Amino acid dipepetide frequency for Geotrypetes seraphini (Gaboon caecilian) (Caecilia seraphini)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.24AlaAla: 5.24 ± 0.027	1.207AlaCys: 1.207 ± 0.008	2.817AlaAsp: 2.817 ± 0.012	4.53AlaGlu: 4.53 ± 0.021	2.322AlaPhe: 2.322 ± 0.011	3.689AlaGly: 3.689 ± 0.024	1.317AlaHis: 1.317 ± 0.009	2.968AlaIle: 2.968 ± 0.012	3.578AlaLys: 3.578 ± 0.024	5.959AlaLeu: 5.959 ± 0.024	1.402AlaMet: 1.402 ± 0.008	2.151AlaAsn: 2.151 ± 0.01	2.868AlaPro: 2.868 ± 0.02	2.681AlaGln: 2.681 ± 0.014	2.799AlaArg: 2.799 ± 0.013	5.342AlaSer: 5.342 ± 0.025	3.462AlaThr: 3.462 ± 0.024	4.355AlaVal: 4.355 ± 0.016	0.622AlaTrp: 0.622 ± 0.006	1.436AlaTyr: 1.436 ± 0.01	0.001AlaXaa: 0.001 ± 0.0
Cys	1.096CysAla: 1.096 ± 0.008	0.557CysCys: 0.557 ± 0.007	1.09CysAsp: 1.09 ± 0.012	1.341CysGlu: 1.341 ± 0.016	0.862CysPhe: 0.862 ± 0.007	1.505CysGly: 1.505 ± 0.015	0.606CysHis: 0.606 ± 0.007	1.14CysIle: 1.14 ± 0.01	1.309CysLys: 1.309 ± 0.011	1.997CysLeu: 1.997 ± 0.015	0.438CysMet: 0.438 ± 0.004	1.08CysAsn: 1.08 ± 0.012	1.134CysPro: 1.134 ± 0.011	1.022CysGln: 1.022 ± 0.011	1.131CysArg: 1.131 ± 0.01	2.168CysSer: 2.168 ± 0.015	1.425CysThr: 1.425 ± 0.014	1.178CysVal: 1.178 ± 0.012	0.25CysTrp: 0.25 ± 0.004	0.595CysTyr: 0.595 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	2.743AspAla: 2.743 ± 0.014	1.075AspCys: 1.075 ± 0.009	2.828AspAsp: 2.828 ± 0.015	3.682AspGlu: 3.682 ± 0.017	2.082AspPhe: 2.082 ± 0.011	3.18AspGly: 3.18 ± 0.022	1.174AspHis: 1.174 ± 0.007	3.069AspIle: 3.069 ± 0.015	2.972AspLys: 2.972 ± 0.02	4.992AspLeu: 4.992 ± 0.021	1.274AspMet: 1.274 ± 0.011	1.889AspAsn: 1.889 ± 0.01	2.621AspPro: 2.621 ± 0.015	1.956AspGln: 1.956 ± 0.01	2.348AspArg: 2.348 ± 0.011	4.439AspSer: 4.439 ± 0.017	2.661AspThr: 2.661 ± 0.017	3.102AspVal: 3.102 ± 0.018	0.605AspTrp: 0.605 ± 0.005	1.556AspTyr: 1.556 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.545GluAla: 4.545 ± 0.019	1.688GluCys: 1.688 ± 0.019	4.53GluAsp: 4.53 ± 0.016	8.042GluGlu: 8.042 ± 0.041	2.108GluPhe: 2.108 ± 0.011	3.864GluGly: 3.864 ± 0.024	1.58GluHis: 1.58 ± 0.009	3.805GluIle: 3.805 ± 0.023	6.246GluLys: 6.246 ± 0.038	6.444GluLeu: 6.444 ± 0.032	1.896GluMet: 1.896 ± 0.012	3.661GluAsn: 3.661 ± 0.014	2.843GluPro: 2.843 ± 0.03	3.436GluGln: 3.436 ± 0.032	4.143GluArg: 4.143 ± 0.021	4.955GluSer: 4.955 ± 0.028	3.892GluThr: 3.892 ± 0.019	4.236GluVal: 4.236 ± 0.019	0.735GluTrp: 0.735 ± 0.006	1.795GluTyr: 1.795 ± 0.021	0.001GluXaa: 0.001 ± 0.0
Phe	1.872PheAla: 1.872 ± 0.011	0.909PheCys: 0.909 ± 0.007	1.701PheAsp: 1.701 ± 0.01	2.021PheGlu: 2.021 ± 0.011	1.522PhePhe: 1.522 ± 0.011	2.049PheGly: 2.049 ± 0.013	1.047PheHis: 1.047 ± 0.007	1.995PheIle: 1.995 ± 0.012	1.983PheLys: 1.983 ± 0.012	3.817PheLeu: 3.817 ± 0.022	0.791PheMet: 0.791 ± 0.006	1.494PheAsn: 1.494 ± 0.012	1.825PhePro: 1.825 ± 0.013	1.823PheGln: 1.823 ± 0.009	1.824PheArg: 1.824 ± 0.015	3.429PheSer: 3.429 ± 0.021	2.428PheThr: 2.428 ± 0.021	2.034PheVal: 2.034 ± 0.012	0.436PheTrp: 0.436 ± 0.005	1.151PheTyr: 1.151 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	3.198GlyAla: 3.198 ± 0.016	1.074GlyCys: 1.074 ± 0.009	2.902GlyAsp: 2.902 ± 0.017	3.914GlyGlu: 3.914 ± 0.025	2.232GlyPhe: 2.232 ± 0.014	3.814GlyGly: 3.814 ± 0.038	1.485GlyHis: 1.485 ± 0.01	2.985GlyIle: 2.985 ± 0.014	3.982GlyLys: 3.982 ± 0.024	4.774GlyLeu: 4.774 ± 0.02	1.316GlyMet: 1.316 ± 0.009	2.579GlyAsn: 2.579 ± 0.014	2.714GlyPro: 2.714 ± 0.031	2.561GlyGln: 2.561 ± 0.016	3.026GlyArg: 3.026 ± 0.015	5.314GlySer: 5.314 ± 0.026	3.412GlyThr: 3.412 ± 0.019	3.106GlyVal: 3.106 ± 0.016	0.667GlyTrp: 0.667 ± 0.007	1.743GlyTyr: 1.743 ± 0.012	0.001GlyXaa: 0.001 ± 0.0
His	1.246HisAla: 1.246 ± 0.009	0.676HisCys: 0.676 ± 0.007	0.951HisAsp: 0.951 ± 0.007	1.517HisGlu: 1.517 ± 0.01	1.073HisPhe: 1.073 ± 0.008	1.372HisGly: 1.372 ± 0.008	0.9HisHis: 0.9 ± 0.008	1.417HisIle: 1.417 ± 0.008	1.54HisLys: 1.54 ± 0.012	2.802HisLeu: 2.802 ± 0.016	0.598HisMet: 0.598 ± 0.005	0.967HisAsn: 0.967 ± 0.007	1.433HisPro: 1.433 ± 0.011	1.485HisGln: 1.485 ± 0.016	1.431HisArg: 1.431 ± 0.009	2.353HisSer: 2.353 ± 0.015	1.745HisThr: 1.745 ± 0.019	1.415HisVal: 1.415 ± 0.01	0.312HisTrp: 0.312 ± 0.004	0.838HisTyr: 0.838 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.857IleAla: 2.857 ± 0.014	1.227IleCys: 1.227 ± 0.009	2.29IleAsp: 2.29 ± 0.013	3.114IleGlu: 3.114 ± 0.023	1.983IlePhe: 1.983 ± 0.012	2.48IleGly: 2.48 ± 0.012	1.839IleHis: 1.839 ± 0.024	2.872IleIle: 2.872 ± 0.017	3.155IleLys: 3.155 ± 0.02	5.016IleLeu: 5.016 ± 0.018	1.112IleMet: 1.112 ± 0.007	2.233IleAsn: 2.233 ± 0.011	2.958IlePro: 2.958 ± 0.014	2.662IleGln: 2.662 ± 0.011	2.471IleArg: 2.471 ± 0.012	4.584IleSer: 4.584 ± 0.019	3.141IleThr: 3.141 ± 0.027	2.851IleVal: 2.851 ± 0.015	0.541IleTrp: 0.541 ± 0.005	1.502IleTyr: 1.502 ± 0.008	0.001IleXaa: 0.001 ± 0.0
Lys	3.982LysAla: 3.982 ± 0.027	1.341LysCys: 1.341 ± 0.011	3.679LysAsp: 3.679 ± 0.027	5.98LysGlu: 5.98 ± 0.034	1.811LysPhe: 1.811 ± 0.011	3.386LysGly: 3.386 ± 0.022	1.627LysHis: 1.627 ± 0.012	3.353LysIle: 3.353 ± 0.018	5.332LysLys: 5.332 ± 0.024	5.641LysLeu: 5.641 ± 0.022	1.677LysMet: 1.677 ± 0.013	2.884LysAsn: 2.884 ± 0.012	3.495LysPro: 3.495 ± 0.023	3.122LysGln: 3.122 ± 0.025	3.709LysArg: 3.709 ± 0.019	4.951LysSer: 4.951 ± 0.025	3.589LysThr: 3.589 ± 0.018	3.829LysVal: 3.829 ± 0.027	0.688LysTrp: 0.688 ± 0.009	1.827LysTyr: 1.827 ± 0.02	0.001LysXaa: 0.001 ± 0.0
Leu	5.625LeuAla: 5.625 ± 0.025	1.983LeuCys: 1.983 ± 0.014	4.684LeuAsp: 4.684 ± 0.016	7.085LeuGlu: 7.085 ± 0.031	3.159LeuPhe: 3.159 ± 0.016	4.705LeuGly: 4.705 ± 0.022	2.724LeuHis: 2.724 ± 0.016	4.187LeuIle: 4.187 ± 0.018	6.662LeuLys: 6.662 ± 0.027	9.479LeuLeu: 9.479 ± 0.043	2.031LeuMet: 2.031 ± 0.013	3.886LeuAsn: 3.886 ± 0.016	5.27LeuPro: 5.27 ± 0.025	5.864LeuGln: 5.864 ± 0.037	5.033LeuArg: 5.033 ± 0.023	7.972LeuSer: 7.972 ± 0.032	4.996LeuThr: 4.996 ± 0.017	4.966LeuVal: 4.966 ± 0.017	0.96LeuTrp: 0.96 ± 0.007	2.516LeuTyr: 2.516 ± 0.014	0.001LeuXaa: 0.001 ± 0.0
Met	1.733MetAla: 1.733 ± 0.009	0.421MetCys: 0.421 ± 0.004	1.367MetAsp: 1.367 ± 0.008	2.072MetGlu: 2.072 ± 0.012	0.751MetPhe: 0.751 ± 0.006	1.219MetGly: 1.219 ± 0.009	0.54MetHis: 0.54 ± 0.005	1.027MetIle: 1.027 ± 0.007	1.679MetLys: 1.679 ± 0.009	2.002MetLeu: 2.002 ± 0.012	0.604MetMet: 0.604 ± 0.006	1.032MetAsn: 1.032 ± 0.007	1.153MetPro: 1.153 ± 0.009	1.136MetGln: 1.136 ± 0.009	1.046MetArg: 1.046 ± 0.008	1.739MetSer: 1.739 ± 0.009	1.204MetThr: 1.204 ± 0.008	1.392MetVal: 1.392 ± 0.007	0.224MetTrp: 0.224 ± 0.003	0.628MetTyr: 0.628 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.269AsnAla: 2.269 ± 0.011	0.962AsnCys: 0.962 ± 0.009	1.792AsnAsp: 1.792 ± 0.011	2.714AsnGlu: 2.714 ± 0.013	1.55AsnPhe: 1.55 ± 0.01	2.658AsnGly: 2.658 ± 0.017	1.046AsnHis: 1.046 ± 0.008	2.579AsnIle: 2.579 ± 0.012	2.764AsnLys: 2.764 ± 0.017	4.151AsnLeu: 4.151 ± 0.019	1.058AsnMet: 1.058 ± 0.007	1.869AsnAsn: 1.869 ± 0.012	2.202AsnPro: 2.202 ± 0.013	1.983AsnGln: 1.983 ± 0.014	2.06AsnArg: 2.06 ± 0.009	3.678AsnSer: 3.678 ± 0.017	2.308AsnThr: 2.308 ± 0.015	2.501AsnVal: 2.501 ± 0.014	0.478AsnTrp: 0.478 ± 0.004	1.298AsnTyr: 1.298 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	3.615ProAla: 3.615 ± 0.023	0.962ProCys: 0.962 ± 0.009	2.634ProAsp: 2.634 ± 0.018	3.944ProGlu: 3.944 ± 0.022	2.033ProPhe: 2.033 ± 0.015	3.678ProGly: 3.678 ± 0.039	1.237ProHis: 1.237 ± 0.011	2.206ProIle: 2.206 ± 0.021	2.855ProLys: 2.855 ± 0.021	4.581ProLeu: 4.581 ± 0.019	0.987ProMet: 0.987 ± 0.007	1.935ProAsn: 1.935 ± 0.012	4.557ProPro: 4.557 ± 0.043	2.48ProGln: 2.48 ± 0.021	2.424ProArg: 2.424 ± 0.013	5.283ProSer: 5.283 ± 0.027	2.859ProThr: 2.859 ± 0.021	3.797ProVal: 3.797 ± 0.021	0.492ProTrp: 0.492 ± 0.006	1.502ProTyr: 1.502 ± 0.014	0.001ProXaa: 0.001 ± 0.0
Gln	3.066GlnAla: 3.066 ± 0.017	0.967GlnCys: 0.967 ± 0.011	2.364GlnAsp: 2.364 ± 0.015	4.106GlnGlu: 4.106 ± 0.028	1.42GlnPhe: 1.42 ± 0.008	2.441GlnGly: 2.441 ± 0.013	1.372GlnHis: 1.372 ± 0.011	2.41GlnIle: 2.41 ± 0.01	3.415GlnLys: 3.415 ± 0.026	4.726GlnLeu: 4.726 ± 0.034	1.259GlnMet: 1.259 ± 0.011	2.216GlnAsn: 2.216 ± 0.011	2.44GlnPro: 2.44 ± 0.019	3.519GlnGln: 3.519 ± 0.047	2.829GlnArg: 2.829 ± 0.018	3.601GlnSer: 3.601 ± 0.022	2.642GlnThr: 2.642 ± 0.018	2.731GlnVal: 2.731 ± 0.014	0.531GlnTrp: 0.531 ± 0.005	1.254GlnTyr: 1.254 ± 0.007	0.0GlnXaa: 0.0 ± 0.0
Arg	2.905ArgAla: 2.905 ± 0.011	1.076ArgCys: 1.076 ± 0.01	2.537ArgAsp: 2.537 ± 0.012	3.795ArgGlu: 3.795 ± 0.022	1.763ArgPhe: 1.763 ± 0.01	2.758ArgGly: 2.758 ± 0.018	1.467ArgHis: 1.467 ± 0.01	2.806ArgIle: 2.806 ± 0.016	3.895ArgLys: 3.895 ± 0.016	4.614ArgLeu: 4.614 ± 0.017	1.209ArgMet: 1.209 ± 0.006	2.265ArgAsn: 2.265 ± 0.011	2.554ArgPro: 2.554 ± 0.013	2.518ArgGln: 2.518 ± 0.013	3.564ArgArg: 3.564 ± 0.022	4.134ArgSer: 4.134 ± 0.025	2.793ArgThr: 2.793 ± 0.014	2.762ArgVal: 2.762 ± 0.022	0.579ArgTrp: 0.579 ± 0.006	1.423ArgTyr: 1.423 ± 0.008	0.001ArgXaa: 0.001 ± 0.0
Ser	5.19SerAla: 5.19 ± 0.024	1.923SerCys: 1.923 ± 0.014	4.415SerAsp: 4.415 ± 0.025	5.808SerGlu: 5.808 ± 0.026	3.476SerPhe: 3.476 ± 0.017	5.145SerGly: 5.145 ± 0.023	2.221SerHis: 2.221 ± 0.013	3.902SerIle: 3.902 ± 0.018	4.754SerLys: 4.754 ± 0.018	8.106SerLeu: 8.106 ± 0.031	1.835SerMet: 1.835 ± 0.011	3.365SerAsn: 3.365 ± 0.016	5.547SerPro: 5.547 ± 0.032	4.019SerGln: 4.019 ± 0.025	4.273SerArg: 4.273 ± 0.022	10.145SerSer: 10.145 ± 0.057	5.28SerThr: 5.28 ± 0.065	5.115SerVal: 5.115 ± 0.018	0.995SerTrp: 0.995 ± 0.01	2.174SerTyr: 2.174 ± 0.014	0.001SerXaa: 0.001 ± 0.0
Thr	3.888ThrAla: 3.888 ± 0.029	1.591ThrCys: 1.591 ± 0.018	2.829ThrAsp: 2.829 ± 0.013	4.332ThrGlu: 4.332 ± 0.027	2.119ThrPhe: 2.119 ± 0.01	3.793ThrGly: 3.793 ± 0.023	1.31ThrHis: 1.31 ± 0.011	2.831ThrIle: 2.831 ± 0.018	3.108ThrLys: 3.108 ± 0.021	5.247ThrLeu: 5.247 ± 0.018	1.172ThrMet: 1.172 ± 0.009	2.063ThrAsn: 2.063 ± 0.011	3.413ThrPro: 3.413 ± 0.027	2.396ThrGln: 2.396 ± 0.017	2.387ThrArg: 2.387 ± 0.012	5.406ThrSer: 5.406 ± 0.054	3.598ThrThr: 3.598 ± 0.079	4.18ThrVal: 4.18 ± 0.029	0.673ThrTrp: 0.673 ± 0.01	1.457ThrTyr: 1.457 ± 0.009	0.001ThrXaa: 0.001 ± 0.0
Val	3.784ValAla: 3.784 ± 0.017	1.39ValCys: 1.39 ± 0.011	2.889ValAsp: 2.889 ± 0.012	3.938ValGlu: 3.938 ± 0.023	2.253ValPhe: 2.253 ± 0.011	2.933ValGly: 2.933 ± 0.015	1.543ValHis: 1.543 ± 0.008	3.11ValIle: 3.11 ± 0.016	3.972ValLys: 3.972 ± 0.032	5.716ValLeu: 5.716 ± 0.016	1.352ValMet: 1.352 ± 0.008	2.534ValAsn: 2.534 ± 0.013	3.404ValPro: 3.404 ± 0.021	2.835ValGln: 2.835 ± 0.012	2.681ValArg: 2.681 ± 0.012	5.019ValSer: 5.019 ± 0.024	3.971ValThr: 3.971 ± 0.036	3.661ValVal: 3.661 ± 0.019	0.651ValTrp: 0.651 ± 0.006	1.629ValTyr: 1.629 ± 0.009	0.0ValXaa: 0.0 ± 0.0
Trp	0.567TrpAla: 0.567 ± 0.005	0.21TrpCys: 0.21 ± 0.003	0.59TrpAsp: 0.59 ± 0.006	0.767TrpGlu: 0.767 ± 0.007	0.428TrpPhe: 0.428 ± 0.006	0.527TrpGly: 0.527 ± 0.006	0.285TrpHis: 0.285 ± 0.003	0.609TrpIle: 0.609 ± 0.006	0.864TrpLys: 0.864 ± 0.007	1.105TrpLeu: 1.105 ± 0.008	0.312TrpMet: 0.312 ± 0.004	0.585TrpAsn: 0.585 ± 0.006	0.393TrpPro: 0.393 ± 0.004	0.522TrpGln: 0.522 ± 0.005	0.612TrpArg: 0.612 ± 0.006	0.816TrpSer: 0.816 ± 0.007	0.657TrpThr: 0.657 ± 0.007	0.567TrpVal: 0.567 ± 0.006	0.16TrpTrp: 0.16 ± 0.003	0.376TrpTyr: 0.376 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.325TyrAla: 1.325 ± 0.008	0.683TyrCys: 0.683 ± 0.006	1.361TyrAsp: 1.361 ± 0.009	1.742TyrGlu: 1.742 ± 0.013	1.2TyrPhe: 1.2 ± 0.008	1.6TyrGly: 1.6 ± 0.01	0.755TyrHis: 0.755 ± 0.006	1.617TyrIle: 1.617 ± 0.011	1.84TyrLys: 1.84 ± 0.032	2.615TyrLeu: 2.615 ± 0.012	0.644TyrMet: 0.644 ± 0.005	1.232TyrAsn: 1.232 ± 0.009	1.235TyrPro: 1.235 ± 0.008	1.288TyrGln: 1.288 ± 0.006	1.629TyrArg: 1.629 ± 0.012	2.36TyrSer: 2.36 ± 0.012	1.732TyrThr: 1.732 ± 0.016	1.488TyrVal: 1.488 ± 0.009	0.355TyrTrp: 0.355 ± 0.005	0.944TyrTyr: 0.944 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 38703 proteins (28253243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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