Amino acid dipepetide frequency for Apis mellifera associated microvirus 35

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.326AlaAla: 7.326 ± 2.718
0.0AlaCys: 0.0 ± 0.0
2.93AlaAsp: 2.93 ± 1.456
6.593AlaGlu: 6.593 ± 4.139
2.93AlaPhe: 2.93 ± 1.312
6.593AlaGly: 6.593 ± 2.659
1.465AlaHis: 1.465 ± 0.637
4.396AlaIle: 4.396 ± 2.163
4.396AlaLys: 4.396 ± 1.341
5.861AlaLeu: 5.861 ± 1.611
2.198AlaMet: 2.198 ± 1.002
2.93AlaAsn: 2.93 ± 1.231
5.128AlaPro: 5.128 ± 2.046
3.663AlaGln: 3.663 ± 0.972
2.198AlaArg: 2.198 ± 1.002
5.128AlaSer: 5.128 ± 1.071
1.465AlaThr: 1.465 ± 1.011
2.198AlaVal: 2.198 ± 1.458
0.733AlaTrp: 0.733 ± 0.505
3.663AlaTyr: 3.663 ± 1.318
0.0AlaXaa: 0.0 ± 0.0
Cys
1.465CysAla: 1.465 ± 1.433
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.733CysPhe: 0.733 ± 0.717
0.733CysGly: 0.733 ± 0.717
0.0CysHis: 0.0 ± 0.0
1.465CysIle: 1.465 ± 0.865
0.0CysLys: 0.0 ± 0.0
0.733CysLeu: 0.733 ± 0.717
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.733CysGln: 0.733 ± 0.505
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.733AspAla: 0.733 ± 0.505
1.465AspCys: 1.465 ± 0.637
2.198AspAsp: 2.198 ± 1.088
4.396AspGlu: 4.396 ± 1.226
4.396AspPhe: 4.396 ± 3.246
3.663AspGly: 3.663 ± 1.774
1.465AspHis: 1.465 ± 0.637
5.128AspIle: 5.128 ± 2.488
0.733AspLys: 0.733 ± 0.505
4.396AspLeu: 4.396 ± 2.175
0.0AspMet: 0.0 ± 0.0
2.198AspAsn: 2.198 ± 0.886
2.93AspPro: 2.93 ± 1.417
3.663AspGln: 3.663 ± 3.511
2.93AspArg: 2.93 ± 0.974
2.198AspSer: 2.198 ± 1.417
2.93AspThr: 2.93 ± 0.802
5.861AspVal: 5.861 ± 1.991
0.0AspTrp: 0.0 ± 0.0
5.861AspTyr: 5.861 ± 1.767
0.0AspXaa: 0.0 ± 0.0
Glu
4.396GluAla: 4.396 ± 1.425
1.465GluCys: 1.465 ± 1.128
3.663GluAsp: 3.663 ± 2.006
2.93GluGlu: 2.93 ± 1.129
0.733GluPhe: 0.733 ± 0.505
4.396GluGly: 4.396 ± 1.568
1.465GluHis: 1.465 ± 0.616
2.198GluIle: 2.198 ± 1.516
5.128GluLys: 5.128 ± 3.38
3.663GluLeu: 3.663 ± 0.962
3.663GluMet: 3.663 ± 2.205
5.861GluAsn: 5.861 ± 1.89
0.0GluPro: 0.0 ± 0.0
5.128GluGln: 5.128 ± 2.041
7.326GluArg: 7.326 ± 3.468
2.198GluSer: 2.198 ± 1.405
2.198GluThr: 2.198 ± 1.002
4.396GluVal: 4.396 ± 1.937
1.465GluTrp: 1.465 ± 0.865
2.198GluTyr: 2.198 ± 0.899
0.0GluXaa: 0.0 ± 0.0
Phe
4.396PheAla: 4.396 ± 1.825
0.733PheCys: 0.733 ± 0.717
2.93PheAsp: 2.93 ± 0.732
0.733PheGlu: 0.733 ± 1.114
2.198PhePhe: 2.198 ± 1.516
4.396PheGly: 4.396 ± 2.254
2.198PheHis: 2.198 ± 1.085
0.733PheIle: 0.733 ± 0.505
2.93PheLys: 2.93 ± 0.896
2.93PheLeu: 2.93 ± 0.732
0.0PheMet: 0.0 ± 0.0
2.198PheAsn: 2.198 ± 1.079
1.465PhePro: 1.465 ± 1.151
0.0PheGln: 0.0 ± 0.0
4.396PheArg: 4.396 ± 1.677
2.93PheSer: 2.93 ± 1.946
2.198PheThr: 2.198 ± 0.899
3.663PheVal: 3.663 ± 1.22
0.733PheTrp: 0.733 ± 0.505
0.733PheTyr: 0.733 ± 0.91
0.0PheXaa: 0.0 ± 0.0
Gly
5.128GlyAla: 5.128 ± 1.465
0.0GlyCys: 0.0 ± 0.0
2.198GlyAsp: 2.198 ± 1.516
4.396GlyGlu: 4.396 ± 1.568
2.198GlyPhe: 2.198 ± 1.079
7.326GlyGly: 7.326 ± 2.212
0.733GlyHis: 0.733 ± 0.505
6.593GlyIle: 6.593 ± 1.719
5.128GlyLys: 5.128 ± 1.681
4.396GlyLeu: 4.396 ± 1.167
0.733GlyMet: 0.733 ± 0.758
2.93GlyAsn: 2.93 ± 1.231
1.465GlyPro: 1.465 ± 1.151
4.396GlyGln: 4.396 ± 1.406
4.396GlyArg: 4.396 ± 1.226
5.128GlySer: 5.128 ± 1.315
1.465GlyThr: 1.465 ± 0.616
5.861GlyVal: 5.861 ± 1.467
0.733GlyTrp: 0.733 ± 0.505
2.198GlyTyr: 2.198 ± 0.583
0.0GlyXaa: 0.0 ± 0.0
His
3.663HisAla: 3.663 ± 2.792
0.0HisCys: 0.0 ± 0.0
0.733HisAsp: 0.733 ± 1.114
2.93HisGlu: 2.93 ± 0.732
2.198HisPhe: 2.198 ± 0.899
1.465HisGly: 1.465 ± 1.011
0.733HisHis: 0.733 ± 0.717
0.733HisIle: 0.733 ± 0.505
3.663HisLys: 3.663 ± 2.205
1.465HisLeu: 1.465 ± 0.616
0.733HisMet: 0.733 ± 0.537
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.733HisGln: 0.733 ± 0.575
1.465HisArg: 1.465 ± 1.011
0.0HisSer: 0.0 ± 0.0
1.465HisThr: 1.465 ± 1.433
0.733HisVal: 0.733 ± 0.717
0.0HisTrp: 0.0 ± 0.0
1.465HisTyr: 1.465 ± 0.637
0.0HisXaa: 0.0 ± 0.0
Ile
1.465IleAla: 1.465 ± 1.151
0.0IleCys: 0.0 ± 0.0
4.396IleAsp: 4.396 ± 0.957
4.396IleGlu: 4.396 ± 2.202
4.396IlePhe: 4.396 ± 2.254
4.396IleGly: 4.396 ± 1.937
1.465IleHis: 1.465 ± 1.433
2.93IleIle: 2.93 ± 2.867
2.93IleLys: 2.93 ± 2.486
2.198IleLeu: 2.198 ± 1.83
2.93IleMet: 2.93 ± 1.417
0.0IleAsn: 0.0 ± 0.0
3.663IlePro: 3.663 ± 1.155
3.663IleGln: 3.663 ± 0.962
2.93IleArg: 2.93 ± 0.802
3.663IleSer: 3.663 ± 1.774
2.198IleThr: 2.198 ± 0.969
2.198IleVal: 2.198 ± 1.002
0.733IleTrp: 0.733 ± 0.717
1.465IleTyr: 1.465 ± 1.13
0.0IleXaa: 0.0 ± 0.0
Lys
4.396LysAla: 4.396 ± 2.043
0.733LysCys: 0.733 ± 0.717
2.198LysAsp: 2.198 ± 0.91
3.663LysGlu: 3.663 ± 2.526
2.93LysPhe: 2.93 ± 0.896
3.663LysGly: 3.663 ± 1.829
2.198LysHis: 2.198 ± 1.417
0.733LysIle: 0.733 ± 0.717
2.93LysLys: 2.93 ± 2.197
5.861LysLeu: 5.861 ± 1.963
1.465LysMet: 1.465 ± 1.711
1.465LysAsn: 1.465 ± 1.011
2.198LysPro: 2.198 ± 2.035
2.93LysGln: 2.93 ± 1.45
7.326LysArg: 7.326 ± 4.132
3.663LysSer: 3.663 ± 1.557
5.128LysThr: 5.128 ± 2.354
4.396LysVal: 4.396 ± 2.528
0.733LysTrp: 0.733 ± 0.717
5.861LysTyr: 5.861 ± 3.218
0.0LysXaa: 0.0 ± 0.0
Leu
5.128LeuAla: 5.128 ± 2.046
0.0LeuCys: 0.0 ± 0.0
5.861LeuAsp: 5.861 ± 1.519
5.128LeuGlu: 5.128 ± 1.921
2.93LeuPhe: 2.93 ± 1.231
5.128LeuGly: 5.128 ± 1.56
0.733LeuHis: 0.733 ± 0.717
1.465LeuIle: 1.465 ± 0.81
3.663LeuLys: 3.663 ± 2.792
5.128LeuLeu: 5.128 ± 2.14
2.93LeuMet: 2.93 ± 0.794
5.861LeuAsn: 5.861 ± 1.863
5.128LeuPro: 5.128 ± 2.046
2.93LeuGln: 2.93 ± 1.129
6.593LeuArg: 6.593 ± 2.069
4.396LeuSer: 4.396 ± 1.406
5.128LeuThr: 5.128 ± 3.068
2.198LeuVal: 2.198 ± 1.701
2.93LeuTrp: 2.93 ± 1.273
3.663LeuTyr: 3.663 ± 1.543
0.0LeuXaa: 0.0 ± 0.0
Met
2.93MetAla: 2.93 ± 1.67
0.0MetCys: 0.0 ± 0.0
1.465MetAsp: 1.465 ± 0.616
0.733MetGlu: 0.733 ± 0.717
1.465MetPhe: 1.465 ± 1.433
1.465MetGly: 1.465 ± 0.616
0.733MetHis: 0.733 ± 0.717
1.465MetIle: 1.465 ± 1.286
0.733MetLys: 0.733 ± 0.505
1.465MetLeu: 1.465 ± 0.637
0.733MetMet: 0.733 ± 0.471
0.0MetAsn: 0.0 ± 0.0
2.198MetPro: 2.198 ± 1.088
4.396MetGln: 4.396 ± 2.029
3.663MetArg: 3.663 ± 1.318
3.663MetSer: 3.663 ± 1.297
0.0MetThr: 0.0 ± 0.0
1.465MetVal: 1.465 ± 0.616
1.465MetTrp: 1.465 ± 0.616
0.733MetTyr: 0.733 ± 0.717
0.0MetXaa: 0.0 ± 0.0
Asn
3.663AsnAla: 3.663 ± 1.617
0.0AsnCys: 0.0 ± 0.0
2.198AsnAsp: 2.198 ± 1.085
0.733AsnGlu: 0.733 ± 1.114
0.0AsnPhe: 0.0 ± 0.0
2.198AsnGly: 2.198 ± 1.126
0.733AsnHis: 0.733 ± 0.575
1.465AsnIle: 1.465 ± 1.011
2.93AsnLys: 2.93 ± 1.417
3.663AsnLeu: 3.663 ± 1.175
2.93AsnMet: 2.93 ± 1.616
2.93AsnAsn: 2.93 ± 1.42
2.93AsnPro: 2.93 ± 1.129
0.733AsnGln: 0.733 ± 1.114
4.396AsnArg: 4.396 ± 1.187
2.93AsnSer: 2.93 ± 1.417
5.128AsnThr: 5.128 ± 1.17
2.198AsnVal: 2.198 ± 0.969
0.0AsnTrp: 0.0 ± 0.0
1.465AsnTyr: 1.465 ± 0.81
0.0AsnXaa: 0.0 ± 0.0
Pro
1.465ProAla: 1.465 ± 0.616
0.733ProCys: 0.733 ± 0.717
2.93ProAsp: 2.93 ± 0.896
3.663ProGlu: 3.663 ± 1.28
0.733ProPhe: 0.733 ± 0.505
1.465ProGly: 1.465 ± 1.011
1.465ProHis: 1.465 ± 0.81
2.198ProIle: 2.198 ± 1.079
2.198ProLys: 2.198 ± 1.002
2.93ProLeu: 2.93 ± 2.022
0.733ProMet: 0.733 ± 0.505
3.663ProAsn: 3.663 ± 2.006
0.733ProPro: 0.733 ± 0.505
2.93ProGln: 2.93 ± 1.231
2.198ProArg: 2.198 ± 0.583
2.198ProSer: 2.198 ± 0.969
1.465ProThr: 1.465 ± 1.151
8.059ProVal: 8.059 ± 3.215
0.733ProTrp: 0.733 ± 0.505
2.198ProTyr: 2.198 ± 0.969
0.0ProXaa: 0.0 ± 0.0
Gln
2.198GlnAla: 2.198 ± 0.969
0.0GlnCys: 0.0 ± 0.0
3.663GlnAsp: 3.663 ± 1.617
4.396GlnGlu: 4.396 ± 1.772
2.198GlnPhe: 2.198 ± 0.91
2.198GlnGly: 2.198 ± 1.209
0.0GlnHis: 0.0 ± 0.0
4.396GlnIle: 4.396 ± 2.28
3.663GlnLys: 3.663 ± 1.976
2.93GlnLeu: 2.93 ± 1.946
1.465GlnMet: 1.465 ± 1.151
3.663GlnAsn: 3.663 ± 2.353
2.93GlnPro: 2.93 ± 0.802
0.733GlnGln: 0.733 ± 0.575
5.128GlnArg: 5.128 ± 2.726
2.198GlnSer: 2.198 ± 1.002
0.733GlnThr: 0.733 ± 0.575
2.93GlnVal: 2.93 ± 0.896
0.733GlnTrp: 0.733 ± 0.575
2.93GlnTyr: 2.93 ± 2.301
0.0GlnXaa: 0.0 ± 0.0
Arg
6.593ArgAla: 6.593 ± 3.839
0.733ArgCys: 0.733 ± 0.505
2.198ArgAsp: 2.198 ± 0.91
3.663ArgGlu: 3.663 ± 1.846
5.128ArgPhe: 5.128 ± 1.068
3.663ArgGly: 3.663 ± 1.113
0.733ArgHis: 0.733 ± 0.575
5.128ArgIle: 5.128 ± 1.67
5.861ArgLys: 5.861 ± 2.378
5.861ArgLeu: 5.861 ± 1.602
2.93ArgMet: 2.93 ± 0.732
0.733ArgAsn: 0.733 ± 0.505
2.198ArgPro: 2.198 ± 0.899
0.733ArgGln: 0.733 ± 0.717
3.663ArgArg: 3.663 ± 0.972
4.396ArgSer: 4.396 ± 1.406
6.593ArgThr: 6.593 ± 1.82
4.396ArgVal: 4.396 ± 0.92
1.465ArgTrp: 1.465 ± 1.011
3.663ArgTyr: 3.663 ± 0.69
0.0ArgXaa: 0.0 ± 0.0
Ser
4.396SerAla: 4.396 ± 0.626
0.0SerCys: 0.0 ± 0.0
2.198SerAsp: 2.198 ± 2.035
6.593SerGlu: 6.593 ± 1.656
0.733SerPhe: 0.733 ± 0.505
4.396SerGly: 4.396 ± 2.158
1.465SerHis: 1.465 ± 1.011
2.93SerIle: 2.93 ± 1.442
3.663SerLys: 3.663 ± 0.962
8.791SerLeu: 8.791 ± 1.381
0.733SerMet: 0.733 ± 0.505
2.198SerAsn: 2.198 ± 1.258
2.93SerPro: 2.93 ± 0.732
0.0SerGln: 0.0 ± 0.0
2.198SerArg: 2.198 ± 1.088
4.396SerSer: 4.396 ± 0.626
2.198SerThr: 2.198 ± 0.851
3.663SerVal: 3.663 ± 1.175
1.465SerTrp: 1.465 ± 0.81
2.198SerTyr: 2.198 ± 1.079
0.0SerXaa: 0.0 ± 0.0
Thr
7.326ThrAla: 7.326 ± 1.511
0.0ThrCys: 0.0 ± 0.0
5.128ThrAsp: 5.128 ± 1.954
1.465ThrGlu: 1.465 ± 0.616
1.465ThrPhe: 1.465 ± 0.637
1.465ThrGly: 1.465 ± 1.011
3.663ThrHis: 3.663 ± 1.237
0.733ThrIle: 0.733 ± 0.575
7.326ThrLys: 7.326 ± 3.23
4.396ThrLeu: 4.396 ± 1.167
1.465ThrMet: 1.465 ± 1.286
0.733ThrAsn: 0.733 ± 0.575
1.465ThrPro: 1.465 ± 1.006
0.733ThrGln: 0.733 ± 0.717
1.465ThrArg: 1.465 ± 0.637
3.663ThrSer: 3.663 ± 1.155
2.198ThrThr: 2.198 ± 0.886
3.663ThrVal: 3.663 ± 1.277
0.0ThrTrp: 0.0 ± 0.0
3.663ThrTyr: 3.663 ± 0.962
0.0ThrXaa: 0.0 ± 0.0
Val
2.93ValAla: 2.93 ± 0.785
0.0ValCys: 0.0 ± 0.0
3.663ValAsp: 3.663 ± 0.972
5.861ValGlu: 5.861 ± 1.868
2.198ValPhe: 2.198 ± 0.851
5.128ValGly: 5.128 ± 1.275
0.0ValHis: 0.0 ± 0.0
2.93ValIle: 2.93 ± 1.417
4.396ValLys: 4.396 ± 1.844
4.396ValLeu: 4.396 ± 1.6
1.465ValMet: 1.465 ± 0.616
2.198ValAsn: 2.198 ± 1.458
5.861ValPro: 5.861 ± 2.329
5.128ValGln: 5.128 ± 0.863
3.663ValArg: 3.663 ± 1.775
1.465ValSer: 1.465 ± 1.011
6.593ValThr: 6.593 ± 2.365
2.198ValVal: 2.198 ± 0.886
0.0ValTrp: 0.0 ± 0.0
2.93ValTyr: 2.93 ± 0.931
0.0ValXaa: 0.0 ± 0.0
Trp
0.733TrpAla: 0.733 ± 0.505
0.0TrpCys: 0.0 ± 0.0
2.198TrpAsp: 2.198 ± 0.899
0.733TrpGlu: 0.733 ± 0.505
0.733TrpPhe: 0.733 ± 0.717
0.0TrpGly: 0.0 ± 0.0
0.733TrpHis: 0.733 ± 0.505
0.733TrpIle: 0.733 ± 0.505
0.0TrpLys: 0.0 ± 0.0
2.198TrpLeu: 2.198 ± 0.91
1.465TrpMet: 1.465 ± 0.81
0.733TrpAsn: 0.733 ± 0.575
0.733TrpPro: 0.733 ± 0.505
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.733TrpSer: 0.733 ± 0.505
1.465TrpThr: 1.465 ± 0.81
0.733TrpVal: 0.733 ± 0.505
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.465TyrAla: 1.465 ± 0.616
0.0TyrCys: 0.0 ± 0.0
4.396TyrAsp: 4.396 ± 1.167
1.465TyrGlu: 1.465 ± 1.151
2.198TyrPhe: 2.198 ± 0.899
3.663TyrGly: 3.663 ± 1.976
2.198TyrHis: 2.198 ± 1.258
3.663TyrIle: 3.663 ± 1.256
2.93TyrLys: 2.93 ± 1.42
3.663TyrLeu: 3.663 ± 1.114
1.465TyrMet: 1.465 ± 0.637
2.93TyrAsn: 2.93 ± 0.968
0.733TyrPro: 0.733 ± 0.505
5.861TyrGln: 5.861 ± 2.528
4.396TyrArg: 4.396 ± 1.568
2.198TyrSer: 2.198 ± 1.458
1.465TyrThr: 1.465 ± 0.81
2.198TyrVal: 2.198 ± 0.583
0.0TyrTrp: 0.0 ± 0.0
2.198TyrTyr: 2.198 ± 1.258
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski