Amino acid dipepetide frequency for Klebsiella phage KpCHEMY26

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.59AlaAla: 8.59 ± 1.141
0.54AlaCys: 0.54 ± 0.216
5.056AlaAsp: 5.056 ± 0.573
5.154AlaGlu: 5.154 ± 0.691
3.191AlaPhe: 3.191 ± 0.42
4.909AlaGly: 4.909 ± 0.411
1.374AlaHis: 1.374 ± 0.258
5.498AlaIle: 5.498 ± 0.516
5.105AlaLys: 5.105 ± 0.464
7.756AlaLeu: 7.756 ± 0.553
1.963AlaMet: 1.963 ± 0.278
4.369AlaAsn: 4.369 ± 0.558
2.553AlaPro: 2.553 ± 0.349
5.007AlaGln: 5.007 ± 0.693
3.24AlaArg: 3.24 ± 0.653
5.4AlaSer: 5.4 ± 0.426
4.467AlaThr: 4.467 ± 0.81
5.301AlaVal: 5.301 ± 0.653
0.54AlaTrp: 0.54 ± 0.128
2.798AlaTyr: 2.798 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.491CysAla: 0.491 ± 0.214
0.098CysCys: 0.098 ± 0.069
0.491CysAsp: 0.491 ± 0.2
0.687CysGlu: 0.687 ± 0.225
0.589CysPhe: 0.589 ± 0.179
0.638CysGly: 0.638 ± 0.242
0.245CysHis: 0.245 ± 0.125
0.834CysIle: 0.834 ± 0.265
0.491CysLys: 0.491 ± 0.161
0.884CysLeu: 0.884 ± 0.27
0.245CysMet: 0.245 ± 0.113
0.196CysAsn: 0.196 ± 0.103
0.344CysPro: 0.344 ± 0.159
0.393CysGln: 0.393 ± 0.202
0.491CysArg: 0.491 ± 0.173
0.589CysSer: 0.589 ± 0.205
0.442CysThr: 0.442 ± 0.184
0.589CysVal: 0.589 ± 0.196
0.098CysTrp: 0.098 ± 0.076
0.245CysTyr: 0.245 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
4.958AspAla: 4.958 ± 0.614
0.589AspCys: 0.589 ± 0.212
3.927AspAsp: 3.927 ± 0.678
4.516AspGlu: 4.516 ± 0.546
1.718AspPhe: 1.718 ± 0.265
4.516AspGly: 4.516 ± 0.682
0.933AspHis: 0.933 ± 0.154
4.811AspIle: 4.811 ± 0.486
4.32AspLys: 4.32 ± 0.449
5.743AspLeu: 5.743 ± 0.438
1.62AspMet: 1.62 ± 0.248
2.405AspAsn: 2.405 ± 0.314
2.111AspPro: 2.111 ± 0.326
1.473AspGln: 1.473 ± 0.242
2.16AspArg: 2.16 ± 0.267
3.78AspSer: 3.78 ± 0.407
3.583AspThr: 3.583 ± 0.43
4.712AspVal: 4.712 ± 0.395
0.933AspTrp: 0.933 ± 0.194
2.7AspTyr: 2.7 ± 0.457
0.0AspXaa: 0.0 ± 0.0
Glu
6.774GluAla: 6.774 ± 0.82
0.736GluCys: 0.736 ± 0.243
3.878GluAsp: 3.878 ± 0.495
4.271GluGlu: 4.271 ± 0.546
2.749GluPhe: 2.749 ± 0.363
3.387GluGly: 3.387 ± 0.467
1.178GluHis: 1.178 ± 0.232
3.387GluIle: 3.387 ± 0.405
3.682GluLys: 3.682 ± 0.364
7.903GluLeu: 7.903 ± 0.62
2.356GluMet: 2.356 ± 0.308
2.553GluAsn: 2.553 ± 0.428
2.994GluPro: 2.994 ± 0.501
4.025GluGln: 4.025 ± 0.581
2.798GluArg: 2.798 ± 0.34
3.731GluSer: 3.731 ± 0.555
3.731GluThr: 3.731 ± 0.641
4.467GluVal: 4.467 ± 0.598
0.834GluTrp: 0.834 ± 0.236
1.963GluTyr: 1.963 ± 0.297
0.0GluXaa: 0.0 ± 0.0
Phe
2.7PheAla: 2.7 ± 0.351
0.393PheCys: 0.393 ± 0.182
2.454PheAsp: 2.454 ± 0.249
1.865PheGlu: 1.865 ± 0.369
1.325PhePhe: 1.325 ± 0.338
2.847PheGly: 2.847 ± 0.367
0.245PheHis: 0.245 ± 0.105
3.092PheIle: 3.092 ± 0.405
2.847PheLys: 2.847 ± 0.305
2.994PheLeu: 2.994 ± 0.351
0.982PheMet: 0.982 ± 0.223
2.307PheAsn: 2.307 ± 0.351
1.374PhePro: 1.374 ± 0.337
1.178PheGln: 1.178 ± 0.234
2.062PheArg: 2.062 ± 0.296
1.571PheSer: 1.571 ± 0.268
1.914PheThr: 1.914 ± 0.297
2.454PheVal: 2.454 ± 0.301
0.344PheTrp: 0.344 ± 0.118
1.865PheTyr: 1.865 ± 0.284
0.0PheXaa: 0.0 ± 0.0
Gly
4.712GlyAla: 4.712 ± 0.491
0.638GlyCys: 0.638 ± 0.243
3.436GlyAsp: 3.436 ± 0.435
3.731GlyGlu: 3.731 ± 0.451
2.798GlyPhe: 2.798 ± 0.27
2.553GlyGly: 2.553 ± 0.391
1.031GlyHis: 1.031 ± 0.205
4.86GlyIle: 4.86 ± 0.439
4.761GlyLys: 4.761 ± 0.442
5.252GlyLeu: 5.252 ± 0.669
1.718GlyMet: 1.718 ± 0.279
3.534GlyAsn: 3.534 ± 0.351
0.785GlyPro: 0.785 ± 0.186
2.602GlyGln: 2.602 ± 0.453
2.503GlyArg: 2.503 ± 0.386
4.271GlySer: 4.271 ± 0.624
4.369GlyThr: 4.369 ± 0.724
4.123GlyVal: 4.123 ± 0.412
0.933GlyTrp: 0.933 ± 0.266
3.289GlyTyr: 3.289 ± 0.331
0.0GlyXaa: 0.0 ± 0.0
His
0.687HisAla: 0.687 ± 0.183
0.344HisCys: 0.344 ± 0.136
1.031HisAsp: 1.031 ± 0.282
1.178HisGlu: 1.178 ± 0.193
0.589HisPhe: 0.589 ± 0.161
0.736HisGly: 0.736 ± 0.185
0.295HisHis: 0.295 ± 0.122
0.982HisIle: 0.982 ± 0.224
1.276HisLys: 1.276 ± 0.337
1.276HisLeu: 1.276 ± 0.186
0.687HisMet: 0.687 ± 0.17
0.884HisAsn: 0.884 ± 0.243
0.933HisPro: 0.933 ± 0.207
0.491HisGln: 0.491 ± 0.149
0.638HisArg: 0.638 ± 0.175
0.785HisSer: 0.785 ± 0.173
0.982HisThr: 0.982 ± 0.217
1.129HisVal: 1.129 ± 0.282
0.196HisTrp: 0.196 ± 0.096
0.687HisTyr: 0.687 ± 0.187
0.0HisXaa: 0.0 ± 0.0
Ile
5.89IleAla: 5.89 ± 0.489
0.638IleCys: 0.638 ± 0.231
4.663IleAsp: 4.663 ± 0.402
5.154IleGlu: 5.154 ± 0.549
2.013IlePhe: 2.013 ± 0.287
3.387IleGly: 3.387 ± 0.492
1.129IleHis: 1.129 ± 0.269
2.749IleIle: 2.749 ± 0.48
4.86IleLys: 4.86 ± 0.423
4.467IleLeu: 4.467 ± 0.381
1.08IleMet: 1.08 ± 0.196
4.074IleAsn: 4.074 ± 0.603
3.24IlePro: 3.24 ± 0.371
2.847IleGln: 2.847 ± 0.452
2.896IleArg: 2.896 ± 0.445
3.976IleSer: 3.976 ± 0.405
3.927IleThr: 3.927 ± 0.328
3.78IleVal: 3.78 ± 0.577
0.589IleTrp: 0.589 ± 0.168
1.767IleTyr: 1.767 ± 0.302
0.0IleXaa: 0.0 ± 0.0
Lys
5.449LysAla: 5.449 ± 0.558
0.442LysCys: 0.442 ± 0.151
3.485LysAsp: 3.485 ± 0.351
5.105LysGlu: 5.105 ± 0.638
2.7LysPhe: 2.7 ± 0.41
3.24LysGly: 3.24 ± 0.419
1.08LysHis: 1.08 ± 0.342
3.829LysIle: 3.829 ± 0.545
2.994LysLys: 2.994 ± 0.602
7.019LysLeu: 7.019 ± 0.738
2.111LysMet: 2.111 ± 0.271
3.191LysAsn: 3.191 ± 0.366
2.749LysPro: 2.749 ± 0.346
2.994LysGln: 2.994 ± 0.475
2.945LysArg: 2.945 ± 0.299
3.632LysSer: 3.632 ± 0.476
3.682LysThr: 3.682 ± 0.468
4.761LysVal: 4.761 ± 0.628
0.442LysTrp: 0.442 ± 0.135
2.258LysTyr: 2.258 ± 0.287
0.0LysXaa: 0.0 ± 0.0
Leu
7.314LeuAla: 7.314 ± 0.701
1.129LeuCys: 1.129 ± 0.311
6.185LeuAsp: 6.185 ± 0.53
4.271LeuGlu: 4.271 ± 0.535
2.798LeuPhe: 2.798 ± 0.297
5.105LeuGly: 5.105 ± 0.489
1.129LeuHis: 1.129 ± 0.198
5.056LeuIle: 5.056 ± 0.536
5.596LeuLys: 5.596 ± 0.563
6.43LeuLeu: 6.43 ± 0.533
2.503LeuMet: 2.503 ± 0.428
6.627LeuAsn: 6.627 ± 0.613
3.927LeuPro: 3.927 ± 0.428
3.731LeuGln: 3.731 ± 0.462
4.418LeuArg: 4.418 ± 0.451
6.136LeuSer: 6.136 ± 0.531
6.185LeuThr: 6.185 ± 0.6
5.596LeuVal: 5.596 ± 0.411
0.638LeuTrp: 0.638 ± 0.218
2.307LeuTyr: 2.307 ± 0.317
0.0LeuXaa: 0.0 ± 0.0
Met
2.651MetAla: 2.651 ± 0.351
0.295MetCys: 0.295 ± 0.144
1.62MetAsp: 1.62 ± 0.259
1.62MetGlu: 1.62 ± 0.289
0.785MetPhe: 0.785 ± 0.224
1.473MetGly: 1.473 ± 0.25
0.589MetHis: 0.589 ± 0.128
1.227MetIle: 1.227 ± 0.258
2.013MetLys: 2.013 ± 0.441
2.307MetLeu: 2.307 ± 0.394
0.736MetMet: 0.736 ± 0.214
1.473MetAsn: 1.473 ± 0.317
1.276MetPro: 1.276 ± 0.194
1.424MetGln: 1.424 ± 0.219
1.129MetArg: 1.129 ± 0.219
2.503MetSer: 2.503 ± 0.283
1.669MetThr: 1.669 ± 0.375
1.963MetVal: 1.963 ± 0.288
0.196MetTrp: 0.196 ± 0.076
0.785MetTyr: 0.785 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
4.074AsnAla: 4.074 ± 0.441
0.442AsnCys: 0.442 ± 0.171
2.454AsnAsp: 2.454 ± 0.383
3.191AsnGlu: 3.191 ± 0.337
1.767AsnPhe: 1.767 ± 0.308
4.123AsnGly: 4.123 ± 0.481
1.031AsnHis: 1.031 ± 0.246
3.092AsnIle: 3.092 ± 0.528
3.387AsnLys: 3.387 ± 0.439
4.32AsnLeu: 4.32 ± 0.402
1.571AsnMet: 1.571 ± 0.222
3.24AsnAsn: 3.24 ± 0.359
3.682AsnPro: 3.682 ± 0.655
3.092AsnGln: 3.092 ± 0.451
2.7AsnArg: 2.7 ± 0.331
3.731AsnSer: 3.731 ± 0.433
3.142AsnThr: 3.142 ± 0.385
3.142AsnVal: 3.142 ± 0.431
0.245AsnTrp: 0.245 ± 0.111
2.553AsnTyr: 2.553 ± 0.268
0.0AsnXaa: 0.0 ± 0.0
Pro
2.7ProAla: 2.7 ± 0.28
0.344ProCys: 0.344 ± 0.152
2.7ProAsp: 2.7 ± 0.43
4.467ProGlu: 4.467 ± 0.47
1.669ProPhe: 1.669 ± 0.275
3.092ProGly: 3.092 ± 0.338
0.245ProHis: 0.245 ± 0.088
2.749ProIle: 2.749 ± 0.268
1.963ProLys: 1.963 ± 0.343
2.503ProLeu: 2.503 ± 0.307
1.227ProMet: 1.227 ± 0.257
2.258ProAsn: 2.258 ± 0.502
1.129ProPro: 1.129 ± 0.32
1.767ProGln: 1.767 ± 0.266
1.129ProArg: 1.129 ± 0.202
2.553ProSer: 2.553 ± 0.313
2.945ProThr: 2.945 ± 0.418
3.142ProVal: 3.142 ± 0.329
0.295ProTrp: 0.295 ± 0.158
0.933ProTyr: 0.933 ± 0.265
0.0ProXaa: 0.0 ± 0.0
Gln
4.172GlnAla: 4.172 ± 0.72
0.295GlnCys: 0.295 ± 0.123
2.209GlnAsp: 2.209 ± 0.454
3.338GlnGlu: 3.338 ± 0.415
1.522GlnPhe: 1.522 ± 0.222
3.142GlnGly: 3.142 ± 0.402
0.491GlnHis: 0.491 ± 0.15
3.043GlnIle: 3.043 ± 0.369
2.896GlnLys: 2.896 ± 0.324
5.154GlnLeu: 5.154 ± 0.525
1.865GlnMet: 1.865 ± 0.311
2.16GlnAsn: 2.16 ± 0.42
1.276GlnPro: 1.276 ± 0.319
2.454GlnGln: 2.454 ± 0.607
1.865GlnArg: 1.865 ± 0.313
2.749GlnSer: 2.749 ± 0.594
3.485GlnThr: 3.485 ± 0.44
2.258GlnVal: 2.258 ± 0.331
0.442GlnTrp: 0.442 ± 0.134
2.356GlnTyr: 2.356 ± 0.356
0.0GlnXaa: 0.0 ± 0.0
Arg
3.583ArgAla: 3.583 ± 0.372
0.344ArgCys: 0.344 ± 0.148
3.092ArgAsp: 3.092 ± 0.342
2.798ArgGlu: 2.798 ± 0.49
1.522ArgPhe: 1.522 ± 0.28
2.503ArgGly: 2.503 ± 0.35
0.736ArgHis: 0.736 ± 0.262
3.043ArgIle: 3.043 ± 0.384
2.651ArgLys: 2.651 ± 0.409
3.878ArgLeu: 3.878 ± 0.371
1.374ArgMet: 1.374 ± 0.209
2.307ArgAsn: 2.307 ± 0.418
1.227ArgPro: 1.227 ± 0.274
2.602ArgGln: 2.602 ± 0.485
2.16ArgArg: 2.16 ± 0.297
2.503ArgSer: 2.503 ± 0.294
3.092ArgThr: 3.092 ± 0.385
2.847ArgVal: 2.847 ± 0.331
0.393ArgTrp: 0.393 ± 0.112
1.227ArgTyr: 1.227 ± 0.274
0.0ArgXaa: 0.0 ± 0.0
Ser
5.4SerAla: 5.4 ± 0.626
0.589SerCys: 0.589 ± 0.172
3.78SerAsp: 3.78 ± 0.432
4.32SerGlu: 4.32 ± 0.483
2.111SerPhe: 2.111 ± 0.34
4.663SerGly: 4.663 ± 0.546
0.982SerHis: 0.982 ± 0.195
3.583SerIle: 3.583 ± 0.503
4.074SerLys: 4.074 ± 0.571
5.547SerLeu: 5.547 ± 0.532
1.571SerMet: 1.571 ± 0.343
3.731SerAsn: 3.731 ± 0.538
2.258SerPro: 2.258 ± 0.417
2.896SerGln: 2.896 ± 0.366
3.191SerArg: 3.191 ± 0.345
2.994SerSer: 2.994 ± 0.488
3.24SerThr: 3.24 ± 0.357
3.976SerVal: 3.976 ± 0.486
0.687SerTrp: 0.687 ± 0.188
2.062SerTyr: 2.062 ± 0.401
0.0SerXaa: 0.0 ± 0.0
Thr
4.467ThrAla: 4.467 ± 0.62
0.393ThrCys: 0.393 ± 0.168
3.338ThrAsp: 3.338 ± 0.347
4.172ThrGlu: 4.172 ± 0.634
2.013ThrPhe: 2.013 ± 0.411
4.663ThrGly: 4.663 ± 0.544
1.178ThrHis: 1.178 ± 0.236
3.78ThrIle: 3.78 ± 0.487
3.927ThrLys: 3.927 ± 0.369
4.516ThrLeu: 4.516 ± 0.527
1.129ThrMet: 1.129 ± 0.263
3.043ThrAsn: 3.043 ± 0.455
2.896ThrPro: 2.896 ± 0.358
3.043ThrGln: 3.043 ± 0.509
2.356ThrArg: 2.356 ± 0.342
3.632ThrSer: 3.632 ± 0.434
3.78ThrThr: 3.78 ± 0.64
5.596ThrVal: 5.596 ± 0.542
0.834ThrTrp: 0.834 ± 0.183
2.258ThrTyr: 2.258 ± 0.398
0.0ThrXaa: 0.0 ± 0.0
Val
5.301ValAla: 5.301 ± 0.616
0.442ValCys: 0.442 ± 0.195
5.154ValAsp: 5.154 ± 0.447
4.811ValGlu: 4.811 ± 0.471
2.503ValPhe: 2.503 ± 0.339
4.123ValGly: 4.123 ± 0.424
0.785ValHis: 0.785 ± 0.141
4.663ValIle: 4.663 ± 0.651
4.712ValLys: 4.712 ± 0.459
4.86ValLeu: 4.86 ± 0.644
1.473ValMet: 1.473 ± 0.28
4.32ValAsn: 4.32 ± 0.485
3.142ValPro: 3.142 ± 0.374
2.896ValGln: 2.896 ± 0.345
3.142ValArg: 3.142 ± 0.535
4.172ValSer: 4.172 ± 0.392
3.829ValThr: 3.829 ± 0.484
4.221ValVal: 4.221 ± 0.565
0.736ValTrp: 0.736 ± 0.215
2.503ValTyr: 2.503 ± 0.39
0.0ValXaa: 0.0 ± 0.0
Trp
0.638TrpAla: 0.638 ± 0.21
0.049TrpCys: 0.049 ± 0.048
0.589TrpAsp: 0.589 ± 0.205
0.638TrpGlu: 0.638 ± 0.164
0.736TrpPhe: 0.736 ± 0.2
0.687TrpGly: 0.687 ± 0.151
0.098TrpHis: 0.098 ± 0.079
0.393TrpIle: 0.393 ± 0.121
0.638TrpLys: 0.638 ± 0.159
0.982TrpLeu: 0.982 ± 0.233
0.245TrpMet: 0.245 ± 0.116
0.834TrpAsn: 0.834 ± 0.308
0.196TrpPro: 0.196 ± 0.086
0.344TrpGln: 0.344 ± 0.13
0.344TrpArg: 0.344 ± 0.15
0.344TrpSer: 0.344 ± 0.106
0.687TrpThr: 0.687 ± 0.187
0.884TrpVal: 0.884 ± 0.243
0.0TrpTrp: 0.0 ± 0.0
0.54TrpTyr: 0.54 ± 0.193
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.258TyrAla: 2.258 ± 0.389
0.344TyrCys: 0.344 ± 0.158
1.963TyrAsp: 1.963 ± 0.293
2.111TyrGlu: 2.111 ± 0.292
1.718TyrPhe: 1.718 ± 0.27
2.111TyrGly: 2.111 ± 0.293
1.031TyrHis: 1.031 ± 0.251
2.454TyrIle: 2.454 ± 0.362
1.914TyrLys: 1.914 ± 0.337
3.338TyrLeu: 3.338 ± 0.464
1.227TyrMet: 1.227 ± 0.254
1.473TyrAsn: 1.473 ± 0.288
1.718TyrPro: 1.718 ± 0.414
1.914TyrGln: 1.914 ± 0.328
1.718TyrArg: 1.718 ± 0.264
2.602TyrSer: 2.602 ± 0.276
1.865TyrThr: 1.865 ± 0.288
2.847TyrVal: 2.847 ± 0.462
0.491TyrTrp: 0.491 ± 0.152
1.374TyrTyr: 1.374 ± 0.283
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (20373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski