Amino acid dipepetide frequency for Geothermobacter ehrlichii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.507AlaAla: 11.507 ± 0.157	1.452AlaCys: 1.452 ± 0.054	5.673AlaAsp: 5.673 ± 0.091	7.266AlaGlu: 7.266 ± 0.1	3.623AlaPhe: 3.623 ± 0.063	9.75AlaGly: 9.75 ± 0.124	1.614AlaHis: 1.614 ± 0.035	5.094AlaIle: 5.094 ± 0.079	2.929AlaLys: 2.929 ± 0.062	10.481AlaLeu: 10.481 ± 0.129	2.502AlaMet: 2.502 ± 0.05	2.304AlaAsn: 2.304 ± 0.054	3.708AlaPro: 3.708 ± 0.08	2.444AlaGln: 2.444 ± 0.051	7.858AlaArg: 7.858 ± 0.117	4.466AlaSer: 4.466 ± 0.077	4.468AlaThr: 4.468 ± 0.081	7.268AlaVal: 7.268 ± 0.104	1.127AlaTrp: 1.127 ± 0.032	2.041AlaTyr: 2.041 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.033	0.28CysCys: 0.28 ± 0.018	0.731CysAsp: 0.731 ± 0.028	0.706CysGlu: 0.706 ± 0.028	0.489CysPhe: 0.489 ± 0.022	1.431CysGly: 1.431 ± 0.046	0.682CysHis: 0.682 ± 0.105	0.58CysIle: 0.58 ± 0.026	0.316CysLys: 0.316 ± 0.02	1.402CysLeu: 1.402 ± 0.04	0.235CysMet: 0.235 ± 0.016	0.363CysAsn: 0.363 ± 0.021	0.824CysPro: 0.824 ± 0.039	0.43CysGln: 0.43 ± 0.027	1.367CysArg: 1.367 ± 0.049	0.764CysSer: 0.764 ± 0.035	0.538CysThr: 0.538 ± 0.031	0.731CysVal: 0.731 ± 0.03	0.16CysTrp: 0.16 ± 0.012	0.364CysTyr: 0.364 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.826AspAla: 4.826 ± 0.08	0.793AspCys: 0.793 ± 0.033	2.971AspAsp: 2.971 ± 0.069	3.947AspGlu: 3.947 ± 0.079	2.504AspPhe: 2.504 ± 0.058	4.663AspGly: 4.663 ± 0.089	1.116AspHis: 1.116 ± 0.032	3.249AspIle: 3.249 ± 0.058	1.743AspLys: 1.743 ± 0.054	6.636AspLeu: 6.636 ± 0.087	1.19AspMet: 1.19 ± 0.038	1.48AspAsn: 1.48 ± 0.049	3.19AspPro: 3.19 ± 0.062	1.669AspGln: 1.669 ± 0.045	4.94AspArg: 4.94 ± 0.078	2.572AspSer: 2.572 ± 0.055	2.134AspThr: 2.134 ± 0.059	3.476AspVal: 3.476 ± 0.057	0.836AspTrp: 0.836 ± 0.027	1.796AspTyr: 1.796 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.637GluAla: 6.637 ± 0.116	0.541GluCys: 0.541 ± 0.025	3.113GluAsp: 3.113 ± 0.059	5.38GluGlu: 5.38 ± 0.099	2.041GluPhe: 2.041 ± 0.045	4.582GluGly: 4.582 ± 0.077	1.361GluHis: 1.361 ± 0.039	4.41GluIle: 4.41 ± 0.071	4.016GluLys: 4.016 ± 0.078	8.044GluLeu: 8.044 ± 0.102	1.723GluMet: 1.723 ± 0.052	1.972GluAsn: 1.972 ± 0.046	2.535GluPro: 2.535 ± 0.059	3.043GluGln: 3.043 ± 0.062	5.688GluArg: 5.688 ± 0.081	2.858GluSer: 2.858 ± 0.063	3.438GluThr: 3.438 ± 0.073	4.825GluVal: 4.825 ± 0.079	0.557GluTrp: 0.557 ± 0.025	1.311GluTyr: 1.311 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.843PheAla: 3.843 ± 0.074	0.712PheCys: 0.712 ± 0.027	2.666PheAsp: 2.666 ± 0.052	2.163PheGlu: 2.163 ± 0.052	1.946PhePhe: 1.946 ± 0.053	3.547PheGly: 3.547 ± 0.067	0.824PheHis: 0.824 ± 0.031	1.874PheIle: 1.874 ± 0.046	1.108PheLys: 1.108 ± 0.031	4.239PheLeu: 4.239 ± 0.083	0.784PheMet: 0.784 ± 0.031	1.167PheAsn: 1.167 ± 0.036	1.731PhePro: 1.731 ± 0.045	1.0PheGln: 1.0 ± 0.036	2.764PheArg: 2.764 ± 0.055	2.495PheSer: 2.495 ± 0.049	1.828PheThr: 1.828 ± 0.042	2.686PheVal: 2.686 ± 0.052	0.495PheTrp: 0.495 ± 0.029	1.139PheTyr: 1.139 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.4GlyAla: 6.4 ± 0.085	1.385GlyCys: 1.385 ± 0.045	4.405GlyAsp: 4.405 ± 0.084	5.602GlyGlu: 5.602 ± 0.082	3.236GlyPhe: 3.236 ± 0.064	6.764GlyGly: 6.764 ± 0.106	1.807GlyHis: 1.807 ± 0.045	5.067GlyIle: 5.067 ± 0.077	3.721GlyLys: 3.721 ± 0.07	9.0GlyLeu: 9.0 ± 0.131	2.318GlyMet: 2.318 ± 0.047	2.272GlyAsn: 2.272 ± 0.067	2.773GlyPro: 2.773 ± 0.062	2.834GlyGln: 2.834 ± 0.062	6.855GlyArg: 6.855 ± 0.098	4.211GlySer: 4.211 ± 0.079	4.044GlyThr: 4.044 ± 0.101	5.834GlyVal: 5.834 ± 0.091	1.078GlyTrp: 1.078 ± 0.035	2.499GlyTyr: 2.499 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.714HisAla: 1.714 ± 0.044	0.322HisCys: 0.322 ± 0.018	1.151HisAsp: 1.151 ± 0.045	1.018HisGlu: 1.018 ± 0.034	0.939HisPhe: 0.939 ± 0.033	1.762HisGly: 1.762 ± 0.053	0.545HisHis: 0.545 ± 0.028	1.004HisIle: 1.004 ± 0.036	0.556HisLys: 0.556 ± 0.022	2.599HisLeu: 2.599 ± 0.055	0.378HisMet: 0.378 ± 0.022	0.656HisAsn: 0.656 ± 0.031	1.545HisPro: 1.545 ± 0.043	0.743HisGln: 0.743 ± 0.03	1.642HisArg: 1.642 ± 0.048	0.965HisSer: 0.965 ± 0.032	0.803HisThr: 0.803 ± 0.033	1.24HisVal: 1.24 ± 0.039	0.222HisTrp: 0.222 ± 0.016	0.659HisTyr: 0.659 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.386IleAla: 5.386 ± 0.08	0.756IleCys: 0.756 ± 0.031	3.991IleAsp: 3.991 ± 0.082	3.916IleGlu: 3.916 ± 0.067	2.168IlePhe: 2.168 ± 0.052	4.484IleGly: 4.484 ± 0.065	1.113IleHis: 1.113 ± 0.033	2.572IleIle: 2.572 ± 0.063	1.725IleLys: 1.725 ± 0.053	5.6IleLeu: 5.6 ± 0.086	0.983IleMet: 0.983 ± 0.039	1.689IleAsn: 1.689 ± 0.042	2.682IlePro: 2.682 ± 0.058	1.355IleGln: 1.355 ± 0.037	4.257IleArg: 4.257 ± 0.069	2.883IleSer: 2.883 ± 0.058	2.365IleThr: 2.365 ± 0.052	3.848IleVal: 3.848 ± 0.068	0.52IleTrp: 0.52 ± 0.024	1.426IleTyr: 1.426 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.676LysAla: 3.676 ± 0.074	0.335LysCys: 0.335 ± 0.02	1.825LysAsp: 1.825 ± 0.048	2.811LysGlu: 2.811 ± 0.063	1.032LysPhe: 1.032 ± 0.037	2.88LysGly: 2.88 ± 0.061	0.661LysHis: 0.661 ± 0.029	2.407LysIle: 2.407 ± 0.049	2.537LysLys: 2.537 ± 0.063	3.81LysLeu: 3.81 ± 0.064	0.958LysMet: 0.958 ± 0.039	1.278LysAsn: 1.278 ± 0.037	1.778LysPro: 1.778 ± 0.052	1.385LysGln: 1.385 ± 0.045	2.695LysArg: 2.695 ± 0.064	1.85LysSer: 1.85 ± 0.046	2.13LysThr: 2.13 ± 0.049	2.895LysVal: 2.895 ± 0.055	0.277LysTrp: 0.277 ± 0.014	0.975LysTyr: 0.975 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	13.342LeuAla: 13.342 ± 0.168	1.457LeuCys: 1.457 ± 0.05	6.409LeuAsp: 6.409 ± 0.082	7.543LeuGlu: 7.543 ± 0.104	4.551LeuPhe: 4.551 ± 0.081	8.365LeuGly: 8.365 ± 0.101	2.119LeuHis: 2.119 ± 0.043	5.141LeuIle: 5.141 ± 0.085	4.508LeuLys: 4.508 ± 0.078	14.046LeuLeu: 14.046 ± 0.208	2.101LeuMet: 2.101 ± 0.054	2.852LeuAsn: 2.852 ± 0.054	6.079LeuPro: 6.079 ± 0.086	4.164LeuGln: 4.164 ± 0.072	8.434LeuArg: 8.434 ± 0.126	5.73LeuSer: 5.73 ± 0.083	5.566LeuThr: 5.566 ± 0.082	8.691LeuVal: 8.691 ± 0.122	1.076LeuTrp: 1.076 ± 0.043	2.509LeuTyr: 2.509 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.543MetAla: 2.543 ± 0.05	0.178MetCys: 0.178 ± 0.015	0.997MetAsp: 0.997 ± 0.034	1.433MetGlu: 1.433 ± 0.043	0.61MetPhe: 0.61 ± 0.028	1.58MetGly: 1.58 ± 0.046	0.39MetHis: 0.39 ± 0.021	1.158MetIle: 1.158 ± 0.038	1.211MetLys: 1.211 ± 0.037	2.405MetLeu: 2.405 ± 0.059	0.457MetMet: 0.457 ± 0.022	0.811MetAsn: 0.811 ± 0.027	1.178MetPro: 1.178 ± 0.036	0.782MetGln: 0.782 ± 0.031	1.516MetArg: 1.516 ± 0.044	1.272MetSer: 1.272 ± 0.038	1.406MetThr: 1.406 ± 0.039	1.82MetVal: 1.82 ± 0.049	0.121MetTrp: 0.121 ± 0.012	0.371MetTyr: 0.371 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.362AsnAla: 2.362 ± 0.062	0.399AsnCys: 0.399 ± 0.022	1.367AsnAsp: 1.367 ± 0.043	1.433AsnGlu: 1.433 ± 0.039	1.068AsnPhe: 1.068 ± 0.034	2.26AsnGly: 2.26 ± 0.079	0.582AsnHis: 0.582 ± 0.023	1.684AsnIle: 1.684 ± 0.047	0.858AsnLys: 0.858 ± 0.033	3.471AsnLeu: 3.471 ± 0.064	0.62AsnMet: 0.62 ± 0.023	0.868AsnAsn: 0.868 ± 0.042	1.88AsnPro: 1.88 ± 0.046	0.908AsnGln: 0.908 ± 0.033	2.456AsnArg: 2.456 ± 0.051	1.239AsnSer: 1.239 ± 0.043	1.171AsnThr: 1.171 ± 0.046	1.824AsnVal: 1.824 ± 0.048	0.37AsnTrp: 0.37 ± 0.023	0.825AsnTyr: 0.825 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.073ProAla: 5.073 ± 0.089	0.522ProCys: 0.522 ± 0.024	3.39ProAsp: 3.39 ± 0.062	4.35ProGlu: 4.35 ± 0.075	1.925ProPhe: 1.925 ± 0.05	4.361ProGly: 4.361 ± 0.085	0.937ProHis: 0.937 ± 0.033	1.765ProIle: 1.765 ± 0.043	1.627ProLys: 1.627 ± 0.04	5.159ProLeu: 5.159 ± 0.084	0.932ProMet: 0.932 ± 0.033	1.118ProAsn: 1.118 ± 0.037	2.409ProPro: 2.409 ± 0.056	1.752ProGln: 1.752 ± 0.043	2.824ProArg: 2.824 ± 0.059	1.997ProSer: 1.997 ± 0.044	2.054ProThr: 2.054 ± 0.045	4.271ProVal: 4.271 ± 0.076	0.609ProTrp: 0.609 ± 0.027	1.14ProTyr: 1.14 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.021GlnAla: 4.021 ± 0.085	0.315GlnCys: 0.315 ± 0.019	1.567GlnAsp: 1.567 ± 0.048	2.14GlnGlu: 2.14 ± 0.063	1.053GlnPhe: 1.053 ± 0.033	2.516GlnGly: 2.516 ± 0.052	0.621GlnHis: 0.621 ± 0.026	2.038GlnIle: 2.038 ± 0.046	1.736GlnLys: 1.736 ± 0.047	3.878GlnLeu: 3.878 ± 0.069	0.897GlnMet: 0.897 ± 0.031	0.977GlnAsn: 0.977 ± 0.034	1.663GlnPro: 1.663 ± 0.039	1.737GlnGln: 1.737 ± 0.047	2.586GlnArg: 2.586 ± 0.06	1.456GlnSer: 1.456 ± 0.04	1.739GlnThr: 1.739 ± 0.048	3.048GlnVal: 3.048 ± 0.054	0.33GlnTrp: 0.33 ± 0.018	0.647GlnTyr: 0.647 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	5.92ArgAla: 5.92 ± 0.09	0.956ArgCys: 0.956 ± 0.033	4.005ArgAsp: 4.005 ± 0.068	5.688ArgGlu: 5.688 ± 0.101	3.42ArgPhe: 3.42 ± 0.059	4.995ArgGly: 4.995 ± 0.089	1.906ArgHis: 1.906 ± 0.049	4.933ArgIle: 4.933 ± 0.079	3.334ArgLys: 3.334 ± 0.067	10.075ArgLeu: 10.075 ± 0.158	1.771ArgMet: 1.771 ± 0.044	2.191ArgAsn: 2.191 ± 0.046	3.767ArgPro: 3.767 ± 0.07	4.604ArgGln: 4.604 ± 0.093	7.343ArgArg: 7.343 ± 0.129	3.411ArgSer: 3.411 ± 0.06	3.26ArgThr: 3.26 ± 0.068	5.083ArgVal: 5.083 ± 0.083	0.883ArgTrp: 0.883 ± 0.032	2.21ArgTyr: 2.21 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.251SerAla: 4.251 ± 0.071	0.784SerCys: 0.784 ± 0.033	2.498SerAsp: 2.498 ± 0.057	2.919SerGlu: 2.919 ± 0.049	2.217SerPhe: 2.217 ± 0.046	4.791SerGly: 4.791 ± 0.079	1.069SerHis: 1.069 ± 0.039	2.454SerIle: 2.454 ± 0.058	1.48SerLys: 1.48 ± 0.043	5.951SerLeu: 5.951 ± 0.084	1.121SerMet: 1.121 ± 0.036	1.263SerAsn: 1.263 ± 0.047	2.507SerPro: 2.507 ± 0.061	1.447SerGln: 1.447 ± 0.035	4.068SerArg: 4.068 ± 0.078	2.641SerSer: 2.641 ± 0.066	2.125SerThr: 2.125 ± 0.055	3.149SerVal: 3.149 ± 0.059	0.729SerTrp: 0.729 ± 0.03	1.35SerTyr: 1.35 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.766ThrAla: 4.766 ± 0.086	0.66ThrCys: 0.66 ± 0.042	2.61ThrAsp: 2.61 ± 0.058	2.698ThrGlu: 2.698 ± 0.053	1.877ThrPhe: 1.877 ± 0.047	5.024ThrGly: 5.024 ± 0.097	0.815ThrHis: 0.815 ± 0.029	2.646ThrIle: 2.646 ± 0.06	1.19ThrLys: 1.19 ± 0.036	5.423ThrLeu: 5.423 ± 0.078	1.005ThrMet: 1.005 ± 0.033	1.143ThrAsn: 1.143 ± 0.04	2.706ThrPro: 2.706 ± 0.059	0.972ThrGln: 0.972 ± 0.033	3.102ThrArg: 3.102 ± 0.057	2.357ThrSer: 2.357 ± 0.06	2.554ThrThr: 2.554 ± 0.081	3.573ThrVal: 3.573 ± 0.065	0.504ThrTrp: 0.504 ± 0.026	1.161ThrTyr: 1.161 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.383ValAla: 7.383 ± 0.103	1.071ValCys: 1.071 ± 0.04	4.423ValAsp: 4.423 ± 0.081	5.162ValGlu: 5.162 ± 0.088	2.748ValPhe: 2.748 ± 0.063	5.47ValGly: 5.47 ± 0.08	1.401ValHis: 1.401 ± 0.042	3.961ValIle: 3.961 ± 0.064	2.483ValLys: 2.483 ± 0.053	7.841ValLeu: 7.841 ± 0.108	1.595ValMet: 1.595 ± 0.041	2.154ValAsn: 2.154 ± 0.051	3.389ValPro: 3.389 ± 0.066	1.986ValGln: 1.986 ± 0.047	5.649ValArg: 5.649 ± 0.083	3.818ValSer: 3.818 ± 0.068	3.612ValThr: 3.612 ± 0.069	5.883ValVal: 5.883 ± 0.096	0.707ValTrp: 0.707 ± 0.033	1.636ValTyr: 1.636 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.728TrpAla: 0.728 ± 0.028	0.168TrpCys: 0.168 ± 0.014	0.513TrpAsp: 0.513 ± 0.023	0.604TrpGlu: 0.604 ± 0.03	0.461TrpPhe: 0.461 ± 0.025	0.745TrpGly: 0.745 ± 0.034	0.273TrpHis: 0.273 ± 0.017	0.588TrpIle: 0.588 ± 0.026	0.426TrpLys: 0.426 ± 0.022	1.486TrpLeu: 1.486 ± 0.048	0.265TrpMet: 0.265 ± 0.016	0.365TrpAsn: 0.365 ± 0.02	0.551TrpPro: 0.551 ± 0.027	0.635TrpGln: 0.635 ± 0.025	1.085TrpArg: 1.085 ± 0.039	0.578TrpSer: 0.578 ± 0.029	0.468TrpThr: 0.468 ± 0.022	0.675TrpVal: 0.675 ± 0.028	0.175TrpTrp: 0.175 ± 0.015	0.295TrpTyr: 0.295 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.13TyrAla: 2.13 ± 0.051	0.373TyrCys: 0.373 ± 0.019	1.428TyrAsp: 1.428 ± 0.04	1.296TyrGlu: 1.296 ± 0.045	1.1TyrPhe: 1.1 ± 0.041	2.135TyrGly: 2.135 ± 0.063	0.626TyrHis: 0.626 ± 0.027	1.094TyrIle: 1.094 ± 0.037	0.689TyrLys: 0.689 ± 0.026	3.139TyrLeu: 3.139 ± 0.064	0.402TyrMet: 0.402 ± 0.02	0.721TyrAsn: 0.721 ± 0.033	1.319TyrPro: 1.319 ± 0.041	1.074TyrGln: 1.074 ± 0.035	2.627TyrArg: 2.627 ± 0.063	1.251TyrSer: 1.251 ± 0.036	1.084TyrThr: 1.084 ± 0.037	1.554TyrVal: 1.554 ± 0.04	0.31TyrTrp: 0.31 ± 0.019	0.757TyrTyr: 0.757 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2981 proteins (958005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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