Amino acid dipepetide frequency for Tepidanaerobacter syntrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.857AlaAla: 6.857 ± 0.129	0.919AlaCys: 0.919 ± 0.037	3.971AlaAsp: 3.971 ± 0.083	5.178AlaGlu: 5.178 ± 0.091	2.966AlaPhe: 2.966 ± 0.077	5.959AlaGly: 5.959 ± 0.117	1.084AlaHis: 1.084 ± 0.047	6.349AlaIle: 6.349 ± 0.105	5.856AlaLys: 5.856 ± 0.087	7.464AlaLeu: 7.464 ± 0.113	2.07AlaMet: 2.07 ± 0.054	2.808AlaAsn: 2.808 ± 0.062	2.153AlaPro: 2.153 ± 0.051	2.279AlaGln: 2.279 ± 0.059	2.99AlaArg: 2.99 ± 0.069	3.997AlaSer: 3.997 ± 0.075	3.212AlaThr: 3.212 ± 0.076	5.817AlaVal: 5.817 ± 0.103	0.512AlaTrp: 0.512 ± 0.03	2.282AlaTyr: 2.282 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.839CysAla: 0.839 ± 0.038	0.179CysCys: 0.179 ± 0.016	0.683CysAsp: 0.683 ± 0.032	0.739CysGlu: 0.739 ± 0.032	0.421CysPhe: 0.421 ± 0.024	1.146CysGly: 1.146 ± 0.044	0.258CysHis: 0.258 ± 0.019	0.915CysIle: 0.915 ± 0.038	0.845CysLys: 0.845 ± 0.037	0.796CysLeu: 0.796 ± 0.031	0.269CysMet: 0.269 ± 0.022	0.483CysAsn: 0.483 ± 0.027	0.617CysPro: 0.617 ± 0.033	0.289CysGln: 0.289 ± 0.023	0.5CysArg: 0.5 ± 0.028	0.72CysSer: 0.72 ± 0.031	0.482CysThr: 0.482 ± 0.027	0.638CysVal: 0.638 ± 0.033	0.083CysTrp: 0.083 ± 0.009	0.39CysTyr: 0.39 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.84AspAla: 3.84 ± 0.076	0.558AspCys: 0.558 ± 0.028	2.686AspAsp: 2.686 ± 0.078	4.909AspGlu: 4.909 ± 0.087	2.799AspPhe: 2.799 ± 0.064	3.456AspGly: 3.456 ± 0.066	0.573AspHis: 0.573 ± 0.027	6.18AspIle: 6.18 ± 0.094	4.497AspLys: 4.497 ± 0.088	4.783AspLeu: 4.783 ± 0.086	1.617AspMet: 1.617 ± 0.044	2.193AspAsn: 2.193 ± 0.06	2.113AspPro: 2.113 ± 0.051	0.869AspGln: 0.869 ± 0.034	2.003AspArg: 2.003 ± 0.051	2.799AspSer: 2.799 ± 0.067	2.596AspThr: 2.596 ± 0.07	3.994AspVal: 3.994 ± 0.084	0.455AspTrp: 0.455 ± 0.029	2.304AspTyr: 2.304 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.471GluAla: 5.471 ± 0.109	0.547GluCys: 0.547 ± 0.026	4.225GluAsp: 4.225 ± 0.08	6.773GluGlu: 6.773 ± 0.123	2.705GluPhe: 2.705 ± 0.061	4.448GluGly: 4.448 ± 0.09	0.98GluHis: 0.98 ± 0.04	7.203GluIle: 7.203 ± 0.106	7.289GluLys: 7.289 ± 0.118	6.87GluLeu: 6.87 ± 0.093	2.111GluMet: 2.111 ± 0.059	4.296GluAsn: 4.296 ± 0.076	2.117GluPro: 2.117 ± 0.058	1.984GluGln: 1.984 ± 0.056	3.241GluArg: 3.241 ± 0.074	3.523GluSer: 3.523 ± 0.07	3.278GluThr: 3.278 ± 0.065	4.84GluVal: 4.84 ± 0.085	0.468GluTrp: 0.468 ± 0.023	2.55GluTyr: 2.55 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	2.867PheAla: 2.867 ± 0.067	0.511PheCys: 0.511 ± 0.029	2.588PheAsp: 2.588 ± 0.064	2.863PheGlu: 2.863 ± 0.068	1.827PhePhe: 1.827 ± 0.056	3.123PheGly: 3.123 ± 0.066	0.548PheHis: 0.548 ± 0.027	3.55PheIle: 3.55 ± 0.082	2.781PheLys: 2.781 ± 0.069	3.763PheLeu: 3.763 ± 0.088	1.024PheMet: 1.024 ± 0.036	1.852PheAsn: 1.852 ± 0.051	1.595PhePro: 1.595 ± 0.051	0.987PheGln: 0.987 ± 0.038	1.328PheArg: 1.328 ± 0.038	2.881PheSer: 2.881 ± 0.075	2.228PheThr: 2.228 ± 0.059	2.603PheVal: 2.603 ± 0.07	0.318PheTrp: 0.318 ± 0.024	1.574PheTyr: 1.574 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.39GlyAla: 5.39 ± 0.1	0.959GlyCys: 0.959 ± 0.042	3.432GlyAsp: 3.432 ± 0.062	4.314GlyGlu: 4.314 ± 0.085	3.199GlyPhe: 3.199 ± 0.072	5.157GlyGly: 5.157 ± 0.109	1.21GlyHis: 1.21 ± 0.047	7.169GlyIle: 7.169 ± 0.125	5.885GlyLys: 5.885 ± 0.093	6.344GlyLeu: 6.344 ± 0.098	1.944GlyMet: 1.944 ± 0.057	2.708GlyAsn: 2.708 ± 0.065	1.913GlyPro: 1.913 ± 0.053	1.883GlyGln: 1.883 ± 0.042	2.979GlyArg: 2.979 ± 0.076	3.879GlySer: 3.879 ± 0.074	3.867GlyThr: 3.867 ± 0.079	4.844GlyVal: 4.844 ± 0.097	0.58GlyTrp: 0.58 ± 0.026	2.828GlyTyr: 2.828 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.874HisAla: 0.874 ± 0.035	0.195HisCys: 0.195 ± 0.017	0.725HisAsp: 0.725 ± 0.029	0.922HisGlu: 0.922 ± 0.037	0.622HisPhe: 0.622 ± 0.03	1.134HisGly: 1.134 ± 0.043	0.324HisHis: 0.324 ± 0.023	1.307HisIle: 1.307 ± 0.048	1.004HisLys: 1.004 ± 0.04	1.364HisLeu: 1.364 ± 0.046	0.395HisMet: 0.395 ± 0.024	0.593HisAsn: 0.593 ± 0.027	0.832HisPro: 0.832 ± 0.034	0.428HisGln: 0.428 ± 0.025	0.63HisArg: 0.63 ± 0.032	0.742HisSer: 0.742 ± 0.031	0.755HisThr: 0.755 ± 0.038	0.878HisVal: 0.878 ± 0.036	0.129HisTrp: 0.129 ± 0.015	0.511HisTyr: 0.511 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.075IleAla: 7.075 ± 0.105	1.113IleCys: 1.113 ± 0.039	5.379IleAsp: 5.379 ± 0.096	6.422IleGlu: 6.422 ± 0.097	3.694IlePhe: 3.694 ± 0.075	6.069IleGly: 6.069 ± 0.11	1.188IleHis: 1.188 ± 0.039	7.745IleIle: 7.745 ± 0.124	7.158IleLys: 7.158 ± 0.114	8.235IleLeu: 8.235 ± 0.131	2.269IleMet: 2.269 ± 0.056	4.459IleAsn: 4.459 ± 0.098	3.831IlePro: 3.831 ± 0.079	2.208IleGln: 2.208 ± 0.06	3.314IleArg: 3.314 ± 0.077	6.197IleSer: 6.197 ± 0.093	4.663IleThr: 4.663 ± 0.087	5.851IleVal: 5.851 ± 0.102	0.539IleTrp: 0.539 ± 0.03	3.031IleTyr: 3.031 ± 0.071	0.0IleXaa: 0.0 ± 0.0
Lys	5.795LysAla: 5.795 ± 0.088	0.684LysCys: 0.684 ± 0.034	4.977LysAsp: 4.977 ± 0.087	7.155LysGlu: 7.155 ± 0.102	2.437LysPhe: 2.437 ± 0.061	4.847LysGly: 4.847 ± 0.083	1.029LysHis: 1.029 ± 0.039	7.382LysIle: 7.382 ± 0.109	6.42LysLys: 6.42 ± 0.098	6.706LysLeu: 6.706 ± 0.108	2.127LysMet: 2.127 ± 0.054	4.652LysAsn: 4.652 ± 0.087	2.787LysPro: 2.787 ± 0.072	2.212LysGln: 2.212 ± 0.053	3.125LysArg: 3.125 ± 0.074	4.231LysSer: 4.231 ± 0.08	4.155LysThr: 4.155 ± 0.066	5.392LysVal: 5.392 ± 0.106	0.533LysTrp: 0.533 ± 0.029	2.895LysTyr: 2.895 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	7.075LeuAla: 7.075 ± 0.1	1.07LeuCys: 1.07 ± 0.04	5.251LeuAsp: 5.251 ± 0.093	6.794LeuGlu: 6.794 ± 0.127	3.415LeuPhe: 3.415 ± 0.078	6.691LeuGly: 6.691 ± 0.114	1.193LeuHis: 1.193 ± 0.041	7.131LeuIle: 7.131 ± 0.124	8.094LeuLys: 8.094 ± 0.116	8.207LeuLeu: 8.207 ± 0.143	2.392LeuMet: 2.392 ± 0.059	4.409LeuAsn: 4.409 ± 0.077	3.867LeuPro: 3.867 ± 0.084	2.449LeuGln: 2.449 ± 0.055	3.695LeuArg: 3.695 ± 0.058	6.344LeuSer: 6.344 ± 0.094	4.747LeuThr: 4.747 ± 0.084	5.485LeuVal: 5.485 ± 0.088	0.565LeuTrp: 0.565 ± 0.028	2.78LeuTyr: 2.78 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.374MetAla: 2.374 ± 0.058	0.242MetCys: 0.242 ± 0.02	1.429MetAsp: 1.429 ± 0.048	1.983MetGlu: 1.983 ± 0.058	0.904MetPhe: 0.904 ± 0.033	1.974MetGly: 1.974 ± 0.062	0.375MetHis: 0.375 ± 0.027	2.059MetIle: 2.059 ± 0.055	2.061MetLys: 2.061 ± 0.055	2.462MetLeu: 2.462 ± 0.065	0.734MetMet: 0.734 ± 0.032	1.228MetAsn: 1.228 ± 0.042	1.245MetPro: 1.245 ± 0.044	0.853MetGln: 0.853 ± 0.035	1.085MetArg: 1.085 ± 0.042	1.614MetSer: 1.614 ± 0.046	1.436MetThr: 1.436 ± 0.045	1.782MetVal: 1.782 ± 0.051	0.145MetTrp: 0.145 ± 0.016	0.66MetTyr: 0.66 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.956AsnAla: 2.956 ± 0.066	0.541AsnCys: 0.541 ± 0.027	2.143AsnAsp: 2.143 ± 0.061	3.062AsnGlu: 3.062 ± 0.066	2.009AsnPhe: 2.009 ± 0.052	2.842AsnGly: 2.842 ± 0.08	0.594AsnHis: 0.594 ± 0.032	4.918AsnIle: 4.918 ± 0.086	3.396AsnLys: 3.396 ± 0.069	4.74AsnLeu: 4.74 ± 0.086	1.332AsnMet: 1.332 ± 0.041	2.167AsnAsn: 2.167 ± 0.06	2.522AsnPro: 2.522 ± 0.059	1.239AsnGln: 1.239 ± 0.045	1.84AsnArg: 1.84 ± 0.057	2.457AsnSer: 2.457 ± 0.061	2.354AsnThr: 2.354 ± 0.057	3.065AsnVal: 3.065 ± 0.074	0.377AsnTrp: 0.377 ± 0.024	1.816AsnTyr: 1.816 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.632ProAla: 2.632 ± 0.059	0.388ProCys: 0.388 ± 0.025	2.271ProAsp: 2.271 ± 0.065	3.353ProGlu: 3.353 ± 0.07	1.704ProPhe: 1.704 ± 0.051	2.725ProGly: 2.725 ± 0.061	0.691ProHis: 0.691 ± 0.03	3.266ProIle: 3.266 ± 0.065	2.621ProLys: 2.621 ± 0.064	3.393ProLeu: 3.393 ± 0.075	0.899ProMet: 0.899 ± 0.04	1.548ProAsn: 1.548 ± 0.043	1.321ProPro: 1.321 ± 0.047	1.121ProGln: 1.121 ± 0.035	1.246ProArg: 1.246 ± 0.042	2.088ProSer: 2.088 ± 0.06	1.931ProThr: 1.931 ± 0.049	3.01ProVal: 3.01 ± 0.076	0.312ProTrp: 0.312 ± 0.022	1.613ProTyr: 1.613 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	2.05GlnAla: 2.05 ± 0.052	0.23GlnCys: 0.23 ± 0.018	1.499GlnAsp: 1.499 ± 0.046	2.348GlnGlu: 2.348 ± 0.064	0.851GlnPhe: 0.851 ± 0.038	1.686GlnGly: 1.686 ± 0.052	0.372GlnHis: 0.372 ± 0.024	2.499GlnIle: 2.499 ± 0.062	2.491GlnLys: 2.491 ± 0.058	2.489GlnLeu: 2.489 ± 0.058	0.775GlnMet: 0.775 ± 0.033	1.533GlnAsn: 1.533 ± 0.05	0.815GlnPro: 0.815 ± 0.036	0.926GlnGln: 0.926 ± 0.045	1.213GlnArg: 1.213 ± 0.045	1.342GlnSer: 1.342 ± 0.043	1.206GlnThr: 1.206 ± 0.042	1.863GlnVal: 1.863 ± 0.058	0.271GlnTrp: 0.271 ± 0.019	0.795GlnTyr: 0.795 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.704ArgAla: 2.704 ± 0.066	0.464ArgCys: 0.464 ± 0.026	1.891ArgAsp: 1.891 ± 0.052	3.284ArgGlu: 3.284 ± 0.07	1.71ArgPhe: 1.71 ± 0.049	2.56ArgGly: 2.56 ± 0.061	0.644ArgHis: 0.644 ± 0.031	3.631ArgIle: 3.631 ± 0.079	3.035ArgLys: 3.035 ± 0.081	3.824ArgLeu: 3.824 ± 0.076	1.076ArgMet: 1.076 ± 0.036	1.818ArgAsn: 1.818 ± 0.052	1.433ArgPro: 1.433 ± 0.042	1.541ArgGln: 1.541 ± 0.052	1.965ArgArg: 1.965 ± 0.051	1.861ArgSer: 1.861 ± 0.052	1.836ArgThr: 1.836 ± 0.054	2.546ArgVal: 2.546 ± 0.057	0.339ArgTrp: 0.339 ± 0.023	1.623ArgTyr: 1.623 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.117SerAla: 4.117 ± 0.086	0.759SerCys: 0.759 ± 0.034	3.053SerAsp: 3.053 ± 0.072	3.932SerGlu: 3.932 ± 0.081	2.563SerPhe: 2.563 ± 0.069	4.648SerGly: 4.648 ± 0.092	0.892SerHis: 0.892 ± 0.036	5.02SerIle: 5.02 ± 0.092	4.393SerLys: 4.393 ± 0.081	5.549SerLeu: 5.549 ± 0.08	1.606SerMet: 1.606 ± 0.051	2.355SerAsn: 2.355 ± 0.059	2.2SerPro: 2.2 ± 0.05	1.8SerGln: 1.8 ± 0.051	2.38SerArg: 2.38 ± 0.064	3.634SerSer: 3.634 ± 0.09	2.78SerThr: 2.78 ± 0.055	3.72SerVal: 3.72 ± 0.069	0.444SerTrp: 0.444 ± 0.027	2.014SerTyr: 2.014 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.008ThrAla: 4.008 ± 0.084	0.552ThrCys: 0.552 ± 0.03	2.744ThrAsp: 2.744 ± 0.066	3.112ThrGlu: 3.112 ± 0.075	2.122ThrPhe: 2.122 ± 0.053	4.32ThrGly: 4.32 ± 0.088	0.795ThrHis: 0.795 ± 0.033	4.281ThrIle: 4.281 ± 0.083	3.085ThrLys: 3.085 ± 0.073	4.686ThrLeu: 4.686 ± 0.073	1.127ThrMet: 1.127 ± 0.037	1.959ThrAsn: 1.959 ± 0.058	2.323ThrPro: 2.323 ± 0.058	1.376ThrGln: 1.376 ± 0.046	1.985ThrArg: 1.985 ± 0.058	2.881ThrSer: 2.881 ± 0.079	2.675ThrThr: 2.675 ± 0.061	3.888ThrVal: 3.888 ± 0.081	0.359ThrTrp: 0.359 ± 0.025	1.721ThrTyr: 1.721 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.983ValAla: 4.983 ± 0.083	0.863ValCys: 0.863 ± 0.036	3.741ValAsp: 3.741 ± 0.079	4.785ValGlu: 4.785 ± 0.087	2.81ValPhe: 2.81 ± 0.061	4.606ValGly: 4.606 ± 0.101	0.901ValHis: 0.901 ± 0.036	6.247ValIle: 6.247 ± 0.111	5.474ValLys: 5.474 ± 0.097	6.045ValLeu: 6.045 ± 0.092	1.839ValMet: 1.839 ± 0.056	3.076ValAsn: 3.076 ± 0.062	2.759ValPro: 2.759 ± 0.068	1.549ValGln: 1.549 ± 0.051	2.507ValArg: 2.507 ± 0.056	4.213ValSer: 4.213 ± 0.077	3.564ValThr: 3.564 ± 0.077	5.125ValVal: 5.125 ± 0.097	0.433ValTrp: 0.433 ± 0.024	2.329ValTyr: 2.329 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.503TrpAla: 0.503 ± 0.032	0.09TrpCys: 0.09 ± 0.011	0.464TrpAsp: 0.464 ± 0.025	0.543TrpGlu: 0.543 ± 0.031	0.335TrpPhe: 0.335 ± 0.026	0.494TrpGly: 0.494 ± 0.026	0.141TrpHis: 0.141 ± 0.014	0.526TrpIle: 0.526 ± 0.024	0.515TrpLys: 0.515 ± 0.025	0.673TrpLeu: 0.673 ± 0.029	0.198TrpMet: 0.198 ± 0.015	0.352TrpAsn: 0.352 ± 0.02	0.266TrpPro: 0.266 ± 0.018	0.33TrpGln: 0.33 ± 0.021	0.263TrpArg: 0.263 ± 0.023	0.397TrpSer: 0.397 ± 0.026	0.328TrpThr: 0.328 ± 0.022	0.482TrpVal: 0.482 ± 0.026	0.076TrpTrp: 0.076 ± 0.011	0.253TrpTyr: 0.253 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.312TyrAla: 2.312 ± 0.062	0.428TyrCys: 0.428 ± 0.026	2.075TyrAsp: 2.075 ± 0.052	2.45TyrGlu: 2.45 ± 0.062	1.718TyrPhe: 1.718 ± 0.057	2.6TyrGly: 2.6 ± 0.066	0.569TyrHis: 0.569 ± 0.028	3.061TyrIle: 3.061 ± 0.069	2.643TyrLys: 2.643 ± 0.07	3.263TyrLeu: 3.263 ± 0.07	0.842TyrMet: 0.842 ± 0.035	1.883TyrAsn: 1.883 ± 0.06	1.422TyrPro: 1.422 ± 0.048	0.932TyrGln: 0.932 ± 0.036	1.492TyrArg: 1.492 ± 0.044	2.057TyrSer: 2.057 ± 0.053	1.908TyrThr: 1.908 ± 0.055	2.024TyrVal: 2.024 ± 0.049	0.289TyrTrp: 0.289 ± 0.02	1.461TyrTyr: 1.461 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2299 proteins (722306 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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