Amino acid dipepetide frequency for Escherichia phage pro483

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.427AlaAla: 11.427 ± 1.879
0.647AlaCys: 0.647 ± 0.298
5.714AlaAsp: 5.714 ± 0.921
5.39AlaGlu: 5.39 ± 0.754
3.126AlaPhe: 3.126 ± 0.618
8.84AlaGly: 8.84 ± 0.953
1.509AlaHis: 1.509 ± 0.357
5.175AlaIle: 5.175 ± 0.709
4.959AlaLys: 4.959 ± 0.647
9.702AlaLeu: 9.702 ± 1.174
2.372AlaMet: 2.372 ± 0.426
2.264AlaAsn: 2.264 ± 0.446
5.282AlaPro: 5.282 ± 0.791
4.204AlaGln: 4.204 ± 0.665
4.959AlaArg: 4.959 ± 0.81
7.223AlaSer: 7.223 ± 0.792
6.468AlaThr: 6.468 ± 0.863
7.115AlaVal: 7.115 ± 0.784
1.617AlaTrp: 1.617 ± 0.419
2.48AlaTyr: 2.48 ± 0.459
0.0AlaXaa: 0.0 ± 0.0
Cys
1.078CysAla: 1.078 ± 0.338
0.0CysCys: 0.0 ± 0.0
0.755CysAsp: 0.755 ± 0.324
0.431CysGlu: 0.431 ± 0.174
0.108CysPhe: 0.108 ± 0.119
0.431CysGly: 0.431 ± 0.222
0.216CysHis: 0.216 ± 0.171
0.431CysIle: 0.431 ± 0.237
0.323CysLys: 0.323 ± 0.175
0.539CysLeu: 0.539 ± 0.216
0.216CysMet: 0.216 ± 0.148
0.323CysAsn: 0.323 ± 0.176
0.431CysPro: 0.431 ± 0.22
0.97CysGln: 0.97 ± 0.37
0.862CysArg: 0.862 ± 0.291
0.431CysSer: 0.431 ± 0.252
0.647CysThr: 0.647 ± 0.277
0.647CysVal: 0.647 ± 0.259
0.108CysTrp: 0.108 ± 0.114
0.539CysTyr: 0.539 ± 0.232
0.0CysXaa: 0.0 ± 0.0
Asp
6.468AspAla: 6.468 ± 0.923
0.539AspCys: 0.539 ± 0.224
3.342AspAsp: 3.342 ± 0.605
3.773AspGlu: 3.773 ± 0.699
2.911AspPhe: 2.911 ± 0.605
4.959AspGly: 4.959 ± 0.737
0.431AspHis: 0.431 ± 0.197
3.558AspIle: 3.558 ± 0.796
2.156AspLys: 2.156 ± 0.509
4.204AspLeu: 4.204 ± 0.658
0.97AspMet: 0.97 ± 0.269
2.048AspAsn: 2.048 ± 0.48
2.156AspPro: 2.156 ± 0.635
1.833AspGln: 1.833 ± 0.436
2.264AspArg: 2.264 ± 0.509
2.48AspSer: 2.48 ± 0.478
3.665AspThr: 3.665 ± 0.524
3.773AspVal: 3.773 ± 0.645
0.755AspTrp: 0.755 ± 0.271
2.264AspTyr: 2.264 ± 0.557
0.0AspXaa: 0.0 ± 0.0
Glu
5.282GluAla: 5.282 ± 0.797
0.431GluCys: 0.431 ± 0.197
2.048GluAsp: 2.048 ± 0.454
3.773GluGlu: 3.773 ± 0.569
2.264GluPhe: 2.264 ± 0.615
3.019GluGly: 3.019 ± 0.573
1.078GluHis: 1.078 ± 0.36
3.342GluIle: 3.342 ± 0.506
3.665GluLys: 3.665 ± 0.6
8.409GluLeu: 8.409 ± 0.801
2.48GluMet: 2.48 ± 0.402
3.234GluAsn: 3.234 ± 0.633
2.911GluPro: 2.911 ± 0.592
2.911GluGln: 2.911 ± 0.574
5.067GluArg: 5.067 ± 0.896
4.528GluSer: 4.528 ± 0.729
3.45GluThr: 3.45 ± 0.609
3.234GluVal: 3.234 ± 0.697
1.078GluTrp: 1.078 ± 0.326
2.803GluTyr: 2.803 ± 0.696
0.0GluXaa: 0.0 ± 0.0
Phe
2.695PheAla: 2.695 ± 0.501
0.323PheCys: 0.323 ± 0.178
1.725PheAsp: 1.725 ± 0.403
2.264PheGlu: 2.264 ± 0.565
1.294PhePhe: 1.294 ± 0.448
1.186PheGly: 1.186 ± 0.343
0.755PheHis: 0.755 ± 0.298
1.509PheIle: 1.509 ± 0.481
2.156PheLys: 2.156 ± 0.43
3.234PheLeu: 3.234 ± 0.539
1.078PheMet: 1.078 ± 0.327
1.833PheAsn: 1.833 ± 0.392
1.509PhePro: 1.509 ± 0.37
1.186PheGln: 1.186 ± 0.314
1.725PheArg: 1.725 ± 0.358
2.48PheSer: 2.48 ± 0.551
3.019PheThr: 3.019 ± 0.508
1.294PheVal: 1.294 ± 0.39
0.755PheTrp: 0.755 ± 0.35
0.97PheTyr: 0.97 ± 0.371
0.0PheXaa: 0.0 ± 0.0
Gly
6.037GlyAla: 6.037 ± 0.888
0.862GlyCys: 0.862 ± 0.343
4.851GlyAsp: 4.851 ± 0.491
5.498GlyGlu: 5.498 ± 0.828
2.264GlyPhe: 2.264 ± 0.562
5.067GlyGly: 5.067 ± 0.844
0.539GlyHis: 0.539 ± 0.181
2.911GlyIle: 2.911 ± 0.57
6.145GlyLys: 6.145 ± 0.79
4.743GlyLeu: 4.743 ± 0.569
2.048GlyMet: 2.048 ± 0.571
1.509GlyAsn: 1.509 ± 0.294
0.431GlyPro: 0.431 ± 0.193
2.48GlyGln: 2.48 ± 0.535
5.929GlyArg: 5.929 ± 0.879
3.234GlySer: 3.234 ± 0.494
3.773GlyThr: 3.773 ± 0.844
6.253GlyVal: 6.253 ± 0.976
1.401GlyTrp: 1.401 ± 0.314
1.94GlyTyr: 1.94 ± 0.414
0.0GlyXaa: 0.0 ± 0.0
His
1.617HisAla: 1.617 ± 0.525
0.431HisCys: 0.431 ± 0.214
0.97HisAsp: 0.97 ± 0.309
0.97HisGlu: 0.97 ± 0.318
0.647HisPhe: 0.647 ± 0.303
1.401HisGly: 1.401 ± 0.428
0.862HisHis: 0.862 ± 0.295
1.186HisIle: 1.186 ± 0.282
0.647HisLys: 0.647 ± 0.249
1.94HisLeu: 1.94 ± 0.403
0.431HisMet: 0.431 ± 0.188
1.186HisAsn: 1.186 ± 0.427
1.078HisPro: 1.078 ± 0.377
0.862HisGln: 0.862 ± 0.309
1.078HisArg: 1.078 ± 0.306
0.755HisSer: 0.755 ± 0.308
0.862HisThr: 0.862 ± 0.329
1.078HisVal: 1.078 ± 0.308
0.323HisTrp: 0.323 ± 0.171
0.539HisTyr: 0.539 ± 0.239
0.0HisXaa: 0.0 ± 0.0
Ile
4.743IleAla: 4.743 ± 0.79
0.323IleCys: 0.323 ± 0.205
3.665IleAsp: 3.665 ± 0.633
3.019IleGlu: 3.019 ± 0.568
1.94IlePhe: 1.94 ± 0.555
4.097IleGly: 4.097 ± 0.621
0.431IleHis: 0.431 ± 0.286
2.911IleIle: 2.911 ± 0.488
2.156IleLys: 2.156 ± 0.71
2.48IleLeu: 2.48 ± 0.541
1.186IleMet: 1.186 ± 0.422
3.126IleAsn: 3.126 ± 0.557
2.48IlePro: 2.48 ± 0.61
1.617IleGln: 1.617 ± 0.436
4.851IleArg: 4.851 ± 0.649
4.528IleSer: 4.528 ± 0.602
4.743IleThr: 4.743 ± 0.688
3.342IleVal: 3.342 ± 0.604
0.755IleTrp: 0.755 ± 0.257
1.401IleTyr: 1.401 ± 0.321
0.0IleXaa: 0.0 ± 0.0
Lys
4.959LysAla: 4.959 ± 0.662
0.323LysCys: 0.323 ± 0.194
1.401LysAsp: 1.401 ± 0.372
3.126LysGlu: 3.126 ± 0.54
1.833LysPhe: 1.833 ± 0.389
3.019LysGly: 3.019 ± 0.38
1.725LysHis: 1.725 ± 0.497
2.372LysIle: 2.372 ± 0.417
3.881LysLys: 3.881 ± 0.757
6.684LysLeu: 6.684 ± 0.954
1.078LysMet: 1.078 ± 0.354
2.911LysAsn: 2.911 ± 0.614
3.126LysPro: 3.126 ± 0.553
1.94LysGln: 1.94 ± 0.452
4.097LysArg: 4.097 ± 0.766
3.126LysSer: 3.126 ± 0.623
3.342LysThr: 3.342 ± 0.695
3.234LysVal: 3.234 ± 0.626
0.862LysTrp: 0.862 ± 0.405
2.264LysTyr: 2.264 ± 0.45
0.0LysXaa: 0.0 ± 0.0
Leu
10.026LeuAla: 10.026 ± 1.053
0.647LeuCys: 0.647 ± 0.254
5.175LeuAsp: 5.175 ± 0.722
6.361LeuGlu: 6.361 ± 0.831
3.342LeuPhe: 3.342 ± 0.616
4.528LeuGly: 4.528 ± 0.776
1.833LeuHis: 1.833 ± 0.471
5.821LeuIle: 5.821 ± 0.69
6.468LeuLys: 6.468 ± 0.829
5.929LeuLeu: 5.929 ± 0.771
2.911LeuMet: 2.911 ± 0.438
4.42LeuAsn: 4.42 ± 0.593
4.204LeuPro: 4.204 ± 0.719
3.019LeuGln: 3.019 ± 0.509
5.175LeuArg: 5.175 ± 0.528
6.361LeuSer: 6.361 ± 0.788
7.546LeuThr: 7.546 ± 0.945
4.42LeuVal: 4.42 ± 0.611
0.862LeuTrp: 0.862 ± 0.305
2.48LeuTyr: 2.48 ± 0.571
0.0LeuXaa: 0.0 ± 0.0
Met
3.019MetAla: 3.019 ± 0.482
0.216MetCys: 0.216 ± 0.16
0.431MetAsp: 0.431 ± 0.23
1.401MetGlu: 1.401 ± 0.357
0.862MetPhe: 0.862 ± 0.258
0.97MetGly: 0.97 ± 0.279
0.647MetHis: 0.647 ± 0.222
1.186MetIle: 1.186 ± 0.294
1.294MetLys: 1.294 ± 0.429
3.126MetLeu: 3.126 ± 0.61
0.97MetMet: 0.97 ± 0.291
2.264MetAsn: 2.264 ± 0.518
1.186MetPro: 1.186 ± 0.404
0.539MetGln: 0.539 ± 0.254
2.48MetArg: 2.48 ± 0.542
1.833MetSer: 1.833 ± 0.45
3.234MetThr: 3.234 ± 0.548
1.186MetVal: 1.186 ± 0.356
0.323MetTrp: 0.323 ± 0.195
0.431MetTyr: 0.431 ± 0.203
0.0MetXaa: 0.0 ± 0.0
Asn
3.665AsnAla: 3.665 ± 0.606
0.539AsnCys: 0.539 ± 0.257
2.372AsnAsp: 2.372 ± 0.436
2.911AsnGlu: 2.911 ± 0.619
1.294AsnPhe: 1.294 ± 0.406
3.558AsnGly: 3.558 ± 0.686
0.539AsnHis: 0.539 ± 0.224
2.372AsnIle: 2.372 ± 0.446
1.617AsnLys: 1.617 ± 0.405
3.019AsnLeu: 3.019 ± 0.555
0.862AsnMet: 0.862 ± 0.35
1.725AsnAsn: 1.725 ± 0.465
1.94AsnPro: 1.94 ± 0.426
1.94AsnGln: 1.94 ± 0.557
2.803AsnArg: 2.803 ± 0.466
2.048AsnSer: 2.048 ± 0.428
2.048AsnThr: 2.048 ± 0.382
2.048AsnVal: 2.048 ± 0.408
0.216AsnTrp: 0.216 ± 0.121
1.186AsnTyr: 1.186 ± 0.371
0.0AsnXaa: 0.0 ± 0.0
Pro
5.175ProAla: 5.175 ± 0.783
0.108ProCys: 0.108 ± 0.11
3.45ProAsp: 3.45 ± 0.572
3.342ProGlu: 3.342 ± 0.634
1.078ProPhe: 1.078 ± 0.44
2.156ProGly: 2.156 ± 0.404
1.078ProHis: 1.078 ± 0.35
1.294ProIle: 1.294 ± 0.363
2.372ProLys: 2.372 ± 0.647
4.097ProLeu: 4.097 ± 0.562
0.862ProMet: 0.862 ± 0.301
1.078ProAsn: 1.078 ± 0.361
1.725ProPro: 1.725 ± 0.53
1.617ProGln: 1.617 ± 0.459
2.803ProArg: 2.803 ± 0.744
2.48ProSer: 2.48 ± 0.557
2.48ProThr: 2.48 ± 0.653
5.175ProVal: 5.175 ± 0.799
0.647ProTrp: 0.647 ± 0.257
1.186ProTyr: 1.186 ± 0.354
0.0ProXaa: 0.0 ± 0.0
Gln
4.636GlnAla: 4.636 ± 1.2
0.323GlnCys: 0.323 ± 0.193
2.156GlnAsp: 2.156 ± 0.531
2.372GlnGlu: 2.372 ± 0.499
0.647GlnPhe: 0.647 ± 0.221
2.156GlnGly: 2.156 ± 0.365
0.539GlnHis: 0.539 ± 0.221
2.695GlnIle: 2.695 ± 0.634
2.156GlnLys: 2.156 ± 0.471
4.097GlnLeu: 4.097 ± 0.632
1.186GlnMet: 1.186 ± 0.387
0.647GlnAsn: 0.647 ± 0.284
1.509GlnPro: 1.509 ± 0.423
1.94GlnGln: 1.94 ± 0.473
4.42GlnArg: 4.42 ± 0.646
2.264GlnSer: 2.264 ± 0.596
2.264GlnThr: 2.264 ± 0.407
1.833GlnVal: 1.833 ± 0.446
0.539GlnTrp: 0.539 ± 0.262
0.647GlnTyr: 0.647 ± 0.28
0.0GlnXaa: 0.0 ± 0.0
Arg
5.498ArgAla: 5.498 ± 0.659
0.97ArgCys: 0.97 ± 0.337
2.803ArgAsp: 2.803 ± 0.378
5.282ArgGlu: 5.282 ± 0.698
1.833ArgPhe: 1.833 ± 0.432
4.42ArgGly: 4.42 ± 0.78
1.833ArgHis: 1.833 ± 0.447
4.42ArgIle: 4.42 ± 0.634
3.234ArgLys: 3.234 ± 0.547
6.145ArgLeu: 6.145 ± 0.867
1.401ArgMet: 1.401 ± 0.455
3.126ArgAsn: 3.126 ± 0.546
2.264ArgPro: 2.264 ± 0.432
3.665ArgGln: 3.665 ± 0.682
4.528ArgArg: 4.528 ± 0.797
2.911ArgSer: 2.911 ± 0.64
3.558ArgThr: 3.558 ± 0.495
4.312ArgVal: 4.312 ± 0.788
1.078ArgTrp: 1.078 ± 0.358
2.587ArgTyr: 2.587 ± 0.554
0.0ArgXaa: 0.0 ± 0.0
Ser
6.792SerAla: 6.792 ± 1.145
0.755SerCys: 0.755 ± 0.258
3.773SerAsp: 3.773 ± 0.633
3.881SerGlu: 3.881 ± 0.623
2.048SerPhe: 2.048 ± 0.496
4.204SerGly: 4.204 ± 0.784
1.186SerHis: 1.186 ± 0.529
2.264SerIle: 2.264 ± 0.477
3.665SerLys: 3.665 ± 0.651
6.576SerLeu: 6.576 ± 1.036
1.94SerMet: 1.94 ± 0.457
2.048SerAsn: 2.048 ± 0.552
2.587SerPro: 2.587 ± 0.649
2.156SerGln: 2.156 ± 0.35
3.234SerArg: 3.234 ± 0.521
2.911SerSer: 2.911 ± 0.622
3.989SerThr: 3.989 ± 0.719
5.175SerVal: 5.175 ± 0.908
0.755SerTrp: 0.755 ± 0.304
0.862SerTyr: 0.862 ± 0.376
0.0SerXaa: 0.0 ± 0.0
Thr
6.684ThrAla: 6.684 ± 0.924
0.647ThrCys: 0.647 ± 0.342
3.665ThrAsp: 3.665 ± 0.545
3.773ThrGlu: 3.773 ± 0.691
2.156ThrPhe: 2.156 ± 0.495
7.115ThrGly: 7.115 ± 0.851
1.294ThrHis: 1.294 ± 0.362
3.234ThrIle: 3.234 ± 0.492
3.234ThrLys: 3.234 ± 0.715
7.007ThrLeu: 7.007 ± 0.974
2.048ThrMet: 2.048 ± 0.379
1.833ThrAsn: 1.833 ± 0.511
3.773ThrPro: 3.773 ± 0.524
1.94ThrGln: 1.94 ± 0.567
4.097ThrArg: 4.097 ± 0.562
4.204ThrSer: 4.204 ± 0.428
3.773ThrThr: 3.773 ± 0.546
4.312ThrVal: 4.312 ± 0.779
0.323ThrTrp: 0.323 ± 0.173
1.078ThrTyr: 1.078 ± 0.3
0.0ThrXaa: 0.0 ± 0.0
Val
6.468ValAla: 6.468 ± 0.969
1.294ValCys: 1.294 ± 0.398
4.097ValAsp: 4.097 ± 0.717
4.312ValGlu: 4.312 ± 0.789
2.048ValPhe: 2.048 ± 0.47
4.636ValGly: 4.636 ± 0.749
0.755ValHis: 0.755 ± 0.267
3.989ValIle: 3.989 ± 0.78
3.773ValLys: 3.773 ± 0.663
5.821ValLeu: 5.821 ± 0.753
2.264ValMet: 2.264 ± 0.372
2.156ValAsn: 2.156 ± 0.525
2.587ValPro: 2.587 ± 0.564
1.94ValGln: 1.94 ± 0.422
2.587ValArg: 2.587 ± 0.428
4.636ValSer: 4.636 ± 0.6
5.606ValThr: 5.606 ± 0.973
4.42ValVal: 4.42 ± 0.634
0.431ValTrp: 0.431 ± 0.221
1.294ValTyr: 1.294 ± 0.396
0.0ValXaa: 0.0 ± 0.0
Trp
1.186TrpAla: 1.186 ± 0.293
0.0TrpCys: 0.0 ± 0.0
1.294TrpAsp: 1.294 ± 0.307
0.97TrpGlu: 0.97 ± 0.325
0.323TrpPhe: 0.323 ± 0.173
0.323TrpGly: 0.323 ± 0.251
0.539TrpHis: 0.539 ± 0.219
0.755TrpIle: 0.755 ± 0.303
0.755TrpLys: 0.755 ± 0.252
1.617TrpLeu: 1.617 ± 0.464
0.323TrpMet: 0.323 ± 0.212
0.323TrpAsn: 0.323 ± 0.208
1.401TrpPro: 1.401 ± 0.414
0.539TrpGln: 0.539 ± 0.187
1.186TrpArg: 1.186 ± 0.381
0.647TrpSer: 0.647 ± 0.187
0.431TrpThr: 0.431 ± 0.171
0.539TrpVal: 0.539 ± 0.191
0.647TrpTrp: 0.647 ± 0.249
0.431TrpTyr: 0.431 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.019TyrAla: 3.019 ± 0.65
0.108TyrCys: 0.108 ± 0.124
0.862TyrAsp: 0.862 ± 0.293
2.264TyrGlu: 2.264 ± 0.552
0.97TyrPhe: 0.97 ± 0.352
1.833TyrGly: 1.833 ± 0.448
1.078TyrHis: 1.078 ± 0.392
2.372TyrIle: 2.372 ± 0.457
0.647TyrLys: 0.647 ± 0.217
2.156TyrLeu: 2.156 ± 0.38
0.862TyrMet: 0.862 ± 0.353
0.647TyrAsn: 0.647 ± 0.254
1.617TyrPro: 1.617 ± 0.517
1.725TyrGln: 1.725 ± 0.52
1.725TyrArg: 1.725 ± 0.381
1.725TyrSer: 1.725 ± 0.364
1.294TyrThr: 1.294 ± 0.424
1.725TyrVal: 1.725 ± 0.412
0.755TyrTrp: 0.755 ± 0.295
0.97TyrTyr: 0.97 ± 0.319
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (9277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski