Amino acid dipepetide frequency for bank vole virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.233AlaAla: 4.233 ± 1.422
1.209AlaCys: 1.209 ± 0.414
2.217AlaAsp: 2.217 ± 0.823
3.024AlaGlu: 3.024 ± 0.813
1.008AlaPhe: 1.008 ± 0.252
3.83AlaGly: 3.83 ± 1.084
1.209AlaHis: 1.209 ± 0.52
4.636AlaIle: 4.636 ± 1.337
1.814AlaLys: 1.814 ± 0.549
7.257AlaLeu: 7.257 ± 0.773
1.411AlaMet: 1.411 ± 0.526
2.822AlaAsn: 2.822 ± 0.821
3.427AlaPro: 3.427 ± 1.393
3.225AlaGln: 3.225 ± 0.932
3.225AlaArg: 3.225 ± 1.406
3.427AlaSer: 3.427 ± 1.542
2.62AlaThr: 2.62 ± 0.661
3.83AlaVal: 3.83 ± 1.25
1.209AlaTrp: 1.209 ± 0.562
2.217AlaTyr: 2.217 ± 0.732
0.0AlaXaa: 0.0 ± 0.0
Cys
0.605CysAla: 0.605 ± 0.253
0.403CysCys: 0.403 ± 0.254
1.814CysAsp: 1.814 ± 0.71
1.008CysGlu: 1.008 ± 0.3
0.605CysPhe: 0.605 ± 0.38
0.202CysGly: 0.202 ± 0.127
0.605CysHis: 0.605 ± 0.38
0.605CysIle: 0.605 ± 0.26
0.605CysLys: 0.605 ± 0.445
1.613CysLeu: 1.613 ± 0.418
0.0CysMet: 0.0 ± 0.0
0.403CysAsn: 0.403 ± 0.218
2.016CysPro: 2.016 ± 0.661
1.209CysGln: 1.209 ± 0.541
0.605CysArg: 0.605 ± 0.595
1.209CysSer: 1.209 ± 0.422
1.209CysThr: 1.209 ± 0.934
1.008CysVal: 1.008 ± 0.407
0.0CysTrp: 0.0 ± 0.0
0.806CysTyr: 0.806 ± 0.285
0.0CysXaa: 0.0 ± 0.0
Asp
1.814AspAla: 1.814 ± 0.821
0.403AspCys: 0.403 ± 0.254
3.225AspAsp: 3.225 ± 0.961
4.031AspGlu: 4.031 ± 1.062
1.209AspPhe: 1.209 ± 0.31
2.217AspGly: 2.217 ± 0.563
1.411AspHis: 1.411 ± 0.511
3.024AspIle: 3.024 ± 0.693
2.016AspLys: 2.016 ± 0.878
6.249AspLeu: 6.249 ± 1.238
0.202AspMet: 0.202 ± 0.241
4.031AspAsn: 4.031 ± 0.601
3.427AspPro: 3.427 ± 0.421
4.435AspGln: 4.435 ± 0.739
2.419AspArg: 2.419 ± 0.48
4.636AspSer: 4.636 ± 1.526
1.411AspThr: 1.411 ± 0.661
3.628AspVal: 3.628 ± 0.421
0.806AspTrp: 0.806 ± 0.346
3.024AspTyr: 3.024 ± 0.419
0.0AspXaa: 0.0 ± 0.0
Glu
4.233GluAla: 4.233 ± 0.854
1.008GluCys: 1.008 ± 0.634
4.233GluAsp: 4.233 ± 1.122
2.822GluGlu: 2.822 ± 1.284
2.217GluPhe: 2.217 ± 0.679
3.628GluGly: 3.628 ± 1.357
1.613GluHis: 1.613 ± 0.621
5.846GluIle: 5.846 ± 0.891
2.217GluLys: 2.217 ± 0.844
4.435GluLeu: 4.435 ± 0.831
1.411GluMet: 1.411 ± 0.478
1.814GluAsn: 1.814 ± 0.626
2.419GluPro: 2.419 ± 0.563
1.411GluGln: 1.411 ± 0.438
2.016GluArg: 2.016 ± 0.538
3.83GluSer: 3.83 ± 1.228
3.427GluThr: 3.427 ± 0.765
3.628GluVal: 3.628 ± 0.69
0.403GluTrp: 0.403 ± 0.311
2.217GluTyr: 2.217 ± 0.851
0.0GluXaa: 0.0 ± 0.0
Phe
1.613PheAla: 1.613 ± 0.638
0.806PheCys: 0.806 ± 0.507
1.008PheAsp: 1.008 ± 0.316
1.814PheGlu: 1.814 ± 0.445
1.209PhePhe: 1.209 ± 0.563
1.411PheGly: 1.411 ± 0.436
1.008PheHis: 1.008 ± 0.486
1.814PheIle: 1.814 ± 0.71
1.411PheLys: 1.411 ± 0.333
3.427PheLeu: 3.427 ± 0.856
1.008PheMet: 1.008 ± 0.47
3.024PheAsn: 3.024 ± 0.579
0.403PhePro: 0.403 ± 0.254
2.217PheGln: 2.217 ± 0.604
2.217PheArg: 2.217 ± 0.476
1.814PheSer: 1.814 ± 0.344
1.209PheThr: 1.209 ± 0.598
2.217PheVal: 2.217 ± 0.638
0.605PheTrp: 0.605 ± 0.38
0.605PheTyr: 0.605 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
3.83GlyAla: 3.83 ± 1.296
0.403GlyCys: 0.403 ± 0.472
2.62GlyAsp: 2.62 ± 1.059
2.419GlyGlu: 2.419 ± 0.691
2.822GlyPhe: 2.822 ± 0.37
3.628GlyGly: 3.628 ± 1.3
2.62GlyHis: 2.62 ± 1.198
2.822GlyIle: 2.822 ± 1.302
1.209GlyLys: 1.209 ± 0.689
5.241GlyLeu: 5.241 ± 0.8
1.411GlyMet: 1.411 ± 0.507
3.225GlyAsn: 3.225 ± 0.848
3.225GlyPro: 3.225 ± 1.27
2.217GlyGln: 2.217 ± 0.588
3.024GlyArg: 3.024 ± 0.662
6.853GlySer: 6.853 ± 1.204
2.419GlyThr: 2.419 ± 1.513
4.636GlyVal: 4.636 ± 1.639
0.605GlyTrp: 0.605 ± 0.427
2.217GlyTyr: 2.217 ± 0.496
0.0GlyXaa: 0.0 ± 0.0
His
1.411HisAla: 1.411 ± 0.623
0.403HisCys: 0.403 ± 0.254
1.008HisAsp: 1.008 ± 0.614
1.209HisGlu: 1.209 ± 0.414
0.605HisPhe: 0.605 ± 0.26
0.806HisGly: 0.806 ± 0.265
1.209HisHis: 1.209 ± 0.386
2.419HisIle: 2.419 ± 0.922
2.62HisLys: 2.62 ± 0.694
3.225HisLeu: 3.225 ± 1.347
0.806HisMet: 0.806 ± 0.294
1.008HisAsn: 1.008 ± 0.446
1.613HisPro: 1.613 ± 0.515
0.605HisGln: 0.605 ± 0.257
0.806HisArg: 0.806 ± 0.285
1.613HisSer: 1.613 ± 0.423
1.411HisThr: 1.411 ± 0.607
1.411HisVal: 1.411 ± 0.497
0.202HisTrp: 0.202 ± 0.127
1.209HisTyr: 1.209 ± 0.396
0.0HisXaa: 0.0 ± 0.0
Ile
5.644IleAla: 5.644 ± 1.253
1.008IleCys: 1.008 ± 0.428
3.024IleAsp: 3.024 ± 0.73
5.442IleGlu: 5.442 ± 1.229
2.217IlePhe: 2.217 ± 0.727
3.83IleGly: 3.83 ± 0.548
1.613IleHis: 1.613 ± 0.523
6.249IleIle: 6.249 ± 1.36
5.442IleLys: 5.442 ± 1.427
5.644IleLeu: 5.644 ± 0.959
2.217IleMet: 2.217 ± 0.796
4.636IleAsn: 4.636 ± 0.67
4.031IlePro: 4.031 ± 1.147
2.217IleGln: 2.217 ± 1.363
5.039IleArg: 5.039 ± 0.96
6.047IleSer: 6.047 ± 1.453
4.233IleThr: 4.233 ± 0.322
3.225IleVal: 3.225 ± 0.663
0.605IleTrp: 0.605 ± 0.283
2.822IleTyr: 2.822 ± 0.696
0.0IleXaa: 0.0 ± 0.0
Lys
3.024LysAla: 3.024 ± 0.586
0.806LysCys: 0.806 ± 0.292
3.225LysAsp: 3.225 ± 0.652
3.427LysGlu: 3.427 ± 0.738
1.209LysPhe: 1.209 ± 0.427
3.024LysGly: 3.024 ± 0.682
1.008LysHis: 1.008 ± 0.493
3.427LysIle: 3.427 ± 0.481
1.814LysLys: 1.814 ± 0.693
6.249LysLeu: 6.249 ± 0.81
2.016LysMet: 2.016 ± 0.546
1.209LysAsn: 1.209 ± 0.386
2.217LysPro: 2.217 ± 0.879
2.419LysGln: 2.419 ± 0.57
3.024LysArg: 3.024 ± 1.023
4.233LysSer: 4.233 ± 1.327
3.628LysThr: 3.628 ± 0.967
3.225LysVal: 3.225 ± 0.962
0.0LysTrp: 0.0 ± 0.0
1.008LysTyr: 1.008 ± 0.526
0.202LysXaa: 0.202 ± 0.127
Leu
6.652LeuAla: 6.652 ± 1.065
1.613LeuCys: 1.613 ± 0.36
5.442LeuAsp: 5.442 ± 1.0
5.644LeuGlu: 5.644 ± 0.353
2.62LeuPhe: 2.62 ± 0.733
6.249LeuGly: 6.249 ± 0.881
2.419LeuHis: 2.419 ± 0.758
7.861LeuIle: 7.861 ± 1.514
7.257LeuLys: 7.257 ± 1.404
9.272LeuLeu: 9.272 ± 1.554
2.016LeuMet: 2.016 ± 0.382
6.853LeuAsn: 6.853 ± 0.732
3.83LeuPro: 3.83 ± 0.424
3.427LeuGln: 3.427 ± 0.794
6.249LeuArg: 6.249 ± 1.321
7.257LeuSer: 7.257 ± 0.866
7.458LeuThr: 7.458 ± 0.724
5.442LeuVal: 5.442 ± 1.081
1.209LeuTrp: 1.209 ± 0.521
3.628LeuTyr: 3.628 ± 0.813
0.0LeuXaa: 0.0 ± 0.0
Met
1.411MetAla: 1.411 ± 0.718
0.605MetCys: 0.605 ± 0.26
2.016MetAsp: 2.016 ± 0.395
1.209MetGlu: 1.209 ± 0.874
0.403MetPhe: 0.403 ± 0.254
1.411MetGly: 1.411 ± 0.63
0.403MetHis: 0.403 ± 0.222
2.217MetIle: 2.217 ± 0.774
1.411MetLys: 1.411 ± 0.373
2.016MetLeu: 2.016 ± 0.861
0.605MetMet: 0.605 ± 0.366
1.209MetAsn: 1.209 ± 0.396
0.403MetPro: 0.403 ± 0.311
0.403MetGln: 0.403 ± 0.218
1.613MetArg: 1.613 ± 0.499
1.411MetSer: 1.411 ± 0.845
0.806MetThr: 0.806 ± 0.292
1.814MetVal: 1.814 ± 0.411
0.403MetTrp: 0.403 ± 0.254
0.806MetTyr: 0.806 ± 0.36
0.0MetXaa: 0.0 ± 0.0
Asn
2.016AsnAla: 2.016 ± 0.787
1.613AsnCys: 1.613 ± 0.564
4.031AsnAsp: 4.031 ± 0.568
3.427AsnGlu: 3.427 ± 0.487
2.016AsnPhe: 2.016 ± 0.562
2.419AsnGly: 2.419 ± 0.705
0.806AsnHis: 0.806 ± 0.292
3.628AsnIle: 3.628 ± 1.082
1.814AsnLys: 1.814 ± 0.607
6.853AsnLeu: 6.853 ± 0.704
1.209AsnMet: 1.209 ± 0.434
2.822AsnAsn: 2.822 ± 0.515
4.031AsnPro: 4.031 ± 0.705
2.419AsnGln: 2.419 ± 0.398
1.209AsnArg: 1.209 ± 0.399
4.031AsnSer: 4.031 ± 0.66
3.83AsnThr: 3.83 ± 1.2
2.016AsnVal: 2.016 ± 0.791
0.403AsnTrp: 0.403 ± 0.254
2.217AsnTyr: 2.217 ± 0.883
0.0AsnXaa: 0.0 ± 0.0
Pro
1.411ProAla: 1.411 ± 0.386
0.403ProCys: 0.403 ± 0.333
2.822ProAsp: 2.822 ± 0.609
3.225ProGlu: 3.225 ± 0.841
1.613ProPhe: 1.613 ± 0.448
2.419ProGly: 2.419 ± 0.262
1.411ProHis: 1.411 ± 0.542
3.225ProIle: 3.225 ± 0.719
2.217ProLys: 2.217 ± 0.596
4.435ProLeu: 4.435 ± 0.951
1.008ProMet: 1.008 ± 0.335
2.016ProAsn: 2.016 ± 0.56
1.814ProPro: 1.814 ± 0.641
1.613ProGln: 1.613 ± 0.86
3.628ProArg: 3.628 ± 1.597
4.838ProSer: 4.838 ± 0.92
4.435ProThr: 4.435 ± 1.342
2.419ProVal: 2.419 ± 1.391
0.605ProTrp: 0.605 ± 0.263
3.83ProTyr: 3.83 ± 0.892
0.0ProXaa: 0.0 ± 0.0
Gln
2.62GlnAla: 2.62 ± 0.593
0.806GlnCys: 0.806 ± 0.621
2.016GlnAsp: 2.016 ± 1.044
2.217GlnGlu: 2.217 ± 0.51
1.411GlnPhe: 1.411 ± 0.716
2.822GlnGly: 2.822 ± 0.34
0.806GlnHis: 0.806 ± 0.359
2.62GlnIle: 2.62 ± 0.75
2.419GlnLys: 2.419 ± 0.711
4.838GlnLeu: 4.838 ± 1.575
0.403GlnMet: 0.403 ± 0.227
2.217GlnAsn: 2.217 ± 0.558
1.008GlnPro: 1.008 ± 0.485
2.419GlnGln: 2.419 ± 0.366
1.209GlnArg: 1.209 ± 0.681
3.628GlnSer: 3.628 ± 0.501
3.024GlnThr: 3.024 ± 0.947
1.613GlnVal: 1.613 ± 0.693
0.403GlnTrp: 0.403 ± 0.254
1.411GlnTyr: 1.411 ± 0.842
0.0GlnXaa: 0.0 ± 0.0
Arg
2.62ArgAla: 2.62 ± 0.968
0.403ArgCys: 0.403 ± 0.209
3.024ArgAsp: 3.024 ± 0.511
3.427ArgGlu: 3.427 ± 0.614
2.217ArgPhe: 2.217 ± 0.579
3.225ArgGly: 3.225 ± 0.906
0.605ArgHis: 0.605 ± 0.273
3.83ArgIle: 3.83 ± 1.16
2.62ArgLys: 2.62 ± 0.741
6.249ArgLeu: 6.249 ± 1.096
1.613ArgMet: 1.613 ± 0.856
2.217ArgAsn: 2.217 ± 0.809
3.024ArgPro: 3.024 ± 1.411
1.411ArgGln: 1.411 ± 0.618
3.024ArgArg: 3.024 ± 1.275
5.241ArgSer: 5.241 ± 1.168
3.024ArgThr: 3.024 ± 1.188
3.427ArgVal: 3.427 ± 1.057
0.403ArgTrp: 0.403 ± 0.469
2.419ArgTyr: 2.419 ± 0.685
0.0ArgXaa: 0.0 ± 0.0
Ser
4.636SerAla: 4.636 ± 1.299
1.814SerCys: 1.814 ± 0.536
2.822SerAsp: 2.822 ± 1.252
3.225SerGlu: 3.225 ± 0.778
2.419SerPhe: 2.419 ± 0.725
5.039SerGly: 5.039 ± 2.071
3.225SerHis: 3.225 ± 0.759
5.442SerIle: 5.442 ± 1.35
4.435SerLys: 4.435 ± 1.041
9.675SerLeu: 9.675 ± 1.214
1.008SerMet: 1.008 ± 0.464
3.628SerAsn: 3.628 ± 0.823
3.83SerPro: 3.83 ± 0.674
2.419SerGln: 2.419 ± 0.781
3.83SerArg: 3.83 ± 1.193
8.063SerSer: 8.063 ± 2.148
7.055SerThr: 7.055 ± 1.25
6.45SerVal: 6.45 ± 0.843
0.605SerTrp: 0.605 ± 0.27
3.225SerTyr: 3.225 ± 0.808
0.0SerXaa: 0.0 ± 0.0
Thr
4.636ThrAla: 4.636 ± 0.861
0.605ThrCys: 0.605 ± 0.263
2.822ThrAsp: 2.822 ± 0.708
2.419ThrGlu: 2.419 ± 0.56
2.217ThrPhe: 2.217 ± 0.738
5.039ThrGly: 5.039 ± 1.249
0.605ThrHis: 0.605 ± 0.263
6.853ThrIle: 6.853 ± 1.406
4.233ThrLys: 4.233 ± 1.003
5.039ThrLeu: 5.039 ± 1.179
1.008ThrMet: 1.008 ± 0.553
3.024ThrAsn: 3.024 ± 0.938
1.814ThrPro: 1.814 ± 0.703
2.822ThrGln: 2.822 ± 0.988
3.83ThrArg: 3.83 ± 1.113
5.039ThrSer: 5.039 ± 1.327
4.838ThrThr: 4.838 ± 1.195
2.419ThrVal: 2.419 ± 0.81
1.209ThrTrp: 1.209 ± 0.427
2.419ThrTyr: 2.419 ± 0.573
0.0ThrXaa: 0.0 ± 0.0
Val
3.83ValAla: 3.83 ± 1.337
1.209ValCys: 1.209 ± 0.31
3.225ValAsp: 3.225 ± 0.883
3.225ValGlu: 3.225 ± 1.184
1.411ValPhe: 1.411 ± 0.746
4.233ValGly: 4.233 ± 0.943
1.411ValHis: 1.411 ± 0.577
5.039ValIle: 5.039 ± 1.209
2.217ValLys: 2.217 ± 0.514
4.838ValLeu: 4.838 ± 0.545
1.209ValMet: 1.209 ± 0.527
2.62ValAsn: 2.62 ± 0.644
3.427ValPro: 3.427 ± 0.919
2.016ValGln: 2.016 ± 0.967
4.636ValArg: 4.636 ± 1.811
4.031ValSer: 4.031 ± 1.21
3.83ValThr: 3.83 ± 1.471
3.83ValVal: 3.83 ± 2.152
0.0ValTrp: 0.0 ± 0.0
2.419ValTyr: 2.419 ± 1.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.605TrpAla: 0.605 ± 0.283
0.0TrpCys: 0.0 ± 0.0
0.605TrpAsp: 0.605 ± 0.253
0.202TrpGlu: 0.202 ± 0.127
0.605TrpPhe: 0.605 ± 0.38
0.202TrpGly: 0.202 ± 0.127
0.0TrpHis: 0.0 ± 0.0
0.605TrpIle: 0.605 ± 0.38
1.008TrpLys: 1.008 ± 0.427
1.209TrpLeu: 1.209 ± 0.599
0.605TrpMet: 0.605 ± 0.44
0.605TrpAsn: 0.605 ± 0.444
0.202TrpPro: 0.202 ± 0.127
0.202TrpGln: 0.202 ± 0.234
0.403TrpArg: 0.403 ± 0.23
1.613TrpSer: 1.613 ± 0.577
0.403TrpThr: 0.403 ± 0.254
0.403TrpVal: 0.403 ± 0.635
0.202TrpTrp: 0.202 ± 0.127
0.605TrpTyr: 0.605 ± 0.253
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.008TyrAla: 1.008 ± 0.277
1.008TyrCys: 1.008 ± 0.3
2.419TyrAsp: 2.419 ± 0.642
1.411TyrGlu: 1.411 ± 0.465
0.806TyrPhe: 0.806 ± 0.376
1.814TyrGly: 1.814 ± 0.435
1.613TyrHis: 1.613 ± 0.682
3.024TyrIle: 3.024 ± 0.668
1.613TyrLys: 1.613 ± 0.569
4.435TyrLeu: 4.435 ± 0.844
1.209TyrMet: 1.209 ± 0.681
3.427TyrAsn: 3.427 ± 0.332
3.225TyrPro: 3.225 ± 0.759
0.806TyrGln: 0.806 ± 0.418
2.016TyrArg: 2.016 ± 0.483
3.83TyrSer: 3.83 ± 0.786
2.822TyrThr: 2.822 ± 0.684
2.016TyrVal: 2.016 ± 0.827
0.403TyrTrp: 0.403 ± 0.254
2.419TyrTyr: 2.419 ± 1.202
0.202TyrXaa: 0.202 ± 0.127
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.202XaaLeu: 0.202 ± 0.127
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.202XaaSer: 0.202 ± 0.127
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski