Amino acid dipepetide frequency for Anelloviridae sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.47AlaAla: 7.47 ± 6.827
1.867AlaCys: 1.867 ± 1.211
2.801AlaAsp: 2.801 ± 2.654
2.801AlaGlu: 2.801 ± 1.679
2.801AlaPhe: 2.801 ± 1.119
4.669AlaGly: 4.669 ± 2.481
1.867AlaHis: 1.867 ± 1.003
0.934AlaIle: 0.934 ± 0.502
4.669AlaLys: 4.669 ± 1.259
5.602AlaLeu: 5.602 ± 2.239
1.867AlaMet: 1.867 ± 1.314
1.867AlaAsn: 1.867 ± 1.206
8.403AlaPro: 8.403 ± 3.62
1.867AlaGln: 1.867 ± 1.211
1.867AlaArg: 1.867 ± 1.206
0.934AlaSer: 0.934 ± 0.502
5.602AlaThr: 5.602 ± 0.221
5.602AlaVal: 5.602 ± 2.065
0.934AlaTrp: 0.934 ± 1.477
6.536AlaTyr: 6.536 ± 3.512
0.0AlaXaa: 0.0 ± 0.0
Cys
1.867CysAla: 1.867 ± 1.211
0.0CysCys: 0.0 ± 0.0
1.867CysAsp: 1.867 ± 1.003
0.934CysGlu: 0.934 ± 0.502
0.934CysPhe: 0.934 ± 0.502
2.801CysGly: 2.801 ± 2.654
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.867CysLys: 1.867 ± 1.211
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
1.867CysAsn: 1.867 ± 1.003
0.934CysPro: 0.934 ± 0.502
0.934CysGln: 0.934 ± 1.555
1.867CysArg: 1.867 ± 1.003
0.934CysSer: 0.934 ± 1.555
0.934CysThr: 0.934 ± 0.502
2.801CysVal: 2.801 ± 1.119
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.801AspAla: 2.801 ± 2.654
0.934AspCys: 0.934 ± 1.477
2.801AspAsp: 2.801 ± 1.119
2.801AspGlu: 2.801 ± 1.679
0.934AspPhe: 0.934 ± 0.502
2.801AspGly: 2.801 ± 1.119
0.934AspHis: 0.934 ± 1.555
0.934AspIle: 0.934 ± 0.502
2.801AspLys: 2.801 ± 0.997
5.602AspLeu: 5.602 ± 1.907
0.0AspMet: 0.0 ± 0.0
0.934AspAsn: 0.934 ± 0.502
1.867AspPro: 1.867 ± 1.003
1.867AspGln: 1.867 ± 1.003
1.867AspArg: 1.867 ± 2.18
0.0AspSer: 0.0 ± 0.0
3.735AspThr: 3.735 ± 2.007
0.934AspVal: 0.934 ± 0.502
0.0AspTrp: 0.0 ± 0.0
1.867AspTyr: 1.867 ± 1.003
0.0AspXaa: 0.0 ± 0.0
Glu
0.934GluAla: 0.934 ± 1.477
0.934GluCys: 0.934 ± 1.555
2.801GluAsp: 2.801 ± 1.119
5.602GluGlu: 5.602 ± 1.907
1.867GluPhe: 1.867 ± 1.003
1.867GluGly: 1.867 ± 2.18
1.867GluHis: 1.867 ± 1.003
2.801GluIle: 2.801 ± 0.997
1.867GluLys: 1.867 ± 1.003
2.801GluLeu: 2.801 ± 1.119
0.934GluMet: 0.934 ± 1.152
2.801GluAsn: 2.801 ± 0.997
2.801GluPro: 2.801 ± 0.997
4.669GluGln: 4.669 ± 2.508
0.934GluArg: 0.934 ± 1.477
5.602GluSer: 5.602 ± 5.474
4.669GluThr: 4.669 ± 1.259
0.0GluVal: 0.0 ± 0.0
0.0GluTrp: 0.0 ± 0.0
0.934GluTyr: 0.934 ± 0.502
0.0GluXaa: 0.0 ± 0.0
Phe
0.934PheAla: 0.934 ± 1.477
2.801PheCys: 2.801 ± 1.119
1.867PheAsp: 1.867 ± 1.003
1.867PheGlu: 1.867 ± 1.003
0.0PhePhe: 0.0 ± 0.0
2.801PheGly: 2.801 ± 1.505
0.934PheHis: 0.934 ± 0.502
1.867PheIle: 1.867 ± 1.003
1.867PheLys: 1.867 ± 1.003
3.735PheLeu: 3.735 ± 1.18
1.867PheMet: 1.867 ± 1.003
1.867PheAsn: 1.867 ± 1.003
1.867PhePro: 1.867 ± 1.003
1.867PheGln: 1.867 ± 1.003
0.934PheArg: 0.934 ± 0.502
0.0PheSer: 0.0 ± 0.0
1.867PheThr: 1.867 ± 1.003
2.801PheVal: 2.801 ± 1.505
0.0PheTrp: 0.0 ± 0.0
3.735PheTyr: 3.735 ± 1.18
0.0PheXaa: 0.0 ± 0.0
Gly
5.602GlyAla: 5.602 ± 0.221
0.934GlyCys: 0.934 ± 1.477
4.669GlyAsp: 4.669 ± 3.851
3.735GlyGlu: 3.735 ± 2.421
1.867GlyPhe: 1.867 ± 1.211
8.403GlyGly: 8.403 ± 4.673
1.867GlyHis: 1.867 ± 1.211
0.934GlyIle: 0.934 ± 0.502
3.735GlyLys: 3.735 ± 2.421
0.934GlyLeu: 0.934 ± 0.502
2.801GlyMet: 2.801 ± 1.119
4.669GlyAsn: 4.669 ± 1.259
4.669GlyPro: 4.669 ± 1.529
1.867GlyGln: 1.867 ± 1.211
5.602GlyArg: 5.602 ± 0.221
5.602GlySer: 5.602 ± 1.623
3.735GlyThr: 3.735 ± 2.412
0.0GlyVal: 0.0 ± 0.0
0.0GlyTrp: 0.0 ± 0.0
2.801GlyTyr: 2.801 ± 1.505
0.0GlyXaa: 0.0 ± 0.0
His
1.867HisAla: 1.867 ± 1.211
0.934HisCys: 0.934 ± 1.477
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.934HisGly: 0.934 ± 0.502
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.867HisLys: 1.867 ± 1.206
5.602HisLeu: 5.602 ± 2.239
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.801HisPro: 2.801 ± 1.505
1.867HisGln: 1.867 ± 1.206
1.867HisArg: 1.867 ± 1.206
1.867HisSer: 1.867 ± 1.003
0.934HisThr: 0.934 ± 0.502
0.934HisVal: 0.934 ± 0.502
0.0HisTrp: 0.0 ± 0.0
0.934HisTyr: 0.934 ± 0.502
0.0HisXaa: 0.0 ± 0.0
Ile
0.934IleAla: 0.934 ± 0.502
0.0IleCys: 0.0 ± 0.0
1.867IleAsp: 1.867 ± 1.003
0.0IleGlu: 0.0 ± 0.0
2.801IlePhe: 2.801 ± 1.505
0.0IleGly: 0.0 ± 0.0
1.867IleHis: 1.867 ± 1.003
1.867IleIle: 1.867 ± 1.003
1.867IleLys: 1.867 ± 1.003
3.735IleLeu: 3.735 ± 2.007
0.0IleMet: 0.0 ± 0.0
1.867IleAsn: 1.867 ± 1.003
0.934IlePro: 0.934 ± 1.555
3.735IleGln: 3.735 ± 2.007
1.867IleArg: 1.867 ± 1.211
0.934IleSer: 0.934 ± 0.502
0.0IleThr: 0.0 ± 0.0
2.801IleVal: 2.801 ± 1.505
0.0IleTrp: 0.0 ± 0.0
2.801IleTyr: 2.801 ± 1.505
0.0IleXaa: 0.0 ± 0.0
Lys
6.536LysAla: 6.536 ± 4.534
0.934LysCys: 0.934 ± 0.502
1.867LysAsp: 1.867 ± 1.003
1.867LysGlu: 1.867 ± 1.206
2.801LysPhe: 2.801 ± 1.505
4.669LysGly: 4.669 ± 1.529
2.801LysHis: 2.801 ± 0.997
1.867LysIle: 1.867 ± 1.003
6.536LysLys: 6.536 ± 8.407
1.867LysLeu: 1.867 ± 2.954
0.934LysMet: 0.934 ± 0.502
4.669LysAsn: 4.669 ± 3.934
0.934LysPro: 0.934 ± 0.502
6.536LysGln: 6.536 ± 3.348
8.403LysArg: 8.403 ± 0.913
5.602LysSer: 5.602 ± 1.995
2.801LysThr: 2.801 ± 1.505
3.735LysVal: 3.735 ± 2.007
3.735LysTrp: 3.735 ± 2.007
1.867LysTyr: 1.867 ± 1.003
0.0LysXaa: 0.0 ± 0.0
Leu
2.801LeuAla: 2.801 ± 3.383
2.801LeuCys: 2.801 ± 1.505
2.801LeuAsp: 2.801 ± 0.997
0.934LeuGlu: 0.934 ± 0.502
3.735LeuPhe: 3.735 ± 2.007
5.602LeuGly: 5.602 ± 2.239
1.867LeuHis: 1.867 ± 1.211
1.867LeuIle: 1.867 ± 1.003
6.536LeuLys: 6.536 ± 1.695
4.669LeuLeu: 4.669 ± 2.481
0.0LeuMet: 0.0 ± 0.0
1.867LeuAsn: 1.867 ± 1.003
2.801LeuPro: 2.801 ± 3.383
3.735LeuGln: 3.735 ± 1.019
5.602LeuArg: 5.602 ± 1.623
10.271LeuSer: 10.271 ± 4.039
4.669LeuThr: 4.669 ± 0.685
4.669LeuVal: 4.669 ± 1.259
0.934LeuTrp: 0.934 ± 0.502
3.735LeuTyr: 3.735 ± 3.002
0.0LeuXaa: 0.0 ± 0.0
Met
0.934MetAla: 0.934 ± 0.502
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.934MetGlu: 0.934 ± 0.502
0.934MetPhe: 0.934 ± 1.477
0.934MetGly: 0.934 ± 1.477
0.0MetHis: 0.0 ± 0.0
0.934MetIle: 0.934 ± 0.502
1.867MetLys: 1.867 ± 1.003
0.934MetLeu: 0.934 ± 0.502
1.867MetMet: 1.867 ± 1.003
0.934MetAsn: 0.934 ± 0.502
0.934MetPro: 0.934 ± 0.502
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.867MetSer: 1.867 ± 1.206
0.934MetThr: 0.934 ± 0.502
0.934MetVal: 0.934 ± 0.502
0.934MetTrp: 0.934 ± 1.477
0.934MetTyr: 0.934 ± 0.502
0.0MetXaa: 0.0 ± 0.0
Asn
2.801AsnAla: 2.801 ± 0.997
2.801AsnCys: 2.801 ± 1.505
0.934AsnAsp: 0.934 ± 0.502
0.934AsnGlu: 0.934 ± 0.502
2.801AsnPhe: 2.801 ± 1.505
1.867AsnGly: 1.867 ± 1.206
0.0AsnHis: 0.0 ± 0.0
2.801AsnIle: 2.801 ± 1.505
3.735AsnLys: 3.735 ± 2.007
0.934AsnLeu: 0.934 ± 1.555
0.934AsnMet: 0.934 ± 0.502
0.934AsnAsn: 0.934 ± 1.555
5.602AsnPro: 5.602 ± 1.907
3.735AsnGln: 3.735 ± 1.019
0.934AsnArg: 0.934 ± 0.502
3.735AsnSer: 3.735 ± 2.412
1.867AsnThr: 1.867 ± 1.003
1.867AsnVal: 1.867 ± 1.211
0.934AsnTrp: 0.934 ± 1.477
2.801AsnTyr: 2.801 ± 0.997
0.0AsnXaa: 0.0 ± 0.0
Pro
4.669ProAla: 4.669 ± 3.859
1.867ProCys: 1.867 ± 1.003
0.934ProAsp: 0.934 ± 1.555
0.0ProGlu: 0.0 ± 0.0
3.735ProPhe: 3.735 ± 1.019
2.801ProGly: 2.801 ± 1.679
0.0ProHis: 0.0 ± 0.0
0.934ProIle: 0.934 ± 0.502
3.735ProLys: 3.735 ± 1.18
6.536ProLeu: 6.536 ± 2.047
0.934ProMet: 0.934 ± 0.502
3.735ProAsn: 3.735 ± 1.243
8.403ProPro: 8.403 ± 7.961
4.669ProGln: 4.669 ± 2.277
3.735ProArg: 3.735 ± 2.007
5.602ProSer: 5.602 ± 2.065
5.602ProThr: 5.602 ± 3.359
3.735ProVal: 3.735 ± 4.939
2.801ProTrp: 2.801 ± 1.505
3.735ProTyr: 3.735 ± 2.007
0.0ProXaa: 0.0 ± 0.0
Gln
9.337GlnAla: 9.337 ± 2.518
0.934GlnCys: 0.934 ± 0.502
0.934GlnAsp: 0.934 ± 1.555
5.602GlnGlu: 5.602 ± 1.907
0.934GlnPhe: 0.934 ± 0.502
1.867GlnGly: 1.867 ± 1.003
0.934GlnHis: 0.934 ± 0.502
0.934GlnIle: 0.934 ± 0.502
3.735GlnLys: 3.735 ± 1.019
4.669GlnLeu: 4.669 ± 1.259
0.0GlnMet: 0.0 ± 0.0
3.735GlnAsn: 3.735 ± 1.18
5.602GlnPro: 5.602 ± 3.632
5.602GlnGln: 5.602 ± 3.01
0.934GlnArg: 0.934 ± 0.502
5.602GlnSer: 5.602 ± 1.623
0.934GlnThr: 0.934 ± 0.502
3.735GlnVal: 3.735 ± 1.019
1.867GlnTrp: 1.867 ± 1.003
0.934GlnTyr: 0.934 ± 1.555
0.0GlnXaa: 0.0 ± 0.0
Arg
2.801ArgAla: 2.801 ± 1.119
0.934ArgCys: 0.934 ± 0.502
0.934ArgAsp: 0.934 ± 0.502
2.801ArgGlu: 2.801 ± 0.997
0.934ArgPhe: 0.934 ± 1.555
4.669ArgGly: 4.669 ± 1.259
1.867ArgHis: 1.867 ± 1.206
0.934ArgIle: 0.934 ± 0.502
8.403ArgLys: 8.403 ± 0.913
4.669ArgLeu: 4.669 ± 2.481
0.934ArgMet: 0.934 ± 0.502
2.801ArgAsn: 2.801 ± 1.119
7.47ArgPro: 7.47 ± 1.411
1.867ArgGln: 1.867 ± 1.003
29.879ArgArg: 29.879 ± 5.269
3.735ArgSer: 3.735 ± 2.412
0.934ArgThr: 0.934 ± 0.502
5.602ArgVal: 5.602 ± 3.01
2.801ArgTrp: 2.801 ± 1.505
2.801ArgTyr: 2.801 ± 0.997
0.0ArgXaa: 0.0 ± 0.0
Ser
5.602SerAla: 5.602 ± 1.907
0.934SerCys: 0.934 ± 1.555
2.801SerAsp: 2.801 ± 1.505
8.403SerGlu: 8.403 ± 6.338
0.0SerPhe: 0.0 ± 0.0
6.536SerGly: 6.536 ± 1.695
0.934SerHis: 0.934 ± 1.477
5.602SerIle: 5.602 ± 3.01
5.602SerLys: 5.602 ± 3.618
6.536SerLeu: 6.536 ± 4.609
0.0SerMet: 0.0 ± 0.0
0.934SerAsn: 0.934 ± 0.502
2.801SerPro: 2.801 ± 2.737
3.735SerGln: 3.735 ± 2.007
3.735SerArg: 3.735 ± 4.285
14.939SerSer: 14.939 ± 11.706
6.536SerThr: 6.536 ± 3.348
0.0SerVal: 0.0 ± 0.0
2.801SerTrp: 2.801 ± 0.997
2.801SerTyr: 2.801 ± 1.679
0.0SerXaa: 0.0 ± 0.0
Thr
3.735ThrAla: 3.735 ± 1.18
0.934ThrCys: 0.934 ± 0.502
0.934ThrAsp: 0.934 ± 1.555
3.735ThrGlu: 3.735 ± 2.007
1.867ThrPhe: 1.867 ± 1.003
4.669ThrGly: 4.669 ± 1.529
2.801ThrHis: 2.801 ± 1.119
1.867ThrIle: 1.867 ± 1.003
1.867ThrLys: 1.867 ± 1.003
6.536ThrLeu: 6.536 ± 1.953
0.0ThrMet: 0.0 ± 0.0
1.867ThrAsn: 1.867 ± 1.003
3.735ThrPro: 3.735 ± 4.285
3.735ThrGln: 3.735 ± 1.18
2.801ThrArg: 2.801 ± 0.997
2.801ThrSer: 2.801 ± 2.737
5.602ThrThr: 5.602 ± 1.623
2.801ThrVal: 2.801 ± 1.505
0.934ThrTrp: 0.934 ± 0.502
1.867ThrTyr: 1.867 ± 1.206
0.0ThrXaa: 0.0 ± 0.0
Val
4.669ValAla: 4.669 ± 2.508
0.0ValCys: 0.0 ± 0.0
3.735ValAsp: 3.735 ± 2.007
1.867ValGlu: 1.867 ± 2.18
2.801ValPhe: 2.801 ± 1.119
3.735ValGly: 3.735 ± 1.243
0.0ValHis: 0.0 ± 0.0
0.934ValIle: 0.934 ± 1.477
2.801ValLys: 2.801 ± 0.997
2.801ValLeu: 2.801 ± 0.997
0.934ValMet: 0.934 ± 0.801
2.801ValAsn: 2.801 ± 1.505
3.735ValPro: 3.735 ± 1.019
5.602ValGln: 5.602 ± 1.623
3.735ValArg: 3.735 ± 2.007
2.801ValSer: 2.801 ± 1.119
0.934ValThr: 0.934 ± 1.555
2.801ValVal: 2.801 ± 1.505
1.867ValTrp: 1.867 ± 1.003
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
1.867TrpAla: 1.867 ± 1.003
0.0TrpCys: 0.0 ± 0.0
0.934TrpAsp: 0.934 ± 0.502
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.934TrpGly: 0.934 ± 0.502
0.0TrpHis: 0.0 ± 0.0
1.867TrpIle: 1.867 ± 1.003
1.867TrpLys: 1.867 ± 1.003
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.934TrpPro: 0.934 ± 1.477
0.934TrpGln: 0.934 ± 0.502
6.536TrpArg: 6.536 ± 2.332
1.867TrpSer: 1.867 ± 1.206
0.934TrpThr: 0.934 ± 0.502
0.0TrpVal: 0.0 ± 0.0
1.867TrpTrp: 1.867 ± 1.003
3.735TrpTyr: 3.735 ± 1.243
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.801TyrAla: 2.801 ± 1.505
0.0TyrCys: 0.0 ± 0.0
0.934TyrAsp: 0.934 ± 1.477
1.867TyrGlu: 1.867 ± 1.003
3.735TyrPhe: 3.735 ± 2.007
1.867TyrGly: 1.867 ± 1.003
1.867TyrHis: 1.867 ± 1.003
0.0TyrIle: 0.0 ± 0.0
3.735TyrLys: 3.735 ± 2.412
3.735TyrLeu: 3.735 ± 3.002
1.867TyrMet: 1.867 ± 1.003
2.801TyrAsn: 2.801 ± 1.505
0.934TyrPro: 0.934 ± 0.502
0.0TyrGln: 0.0 ± 0.0
4.669TyrArg: 4.669 ± 1.529
6.536TyrSer: 6.536 ± 1.611
1.867TyrThr: 1.867 ± 1.206
3.735TyrVal: 3.735 ± 1.019
1.867TyrTrp: 1.867 ± 1.003
1.867TyrTyr: 1.867 ± 1.003
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1072 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski