Amino acid dipepetide frequency for Cronobacter phage vB_CsaP_Ss1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.453AlaAla: 7.453 ± 1.114
0.745AlaCys: 0.745 ± 0.262
5.441AlaAsp: 5.441 ± 0.718
4.919AlaGlu: 4.919 ± 0.527
2.609AlaPhe: 2.609 ± 0.431
7.453AlaGly: 7.453 ± 0.637
2.012AlaHis: 2.012 ± 0.329
5.366AlaIle: 5.366 ± 0.575
5.739AlaLys: 5.739 ± 0.757
7.379AlaLeu: 7.379 ± 0.701
3.056AlaMet: 3.056 ± 0.472
4.174AlaAsn: 4.174 ± 0.621
3.205AlaPro: 3.205 ± 0.555
3.876AlaGln: 3.876 ± 0.626
4.248AlaArg: 4.248 ± 0.65
3.279AlaSer: 3.279 ± 0.482
5.441AlaThr: 5.441 ± 0.702
4.845AlaVal: 4.845 ± 0.663
0.82AlaTrp: 0.82 ± 0.244
3.578AlaTyr: 3.578 ± 0.69
0.0AlaXaa: 0.0 ± 0.0
Cys
1.118CysAla: 1.118 ± 0.368
0.298CysCys: 0.298 ± 0.154
0.745CysAsp: 0.745 ± 0.231
0.447CysGlu: 0.447 ± 0.186
0.522CysPhe: 0.522 ± 0.173
0.522CysGly: 0.522 ± 0.216
0.298CysHis: 0.298 ± 0.131
0.745CysIle: 0.745 ± 0.25
0.894CysLys: 0.894 ± 0.326
1.342CysLeu: 1.342 ± 0.328
0.373CysMet: 0.373 ± 0.168
0.298CysAsn: 0.298 ± 0.18
0.373CysPro: 0.373 ± 0.197
0.149CysGln: 0.149 ± 0.102
0.075CysArg: 0.075 ± 0.071
0.298CysSer: 0.298 ± 0.144
0.522CysThr: 0.522 ± 0.189
0.82CysVal: 0.82 ± 0.24
0.075CysTrp: 0.075 ± 0.079
0.82CysTyr: 0.82 ± 0.266
0.0CysXaa: 0.0 ± 0.0
Asp
6.261AspAla: 6.261 ± 0.618
0.447AspCys: 0.447 ± 0.155
3.801AspAsp: 3.801 ± 0.542
4.397AspGlu: 4.397 ± 0.821
2.236AspPhe: 2.236 ± 0.473
5.441AspGly: 5.441 ± 0.839
1.64AspHis: 1.64 ± 0.434
4.099AspIle: 4.099 ± 0.564
4.174AspLys: 4.174 ± 0.591
4.323AspLeu: 4.323 ± 0.548
2.534AspMet: 2.534 ± 0.365
3.056AspAsn: 3.056 ± 0.631
2.46AspPro: 2.46 ± 0.397
2.683AspGln: 2.683 ± 0.466
2.161AspArg: 2.161 ± 0.444
4.099AspSer: 4.099 ± 0.626
3.876AspThr: 3.876 ± 0.52
3.354AspVal: 3.354 ± 0.485
1.491AspTrp: 1.491 ± 0.385
2.46AspTyr: 2.46 ± 0.33
0.0AspXaa: 0.0 ± 0.0
Glu
5.515GluAla: 5.515 ± 0.772
0.894GluCys: 0.894 ± 0.251
3.056GluAsp: 3.056 ± 0.487
3.95GluGlu: 3.95 ± 0.813
2.758GluPhe: 2.758 ± 0.519
3.95GluGly: 3.95 ± 0.573
1.118GluHis: 1.118 ± 0.332
3.95GluIle: 3.95 ± 0.658
2.758GluLys: 2.758 ± 0.465
6.186GluLeu: 6.186 ± 0.671
1.863GluMet: 1.863 ± 0.367
2.981GluAsn: 2.981 ± 0.569
2.087GluPro: 2.087 ± 0.392
3.428GluGln: 3.428 ± 0.562
3.578GluArg: 3.578 ± 0.55
3.876GluSer: 3.876 ± 0.767
2.46GluThr: 2.46 ± 0.381
3.13GluVal: 3.13 ± 0.584
1.565GluTrp: 1.565 ± 0.433
3.056GluTyr: 3.056 ± 0.379
0.0GluXaa: 0.0 ± 0.0
Phe
2.161PheAla: 2.161 ± 0.423
0.447PheCys: 0.447 ± 0.21
2.832PheAsp: 2.832 ± 0.435
2.236PheGlu: 2.236 ± 0.413
1.118PhePhe: 1.118 ± 0.245
3.13PheGly: 3.13 ± 0.529
0.745PheHis: 0.745 ± 0.301
1.714PheIle: 1.714 ± 0.386
3.354PheLys: 3.354 ± 0.398
2.609PheLeu: 2.609 ± 0.445
1.342PheMet: 1.342 ± 0.264
2.907PheAsn: 2.907 ± 0.467
1.416PhePro: 1.416 ± 0.385
1.342PheGln: 1.342 ± 0.355
1.416PheArg: 1.416 ± 0.295
1.789PheSer: 1.789 ± 0.399
2.385PheThr: 2.385 ± 0.389
2.087PheVal: 2.087 ± 0.441
0.373PheTrp: 0.373 ± 0.178
1.043PheTyr: 1.043 ± 0.392
0.0PheXaa: 0.0 ± 0.0
Gly
7.006GlyAla: 7.006 ± 0.873
0.298GlyCys: 0.298 ± 0.144
4.099GlyAsp: 4.099 ± 0.335
4.77GlyGlu: 4.77 ± 0.794
3.13GlyPhe: 3.13 ± 0.509
6.335GlyGly: 6.335 ± 0.947
1.342GlyHis: 1.342 ± 0.362
3.727GlyIle: 3.727 ± 0.491
6.484GlyLys: 6.484 ± 0.757
5.515GlyLeu: 5.515 ± 0.6
3.056GlyMet: 3.056 ± 0.628
3.578GlyAsn: 3.578 ± 0.568
1.863GlyPro: 1.863 ± 0.315
2.683GlyGln: 2.683 ± 0.459
3.503GlyArg: 3.503 ± 0.498
4.994GlySer: 4.994 ± 0.979
4.397GlyThr: 4.397 ± 0.783
4.174GlyVal: 4.174 ± 0.461
1.193GlyTrp: 1.193 ± 0.251
2.683GlyTyr: 2.683 ± 0.464
0.0GlyXaa: 0.0 ± 0.0
His
1.863HisAla: 1.863 ± 0.461
0.82HisCys: 0.82 ± 0.249
1.193HisAsp: 1.193 ± 0.244
1.043HisGlu: 1.043 ± 0.351
0.522HisPhe: 0.522 ± 0.167
1.416HisGly: 1.416 ± 0.297
0.522HisHis: 0.522 ± 0.159
1.491HisIle: 1.491 ± 0.315
2.161HisLys: 2.161 ± 0.359
1.416HisLeu: 1.416 ± 0.282
0.969HisMet: 0.969 ± 0.25
1.491HisAsn: 1.491 ± 0.381
0.671HisPro: 0.671 ± 0.193
0.82HisGln: 0.82 ± 0.2
1.043HisArg: 1.043 ± 0.307
0.894HisSer: 0.894 ± 0.232
1.043HisThr: 1.043 ± 0.309
1.342HisVal: 1.342 ± 0.35
0.522HisTrp: 0.522 ± 0.15
1.342HisTyr: 1.342 ± 0.276
0.0HisXaa: 0.0 ± 0.0
Ile
4.397IleAla: 4.397 ± 0.584
1.118IleCys: 1.118 ± 0.395
4.994IleAsp: 4.994 ± 0.62
5.217IleGlu: 5.217 ± 0.694
1.565IlePhe: 1.565 ± 0.342
4.174IleGly: 4.174 ± 0.658
1.043IleHis: 1.043 ± 0.261
3.801IleIle: 3.801 ± 0.602
4.621IleLys: 4.621 ± 0.574
3.801IleLeu: 3.801 ± 0.364
1.342IleMet: 1.342 ± 0.302
2.46IleAsn: 2.46 ± 0.401
2.161IlePro: 2.161 ± 0.408
3.056IleGln: 3.056 ± 0.404
3.056IleArg: 3.056 ± 0.443
2.758IleSer: 2.758 ± 0.491
3.95IleThr: 3.95 ± 0.689
3.578IleVal: 3.578 ± 0.495
0.894IleTrp: 0.894 ± 0.222
2.087IleTyr: 2.087 ± 0.4
0.0IleXaa: 0.0 ± 0.0
Lys
5.888LysAla: 5.888 ± 0.775
0.373LysCys: 0.373 ± 0.162
3.95LysAsp: 3.95 ± 0.738
4.621LysGlu: 4.621 ± 0.611
3.13LysPhe: 3.13 ± 0.385
4.248LysGly: 4.248 ± 0.612
1.789LysHis: 1.789 ± 0.384
3.578LysIle: 3.578 ± 0.372
4.248LysLys: 4.248 ± 0.585
5.143LysLeu: 5.143 ± 0.552
2.385LysMet: 2.385 ± 0.453
3.503LysAsn: 3.503 ± 0.645
3.428LysPro: 3.428 ± 0.4
2.758LysGln: 2.758 ± 0.506
2.981LysArg: 2.981 ± 0.469
3.354LysSer: 3.354 ± 0.493
2.907LysThr: 2.907 ± 0.435
4.696LysVal: 4.696 ± 0.606
0.373LysTrp: 0.373 ± 0.152
2.683LysTyr: 2.683 ± 0.465
0.0LysXaa: 0.0 ± 0.0
Leu
6.857LeuAla: 6.857 ± 0.72
0.671LeuCys: 0.671 ± 0.236
5.814LeuAsp: 5.814 ± 0.701
4.845LeuGlu: 4.845 ± 0.774
3.056LeuPhe: 3.056 ± 0.353
4.845LeuGly: 4.845 ± 0.464
1.64LeuHis: 1.64 ± 0.268
4.696LeuIle: 4.696 ± 0.474
4.845LeuLys: 4.845 ± 0.555
4.174LeuLeu: 4.174 ± 0.589
2.385LeuMet: 2.385 ± 0.503
4.323LeuAsn: 4.323 ± 0.646
3.95LeuPro: 3.95 ± 0.61
3.578LeuGln: 3.578 ± 0.587
3.652LeuArg: 3.652 ± 0.501
4.696LeuSer: 4.696 ± 0.439
4.025LeuThr: 4.025 ± 0.454
4.696LeuVal: 4.696 ± 0.492
0.82LeuTrp: 0.82 ± 0.262
2.087LeuTyr: 2.087 ± 0.467
0.0LeuXaa: 0.0 ± 0.0
Met
2.683MetAla: 2.683 ± 0.503
0.298MetCys: 0.298 ± 0.127
2.012MetAsp: 2.012 ± 0.336
1.789MetGlu: 1.789 ± 0.299
1.342MetPhe: 1.342 ± 0.291
2.758MetGly: 2.758 ± 0.516
0.522MetHis: 0.522 ± 0.239
2.161MetIle: 2.161 ± 0.436
2.236MetLys: 2.236 ± 0.383
2.161MetLeu: 2.161 ± 0.386
1.118MetMet: 1.118 ± 0.272
1.416MetAsn: 1.416 ± 0.271
1.64MetPro: 1.64 ± 0.399
1.714MetGln: 1.714 ± 0.496
1.565MetArg: 1.565 ± 0.313
1.714MetSer: 1.714 ± 0.347
2.683MetThr: 2.683 ± 0.497
1.565MetVal: 1.565 ± 0.32
0.298MetTrp: 0.298 ± 0.147
1.416MetTyr: 1.416 ± 0.329
0.0MetXaa: 0.0 ± 0.0
Asn
4.472AsnAla: 4.472 ± 0.607
0.671AsnCys: 0.671 ± 0.185
2.385AsnAsp: 2.385 ± 0.449
2.832AsnGlu: 2.832 ± 0.505
0.82AsnPhe: 0.82 ± 0.24
4.845AsnGly: 4.845 ± 0.673
1.491AsnHis: 1.491 ± 0.33
3.503AsnIle: 3.503 ± 0.411
2.758AsnLys: 2.758 ± 0.476
2.981AsnLeu: 2.981 ± 0.376
1.416AsnMet: 1.416 ± 0.309
2.012AsnAsn: 2.012 ± 0.371
2.46AsnPro: 2.46 ± 0.427
2.161AsnGln: 2.161 ± 0.449
2.758AsnArg: 2.758 ± 0.412
2.907AsnSer: 2.907 ± 0.55
2.609AsnThr: 2.609 ± 0.414
3.801AsnVal: 3.801 ± 0.398
1.043AsnTrp: 1.043 ± 0.319
2.236AsnTyr: 2.236 ± 0.418
0.0AsnXaa: 0.0 ± 0.0
Pro
3.13ProAla: 3.13 ± 0.433
0.298ProCys: 0.298 ± 0.15
3.056ProAsp: 3.056 ± 0.508
3.354ProGlu: 3.354 ± 0.441
1.714ProPhe: 1.714 ± 0.461
2.311ProGly: 2.311 ± 0.347
0.596ProHis: 0.596 ± 0.185
2.907ProIle: 2.907 ± 0.519
2.311ProLys: 2.311 ± 0.335
2.981ProLeu: 2.981 ± 0.511
1.043ProMet: 1.043 ± 0.347
2.758ProAsn: 2.758 ± 0.518
1.565ProPro: 1.565 ± 0.354
0.82ProGln: 0.82 ± 0.21
1.491ProArg: 1.491 ± 0.41
2.385ProSer: 2.385 ± 0.454
3.205ProThr: 3.205 ± 0.502
2.385ProVal: 2.385 ± 0.485
0.671ProTrp: 0.671 ± 0.213
0.894ProTyr: 0.894 ± 0.291
0.0ProXaa: 0.0 ± 0.0
Gln
4.546GlnAla: 4.546 ± 0.666
0.373GlnCys: 0.373 ± 0.143
2.236GlnAsp: 2.236 ± 0.466
3.13GlnGlu: 3.13 ± 0.548
2.012GlnPhe: 2.012 ± 0.329
2.087GlnGly: 2.087 ± 0.488
0.596GlnHis: 0.596 ± 0.183
2.236GlnIle: 2.236 ± 0.47
2.683GlnLys: 2.683 ± 0.458
3.354GlnLeu: 3.354 ± 0.579
1.789GlnMet: 1.789 ± 0.406
2.161GlnAsn: 2.161 ± 0.706
1.64GlnPro: 1.64 ± 0.392
3.13GlnGln: 3.13 ± 0.675
2.385GlnArg: 2.385 ± 0.412
2.46GlnSer: 2.46 ± 0.371
2.012GlnThr: 2.012 ± 0.295
2.385GlnVal: 2.385 ± 0.378
0.447GlnTrp: 0.447 ± 0.212
1.342GlnTyr: 1.342 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
3.801ArgAla: 3.801 ± 0.493
0.447ArgCys: 0.447 ± 0.206
2.758ArgAsp: 2.758 ± 0.446
2.012ArgGlu: 2.012 ± 0.351
1.342ArgPhe: 1.342 ± 0.283
2.385ArgGly: 2.385 ± 0.487
1.193ArgHis: 1.193 ± 0.293
3.205ArgIle: 3.205 ± 0.481
3.354ArgLys: 3.354 ± 0.614
4.174ArgLeu: 4.174 ± 0.576
1.938ArgMet: 1.938 ± 0.386
2.46ArgAsn: 2.46 ± 0.393
1.565ArgPro: 1.565 ± 0.385
2.012ArgGln: 2.012 ± 0.374
1.64ArgArg: 1.64 ± 0.295
2.832ArgSer: 2.832 ± 0.541
2.683ArgThr: 2.683 ± 0.49
2.683ArgVal: 2.683 ± 0.448
0.969ArgTrp: 0.969 ± 0.358
1.64ArgTyr: 1.64 ± 0.408
0.0ArgXaa: 0.0 ± 0.0
Ser
4.397SerAla: 4.397 ± 0.621
0.447SerCys: 0.447 ± 0.195
3.876SerAsp: 3.876 ± 0.482
3.428SerGlu: 3.428 ± 0.651
1.267SerPhe: 1.267 ± 0.384
5.515SerGly: 5.515 ± 0.756
1.714SerHis: 1.714 ± 0.36
3.279SerIle: 3.279 ± 0.574
3.056SerLys: 3.056 ± 0.555
4.994SerLeu: 4.994 ± 0.722
2.087SerMet: 2.087 ± 0.46
2.385SerAsn: 2.385 ± 0.472
2.161SerPro: 2.161 ± 0.307
2.311SerGln: 2.311 ± 0.703
2.385SerArg: 2.385 ± 0.489
3.205SerSer: 3.205 ± 0.669
2.981SerThr: 2.981 ± 0.527
3.801SerVal: 3.801 ± 0.378
1.043SerTrp: 1.043 ± 0.254
2.012SerTyr: 2.012 ± 0.337
0.0SerXaa: 0.0 ± 0.0
Thr
5.217ThrAla: 5.217 ± 0.574
0.298ThrCys: 0.298 ± 0.134
3.95ThrAsp: 3.95 ± 0.613
3.801ThrGlu: 3.801 ± 0.53
2.832ThrPhe: 2.832 ± 0.363
6.112ThrGly: 6.112 ± 0.804
1.043ThrHis: 1.043 ± 0.341
3.279ThrIle: 3.279 ± 0.517
2.609ThrLys: 2.609 ± 0.49
5.068ThrLeu: 5.068 ± 0.608
1.416ThrMet: 1.416 ± 0.277
2.534ThrAsn: 2.534 ± 0.443
3.428ThrPro: 3.428 ± 0.567
2.161ThrGln: 2.161 ± 0.507
2.311ThrArg: 2.311 ± 0.369
2.311ThrSer: 2.311 ± 0.396
4.323ThrThr: 4.323 ± 0.716
4.025ThrVal: 4.025 ± 0.616
1.193ThrTrp: 1.193 ± 0.301
2.012ThrTyr: 2.012 ± 0.484
0.0ThrXaa: 0.0 ± 0.0
Val
5.292ValAla: 5.292 ± 0.597
0.745ValCys: 0.745 ± 0.234
4.621ValAsp: 4.621 ± 0.543
2.832ValGlu: 2.832 ± 0.442
2.161ValPhe: 2.161 ± 0.37
4.323ValGly: 4.323 ± 0.545
1.64ValHis: 1.64 ± 0.404
2.981ValIle: 2.981 ± 0.42
4.621ValLys: 4.621 ± 0.59
3.876ValLeu: 3.876 ± 0.673
1.491ValMet: 1.491 ± 0.27
3.652ValAsn: 3.652 ± 0.496
2.087ValPro: 2.087 ± 0.479
2.012ValGln: 2.012 ± 0.423
2.311ValArg: 2.311 ± 0.41
4.919ValSer: 4.919 ± 0.587
4.174ValThr: 4.174 ± 0.565
3.279ValVal: 3.279 ± 0.379
0.596ValTrp: 0.596 ± 0.187
2.46ValTyr: 2.46 ± 0.37
0.0ValXaa: 0.0 ± 0.0
Trp
0.894TrpAla: 0.894 ± 0.249
0.373TrpCys: 0.373 ± 0.189
1.118TrpAsp: 1.118 ± 0.498
0.82TrpGlu: 0.82 ± 0.285
0.969TrpPhe: 0.969 ± 0.245
0.596TrpGly: 0.596 ± 0.234
0.373TrpHis: 0.373 ± 0.203
0.82TrpIle: 0.82 ± 0.266
1.118TrpLys: 1.118 ± 0.259
1.565TrpLeu: 1.565 ± 0.356
0.149TrpMet: 0.149 ± 0.098
0.298TrpAsn: 0.298 ± 0.144
0.447TrpPro: 0.447 ± 0.167
0.522TrpGln: 0.522 ± 0.185
0.671TrpArg: 0.671 ± 0.176
1.118TrpSer: 1.118 ± 0.337
1.416TrpThr: 1.416 ± 0.394
0.894TrpVal: 0.894 ± 0.224
0.0TrpTrp: 0.0 ± 0.0
0.82TrpTyr: 0.82 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.683TyrAla: 2.683 ± 0.492
0.671TyrCys: 0.671 ± 0.223
3.056TyrAsp: 3.056 ± 0.397
1.714TyrGlu: 1.714 ± 0.36
1.342TyrPhe: 1.342 ± 0.411
2.385TyrGly: 2.385 ± 0.521
1.267TyrHis: 1.267 ± 0.319
2.534TyrIle: 2.534 ± 0.454
2.012TyrLys: 2.012 ± 0.448
2.683TyrLeu: 2.683 ± 0.398
1.267TyrMet: 1.267 ± 0.282
1.714TyrAsn: 1.714 ± 0.332
1.267TyrPro: 1.267 ± 0.393
1.789TyrGln: 1.789 ± 0.407
1.863TyrArg: 1.863 ± 0.349
2.46TyrSer: 2.46 ± 0.449
2.832TyrThr: 2.832 ± 0.416
2.534TyrVal: 2.534 ± 0.441
0.596TyrTrp: 0.596 ± 0.212
1.64TyrTyr: 1.64 ± 0.348
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13418 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski