Amino acid dipepetide frequency for Sphingobium chlorophenolicum L-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.435AlaAla: 18.435 ± 0.161	1.047AlaCys: 1.047 ± 0.031	7.583AlaAsp: 7.583 ± 0.08	7.323AlaGlu: 7.323 ± 0.083	4.33AlaPhe: 4.33 ± 0.062	11.233AlaGly: 11.233 ± 0.114	2.433AlaHis: 2.433 ± 0.048	6.658AlaIle: 6.658 ± 0.074	3.995AlaLys: 3.995 ± 0.068	13.834AlaLeu: 13.834 ± 0.118	3.885AlaMet: 3.885 ± 0.059	3.208AlaAsn: 3.208 ± 0.056	6.076AlaPro: 6.076 ± 0.077	4.779AlaGln: 4.779 ± 0.07	9.34AlaArg: 9.34 ± 0.102	6.604AlaSer: 6.604 ± 0.09	6.132AlaThr: 6.132 ± 0.073	8.451AlaVal: 8.451 ± 0.095	1.476AlaTrp: 1.476 ± 0.035	2.704AlaTyr: 2.704 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.063CysAla: 1.063 ± 0.029	0.087CysCys: 0.087 ± 0.008	0.532CysAsp: 0.532 ± 0.02	0.398CysGlu: 0.398 ± 0.02	0.292CysPhe: 0.292 ± 0.013	0.882CysGly: 0.882 ± 0.023	0.218CysHis: 0.218 ± 0.019	0.389CysIle: 0.389 ± 0.018	0.17CysLys: 0.17 ± 0.012	0.703CysLeu: 0.703 ± 0.022	0.176CysMet: 0.176 ± 0.013	0.196CysAsn: 0.196 ± 0.012	0.457CysPro: 0.457 ± 0.02	0.207CysGln: 0.207 ± 0.013	0.571CysArg: 0.571 ± 0.022	0.459CysSer: 0.459 ± 0.019	0.418CysThr: 0.418 ± 0.018	0.562CysVal: 0.562 ± 0.021	0.123CysTrp: 0.123 ± 0.01	0.16CysTyr: 0.16 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.592AspAla: 7.592 ± 0.083	0.481AspCys: 0.481 ± 0.021	3.188AspAsp: 3.188 ± 0.058	3.258AspGlu: 3.258 ± 0.06	2.217AspPhe: 2.217 ± 0.048	5.568AspGly: 5.568 ± 0.1	1.403AspHis: 1.403 ± 0.034	3.236AspIle: 3.236 ± 0.053	1.656AspLys: 1.656 ± 0.042	5.804AspLeu: 5.804 ± 0.066	1.59AspMet: 1.59 ± 0.033	1.439AspAsn: 1.439 ± 0.036	3.658AspPro: 3.658 ± 0.05	1.839AspGln: 1.839 ± 0.034	4.916AspArg: 4.916 ± 0.069	2.496AspSer: 2.496 ± 0.044	2.262AspThr: 2.262 ± 0.036	3.998AspVal: 3.998 ± 0.059	1.07AspTrp: 1.07 ± 0.03	1.762AspTyr: 1.762 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.543GluAla: 7.543 ± 0.091	0.333GluCys: 0.333 ± 0.015	2.751GluAsp: 2.751 ± 0.044	3.324GluGlu: 3.324 ± 0.068	1.472GluPhe: 1.472 ± 0.037	4.713GluGly: 4.713 ± 0.065	1.067GluHis: 1.067 ± 0.031	2.989GluIle: 2.989 ± 0.046	2.153GluLys: 2.153 ± 0.04	4.794GluLeu: 4.794 ± 0.059	1.492GluMet: 1.492 ± 0.038	1.397GluAsn: 1.397 ± 0.035	2.361GluPro: 2.361 ± 0.044	2.168GluGln: 2.168 ± 0.046	4.918GluArg: 4.918 ± 0.065	2.373GluSer: 2.373 ± 0.045	2.895GluThr: 2.895 ± 0.046	3.342GluVal: 3.342 ± 0.059	0.746GluTrp: 0.746 ± 0.024	1.012GluTyr: 1.012 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.626PheAla: 4.626 ± 0.06	0.373PheCys: 0.373 ± 0.016	2.646PheAsp: 2.646 ± 0.048	1.946PheGlu: 1.946 ± 0.042	1.281PhePhe: 1.281 ± 0.035	3.674PheGly: 3.674 ± 0.058	0.756PheHis: 0.756 ± 0.028	1.575PheIle: 1.575 ± 0.035	0.872PheLys: 0.872 ± 0.028	3.181PheLeu: 3.181 ± 0.055	0.8PheMet: 0.8 ± 0.024	1.112PheAsn: 1.112 ± 0.027	1.609PhePro: 1.609 ± 0.032	0.944PheGln: 0.944 ± 0.027	2.305PheArg: 2.305 ± 0.047	2.153PheSer: 2.153 ± 0.039	2.047PheThr: 2.047 ± 0.046	2.402PheVal: 2.402 ± 0.046	0.506PheTrp: 0.506 ± 0.023	0.948PheTyr: 0.948 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.054GlyAla: 10.054 ± 0.105	0.827GlyCys: 0.827 ± 0.03	4.874GlyAsp: 4.874 ± 0.076	4.788GlyGlu: 4.788 ± 0.069	3.62GlyPhe: 3.62 ± 0.056	8.632GlyGly: 8.632 ± 0.164	1.924GlyHis: 1.924 ± 0.039	4.553GlyIle: 4.553 ± 0.061	3.28GlyLys: 3.28 ± 0.059	8.812GlyLeu: 8.812 ± 0.09	2.527GlyMet: 2.527 ± 0.045	2.455GlyAsn: 2.455 ± 0.06	3.767GlyPro: 3.767 ± 0.057	3.209GlyGln: 3.209 ± 0.046	6.716GlyArg: 6.716 ± 0.078	4.988GlySer: 4.988 ± 0.094	4.766GlyThr: 4.766 ± 0.138	6.382GlyVal: 6.382 ± 0.082	1.689GlyTrp: 1.689 ± 0.039	2.443GlyTyr: 2.443 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.43HisAla: 2.43 ± 0.048	0.233HisCys: 0.233 ± 0.014	1.261HisAsp: 1.261 ± 0.033	0.957HisGlu: 0.957 ± 0.028	0.888HisPhe: 0.888 ± 0.025	2.052HisGly: 2.052 ± 0.04	0.587HisHis: 0.587 ± 0.023	1.032HisIle: 1.032 ± 0.027	0.462HisLys: 0.462 ± 0.02	1.927HisLeu: 1.927 ± 0.037	0.53HisMet: 0.53 ± 0.018	0.461HisAsn: 0.461 ± 0.019	1.331HisPro: 1.331 ± 0.034	0.578HisGln: 0.578 ± 0.021	1.437HisArg: 1.437 ± 0.029	1.011HisSer: 1.011 ± 0.029	0.556HisThr: 0.556 ± 0.021	1.601HisVal: 1.601 ± 0.039	0.376HisTrp: 0.376 ± 0.018	0.634HisTyr: 0.634 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.801IleAla: 7.801 ± 0.086	0.485IleCys: 0.485 ± 0.02	4.002IleAsp: 4.002 ± 0.051	3.262IleGlu: 3.262 ± 0.046	1.778IlePhe: 1.778 ± 0.04	5.091IleGly: 5.091 ± 0.065	0.923IleHis: 0.923 ± 0.029	2.211IleIle: 2.211 ± 0.048	1.203IleLys: 1.203 ± 0.031	4.314IleLeu: 4.314 ± 0.067	1.027IleMet: 1.027 ± 0.03	1.44IleAsn: 1.44 ± 0.04	2.317IlePro: 2.317 ± 0.044	1.285IleGln: 1.285 ± 0.037	3.323IleArg: 3.323 ± 0.053	2.91IleSer: 2.91 ± 0.045	2.432IleThr: 2.432 ± 0.048	4.291IleVal: 4.291 ± 0.057	0.615IleTrp: 0.615 ± 0.022	1.075IleTyr: 1.075 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.205LysAla: 4.205 ± 0.068	0.16LysCys: 0.16 ± 0.011	1.68LysAsp: 1.68 ± 0.037	1.322LysGlu: 1.322 ± 0.035	0.867LysPhe: 0.867 ± 0.028	2.861LysGly: 2.861 ± 0.05	0.475LysHis: 0.475 ± 0.02	1.522LysIle: 1.522 ± 0.038	1.085LysLys: 1.085 ± 0.035	3.133LysLeu: 3.133 ± 0.055	0.756LysMet: 0.756 ± 0.023	0.747LysAsn: 0.747 ± 0.025	1.978LysPro: 1.978 ± 0.04	0.935LysGln: 0.935 ± 0.027	2.199LysArg: 2.199 ± 0.042	1.595LysSer: 1.595 ± 0.033	1.602LysThr: 1.602 ± 0.036	2.216LysVal: 2.216 ± 0.043	0.41LysTrp: 0.41 ± 0.018	0.6LysTyr: 0.6 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.397LeuAla: 13.397 ± 0.123	0.905LeuCys: 0.905 ± 0.028	5.956LeuAsp: 5.956 ± 0.066	4.821LeuGlu: 4.821 ± 0.069	3.759LeuPhe: 3.759 ± 0.061	8.127LeuGly: 8.127 ± 0.089	1.921LeuHis: 1.921 ± 0.036	5.087LeuIle: 5.087 ± 0.07	3.151LeuLys: 3.151 ± 0.052	9.696LeuLeu: 9.696 ± 0.129	2.314LeuMet: 2.314 ± 0.046	2.617LeuAsn: 2.617 ± 0.052	5.613LeuPro: 5.613 ± 0.069	2.49LeuGln: 2.49 ± 0.048	6.974LeuArg: 6.974 ± 0.08	6.415LeuSer: 6.415 ± 0.078	5.66LeuThr: 5.66 ± 0.072	6.552LeuVal: 6.552 ± 0.072	1.255LeuTrp: 1.255 ± 0.032	2.045LeuTyr: 2.045 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.555MetAla: 3.555 ± 0.06	0.156MetCys: 0.156 ± 0.012	1.259MetAsp: 1.259 ± 0.036	1.237MetGlu: 1.237 ± 0.029	0.697MetPhe: 0.697 ± 0.022	2.087MetGly: 2.087 ± 0.047	0.457MetHis: 0.457 ± 0.02	1.376MetIle: 1.376 ± 0.037	0.965MetLys: 0.965 ± 0.029	2.738MetLeu: 2.738 ± 0.054	0.764MetMet: 0.764 ± 0.026	0.791MetAsn: 0.791 ± 0.024	1.507MetPro: 1.507 ± 0.032	0.821MetGln: 0.821 ± 0.024	1.873MetArg: 1.873 ± 0.041	1.525MetSer: 1.525 ± 0.037	1.875MetThr: 1.875 ± 0.04	1.631MetVal: 1.631 ± 0.041	0.216MetTrp: 0.216 ± 0.012	0.246MetTyr: 0.246 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.431AsnAla: 3.431 ± 0.064	0.234AsnCys: 0.234 ± 0.015	1.489AsnAsp: 1.489 ± 0.039	1.138AsnGlu: 1.138 ± 0.032	1.008AsnPhe: 1.008 ± 0.031	2.742AsnGly: 2.742 ± 0.069	0.468AsnHis: 0.468 ± 0.018	1.475AsnIle: 1.475 ± 0.035	0.659AsnLys: 0.659 ± 0.021	2.652AsnLeu: 2.652 ± 0.057	0.622AsnMet: 0.622 ± 0.023	0.798AsnAsn: 0.798 ± 0.034	1.751AsnPro: 1.751 ± 0.036	0.772AsnGln: 0.772 ± 0.024	1.978AsnArg: 1.978 ± 0.042	1.346AsnSer: 1.346 ± 0.048	0.955AsnThr: 0.955 ± 0.032	1.973AsnVal: 1.973 ± 0.048	0.464AsnTrp: 0.464 ± 0.02	0.725AsnTyr: 0.725 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.708ProAla: 6.708 ± 0.078	0.339ProCys: 0.339 ± 0.017	3.764ProAsp: 3.764 ± 0.056	3.361ProGlu: 3.361 ± 0.055	1.985ProPhe: 1.985 ± 0.041	4.816ProGly: 4.816 ± 0.065	1.125ProHis: 1.125 ± 0.03	2.43ProIle: 2.43 ± 0.041	1.478ProLys: 1.478 ± 0.035	5.033ProLeu: 5.033 ± 0.066	1.316ProMet: 1.316 ± 0.031	1.357ProAsn: 1.357 ± 0.034	2.735ProPro: 2.735 ± 0.065	1.777ProGln: 1.777 ± 0.037	3.006ProArg: 3.006 ± 0.056	2.746ProSer: 2.746 ± 0.047	2.54ProThr: 2.54 ± 0.043	4.46ProVal: 4.46 ± 0.066	0.723ProTrp: 0.723 ± 0.024	1.076ProTyr: 1.076 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.424GlnAla: 4.424 ± 0.06	0.248GlnCys: 0.248 ± 0.016	1.509GlnAsp: 1.509 ± 0.034	1.509GlnGlu: 1.509 ± 0.035	1.142GlnPhe: 1.142 ± 0.027	2.711GlnGly: 2.711 ± 0.048	0.6GlnHis: 0.6 ± 0.021	1.872GlnIle: 1.872 ± 0.04	0.988GlnLys: 0.988 ± 0.029	3.03GlnLeu: 3.03 ± 0.049	0.93GlnMet: 0.93 ± 0.028	0.821GlnAsn: 0.821 ± 0.024	1.902GlnPro: 1.902 ± 0.036	1.188GlnGln: 1.188 ± 0.034	2.524GlnArg: 2.524 ± 0.045	1.826GlnSer: 1.826 ± 0.039	1.62GlnThr: 1.62 ± 0.033	2.253GlnVal: 2.253 ± 0.045	0.505GlnTrp: 0.505 ± 0.019	0.676GlnTyr: 0.676 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.322ArgAla: 8.322 ± 0.086	0.489ArgCys: 0.489 ± 0.02	4.23ArgAsp: 4.23 ± 0.058	3.943ArgGlu: 3.943 ± 0.059	3.142ArgPhe: 3.142 ± 0.049	5.054ArgGly: 5.054 ± 0.078	1.768ArgHis: 1.768 ± 0.038	4.41ArgIle: 4.41 ± 0.056	2.255ArgLys: 2.255 ± 0.047	8.249ArgLeu: 8.249 ± 0.094	1.994ArgMet: 1.994 ± 0.043	1.956ArgAsn: 1.956 ± 0.037	3.865ArgPro: 3.865 ± 0.07	2.699ArgGln: 2.699 ± 0.05	5.713ArgArg: 5.713 ± 0.09	3.796ArgSer: 3.796 ± 0.05	3.373ArgThr: 3.373 ± 0.061	4.586ArgVal: 4.586 ± 0.059	1.212ArgTrp: 1.212 ± 0.034	1.93ArgTyr: 1.93 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.478SerAla: 6.478 ± 0.089	0.458SerCys: 0.458 ± 0.02	3.085SerAsp: 3.085 ± 0.044	2.573SerGlu: 2.573 ± 0.045	2.282SerPhe: 2.282 ± 0.048	5.849SerGly: 5.849 ± 0.103	1.038SerHis: 1.038 ± 0.028	2.857SerIle: 2.857 ± 0.047	1.387SerLys: 1.387 ± 0.036	5.316SerLeu: 5.316 ± 0.068	1.314SerMet: 1.314 ± 0.033	1.419SerAsn: 1.419 ± 0.039	2.911SerPro: 2.911 ± 0.051	1.641SerGln: 1.641 ± 0.038	3.689SerArg: 3.689 ± 0.049	2.969SerSer: 2.969 ± 0.061	2.651SerThr: 2.651 ± 0.055	3.803SerVal: 3.803 ± 0.054	0.768SerTrp: 0.768 ± 0.024	1.487SerTyr: 1.487 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.138ThrAla: 6.138 ± 0.069	0.364ThrCys: 0.364 ± 0.019	2.831ThrAsp: 2.831 ± 0.053	2.266ThrGlu: 2.266 ± 0.041	1.613ThrPhe: 1.613 ± 0.038	5.308ThrGly: 5.308 ± 0.099	0.945ThrHis: 0.945 ± 0.028	2.834ThrIle: 2.834 ± 0.064	1.26ThrLys: 1.26 ± 0.034	5.703ThrLeu: 5.703 ± 0.104	1.14ThrMet: 1.14 ± 0.031	1.2ThrAsn: 1.2 ± 0.037	3.318ThrPro: 3.318 ± 0.048	1.493ThrGln: 1.493 ± 0.036	3.175ThrArg: 3.175 ± 0.051	2.566ThrSer: 2.566 ± 0.054	2.454ThrThr: 2.454 ± 0.059	4.066ThrVal: 4.066 ± 0.062	0.544ThrTrp: 0.544 ± 0.022	1.159ThrTyr: 1.159 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.201ValAla: 9.201 ± 0.096	0.489ValCys: 0.489 ± 0.019	4.407ValAsp: 4.407 ± 0.061	4.64ValGlu: 4.64 ± 0.068	1.988ValPhe: 1.988 ± 0.041	5.6ValGly: 5.6 ± 0.066	1.346ValHis: 1.346 ± 0.035	3.635ValIle: 3.635 ± 0.058	2.219ValLys: 2.219 ± 0.045	6.014ValLeu: 6.014 ± 0.064	1.717ValMet: 1.717 ± 0.041	2.156ValAsn: 2.156 ± 0.058	3.862ValPro: 3.862 ± 0.056	2.159ValGln: 2.159 ± 0.045	5.019ValArg: 5.019 ± 0.068	3.978ValSer: 3.978 ± 0.052	4.359ValThr: 4.359 ± 0.069	4.986ValVal: 4.986 ± 0.071	0.746ValTrp: 0.746 ± 0.024	1.376ValTyr: 1.376 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.413TrpAla: 1.413 ± 0.038	0.117TrpCys: 0.117 ± 0.01	0.737TrpAsp: 0.737 ± 0.025	0.624TrpGlu: 0.624 ± 0.024	0.506TrpPhe: 0.506 ± 0.022	1.011TrpGly: 1.011 ± 0.032	0.342TrpHis: 0.342 ± 0.014	0.697TrpIle: 0.697 ± 0.023	0.488TrpLys: 0.488 ± 0.019	1.677TrpLeu: 1.677 ± 0.042	0.381TrpMet: 0.381 ± 0.016	0.467TrpAsn: 0.467 ± 0.019	0.698TrpPro: 0.698 ± 0.025	0.578TrpGln: 0.578 ± 0.02	1.329TrpArg: 1.329 ± 0.037	0.897TrpSer: 0.897 ± 0.028	0.806TrpThr: 0.806 ± 0.029	0.775TrpVal: 0.775 ± 0.024	0.228TrpTrp: 0.228 ± 0.013	0.288TrpTyr: 0.288 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.713TyrAla: 2.713 ± 0.044	0.238TyrCys: 0.238 ± 0.013	1.65TyrAsp: 1.65 ± 0.042	1.155TyrGlu: 1.155 ± 0.03	0.888TyrPhe: 0.888 ± 0.029	2.299TyrGly: 2.299 ± 0.041	0.546TyrHis: 0.546 ± 0.021	0.947TyrIle: 0.947 ± 0.026	0.623TyrLys: 0.623 ± 0.023	2.146TyrLeu: 2.146 ± 0.046	0.499TyrMet: 0.499 ± 0.022	0.641TyrAsn: 0.641 ± 0.021	1.058TyrPro: 1.058 ± 0.027	0.715TyrGln: 0.715 ± 0.025	1.978TyrArg: 1.978 ± 0.037	1.325TyrSer: 1.325 ± 0.038	0.976TyrThr: 0.976 ± 0.036	1.565TyrVal: 1.565 ± 0.032	0.386TyrTrp: 0.386 ± 0.019	0.685TyrTyr: 0.685 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4062 proteins (1340733 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---