Amino acid dipepetide frequency for Porphyromonas sp. oral taxon 279 str. F0450

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.289AlaAla: 7.289 ± 0.135	0.847AlaCys: 0.847 ± 0.039	4.396AlaAsp: 4.396 ± 0.081	6.046AlaGlu: 6.046 ± 0.11	3.501AlaPhe: 3.501 ± 0.073	6.188AlaGly: 6.188 ± 0.119	1.733AlaHis: 1.733 ± 0.057	4.811AlaIle: 4.811 ± 0.103	4.126AlaLys: 4.126 ± 0.087	10.176AlaLeu: 10.176 ± 0.166	1.842AlaMet: 1.842 ± 0.053	2.533AlaAsn: 2.533 ± 0.075	3.935AlaPro: 3.935 ± 0.108	3.492AlaGln: 3.492 ± 0.082	4.774AlaArg: 4.774 ± 0.091	5.769AlaSer: 5.769 ± 0.1	5.067AlaThr: 5.067 ± 0.101	5.139AlaVal: 5.139 ± 0.088	0.892AlaTrp: 0.892 ± 0.04	3.392AlaTyr: 3.392 ± 0.077	0.0AlaXaa: 0.0 ± 0.0
Cys	0.655CysAla: 0.655 ± 0.032	0.109CysCys: 0.109 ± 0.014	0.482CysAsp: 0.482 ± 0.03	0.483CysGlu: 0.483 ± 0.033	0.373CysPhe: 0.373 ± 0.027	0.735CysGly: 0.735 ± 0.043	0.265CysHis: 0.265 ± 0.021	0.554CysIle: 0.554 ± 0.03	0.327CysLys: 0.327 ± 0.021	0.864CysLeu: 0.864 ± 0.039	0.182CysMet: 0.182 ± 0.021	0.276CysAsn: 0.276 ± 0.021	0.454CysPro: 0.454 ± 0.028	0.25CysGln: 0.25 ± 0.02	0.596CysArg: 0.596 ± 0.034	0.633CysSer: 0.633 ± 0.033	0.487CysThr: 0.487 ± 0.027	0.508CysVal: 0.508 ± 0.029	0.067CysTrp: 0.067 ± 0.01	0.377CysTyr: 0.377 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.36AspAla: 4.36 ± 0.089	0.398AspCys: 0.398 ± 0.024	2.316AspAsp: 2.316 ± 0.067	3.805AspGlu: 3.805 ± 0.086	2.69AspPhe: 2.69 ± 0.07	3.891AspGly: 3.891 ± 0.086	1.126AspHis: 1.126 ± 0.045	3.167AspIle: 3.167 ± 0.076	3.078AspLys: 3.078 ± 0.074	5.63AspLeu: 5.63 ± 0.095	1.177AspMet: 1.177 ± 0.038	1.645AspAsn: 1.645 ± 0.061	2.528AspPro: 2.528 ± 0.071	1.611AspGln: 1.611 ± 0.054	3.153AspArg: 3.153 ± 0.092	3.124AspSer: 3.124 ± 0.094	2.639AspThr: 2.639 ± 0.067	3.038AspVal: 3.038 ± 0.069	0.739AspTrp: 0.739 ± 0.036	2.728AspTyr: 2.728 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	7.113GluAla: 7.113 ± 0.127	0.463GluCys: 0.463 ± 0.029	3.476GluAsp: 3.476 ± 0.081	5.837GluGlu: 5.837 ± 0.139	1.82GluPhe: 1.82 ± 0.056	5.067GluGly: 5.067 ± 0.105	1.555GluHis: 1.555 ± 0.052	3.673GluIle: 3.673 ± 0.094	3.22GluLys: 3.22 ± 0.087	7.486GluLeu: 7.486 ± 0.109	1.436GluMet: 1.436 ± 0.042	1.712GluAsn: 1.712 ± 0.055	2.196GluPro: 2.196 ± 0.059	2.77GluGln: 2.77 ± 0.07	4.82GluArg: 4.82 ± 0.121	3.107GluSer: 3.107 ± 0.071	3.052GluThr: 3.052 ± 0.064	4.828GluVal: 4.828 ± 0.096	0.653GluTrp: 0.653 ± 0.031	2.278GluTyr: 2.278 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	3.62PheAla: 3.62 ± 0.077	0.388PheCys: 0.388 ± 0.025	2.671PheAsp: 2.671 ± 0.058	2.043PheGlu: 2.043 ± 0.063	1.957PhePhe: 1.957 ± 0.066	3.155PheGly: 3.155 ± 0.08	0.806PheHis: 0.806 ± 0.034	2.561PheIle: 2.561 ± 0.075	1.446PheLys: 1.446 ± 0.054	3.751PheLeu: 3.751 ± 0.08	0.803PheMet: 0.803 ± 0.037	1.357PheAsn: 1.357 ± 0.061	1.655PhePro: 1.655 ± 0.052	0.95PheGln: 0.95 ± 0.038	2.246PheArg: 2.246 ± 0.07	3.23PheSer: 3.23 ± 0.077	2.823PheThr: 2.823 ± 0.068	2.793PheVal: 2.793 ± 0.071	0.399PheTrp: 0.399 ± 0.028	1.505PheTyr: 1.505 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	6.19GlyAla: 6.19 ± 0.115	0.705GlyCys: 0.705 ± 0.047	3.606GlyAsp: 3.606 ± 0.071	4.721GlyGlu: 4.721 ± 0.098	3.038GlyPhe: 3.038 ± 0.065	5.493GlyGly: 5.493 ± 0.101	1.561GlyHis: 1.561 ± 0.055	4.63GlyIle: 4.63 ± 0.104	4.532GlyLys: 4.532 ± 0.095	7.386GlyLeu: 7.386 ± 0.131	1.776GlyMet: 1.776 ± 0.055	2.458GlyAsn: 2.458 ± 0.071	1.447GlyPro: 1.447 ± 0.05	2.469GlyGln: 2.469 ± 0.064	4.431GlyArg: 4.431 ± 0.093	4.591GlySer: 4.591 ± 0.098	4.137GlyThr: 4.137 ± 0.079	5.114GlyVal: 5.114 ± 0.107	0.909GlyTrp: 0.909 ± 0.037	3.47GlyTyr: 3.47 ± 0.089	0.0GlyXaa: 0.0 ± 0.0
His	1.491HisAla: 1.491 ± 0.055	0.226HisCys: 0.226 ± 0.017	1.025HisAsp: 1.025 ± 0.048	1.232HisGlu: 1.232 ± 0.048	1.098HisPhe: 1.098 ± 0.042	1.386HisGly: 1.386 ± 0.05	0.608HisHis: 0.608 ± 0.031	1.455HisIle: 1.455 ± 0.048	0.88HisLys: 0.88 ± 0.036	2.511HisLeu: 2.511 ± 0.07	0.362HisMet: 0.362 ± 0.024	0.708HisAsn: 0.708 ± 0.035	1.343HisPro: 1.343 ± 0.048	0.819HisGln: 0.819 ± 0.037	1.321HisArg: 1.321 ± 0.05	1.421HisSer: 1.421 ± 0.053	1.274HisThr: 1.274 ± 0.049	1.131HisVal: 1.131 ± 0.042	0.285HisTrp: 0.285 ± 0.022	1.067HisTyr: 1.067 ± 0.047	0.0HisXaa: 0.0 ± 0.0
Ile	5.566IleAla: 5.566 ± 0.107	0.586IleCys: 0.586 ± 0.034	3.864IleAsp: 3.864 ± 0.08	4.173IleGlu: 4.173 ± 0.092	2.272IlePhe: 2.272 ± 0.068	4.203IleGly: 4.203 ± 0.106	1.249IleHis: 1.249 ± 0.047	3.573IleIle: 3.573 ± 0.093	2.439IleLys: 2.439 ± 0.069	5.45IleLeu: 5.45 ± 0.11	0.926IleMet: 0.926 ± 0.044	2.241IleAsn: 2.241 ± 0.064	2.985IlePro: 2.985 ± 0.072	1.979IleGln: 1.979 ± 0.062	3.762IleArg: 3.762 ± 0.078	4.063IleSer: 4.063 ± 0.076	3.673IleThr: 3.673 ± 0.072	3.593IleVal: 3.593 ± 0.084	0.449IleTrp: 0.449 ± 0.026	2.311IleTyr: 2.311 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.423LysAla: 4.423 ± 0.087	0.248LysCys: 0.248 ± 0.022	2.829LysAsp: 2.829 ± 0.076	3.581LysGlu: 3.581 ± 0.08	1.333LysPhe: 1.333 ± 0.051	3.668LysGly: 3.668 ± 0.08	1.064LysHis: 1.064 ± 0.042	2.745LysIle: 2.745 ± 0.077	3.365LysLys: 3.365 ± 0.102	4.618LysLeu: 4.618 ± 0.097	1.332LysMet: 1.332 ± 0.048	1.672LysAsn: 1.672 ± 0.06	1.809LysPro: 1.809 ± 0.065	1.945LysGln: 1.945 ± 0.058	2.857LysArg: 2.857 ± 0.069	2.955LysSer: 2.955 ± 0.082	3.036LysThr: 3.036 ± 0.066	3.091LysVal: 3.091 ± 0.091	0.487LysTrp: 0.487 ± 0.031	1.857LysTyr: 1.857 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	8.162LeuAla: 8.162 ± 0.132	1.118LeuCys: 1.118 ± 0.048	5.273LeuAsp: 5.273 ± 0.104	5.96LeuGlu: 5.96 ± 0.105	4.435LeuPhe: 4.435 ± 0.097	7.712LeuGly: 7.712 ± 0.137	2.389LeuHis: 2.389 ± 0.073	5.8LeuIle: 5.8 ± 0.11	4.643LeuLys: 4.643 ± 0.088	11.539LeuLeu: 11.539 ± 0.21	2.197LeuMet: 2.197 ± 0.051	3.172LeuAsn: 3.172 ± 0.078	5.78LeuPro: 5.78 ± 0.102	4.162LeuGln: 4.162 ± 0.1	7.941LeuArg: 7.941 ± 0.146	8.92LeuSer: 8.92 ± 0.138	6.667LeuThr: 6.667 ± 0.115	5.702LeuVal: 5.702 ± 0.108	1.134LeuTrp: 1.134 ± 0.045	3.843LeuTyr: 3.843 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	1.935MetAla: 1.935 ± 0.064	0.14MetCys: 0.14 ± 0.015	1.089MetAsp: 1.089 ± 0.045	1.287MetGlu: 1.287 ± 0.049	0.448MetPhe: 0.448 ± 0.03	1.606MetGly: 1.606 ± 0.053	0.482MetHis: 0.482 ± 0.026	1.226MetIle: 1.226 ± 0.041	1.429MetLys: 1.429 ± 0.044	2.083MetLeu: 2.083 ± 0.061	0.544MetMet: 0.544 ± 0.031	1.009MetAsn: 1.009 ± 0.034	1.012MetPro: 1.012 ± 0.038	0.993MetGln: 0.993 ± 0.044	1.391MetArg: 1.391 ± 0.051	1.365MetSer: 1.365 ± 0.045	1.346MetThr: 1.346 ± 0.036	1.143MetVal: 1.143 ± 0.042	0.159MetTrp: 0.159 ± 0.016	0.574MetTyr: 0.574 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.723AsnAla: 2.723 ± 0.066	0.242AsnCys: 0.242 ± 0.02	1.581AsnAsp: 1.581 ± 0.059	1.845AsnGlu: 1.845 ± 0.056	1.422AsnPhe: 1.422 ± 0.056	2.327AsnGly: 2.327 ± 0.068	0.614AsnHis: 0.614 ± 0.027	2.155AsnIle: 2.155 ± 0.061	1.867AsnLys: 1.867 ± 0.059	3.099AsnLeu: 3.099 ± 0.079	0.692AsnMet: 0.692 ± 0.037	1.204AsnAsn: 1.204 ± 0.052	1.901AsnPro: 1.901 ± 0.053	1.05AsnGln: 1.05 ± 0.047	1.667AsnArg: 1.667 ± 0.057	1.962AsnSer: 1.962 ± 0.06	1.759AsnThr: 1.759 ± 0.057	2.204AsnVal: 2.204 ± 0.079	0.416AsnTrp: 0.416 ± 0.027	1.617AsnTyr: 1.617 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	3.933ProAla: 3.933 ± 0.103	0.281ProCys: 0.281 ± 0.02	2.48ProAsp: 2.48 ± 0.076	3.994ProGlu: 3.994 ± 0.08	1.893ProPhe: 1.893 ± 0.055	2.542ProGly: 2.542 ± 0.058	1.023ProHis: 1.023 ± 0.043	2.74ProIle: 2.74 ± 0.064	2.268ProLys: 2.268 ± 0.061	4.393ProLeu: 4.393 ± 0.087	0.942ProMet: 0.942 ± 0.035	1.555ProAsn: 1.555 ± 0.048	1.11ProPro: 1.11 ± 0.048	1.904ProGln: 1.904 ± 0.055	2.211ProArg: 2.211 ± 0.062	3.114ProSer: 3.114 ± 0.077	3.071ProThr: 3.071 ± 0.083	2.575ProVal: 2.575 ± 0.058	0.496ProTrp: 0.496 ± 0.032	1.8ProTyr: 1.8 ± 0.058	0.0ProXaa: 0.0 ± 0.0
Gln	3.373GlnAla: 3.373 ± 0.08	0.268GlnCys: 0.268 ± 0.02	1.751GlnAsp: 1.751 ± 0.055	2.413GlnGlu: 2.413 ± 0.07	1.082GlnPhe: 1.082 ± 0.048	2.646GlnGly: 2.646 ± 0.063	0.834GlnHis: 0.834 ± 0.037	2.241GlnIle: 2.241 ± 0.061	1.641GlnLys: 1.641 ± 0.06	4.378GlnLeu: 4.378 ± 0.084	0.845GlnMet: 0.845 ± 0.04	0.993GlnAsn: 0.993 ± 0.042	1.594GlnPro: 1.594 ± 0.052	1.691GlnGln: 1.691 ± 0.059	2.673GlnArg: 2.673 ± 0.065	2.218GlnSer: 2.218 ± 0.064	1.999GlnThr: 1.999 ± 0.056	2.282GlnVal: 2.282 ± 0.062	0.454GlnTrp: 0.454 ± 0.027	1.19GlnTyr: 1.19 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	4.891ArgAla: 4.891 ± 0.099	0.418ArgCys: 0.418 ± 0.027	2.894ArgAsp: 2.894 ± 0.073	4.42ArgGlu: 4.42 ± 0.104	2.551ArgPhe: 2.551 ± 0.055	4.033ArgGly: 4.033 ± 0.095	1.452ArgHis: 1.452 ± 0.045	3.883ArgIle: 3.883 ± 0.078	2.737ArgLys: 2.737 ± 0.065	7.236ArgLeu: 7.236 ± 0.135	1.541ArgMet: 1.541 ± 0.052	1.784ArgAsn: 1.784 ± 0.065	2.983ArgPro: 2.983 ± 0.09	2.316ArgGln: 2.316 ± 0.075	4.12ArgArg: 4.12 ± 0.098	3.924ArgSer: 3.924 ± 0.08	3.42ArgThr: 3.42 ± 0.076	3.563ArgVal: 3.563 ± 0.073	0.788ArgTrp: 0.788 ± 0.032	3.004ArgTyr: 3.004 ± 0.082	0.0ArgXaa: 0.0 ± 0.0
Ser	5.547SerAla: 5.547 ± 0.099	0.722SerCys: 0.722 ± 0.034	3.457SerAsp: 3.457 ± 0.077	4.126SerGlu: 4.126 ± 0.086	3.135SerPhe: 3.135 ± 0.071	5.096SerGly: 5.096 ± 0.098	1.287SerHis: 1.287 ± 0.049	3.958SerIle: 3.958 ± 0.081	2.932SerLys: 2.932 ± 0.08	7.623SerLeu: 7.623 ± 0.129	1.352SerMet: 1.352 ± 0.048	2.002SerAsn: 2.002 ± 0.061	3.086SerPro: 3.086 ± 0.079	2.116SerGln: 2.116 ± 0.06	3.543SerArg: 3.543 ± 0.077	4.849SerSer: 4.849 ± 0.098	3.902SerThr: 3.902 ± 0.086	4.17SerVal: 4.17 ± 0.086	0.842SerTrp: 0.842 ± 0.034	3.259SerTyr: 3.259 ± 0.079	0.0SerXaa: 0.0 ± 0.0
Thr	5.107ThrAla: 5.107 ± 0.094	0.435ThrCys: 0.435 ± 0.026	3.22ThrAsp: 3.22 ± 0.077	3.721ThrGlu: 3.721 ± 0.079	2.731ThrPhe: 2.731 ± 0.063	4.278ThrGly: 4.278 ± 0.082	1.179ThrHis: 1.179 ± 0.043	3.616ThrIle: 3.616 ± 0.07	2.802ThrLys: 2.802 ± 0.082	6.898ThrLeu: 6.898 ± 0.114	1.05ThrMet: 1.05 ± 0.045	1.832ThrAsn: 1.832 ± 0.062	3.684ThrPro: 3.684 ± 0.087	1.959ThrGln: 1.959 ± 0.056	2.81ThrArg: 2.81 ± 0.079	4.009ThrSer: 4.009 ± 0.078	3.972ThrThr: 3.972 ± 0.091	3.192ThrVal: 3.192 ± 0.072	0.552ThrTrp: 0.552 ± 0.032	2.441ThrTyr: 2.441 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	5.45ValAla: 5.45 ± 0.097	0.614ValCys: 0.614 ± 0.034	3.387ValAsp: 3.387 ± 0.074	3.836ValGlu: 3.836 ± 0.076	2.249ValPhe: 2.249 ± 0.065	4.661ValGly: 4.661 ± 0.102	1.22ValHis: 1.22 ± 0.041	3.59ValIle: 3.59 ± 0.083	2.759ValLys: 2.759 ± 0.069	6.171ValLeu: 6.171 ± 0.116	1.146ValMet: 1.146 ± 0.044	2.121ValAsn: 2.121 ± 0.059	2.614ValPro: 2.614 ± 0.065	2.055ValGln: 2.055 ± 0.056	4.016ValArg: 4.016 ± 0.076	4.265ValSer: 4.265 ± 0.096	3.702ValThr: 3.702 ± 0.097	4.262ValVal: 4.262 ± 0.1	0.585ValTrp: 0.585 ± 0.034	2.495ValTyr: 2.495 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.892TrpAla: 0.892 ± 0.033	0.12TrpCys: 0.12 ± 0.012	0.644TrpAsp: 0.644 ± 0.034	0.685TrpGlu: 0.685 ± 0.038	0.373TrpPhe: 0.373 ± 0.026	0.95TrpGly: 0.95 ± 0.046	0.257TrpHis: 0.257 ± 0.018	0.621TrpIle: 0.621 ± 0.03	0.522TrpLys: 0.522 ± 0.028	1.018TrpLeu: 1.018 ± 0.042	0.309TrpMet: 0.309 ± 0.021	0.391TrpAsn: 0.391 ± 0.027	0.245TrpPro: 0.245 ± 0.021	0.51TrpGln: 0.51 ± 0.028	0.803TrpArg: 0.803 ± 0.038	0.747TrpSer: 0.747 ± 0.037	0.608TrpThr: 0.608 ± 0.029	0.677TrpVal: 0.677 ± 0.033	0.15TrpTrp: 0.15 ± 0.014	0.44TrpTyr: 0.44 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.225TyrAla: 3.225 ± 0.082	0.348TyrCys: 0.348 ± 0.026	2.402TyrAsp: 2.402 ± 0.058	2.355TyrGlu: 2.355 ± 0.065	1.756TyrPhe: 1.756 ± 0.05	3.025TyrGly: 3.025 ± 0.076	0.937TyrHis: 0.937 ± 0.038	2.36TyrIle: 2.36 ± 0.062	1.901TyrLys: 1.901 ± 0.059	4.24TyrLeu: 4.24 ± 0.089	0.803TyrMet: 0.803 ± 0.034	1.681TyrAsn: 1.681 ± 0.068	1.965TyrPro: 1.965 ± 0.061	1.527TyrGln: 1.527 ± 0.049	2.823TyrArg: 2.823 ± 0.071	2.742TyrSer: 2.742 ± 0.077	2.855TyrThr: 2.855 ± 0.072	2.196TyrVal: 2.196 ± 0.054	0.505TyrTrp: 0.505 ± 0.03	1.932TyrTyr: 1.932 ± 0.073	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1729 proteins (641230 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---