Amino acid dipepetide frequency for Aphanomyces euteiches

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.004AlaAla: 9.004 ± 0.062
1.485AlaCys: 1.485 ± 0.016
3.941AlaAsp: 3.941 ± 0.026
4.073AlaGlu: 4.073 ± 0.031
3.516AlaPhe: 3.516 ± 0.021
3.911AlaGly: 3.911 ± 0.031
1.999AlaHis: 1.999 ± 0.016
4.738AlaIle: 4.738 ± 0.027
5.006AlaLys: 5.006 ± 0.031
8.706AlaLeu: 8.706 ± 0.042
2.592AlaMet: 2.592 ± 0.021
3.229AlaAsn: 3.229 ± 0.023
4.336AlaPro: 4.336 ± 0.039
3.462AlaGln: 3.462 ± 0.026
4.117AlaArg: 4.117 ± 0.026
7.019AlaSer: 7.019 ± 0.037
5.957AlaThr: 5.957 ± 0.033
5.813AlaVal: 5.813 ± 0.029
1.156AlaTrp: 1.156 ± 0.013
2.15AlaTyr: 2.15 ± 0.017
0.0AlaXaa: 0.0 ± 0.0
Cys
1.332CysAla: 1.332 ± 0.013
0.416CysCys: 0.416 ± 0.008
0.928CysAsp: 0.928 ± 0.011
0.784CysGlu: 0.784 ± 0.01
0.802CysPhe: 0.802 ± 0.011
1.269CysGly: 1.269 ± 0.017
0.512CysHis: 0.512 ± 0.008
1.004CysIle: 1.004 ± 0.012
0.78CysLys: 0.78 ± 0.011
1.743CysLeu: 1.743 ± 0.014
0.456CysMet: 0.456 ± 0.007
0.648CysAsn: 0.648 ± 0.009
0.935CysPro: 0.935 ± 0.014
0.716CysGln: 0.716 ± 0.009
1.069CysArg: 1.069 ± 0.012
1.348CysSer: 1.348 ± 0.017
1.139CysThr: 1.139 ± 0.015
1.343CysVal: 1.343 ± 0.015
0.241CysTrp: 0.241 ± 0.005
0.474CysTyr: 0.474 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.13AspAla: 5.13 ± 0.031
0.883AspCys: 0.883 ± 0.012
4.671AspAsp: 4.671 ± 0.066
4.306AspGlu: 4.306 ± 0.031
2.234AspPhe: 2.234 ± 0.017
3.478AspGly: 3.478 ± 0.024
1.344AspHis: 1.344 ± 0.014
3.061AspIle: 3.061 ± 0.019
2.752AspLys: 2.752 ± 0.023
5.047AspLeu: 5.047 ± 0.025
1.566AspMet: 1.566 ± 0.014
1.993AspAsn: 1.993 ± 0.014
2.613AspPro: 2.613 ± 0.017
1.865AspGln: 1.865 ± 0.014
2.57AspArg: 2.57 ± 0.02
3.644AspSer: 3.644 ± 0.024
2.843AspThr: 2.843 ± 0.021
4.425AspVal: 4.425 ± 0.024
0.686AspTrp: 0.686 ± 0.009
1.456AspTyr: 1.456 ± 0.015
0.0AspXaa: 0.0 ± 0.0
Glu
5.155GluAla: 5.155 ± 0.035
0.931GluCys: 0.931 ± 0.01
3.444GluAsp: 3.444 ± 0.023
4.394GluGlu: 4.394 ± 0.037
2.055GluPhe: 2.055 ± 0.018
2.585GluGly: 2.585 ± 0.02
1.411GluHis: 1.411 ± 0.013
2.953GluIle: 2.953 ± 0.02
3.36GluLys: 3.36 ± 0.032
5.591GluLeu: 5.591 ± 0.035
1.683GluMet: 1.683 ± 0.015
2.213GluAsn: 2.213 ± 0.019
2.284GluPro: 2.284 ± 0.018
2.229GluGln: 2.229 ± 0.018
3.398GluArg: 3.398 ± 0.027
4.146GluSer: 4.146 ± 0.025
3.457GluThr: 3.457 ± 0.024
3.493GluVal: 3.493 ± 0.022
0.926GluTrp: 0.926 ± 0.011
1.628GluTyr: 1.628 ± 0.014
0.0GluXaa: 0.0 ± 0.0
Phe
3.195PheAla: 3.195 ± 0.022
0.808PheCys: 0.808 ± 0.009
2.573PheAsp: 2.573 ± 0.02
2.268PheGlu: 2.268 ± 0.015
1.674PhePhe: 1.674 ± 0.018
2.795PheGly: 2.795 ± 0.025
1.174PheHis: 1.174 ± 0.011
1.772PheIle: 1.772 ± 0.017
1.703PheLys: 1.703 ± 0.014
3.815PheLeu: 3.815 ± 0.028
0.935PheMet: 0.935 ± 0.009
1.538PheAsn: 1.538 ± 0.014
1.763PhePro: 1.763 ± 0.015
1.77PheGln: 1.77 ± 0.015
2.04PheArg: 2.04 ± 0.015
2.813PheSer: 2.813 ± 0.021
2.106PheThr: 2.106 ± 0.018
3.222PheVal: 3.222 ± 0.021
0.494PheTrp: 0.494 ± 0.008
1.188PheTyr: 1.188 ± 0.012
0.0PheXaa: 0.0 ± 0.0
Gly
4.118GlyAla: 4.118 ± 0.031
1.173GlyCys: 1.173 ± 0.016
3.016GlyAsp: 3.016 ± 0.021
2.598GlyGlu: 2.598 ± 0.02
2.484GlyPhe: 2.484 ± 0.021
4.124GlyGly: 4.124 ± 0.059
1.753GlyHis: 1.753 ± 0.02
2.816GlyIle: 2.816 ± 0.019
2.831GlyLys: 2.831 ± 0.019
4.93GlyLeu: 4.93 ± 0.024
1.357GlyMet: 1.357 ± 0.012
2.175GlyAsn: 2.175 ± 0.023
2.014GlyPro: 2.014 ± 0.018
2.069GlyGln: 2.069 ± 0.019
2.947GlyArg: 2.947 ± 0.02
4.181GlySer: 4.181 ± 0.035
3.078GlyThr: 3.078 ± 0.025
3.913GlyVal: 3.913 ± 0.027
0.836GlyTrp: 0.836 ± 0.009
1.857GlyTyr: 1.857 ± 0.018
0.0GlyXaa: 0.0 ± 0.0
His
2.394HisAla: 2.394 ± 0.021
0.531HisCys: 0.531 ± 0.009
1.579HisAsp: 1.579 ± 0.014
1.653HisGlu: 1.653 ± 0.015
1.13HisPhe: 1.13 ± 0.012
1.894HisGly: 1.894 ± 0.018
0.945HisHis: 0.945 ± 0.012
1.299HisIle: 1.299 ± 0.012
1.1HisLys: 1.1 ± 0.012
2.802HisLeu: 2.802 ± 0.022
0.65HisMet: 0.65 ± 0.009
0.889HisAsn: 0.889 ± 0.01
1.453HisPro: 1.453 ± 0.015
1.107HisGln: 1.107 ± 0.012
1.7HisArg: 1.7 ± 0.014
1.763HisSer: 1.763 ± 0.015
1.336HisThr: 1.336 ± 0.012
2.216HisVal: 2.216 ± 0.017
0.376HisTrp: 0.376 ± 0.007
0.723HisTyr: 0.723 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
4.436IleAla: 4.436 ± 0.023
0.898IleCys: 0.898 ± 0.012
3.057IleAsp: 3.057 ± 0.02
3.006IleGlu: 3.006 ± 0.021
1.919IlePhe: 1.919 ± 0.018
2.558IleGly: 2.558 ± 0.02
1.44IleHis: 1.44 ± 0.014
1.863IleIle: 1.863 ± 0.017
2.298IleLys: 2.298 ± 0.019
4.587IleLeu: 4.587 ± 0.024
1.043IleMet: 1.043 ± 0.012
1.704IleAsn: 1.704 ± 0.014
2.569IlePro: 2.569 ± 0.019
2.53IleGln: 2.53 ± 0.019
2.582IleArg: 2.582 ± 0.02
3.358IleSer: 3.358 ± 0.025
2.408IleThr: 2.408 ± 0.017
3.907IleVal: 3.907 ± 0.019
0.563IleTrp: 0.563 ± 0.009
1.384IleTyr: 1.384 ± 0.013
0.0IleXaa: 0.0 ± 0.0
Lys
4.502LysAla: 4.502 ± 0.034
0.937LysCys: 0.937 ± 0.011
2.648LysAsp: 2.648 ± 0.019
3.274LysGlu: 3.274 ± 0.03
1.696LysPhe: 1.696 ± 0.016
2.257LysGly: 2.257 ± 0.02
1.411LysHis: 1.411 ± 0.014
2.343LysIle: 2.343 ± 0.02
3.784LysLys: 3.784 ± 0.04
4.908LysLeu: 4.908 ± 0.03
1.282LysMet: 1.282 ± 0.013
1.873LysAsn: 1.873 ± 0.018
2.643LysPro: 2.643 ± 0.022
2.478LysGln: 2.478 ± 0.02
3.422LysArg: 3.422 ± 0.026
3.931LysSer: 3.931 ± 0.025
3.35LysThr: 3.35 ± 0.026
2.973LysVal: 2.973 ± 0.019
0.79LysTrp: 0.79 ± 0.01
1.579LysTyr: 1.579 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
8.317LeuAla: 8.317 ± 0.032
1.769LeuCys: 1.769 ± 0.016
5.789LeuAsp: 5.789 ± 0.028
5.96LeuGlu: 5.96 ± 0.037
3.737LeuPhe: 3.737 ± 0.026
5.006LeuGly: 5.006 ± 0.027
3.195LeuHis: 3.195 ± 0.025
3.73LeuIle: 3.73 ± 0.025
4.933LeuLys: 4.933 ± 0.03
9.541LeuLeu: 9.541 ± 0.049
2.125LeuMet: 2.125 ± 0.016
3.555LeuAsn: 3.555 ± 0.025
4.938LeuPro: 4.938 ± 0.027
4.699LeuGln: 4.699 ± 0.03
5.634LeuArg: 5.634 ± 0.033
7.412LeuSer: 7.412 ± 0.033
5.41LeuThr: 5.41 ± 0.034
7.078LeuVal: 7.078 ± 0.03
1.254LeuTrp: 1.254 ± 0.013
2.54LeuTyr: 2.54 ± 0.016
0.0LeuXaa: 0.0 ± 0.0
Met
2.381MetAla: 2.381 ± 0.017
0.383MetCys: 0.383 ± 0.007
1.687MetAsp: 1.687 ± 0.015
1.719MetGlu: 1.719 ± 0.014
0.859MetPhe: 0.859 ± 0.01
1.297MetGly: 1.297 ± 0.012
0.706MetHis: 0.706 ± 0.009
1.045MetIle: 1.045 ± 0.01
1.367MetLys: 1.367 ± 0.013
2.394MetLeu: 2.394 ± 0.019
0.679MetMet: 0.679 ± 0.009
0.965MetAsn: 0.965 ± 0.012
1.21MetPro: 1.21 ± 0.011
1.209MetGln: 1.209 ± 0.013
1.347MetArg: 1.347 ± 0.013
1.886MetSer: 1.886 ± 0.015
1.657MetThr: 1.657 ± 0.015
1.527MetVal: 1.527 ± 0.015
0.328MetTrp: 0.328 ± 0.006
0.718MetTyr: 0.718 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
3.42AsnAla: 3.42 ± 0.02
0.662AsnCys: 0.662 ± 0.01
2.276AsnAsp: 2.276 ± 0.018
2.254AsnGlu: 2.254 ± 0.017
1.348AsnPhe: 1.348 ± 0.012
2.552AsnGly: 2.552 ± 0.024
0.972AsnHis: 0.972 ± 0.012
1.842AsnIle: 1.842 ± 0.016
1.721AsnLys: 1.721 ± 0.016
3.342AsnLeu: 3.342 ± 0.02
0.971AsnMet: 0.971 ± 0.011
1.477AsnAsn: 1.477 ± 0.017
2.06AsnPro: 2.06 ± 0.017
1.661AsnGln: 1.661 ± 0.016
1.909AsnArg: 1.909 ± 0.017
2.573AsnSer: 2.573 ± 0.02
2.016AsnThr: 2.016 ± 0.019
2.865AsnVal: 2.865 ± 0.02
0.484AsnTrp: 0.484 ± 0.008
1.032AsnTyr: 1.032 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
3.977ProAla: 3.977 ± 0.035
0.681ProCys: 0.681 ± 0.01
2.392ProAsp: 2.392 ± 0.015
2.637ProGlu: 2.637 ± 0.019
1.899ProPhe: 1.899 ± 0.016
2.225ProGly: 2.225 ± 0.02
1.264ProHis: 1.264 ± 0.013
2.23ProIle: 2.23 ± 0.019
2.548ProLys: 2.548 ± 0.02
4.673ProLeu: 4.673 ± 0.03
1.112ProMet: 1.112 ± 0.012
1.919ProAsn: 1.919 ± 0.017
4.155ProPro: 4.155 ± 0.044
2.026ProGln: 2.026 ± 0.018
2.754ProArg: 2.754 ± 0.021
5.228ProSer: 5.228 ± 0.037
4.166ProThr: 4.166 ± 0.044
3.332ProVal: 3.332 ± 0.023
0.668ProTrp: 0.668 ± 0.009
1.188ProTyr: 1.188 ± 0.014
0.0ProXaa: 0.0 ± 0.0
Gln
3.914GlnAla: 3.914 ± 0.027
0.799GlnCys: 0.799 ± 0.01
2.228GlnAsp: 2.228 ± 0.018
2.515GlnGlu: 2.515 ± 0.025
1.54GlnPhe: 1.54 ± 0.014
2.076GlnGly: 2.076 ± 0.017
1.22GlnHis: 1.22 ± 0.012
1.881GlnIle: 1.881 ± 0.014
1.948GlnLys: 1.948 ± 0.019
4.512GlnLeu: 4.512 ± 0.027
1.047GlnMet: 1.047 ± 0.011
1.459GlnAsn: 1.459 ± 0.015
2.049GlnPro: 2.049 ± 0.017
2.241GlnGln: 2.241 ± 0.026
2.752GlnArg: 2.752 ± 0.021
3.11GlnSer: 3.11 ± 0.022
2.516GlnThr: 2.516 ± 0.019
3.176GlnVal: 3.176 ± 0.022
0.699GlnTrp: 0.699 ± 0.01
1.205GlnTyr: 1.205 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
4.164ArgAla: 4.164 ± 0.028
0.974ArgCys: 0.974 ± 0.011
2.834ArgAsp: 2.834 ± 0.022
3.156ArgGlu: 3.156 ± 0.026
2.226ArgPhe: 2.226 ± 0.018
2.966ArgGly: 2.966 ± 0.023
1.772ArgHis: 1.772 ± 0.016
2.682ArgIle: 2.682 ± 0.019
2.943ArgLys: 2.943 ± 0.023
5.616ArgLeu: 5.616 ± 0.034
1.382ArgMet: 1.382 ± 0.013
2.0ArgAsn: 2.0 ± 0.016
2.53ArgPro: 2.53 ± 0.018
2.871ArgGln: 2.871 ± 0.022
4.421ArgArg: 4.421 ± 0.036
4.009ArgSer: 4.009 ± 0.023
2.812ArgThr: 2.812 ± 0.019
3.681ArgVal: 3.681 ± 0.021
0.807ArgTrp: 0.807 ± 0.011
1.495ArgTyr: 1.495 ± 0.014
0.0ArgXaa: 0.0 ± 0.0
Ser
5.763SerAla: 5.763 ± 0.034
1.269SerCys: 1.269 ± 0.014
3.898SerAsp: 3.898 ± 0.024
3.415SerGlu: 3.415 ± 0.023
3.289SerPhe: 3.289 ± 0.024
4.08SerGly: 4.08 ± 0.04
1.909SerHis: 1.909 ± 0.016
4.263SerIle: 4.263 ± 0.022
4.11SerLys: 4.11 ± 0.027
7.305SerLeu: 7.305 ± 0.037
2.135SerMet: 2.135 ± 0.016
3.118SerAsn: 3.118 ± 0.023
4.344SerPro: 4.344 ± 0.031
2.892SerGln: 2.892 ± 0.019
3.993SerArg: 3.993 ± 0.026
8.026SerSer: 8.026 ± 0.054
5.792SerThr: 5.792 ± 0.038
5.007SerVal: 5.007 ± 0.027
1.07SerTrp: 1.07 ± 0.011
1.958SerTyr: 1.958 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
5.24ThrAla: 5.24 ± 0.031
1.114ThrCys: 1.114 ± 0.015
2.853ThrAsp: 2.853 ± 0.024
2.833ThrGlu: 2.833 ± 0.02
2.409ThrPhe: 2.409 ± 0.022
2.914ThrGly: 2.914 ± 0.033
1.436ThrHis: 1.436 ± 0.014
3.322ThrIle: 3.322 ± 0.022
3.412ThrLys: 3.412 ± 0.022
5.917ThrLeu: 5.917 ± 0.028
1.553ThrMet: 1.553 ± 0.013
2.381ThrAsn: 2.381 ± 0.018
4.082ThrPro: 4.082 ± 0.05
2.339ThrGln: 2.339 ± 0.017
2.896ThrArg: 2.896 ± 0.019
5.356ThrSer: 5.356 ± 0.035
5.302ThrThr: 5.302 ± 0.045
3.767ThrVal: 3.767 ± 0.026
0.941ThrTrp: 0.941 ± 0.01
1.575ThrTyr: 1.575 ± 0.014
0.0ThrXaa: 0.0 ± 0.0
Val
6.655ValAla: 6.655 ± 0.031
1.346ValCys: 1.346 ± 0.014
4.455ValAsp: 4.455 ± 0.025
4.383ValGlu: 4.383 ± 0.025
2.875ValPhe: 2.875 ± 0.023
3.797ValGly: 3.797 ± 0.024
1.963ValHis: 1.963 ± 0.015
2.997ValIle: 2.997 ± 0.02
3.422ValLys: 3.422 ± 0.022
7.015ValLeu: 7.015 ± 0.035
1.627ValMet: 1.627 ± 0.015
2.485ValAsn: 2.485 ± 0.019
3.427ValPro: 3.427 ± 0.025
3.142ValGln: 3.142 ± 0.022
3.439ValArg: 3.439 ± 0.018
4.831ValSer: 4.831 ± 0.028
3.644ValThr: 3.644 ± 0.028
6.31ValVal: 6.31 ± 0.038
0.997ValTrp: 0.997 ± 0.012
2.025ValTyr: 2.025 ± 0.017
0.001ValXaa: 0.001 ± 0.0
Trp
0.894TrpAla: 0.894 ± 0.01
0.268TrpCys: 0.268 ± 0.005
0.672TrpAsp: 0.672 ± 0.011
0.662TrpGlu: 0.662 ± 0.008
0.614TrpPhe: 0.614 ± 0.008
0.66TrpGly: 0.66 ± 0.011
0.388TrpHis: 0.388 ± 0.007
0.879TrpIle: 0.879 ± 0.01
0.839TrpLys: 0.839 ± 0.011
1.459TrpLeu: 1.459 ± 0.014
0.42TrpMet: 0.42 ± 0.008
0.674TrpAsn: 0.674 ± 0.01
0.53TrpPro: 0.53 ± 0.009
0.566TrpGln: 0.566 ± 0.009
0.867TrpArg: 0.867 ± 0.012
1.099TrpSer: 1.099 ± 0.012
1.066TrpThr: 1.066 ± 0.013
0.746TrpVal: 0.746 ± 0.01
0.24TrpTrp: 0.24 ± 0.006
0.396TrpTyr: 0.396 ± 0.007
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.221TyrAla: 2.221 ± 0.018
0.613TyrCys: 0.613 ± 0.009
1.624TyrAsp: 1.624 ± 0.015
1.446TyrGlu: 1.446 ± 0.013
1.337TyrPhe: 1.337 ± 0.014
1.825TyrGly: 1.825 ± 0.018
0.725TyrHis: 0.725 ± 0.011
1.393TyrIle: 1.393 ± 0.015
1.222TyrLys: 1.222 ± 0.012
2.723TyrLeu: 2.723 ± 0.019
0.748TyrMet: 0.748 ± 0.009
1.144TyrAsn: 1.144 ± 0.013
1.139TyrPro: 1.139 ± 0.014
1.017TyrGln: 1.017 ± 0.012
1.485TyrArg: 1.485 ± 0.012
1.903TyrSer: 1.903 ± 0.018
1.587TyrThr: 1.587 ± 0.014
2.04TyrVal: 2.04 ± 0.017
0.38TyrTrp: 0.38 ± 0.008
0.907TyrTyr: 0.907 ± 0.011
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.046XaaXaa: 0.046 ± 0.017
Statistics based on 20021 proteins (9106444 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski