Amino acid dipepetide frequency for Bat coronavirus 1B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.743AlaAla: 3.743 ± 0.524
2.789AlaCys: 2.789 ± 0.63
3.449AlaAsp: 3.449 ± 0.408
4.183AlaGlu: 4.183 ± 0.512
4.77AlaPhe: 4.77 ± 0.214
3.889AlaGly: 3.889 ± 0.609
1.394AlaHis: 1.394 ± 0.213
3.743AlaIle: 3.743 ± 0.355
4.843AlaLys: 4.843 ± 0.69
5.577AlaLeu: 5.577 ± 0.659
1.835AlaMet: 1.835 ± 0.22
4.256AlaAsn: 4.256 ± 0.733
1.468AlaPro: 1.468 ± 0.342
1.321AlaGln: 1.321 ± 0.197
1.908AlaArg: 1.908 ± 0.37
4.403AlaSer: 4.403 ± 0.413
4.917AlaThr: 4.917 ± 0.371
6.458AlaVal: 6.458 ± 0.632
0.734AlaTrp: 0.734 ± 0.134
1.908AlaTyr: 1.908 ± 0.156
0.0AlaXaa: 0.0 ± 0.0
Cys
2.275CysAla: 2.275 ± 0.159
0.954CysCys: 0.954 ± 0.175
2.348CysAsp: 2.348 ± 0.71
0.44CysGlu: 0.44 ± 0.18
2.275CysPhe: 2.275 ± 0.338
3.082CysGly: 3.082 ± 0.451
0.734CysHis: 0.734 ± 0.182
1.248CysIle: 1.248 ± 0.234
2.422CysLys: 2.422 ± 0.612
2.568CysLeu: 2.568 ± 0.382
0.294CysMet: 0.294 ± 0.205
2.348CysAsn: 2.348 ± 0.42
0.66CysPro: 0.66 ± 0.098
0.66CysGln: 0.66 ± 0.261
0.954CysArg: 0.954 ± 0.189
1.614CysSer: 1.614 ± 0.211
2.789CysThr: 2.789 ± 0.391
3.229CysVal: 3.229 ± 0.474
0.66CysTrp: 0.66 ± 0.2
2.275CysTyr: 2.275 ± 0.479
0.0CysXaa: 0.0 ± 0.0
Asp
3.816AspAla: 3.816 ± 0.839
1.835AspCys: 1.835 ± 0.344
3.302AspAsp: 3.302 ± 0.62
1.981AspGlu: 1.981 ± 0.163
3.816AspPhe: 3.816 ± 0.607
5.284AspGly: 5.284 ± 0.671
1.321AspHis: 1.321 ± 0.291
2.789AspIle: 2.789 ± 0.559
2.495AspLys: 2.495 ± 0.453
4.843AspLeu: 4.843 ± 0.48
1.394AspMet: 1.394 ± 0.157
3.522AspAsn: 3.522 ± 0.543
1.835AspPro: 1.835 ± 0.323
0.807AspGln: 0.807 ± 0.174
0.881AspArg: 0.881 ± 0.353
4.036AspSer: 4.036 ± 0.488
2.275AspThr: 2.275 ± 0.275
4.99AspVal: 4.99 ± 0.497
0.587AspTrp: 0.587 ± 0.178
3.156AspTyr: 3.156 ± 0.592
0.0AspXaa: 0.0 ± 0.0
Glu
3.229GluAla: 3.229 ± 0.365
1.321GluCys: 1.321 ± 0.277
2.642GluAsp: 2.642 ± 0.36
3.229GluGlu: 3.229 ± 0.324
2.422GluPhe: 2.422 ± 0.349
3.522GluGly: 3.522 ± 0.705
1.394GluHis: 1.394 ± 0.31
1.321GluIle: 1.321 ± 0.243
2.862GluLys: 2.862 ± 0.447
3.376GluLeu: 3.376 ± 0.615
0.294GluMet: 0.294 ± 0.205
2.348GluAsn: 2.348 ± 0.236
2.055GluPro: 2.055 ± 0.304
1.027GluGln: 1.027 ± 0.435
1.321GluArg: 1.321 ± 0.182
0.881GluSer: 0.881 ± 0.21
2.495GluThr: 2.495 ± 0.379
5.21GluVal: 5.21 ± 0.295
0.294GluTrp: 0.294 ± 0.205
1.688GluTyr: 1.688 ± 0.395
0.0GluXaa: 0.0 ± 0.0
Phe
3.156PheAla: 3.156 ± 0.311
2.128PheCys: 2.128 ± 0.314
4.183PheAsp: 4.183 ± 0.336
3.229PheGlu: 3.229 ± 0.577
2.202PhePhe: 2.202 ± 0.352
4.476PheGly: 4.476 ± 0.439
0.66PheHis: 0.66 ± 0.098
3.963PheIle: 3.963 ± 0.829
4.697PheLys: 4.697 ± 0.891
3.743PheLeu: 3.743 ± 0.49
1.101PheMet: 1.101 ± 0.342
6.017PheAsn: 6.017 ± 0.96
0.66PhePro: 0.66 ± 0.129
1.027PheGln: 1.027 ± 0.38
0.66PheArg: 0.66 ± 0.725
4.33PheSer: 4.33 ± 1.138
3.156PheThr: 3.156 ± 0.399
7.192PheVal: 7.192 ± 0.752
0.881PheTrp: 0.881 ± 0.158
2.422PheTyr: 2.422 ± 0.27
0.0PheXaa: 0.0 ± 0.0
Gly
4.183GlyAla: 4.183 ± 1.133
2.495GlyCys: 2.495 ± 0.355
4.917GlyAsp: 4.917 ± 0.746
1.688GlyGlu: 1.688 ± 0.364
4.256GlyPhe: 4.256 ± 0.595
4.77GlyGly: 4.77 ± 0.362
0.66GlyHis: 0.66 ± 0.098
2.642GlyIle: 2.642 ± 0.569
2.862GlyLys: 2.862 ± 0.439
4.843GlyLeu: 4.843 ± 0.183
0.881GlyMet: 0.881 ± 0.159
4.036GlyAsn: 4.036 ± 0.496
1.101GlyPro: 1.101 ± 0.34
1.101GlyGln: 1.101 ± 0.37
2.128GlyArg: 2.128 ± 1.102
6.311GlySer: 6.311 ± 0.891
4.109GlyThr: 4.109 ± 0.346
8.513GlyVal: 8.513 ± 0.711
0.66GlyTrp: 0.66 ± 0.111
2.568GlyTyr: 2.568 ± 0.404
0.0GlyXaa: 0.0 ± 0.0
His
1.541HisAla: 1.541 ± 0.281
0.881HisCys: 0.881 ± 0.334
0.881HisAsp: 0.881 ± 0.28
1.174HisGlu: 1.174 ± 0.258
0.514HisPhe: 0.514 ± 0.207
0.954HisGly: 0.954 ± 0.33
0.147HisHis: 0.147 ± 0.108
0.367HisIle: 0.367 ± 0.086
1.394HisLys: 1.394 ± 0.342
1.101HisLeu: 1.101 ± 0.585
0.294HisMet: 0.294 ± 0.096
1.174HisAsn: 1.174 ± 0.258
0.514HisPro: 0.514 ± 0.146
0.514HisGln: 0.514 ± 0.079
0.66HisArg: 0.66 ± 0.171
1.174HisSer: 1.174 ± 0.174
1.101HisThr: 1.101 ± 0.151
1.981HisVal: 1.981 ± 0.222
0.294HisTrp: 0.294 ± 0.096
0.807HisTyr: 0.807 ± 0.463
0.0HisXaa: 0.0 ± 0.0
Ile
3.449IleAla: 3.449 ± 0.317
1.541IleCys: 1.541 ± 0.488
2.862IleAsp: 2.862 ± 0.276
2.202IleGlu: 2.202 ± 0.364
3.669IlePhe: 3.669 ± 0.465
2.568IleGly: 2.568 ± 0.256
0.954IleHis: 0.954 ± 0.243
2.422IleIle: 2.422 ± 0.761
2.862IleLys: 2.862 ± 0.51
3.963IleLeu: 3.963 ± 0.43
0.807IleMet: 0.807 ± 0.361
3.156IleAsn: 3.156 ± 0.336
2.642IlePro: 2.642 ± 0.848
1.321IleGln: 1.321 ± 0.333
1.614IleArg: 1.614 ± 0.242
4.697IleSer: 4.697 ± 0.721
4.109IleThr: 4.109 ± 0.778
5.284IleVal: 5.284 ± 0.409
0.66IleTrp: 0.66 ± 0.2
1.101IleTyr: 1.101 ± 0.324
0.0IleXaa: 0.0 ± 0.0
Lys
4.476LysAla: 4.476 ± 0.601
1.835LysCys: 1.835 ± 0.433
2.935LysAsp: 2.935 ± 0.526
2.202LysGlu: 2.202 ± 0.205
3.816LysPhe: 3.816 ± 0.761
3.009LysGly: 3.009 ± 0.377
1.981LysHis: 1.981 ± 0.676
1.614LysIle: 1.614 ± 0.268
2.568LysLys: 2.568 ± 0.587
6.238LysLeu: 6.238 ± 0.584
1.174LysMet: 1.174 ± 0.212
2.422LysAsn: 2.422 ± 0.408
4.256LysPro: 4.256 ± 0.55
2.715LysGln: 2.715 ± 0.454
2.495LysArg: 2.495 ± 0.635
4.036LysSer: 4.036 ± 0.59
4.183LysThr: 4.183 ± 0.607
5.724LysVal: 5.724 ± 0.907
0.367LysTrp: 0.367 ± 0.106
3.449LysTyr: 3.449 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
5.871LeuAla: 5.871 ± 0.723
3.156LeuCys: 3.156 ± 0.319
3.816LeuAsp: 3.816 ± 0.331
3.302LeuGlu: 3.302 ± 0.233
3.669LeuPhe: 3.669 ± 1.26
4.33LeuGly: 4.33 ± 0.837
1.541LeuHis: 1.541 ± 0.207
3.156LeuIle: 3.156 ± 0.863
6.384LeuLys: 6.384 ± 0.555
5.871LeuLeu: 5.871 ± 0.653
1.248LeuMet: 1.248 ± 0.136
5.063LeuAsn: 5.063 ± 0.929
3.522LeuPro: 3.522 ± 1.445
3.009LeuGln: 3.009 ± 0.158
2.715LeuArg: 2.715 ± 0.397
7.705LeuSer: 7.705 ± 0.934
5.651LeuThr: 5.651 ± 1.197
6.678LeuVal: 6.678 ± 0.788
0.734LeuTrp: 0.734 ± 0.527
4.036LeuTyr: 4.036 ± 0.603
0.0LeuXaa: 0.0 ± 0.0
Met
1.248MetAla: 1.248 ± 0.247
0.881MetCys: 0.881 ± 0.409
1.174MetAsp: 1.174 ± 0.388
0.954MetGlu: 0.954 ± 0.203
1.981MetPhe: 1.981 ± 0.234
1.248MetGly: 1.248 ± 0.277
0.587MetHis: 0.587 ± 0.192
1.174MetIle: 1.174 ± 0.305
0.0MetLys: 0.0 ± 0.0
2.642MetLeu: 2.642 ± 0.423
0.734MetMet: 0.734 ± 0.128
0.587MetAsn: 0.587 ± 0.152
0.881MetPro: 0.881 ± 0.108
0.881MetGln: 0.881 ± 0.317
0.881MetArg: 0.881 ± 0.158
1.614MetSer: 1.614 ± 0.19
0.954MetThr: 0.954 ± 0.168
0.66MetVal: 0.66 ± 0.129
0.367MetTrp: 0.367 ± 0.212
1.174MetTyr: 1.174 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
5.651AsnAla: 5.651 ± 1.155
2.789AsnCys: 2.789 ± 0.464
2.715AsnAsp: 2.715 ± 0.289
2.789AsnGlu: 2.789 ± 0.315
2.275AsnPhe: 2.275 ± 0.653
5.43AsnGly: 5.43 ± 0.484
0.734AsnHis: 0.734 ± 0.248
3.596AsnIle: 3.596 ± 0.425
3.229AsnLys: 3.229 ± 0.341
4.403AsnLeu: 4.403 ± 1.067
1.174AsnMet: 1.174 ± 0.234
4.33AsnAsn: 4.33 ± 0.454
1.394AsnPro: 1.394 ± 0.373
0.954AsnGln: 0.954 ± 0.443
1.394AsnArg: 1.394 ± 0.495
4.843AsnSer: 4.843 ± 1.126
3.596AsnThr: 3.596 ± 0.39
8.513AsnVal: 8.513 ± 1.058
0.514AsnTrp: 0.514 ± 0.253
1.981AsnTyr: 1.981 ± 0.421
0.0AsnXaa: 0.0 ± 0.0
Pro
1.908ProAla: 1.908 ± 0.538
0.734ProCys: 0.734 ± 0.128
1.835ProAsp: 1.835 ± 0.215
2.128ProGlu: 2.128 ± 0.272
1.835ProPhe: 1.835 ± 0.352
1.835ProGly: 1.835 ± 0.26
0.734ProHis: 0.734 ± 0.176
2.568ProIle: 2.568 ± 0.29
1.761ProLys: 1.761 ± 0.54
2.715ProLeu: 2.715 ± 0.666
0.66ProMet: 0.66 ± 0.2
1.321ProAsn: 1.321 ± 0.991
1.394ProPro: 1.394 ± 0.184
0.807ProGln: 0.807 ± 0.17
1.101ProArg: 1.101 ± 0.501
3.522ProSer: 3.522 ± 0.304
2.202ProThr: 2.202 ± 0.711
3.522ProVal: 3.522 ± 0.528
0.44ProTrp: 0.44 ± 0.066
0.66ProTyr: 0.66 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
2.055GlnAla: 2.055 ± 0.191
0.587GlnCys: 0.587 ± 0.178
0.881GlnAsp: 0.881 ± 0.249
1.027GlnGlu: 1.027 ± 0.337
0.954GlnPhe: 0.954 ± 0.243
1.248GlnGly: 1.248 ± 0.159
0.22GlnHis: 0.22 ± 0.07
1.174GlnIle: 1.174 ± 0.336
1.027GlnLys: 1.027 ± 0.637
3.596GlnLeu: 3.596 ± 1.065
0.807GlnMet: 0.807 ± 0.29
1.174GlnAsn: 1.174 ± 0.174
1.101GlnPro: 1.101 ± 0.129
1.101GlnGln: 1.101 ± 0.897
1.101GlnArg: 1.101 ± 0.545
2.128GlnSer: 2.128 ± 0.824
1.248GlnThr: 1.248 ± 0.348
2.275GlnVal: 2.275 ± 0.368
0.22GlnTrp: 0.22 ± 0.07
1.101GlnTyr: 1.101 ± 0.227
0.0GlnXaa: 0.0 ± 0.0
Arg
2.422ArgAla: 2.422 ± 0.268
1.174ArgCys: 1.174 ± 0.26
1.174ArgAsp: 1.174 ± 0.171
1.101ArgGlu: 1.101 ± 0.422
2.789ArgPhe: 2.789 ± 0.496
1.101ArgGly: 1.101 ± 0.262
0.514ArgHis: 0.514 ± 0.201
1.394ArgIle: 1.394 ± 0.375
2.055ArgLys: 2.055 ± 0.222
2.422ArgLeu: 2.422 ± 1.272
0.881ArgMet: 0.881 ± 0.136
2.055ArgAsn: 2.055 ± 0.461
0.881ArgPro: 0.881 ± 0.259
0.954ArgGln: 0.954 ± 0.518
0.66ArgArg: 0.66 ± 0.478
1.614ArgSer: 1.614 ± 1.297
1.761ArgThr: 1.761 ± 0.549
3.082ArgVal: 3.082 ± 0.331
0.367ArgTrp: 0.367 ± 0.206
1.101ArgTyr: 1.101 ± 0.189
0.0ArgXaa: 0.0 ± 0.0
Ser
3.669SerAla: 3.669 ± 0.23
1.468SerCys: 1.468 ± 0.409
3.816SerAsp: 3.816 ± 0.352
3.082SerGlu: 3.082 ± 0.219
4.843SerPhe: 4.843 ± 1.1
5.504SerGly: 5.504 ± 0.47
0.66SerHis: 0.66 ± 0.286
4.77SerIle: 4.77 ± 0.409
4.697SerLys: 4.697 ± 0.739
6.091SerLeu: 6.091 ± 0.579
2.055SerMet: 2.055 ± 0.381
4.403SerAsn: 4.403 ± 1.114
1.688SerPro: 1.688 ± 0.212
1.835SerGln: 1.835 ± 0.457
1.981SerArg: 1.981 ± 1.494
5.651SerSer: 5.651 ± 0.427
4.036SerThr: 4.036 ± 0.19
8.953SerVal: 8.953 ± 0.581
0.734SerTrp: 0.734 ± 0.364
3.743SerTyr: 3.743 ± 0.469
0.0SerXaa: 0.0 ± 0.0
Thr
4.403ThrAla: 4.403 ± 0.553
1.688ThrCys: 1.688 ± 0.149
2.642ThrAsp: 2.642 ± 0.354
2.642ThrGlu: 2.642 ± 0.541
4.917ThrPhe: 4.917 ± 0.682
3.522ThrGly: 3.522 ± 0.521
1.027ThrHis: 1.027 ± 0.246
4.476ThrIle: 4.476 ± 1.019
2.862ThrLys: 2.862 ± 0.576
4.917ThrLeu: 4.917 ± 0.536
1.908ThrMet: 1.908 ± 0.488
3.156ThrAsn: 3.156 ± 0.399
2.862ThrPro: 2.862 ± 0.851
1.248ThrGln: 1.248 ± 0.627
1.908ThrArg: 1.908 ± 0.408
4.109ThrSer: 4.109 ± 0.376
4.77ThrThr: 4.77 ± 1.126
6.384ThrVal: 6.384 ± 0.398
0.514ThrTrp: 0.514 ± 0.154
1.688ThrTyr: 1.688 ± 0.383
0.0ThrXaa: 0.0 ± 0.0
Val
7.192ValAla: 7.192 ± 0.38
3.669ValCys: 3.669 ± 0.41
6.458ValAsp: 6.458 ± 0.861
3.889ValGlu: 3.889 ± 0.801
5.137ValPhe: 5.137 ± 0.593
5.137ValGly: 5.137 ± 0.52
0.734ValHis: 0.734 ± 0.248
7.265ValIle: 7.265 ± 0.661
9.907ValLys: 9.907 ± 2.156
8.366ValLeu: 8.366 ± 0.564
2.055ValMet: 2.055 ± 0.763
6.971ValAsn: 6.971 ± 0.323
3.522ValPro: 3.522 ± 0.424
2.789ValGln: 2.789 ± 0.14
2.935ValArg: 2.935 ± 0.213
7.632ValSer: 7.632 ± 0.955
6.017ValThr: 6.017 ± 0.763
9.613ValVal: 9.613 ± 1.418
0.807ValTrp: 0.807 ± 0.144
4.036ValTyr: 4.036 ± 0.413
0.0ValXaa: 0.0 ± 0.0
Trp
0.294TrpAla: 0.294 ± 0.095
0.294TrpCys: 0.294 ± 0.076
0.734TrpAsp: 0.734 ± 0.248
0.22TrpGlu: 0.22 ± 0.07
0.807TrpPhe: 0.807 ± 0.174
0.22TrpGly: 0.22 ± 0.236
0.367TrpHis: 0.367 ± 0.153
0.44TrpIle: 0.44 ± 0.144
0.367TrpLys: 0.367 ± 0.151
1.394TrpLeu: 1.394 ± 0.31
0.073TrpMet: 0.073 ± 0.049
0.881TrpAsn: 0.881 ± 0.229
0.66TrpPro: 0.66 ± 0.22
0.073TrpGln: 0.073 ± 0.049
0.66TrpArg: 0.66 ± 0.129
1.174TrpSer: 1.174 ± 0.208
0.367TrpThr: 0.367 ± 0.179
0.807TrpVal: 0.807 ± 0.177
0.147TrpTrp: 0.147 ± 0.048
0.807TrpTyr: 0.807 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.082TyrAla: 3.082 ± 0.504
1.614TyrCys: 1.614 ± 0.265
2.202TyrAsp: 2.202 ± 0.943
1.468TyrGlu: 1.468 ± 0.497
2.935TyrPhe: 2.935 ± 0.385
3.596TyrGly: 3.596 ± 0.399
1.101TyrHis: 1.101 ± 0.127
1.761TyrIle: 1.761 ± 0.305
2.202TyrLys: 2.202 ± 0.464
2.789TyrLeu: 2.789 ± 0.378
0.881TyrMet: 0.881 ± 0.162
3.082TyrAsn: 3.082 ± 0.608
0.587TyrPro: 0.587 ± 0.395
0.881TyrGln: 0.881 ± 0.202
1.541TyrArg: 1.541 ± 0.484
2.202TyrSer: 2.202 ± 0.415
1.908TyrThr: 1.908 ± 0.386
5.063TyrVal: 5.063 ± 0.703
0.807TyrTrp: 0.807 ± 0.18
2.715TyrTyr: 2.715 ± 0.696
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (13628 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski