Amino acid dipepetide frequency for Lachnospiraceae bacterium A2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.12AlaAla: 8.12 ± 0.1
1.115AlaCys: 1.115 ± 0.032
4.241AlaAsp: 4.241 ± 0.057
6.164AlaGlu: 6.164 ± 0.083
3.1AlaPhe: 3.1 ± 0.046
6.884AlaGly: 6.884 ± 0.072
1.107AlaHis: 1.107 ± 0.026
4.748AlaIle: 4.748 ± 0.06
5.184AlaLys: 5.184 ± 0.065
6.922AlaLeu: 6.922 ± 0.079
2.486AlaMet: 2.486 ± 0.042
2.549AlaAsn: 2.549 ± 0.048
2.15AlaPro: 2.15 ± 0.047
2.607AlaGln: 2.607 ± 0.047
3.124AlaArg: 3.124 ± 0.053
3.982AlaSer: 3.982 ± 0.061
3.013AlaThr: 3.013 ± 0.055
6.203AlaVal: 6.203 ± 0.07
0.738AlaTrp: 0.738 ± 0.022
2.875AlaTyr: 2.875 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.007CysAla: 1.007 ± 0.027
0.305CysCys: 0.305 ± 0.015
0.674CysAsp: 0.674 ± 0.02
0.857CysGlu: 0.857 ± 0.024
0.707CysPhe: 0.707 ± 0.023
1.54CysGly: 1.54 ± 0.044
0.344CysHis: 0.344 ± 0.016
1.128CysIle: 1.128 ± 0.027
0.935CysLys: 0.935 ± 0.029
1.305CysLeu: 1.305 ± 0.031
0.49CysMet: 0.49 ± 0.016
0.565CysAsn: 0.565 ± 0.021
0.684CysPro: 0.684 ± 0.026
0.502CysGln: 0.502 ± 0.019
0.878CysArg: 0.878 ± 0.025
1.007CysSer: 1.007 ± 0.028
0.766CysThr: 0.766 ± 0.023
0.88CysVal: 0.88 ± 0.024
0.134CysTrp: 0.134 ± 0.009
0.602CysTyr: 0.602 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.825AspAla: 3.825 ± 0.053
0.824AspCys: 0.824 ± 0.028
2.436AspAsp: 2.436 ± 0.043
3.823AspGlu: 3.823 ± 0.058
2.631AspPhe: 2.631 ± 0.044
4.659AspGly: 4.659 ± 0.062
0.61AspHis: 0.61 ± 0.02
4.277AspIle: 4.277 ± 0.057
3.394AspLys: 3.394 ± 0.059
4.103AspLeu: 4.103 ± 0.061
1.793AspMet: 1.793 ± 0.038
1.998AspAsn: 1.998 ± 0.039
1.412AspPro: 1.412 ± 0.034
0.961AspGln: 0.961 ± 0.025
2.32AspArg: 2.32 ± 0.044
3.027AspSer: 3.027 ± 0.053
2.956AspThr: 2.956 ± 0.049
3.249AspVal: 3.249 ± 0.051
0.554AspTrp: 0.554 ± 0.025
2.648AspTyr: 2.648 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.371GluAla: 5.371 ± 0.07
0.871GluCys: 0.871 ± 0.025
4.281GluAsp: 4.281 ± 0.062
7.575GluGlu: 7.575 ± 0.093
2.824GluPhe: 2.824 ± 0.048
5.321GluGly: 5.321 ± 0.065
1.502GluHis: 1.502 ± 0.036
5.668GluIle: 5.668 ± 0.064
7.039GluLys: 7.039 ± 0.084
7.396GluLeu: 7.396 ± 0.076
2.35GluMet: 2.35 ± 0.043
4.139GluAsn: 4.139 ± 0.053
2.25GluPro: 2.25 ± 0.049
3.724GluGln: 3.724 ± 0.061
3.83GluArg: 3.83 ± 0.058
3.5GluSer: 3.5 ± 0.047
3.83GluThr: 3.83 ± 0.055
4.25GluVal: 4.25 ± 0.053
0.765GluTrp: 0.765 ± 0.021
3.365GluTyr: 3.365 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
2.996PheAla: 2.996 ± 0.045
0.88PheCys: 0.88 ± 0.024
2.224PheAsp: 2.224 ± 0.036
2.704PheGlu: 2.704 ± 0.049
1.897PhePhe: 1.897 ± 0.047
3.088PheGly: 3.088 ± 0.054
0.947PheHis: 0.947 ± 0.028
2.522PheIle: 2.522 ± 0.052
1.869PheLys: 1.869 ± 0.039
4.339PheLeu: 4.339 ± 0.074
1.111PheMet: 1.111 ± 0.026
1.364PheAsn: 1.364 ± 0.032
1.505PhePro: 1.505 ± 0.034
1.78PheGln: 1.78 ± 0.036
1.926PheArg: 1.926 ± 0.037
3.126PheSer: 3.126 ± 0.055
2.225PheThr: 2.225 ± 0.045
2.581PheVal: 2.581 ± 0.044
0.484PheTrp: 0.484 ± 0.019
1.843PheTyr: 1.843 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.282GlyAla: 5.282 ± 0.072
1.319GlyCys: 1.319 ± 0.034
3.353GlyAsp: 3.353 ± 0.048
5.372GlyGlu: 5.372 ± 0.065
3.223GlyPhe: 3.223 ± 0.047
4.889GlyGly: 4.889 ± 0.094
1.365GlyHis: 1.365 ± 0.031
6.219GlyIle: 6.219 ± 0.072
6.392GlyLys: 6.392 ± 0.08
5.979GlyLeu: 5.979 ± 0.071
2.735GlyMet: 2.735 ± 0.049
3.645GlyAsn: 3.645 ± 0.059
1.068GlyPro: 1.068 ± 0.029
2.858GlyGln: 2.858 ± 0.05
3.689GlyArg: 3.689 ± 0.052
4.327GlySer: 4.327 ± 0.06
4.301GlyThr: 4.301 ± 0.078
4.337GlyVal: 4.337 ± 0.058
0.801GlyTrp: 0.801 ± 0.027
3.412GlyTyr: 3.412 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.217HisAla: 1.217 ± 0.03
0.319HisCys: 0.319 ± 0.016
0.814HisAsp: 0.814 ± 0.025
1.075HisGlu: 1.075 ± 0.029
0.782HisPhe: 0.782 ± 0.022
1.44HisGly: 1.44 ± 0.037
0.406HisHis: 0.406 ± 0.017
1.42HisIle: 1.42 ± 0.03
1.035HisLys: 1.035 ± 0.027
1.56HisLeu: 1.56 ± 0.037
0.592HisMet: 0.592 ± 0.019
0.757HisAsn: 0.757 ± 0.024
0.84HisPro: 0.84 ± 0.026
0.601HisGln: 0.601 ± 0.022
0.833HisArg: 0.833 ± 0.024
0.978HisSer: 0.978 ± 0.028
0.983HisThr: 0.983 ± 0.025
1.084HisVal: 1.084 ± 0.025
0.191HisTrp: 0.191 ± 0.011
0.745HisTyr: 0.745 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.235IleAla: 5.235 ± 0.072
1.28IleCys: 1.28 ± 0.033
3.5IleAsp: 3.5 ± 0.047
4.494IleGlu: 4.494 ± 0.067
2.826IlePhe: 2.826 ± 0.052
4.805IleGly: 4.805 ± 0.061
1.292IleHis: 1.292 ± 0.033
4.169IleIle: 4.169 ± 0.064
3.95IleLys: 3.95 ± 0.068
6.72IleLeu: 6.72 ± 0.072
1.785IleMet: 1.785 ± 0.038
2.65IleAsn: 2.65 ± 0.039
2.932IlePro: 2.932 ± 0.048
2.511IleGln: 2.511 ± 0.041
3.56IleArg: 3.56 ± 0.052
4.947IleSer: 4.947 ± 0.058
3.811IleThr: 3.811 ± 0.055
4.169IleVal: 4.169 ± 0.059
0.621IleTrp: 0.621 ± 0.023
2.545IleTyr: 2.545 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
5.477LysAla: 5.477 ± 0.074
0.723LysCys: 0.723 ± 0.022
3.704LysAsp: 3.704 ± 0.048
7.053LysGlu: 7.053 ± 0.082
2.122LysPhe: 2.122 ± 0.04
4.679LysGly: 4.679 ± 0.064
1.058LysHis: 1.058 ± 0.025
4.851LysIle: 4.851 ± 0.061
6.295LysLys: 6.295 ± 0.09
5.578LysLeu: 5.578 ± 0.075
2.136LysMet: 2.136 ± 0.037
3.558LysAsn: 3.558 ± 0.054
2.2LysPro: 2.2 ± 0.046
2.831LysGln: 2.831 ± 0.047
3.405LysArg: 3.405 ± 0.054
3.634LysSer: 3.634 ± 0.056
3.679LysThr: 3.679 ± 0.06
4.172LysVal: 4.172 ± 0.067
0.668LysTrp: 0.668 ± 0.022
2.885LysTyr: 2.885 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
7.43LeuAla: 7.43 ± 0.089
1.62LeuCys: 1.62 ± 0.032
4.787LeuAsp: 4.787 ± 0.062
7.096LeuGlu: 7.096 ± 0.079
3.848LeuPhe: 3.848 ± 0.071
5.999LeuGly: 5.999 ± 0.075
1.558LeuHis: 1.558 ± 0.037
4.996LeuIle: 4.996 ± 0.07
6.37LeuLys: 6.37 ± 0.08
8.911LeuLeu: 8.911 ± 0.105
2.597LeuMet: 2.597 ± 0.043
3.561LeuAsn: 3.561 ± 0.051
3.616LeuPro: 3.616 ± 0.054
3.194LeuGln: 3.194 ± 0.047
3.838LeuArg: 3.838 ± 0.055
6.363LeuSer: 6.363 ± 0.068
4.584LeuThr: 4.584 ± 0.068
5.382LeuVal: 5.382 ± 0.072
0.848LeuTrp: 0.848 ± 0.027
3.349LeuTyr: 3.349 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.746MetAla: 2.746 ± 0.051
0.335MetCys: 0.335 ± 0.016
1.936MetAsp: 1.936 ± 0.045
3.275MetGlu: 3.275 ± 0.049
1.001MetPhe: 1.001 ± 0.028
2.351MetGly: 2.351 ± 0.043
0.433MetHis: 0.433 ± 0.015
1.525MetIle: 1.525 ± 0.035
2.481MetLys: 2.481 ± 0.04
2.74MetLeu: 2.74 ± 0.043
0.83MetMet: 0.83 ± 0.025
1.326MetAsn: 1.326 ± 0.029
1.229MetPro: 1.229 ± 0.037
1.233MetGln: 1.233 ± 0.033
1.252MetArg: 1.252 ± 0.028
1.541MetSer: 1.541 ± 0.034
1.263MetThr: 1.263 ± 0.031
2.121MetVal: 2.121 ± 0.044
0.215MetTrp: 0.215 ± 0.013
0.884MetTyr: 0.884 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.08AsnAla: 3.08 ± 0.051
0.673AsnCys: 0.673 ± 0.022
1.833AsnAsp: 1.833 ± 0.038
2.59AsnGlu: 2.59 ± 0.044
1.642AsnPhe: 1.642 ± 0.034
3.689AsnGly: 3.689 ± 0.058
0.78AsnHis: 0.78 ± 0.027
3.312AsnIle: 3.312 ± 0.048
2.303AsnLys: 2.303 ± 0.042
3.637AsnLeu: 3.637 ± 0.047
1.358AsnMet: 1.358 ± 0.029
1.693AsnAsn: 1.693 ± 0.045
1.992AsnPro: 1.992 ± 0.037
1.587AsnGln: 1.587 ± 0.033
2.231AsnArg: 2.231 ± 0.04
2.398AsnSer: 2.398 ± 0.043
2.239AsnThr: 2.239 ± 0.045
2.661AsnVal: 2.661 ± 0.044
0.422AsnTrp: 0.422 ± 0.017
1.796AsnTyr: 1.796 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.669ProAla: 2.669 ± 0.051
0.506ProCys: 0.506 ± 0.022
2.186ProAsp: 2.186 ± 0.044
3.643ProGlu: 3.643 ± 0.068
1.526ProPhe: 1.526 ± 0.033
2.216ProGly: 2.216 ± 0.044
0.556ProHis: 0.556 ± 0.021
1.963ProIle: 1.963 ± 0.041
2.273ProLys: 2.273 ± 0.042
2.698ProLeu: 2.698 ± 0.044
0.978ProMet: 0.978 ± 0.025
1.209ProAsn: 1.209 ± 0.031
0.938ProPro: 0.938 ± 0.03
1.288ProGln: 1.288 ± 0.044
1.017ProArg: 1.017 ± 0.028
1.748ProSer: 1.748 ± 0.032
1.506ProThr: 1.506 ± 0.033
2.784ProVal: 2.784 ± 0.05
0.324ProTrp: 0.324 ± 0.016
1.429ProTyr: 1.429 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.148GlnAla: 3.148 ± 0.053
0.403GlnCys: 0.403 ± 0.016
1.683GlnAsp: 1.683 ± 0.034
3.881GlnGlu: 3.881 ± 0.062
1.31GlnPhe: 1.31 ± 0.031
2.765GlnGly: 2.765 ± 0.052
0.543GlnHis: 0.543 ± 0.021
2.608GlnIle: 2.608 ± 0.041
3.274GlnLys: 3.274 ± 0.059
2.89GlnLeu: 2.89 ± 0.049
1.37GlnMet: 1.37 ± 0.029
1.757GlnAsn: 1.757 ± 0.037
1.148GlnPro: 1.148 ± 0.034
1.775GlnGln: 1.775 ± 0.045
1.717GlnArg: 1.717 ± 0.038
1.811GlnSer: 1.811 ± 0.038
1.72GlnThr: 1.72 ± 0.035
2.223GlnVal: 2.223 ± 0.041
0.371GlnTrp: 0.371 ± 0.017
1.496GlnTyr: 1.496 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.069ArgAla: 3.069 ± 0.048
0.64ArgCys: 0.64 ± 0.023
2.211ArgAsp: 2.211 ± 0.041
4.436ArgGlu: 4.436 ± 0.069
1.959ArgPhe: 1.959 ± 0.039
2.577ArgGly: 2.577 ± 0.042
0.907ArgHis: 0.907 ± 0.026
3.336ArgIle: 3.336 ± 0.049
4.069ArgLys: 4.069 ± 0.062
4.226ArgLeu: 4.226 ± 0.059
1.699ArgMet: 1.699 ± 0.035
2.252ArgAsn: 2.252 ± 0.041
1.429ArgPro: 1.429 ± 0.039
2.087ArgGln: 2.087 ± 0.037
2.593ArgArg: 2.593 ± 0.052
2.116ArgSer: 2.116 ± 0.042
2.098ArgThr: 2.098 ± 0.038
2.507ArgVal: 2.507 ± 0.044
0.444ArgTrp: 0.444 ± 0.017
1.984ArgTyr: 1.984 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.182SerAla: 4.182 ± 0.064
0.85SerCys: 0.85 ± 0.023
2.841SerAsp: 2.841 ± 0.048
3.788SerGlu: 3.788 ± 0.052
2.736SerPhe: 2.736 ± 0.041
5.272SerGly: 5.272 ± 0.073
1.232SerHis: 1.232 ± 0.028
4.116SerIle: 4.116 ± 0.058
3.436SerLys: 3.436 ± 0.051
5.358SerLeu: 5.358 ± 0.065
1.826SerMet: 1.826 ± 0.041
2.272SerAsn: 2.272 ± 0.045
1.958SerPro: 1.958 ± 0.037
2.197SerGln: 2.197 ± 0.046
2.941SerArg: 2.941 ± 0.052
3.6SerSer: 3.6 ± 0.072
2.543SerThr: 2.543 ± 0.046
4.042SerVal: 4.042 ± 0.052
0.56SerTrp: 0.56 ± 0.021
2.54SerTyr: 2.54 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.426ThrAla: 4.426 ± 0.075
0.618ThrCys: 0.618 ± 0.02
2.835ThrAsp: 2.835 ± 0.053
3.969ThrGlu: 3.969 ± 0.063
1.965ThrPhe: 1.965 ± 0.038
4.345ThrGly: 4.345 ± 0.07
0.851ThrHis: 0.851 ± 0.021
3.466ThrIle: 3.466 ± 0.055
2.96ThrLys: 2.96 ± 0.052
4.49ThrLeu: 4.49 ± 0.063
1.318ThrMet: 1.318 ± 0.032
1.835ThrAsn: 1.835 ± 0.041
2.086ThrPro: 2.086 ± 0.046
1.531ThrGln: 1.531 ± 0.036
1.914ThrArg: 1.914 ± 0.032
2.711ThrSer: 2.711 ± 0.048
2.246ThrThr: 2.246 ± 0.044
4.222ThrVal: 4.222 ± 0.068
0.442ThrTrp: 0.442 ± 0.018
1.895ThrTyr: 1.895 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
4.539ValAla: 4.539 ± 0.058
1.171ValCys: 1.171 ± 0.029
3.296ValAsp: 3.296 ± 0.051
4.335ValGlu: 4.335 ± 0.059
2.99ValPhe: 2.99 ± 0.05
4.011ValGly: 4.011 ± 0.055
1.048ValHis: 1.048 ± 0.024
4.218ValIle: 4.218 ± 0.06
4.275ValLys: 4.275 ± 0.049
6.351ValLeu: 6.351 ± 0.083
1.857ValMet: 1.857 ± 0.037
2.547ValAsn: 2.547 ± 0.043
2.408ValPro: 2.408 ± 0.041
2.16ValGln: 2.16 ± 0.042
2.935ValArg: 2.935 ± 0.053
4.682ValSer: 4.682 ± 0.062
3.892ValThr: 3.892 ± 0.069
4.183ValVal: 4.183 ± 0.058
0.621ValTrp: 0.621 ± 0.018
2.51ValTyr: 2.51 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.661TrpAla: 0.661 ± 0.023
0.159TrpCys: 0.159 ± 0.011
0.563TrpAsp: 0.563 ± 0.02
0.863TrpGlu: 0.863 ± 0.026
0.44TrpPhe: 0.44 ± 0.02
0.692TrpGly: 0.692 ± 0.022
0.193TrpHis: 0.193 ± 0.012
0.592TrpIle: 0.592 ± 0.021
0.863TrpLys: 0.863 ± 0.027
0.905TrpLeu: 0.905 ± 0.026
0.335TrpMet: 0.335 ± 0.015
0.522TrpAsn: 0.522 ± 0.021
0.163TrpPro: 0.163 ± 0.011
0.473TrpGln: 0.473 ± 0.019
0.401TrpArg: 0.401 ± 0.017
0.45TrpSer: 0.45 ± 0.018
0.376TrpThr: 0.376 ± 0.016
0.558TrpVal: 0.558 ± 0.018
0.107TrpTrp: 0.107 ± 0.009
0.407TrpTyr: 0.407 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.83TyrAla: 2.83 ± 0.047
0.698TyrCys: 0.698 ± 0.022
2.101TyrAsp: 2.101 ± 0.043
2.858TyrGlu: 2.858 ± 0.045
1.881TyrPhe: 1.881 ± 0.035
3.343TyrGly: 3.343 ± 0.053
0.939TyrHis: 0.939 ± 0.025
2.669TyrIle: 2.669 ± 0.044
2.313TyrLys: 2.313 ± 0.039
3.843TyrLeu: 3.843 ± 0.057
1.072TyrMet: 1.072 ± 0.029
1.716TyrAsn: 1.716 ± 0.04
1.451TyrPro: 1.451 ± 0.038
1.992TyrGln: 1.992 ± 0.036
2.233TyrArg: 2.233 ± 0.042
2.341TyrSer: 2.341 ± 0.044
2.092TyrThr: 2.092 ± 0.046
2.423TyrVal: 2.423 ± 0.037
0.414TyrTrp: 0.414 ± 0.017
1.917TyrTyr: 1.917 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5159 proteins (1470053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski