArg: 0.719 ± 0.259
0.319TrpSer: 0.319 ± 0.181
1.118TrpThr: 1.118 ± 0.298
1.198TrpVal: 1.198 ± 0.356
0.16TrpTrp: 0.16 ± 0.126
0.559TrpTyr: 0.559 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.795TyrAla: 2.795 ± 0.567
0.399TyrCys: 0.399 ± 0.176
2.635TyrAsp: 2.635 ± 0.424
2.795TyrGlu: 2.795 ± 0.434
1.278TyrPhe: 1.278 ± 0.319
2.715TyrGly: 2.715 ± 0.662
0.399TyrHis: 0.399 ± 0.216
1.837TyrIle: 1.837 ± 0.378
2.076TyrLys: 2.076 ± 0.445
3.274TyrLeu: 3.274 ± 0.535
1.118TyrMet: 1.118 ± 0.28
1.358TyrAsn: 1.358 ± 0.32
1.118TyrPro: 1.118 ± 0.317
1.517TyrGln: 1.517 ± 0.385
2.076TyrArg: 2.076 ± 0.388
2.396TyrSer: 2.396 ± 0.552
2.236TyrThr: 2.236 ± 0.473
1.917TyrVal: 1.917 ± 0.425
0.479TyrTrp: 0.479 ± 0.214
1.038TyrTyr: 1.038 ± 0.312
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (12523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski