Amino acid dipepetide frequency for Gordonia phage Sidious

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.839AlaAla: 18.839 ± 2.033
0.829AlaCys: 0.829 ± 0.25
8.827AlaAsp: 8.827 ± 0.537
9.301AlaGlu: 9.301 ± 0.84
2.429AlaPhe: 2.429 ± 0.429
9.123AlaGly: 9.123 ± 0.651
1.777AlaHis: 1.777 ± 0.318
5.213AlaIle: 5.213 ± 0.624
4.621AlaLys: 4.621 ± 0.7
10.012AlaLeu: 10.012 ± 0.845
3.555AlaMet: 3.555 ± 0.689
4.206AlaAsn: 4.206 ± 0.59
5.154AlaPro: 5.154 ± 0.623
4.147AlaGln: 4.147 ± 0.648
8.353AlaArg: 8.353 ± 0.75
6.694AlaSer: 6.694 ± 0.923
7.642AlaThr: 7.642 ± 0.778
8.412AlaVal: 8.412 ± 0.871
1.836AlaTrp: 1.836 ± 0.365
2.251AlaTyr: 2.251 ± 0.324
0.0AlaXaa: 0.0 ± 0.0
Cys
0.711CysAla: 0.711 ± 0.2
0.237CysCys: 0.237 ± 0.143
0.533CysAsp: 0.533 ± 0.202
0.533CysGlu: 0.533 ± 0.209
0.178CysPhe: 0.178 ± 0.098
0.829CysGly: 0.829 ± 0.255
0.237CysHis: 0.237 ± 0.133
0.118CysIle: 0.118 ± 0.08
0.178CysLys: 0.178 ± 0.102
0.474CysLeu: 0.474 ± 0.171
0.059CysMet: 0.059 ± 0.053
0.296CysAsn: 0.296 ± 0.132
0.355CysPro: 0.355 ± 0.151
0.118CysGln: 0.118 ± 0.087
0.77CysArg: 0.77 ± 0.234
0.415CysSer: 0.415 ± 0.221
0.237CysThr: 0.237 ± 0.127
0.592CysVal: 0.592 ± 0.183
0.178CysTrp: 0.178 ± 0.121
0.118CysTyr: 0.118 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
7.227AspAla: 7.227 ± 0.821
0.355AspCys: 0.355 ± 0.177
6.043AspAsp: 6.043 ± 0.689
4.858AspGlu: 4.858 ± 0.589
1.6AspPhe: 1.6 ± 0.306
5.391AspGly: 5.391 ± 0.651
1.54AspHis: 1.54 ± 0.327
2.31AspIle: 2.31 ± 0.306
1.777AspLys: 1.777 ± 0.271
6.872AspLeu: 6.872 ± 0.634
1.363AspMet: 1.363 ± 0.317
2.37AspAsn: 2.37 ± 0.427
4.976AspPro: 4.976 ± 0.558
2.725AspGln: 2.725 ± 0.443
5.332AspArg: 5.332 ± 0.555
3.436AspSer: 3.436 ± 0.444
3.851AspThr: 3.851 ± 0.436
4.799AspVal: 4.799 ± 0.533
1.422AspTrp: 1.422 ± 0.277
1.422AspTyr: 1.422 ± 0.259
0.0AspXaa: 0.0 ± 0.0
Glu
7.524GluAla: 7.524 ± 0.832
0.474GluCys: 0.474 ± 0.196
2.903GluAsp: 2.903 ± 0.459
2.251GluGlu: 2.251 ± 0.432
2.784GluPhe: 2.784 ± 0.474
3.555GluGly: 3.555 ± 0.368
1.185GluHis: 1.185 ± 0.257
3.791GluIle: 3.791 ± 0.448
2.073GluLys: 2.073 ± 0.342
4.858GluLeu: 4.858 ± 0.67
0.948GluMet: 0.948 ± 0.328
1.6GluAsn: 1.6 ± 0.297
2.784GluPro: 2.784 ± 0.451
3.318GluGln: 3.318 ± 0.482
4.443GluArg: 4.443 ± 0.527
3.14GluSer: 3.14 ± 0.549
3.199GluThr: 3.199 ± 0.467
4.325GluVal: 4.325 ± 0.439
1.185GluTrp: 1.185 ± 0.252
1.303GluTyr: 1.303 ± 0.235
0.0GluXaa: 0.0 ± 0.0
Phe
3.732PheAla: 3.732 ± 0.505
0.118PheCys: 0.118 ± 0.083
2.844PheAsp: 2.844 ± 0.456
1.6PheGlu: 1.6 ± 0.256
0.77PhePhe: 0.77 ± 0.211
2.666PheGly: 2.666 ± 0.291
0.474PheHis: 0.474 ± 0.217
0.592PheIle: 0.592 ± 0.228
0.77PheLys: 0.77 ± 0.27
1.126PheLeu: 1.126 ± 0.24
0.355PheMet: 0.355 ± 0.119
0.889PheAsn: 0.889 ± 0.221
1.363PhePro: 1.363 ± 0.238
0.533PheGln: 0.533 ± 0.169
2.133PheArg: 2.133 ± 0.478
1.422PheSer: 1.422 ± 0.268
1.896PheThr: 1.896 ± 0.364
2.133PheVal: 2.133 ± 0.397
0.948PheTrp: 0.948 ± 0.254
0.77PheTyr: 0.77 ± 0.244
0.0PheXaa: 0.0 ± 0.0
Gly
8.175GlyAla: 8.175 ± 0.724
0.355GlyCys: 0.355 ± 0.212
5.509GlyAsp: 5.509 ± 0.468
4.739GlyGlu: 4.739 ± 0.419
2.429GlyPhe: 2.429 ± 0.342
8.531GlyGly: 8.531 ± 1.505
1.244GlyHis: 1.244 ± 0.254
3.318GlyIle: 3.318 ± 0.409
3.732GlyLys: 3.732 ± 0.433
7.227GlyLeu: 7.227 ± 0.733
2.488GlyMet: 2.488 ± 0.379
2.844GlyAsn: 2.844 ± 0.42
4.088GlyPro: 4.088 ± 0.492
2.666GlyGln: 2.666 ± 0.443
5.036GlyArg: 5.036 ± 0.673
5.095GlySer: 5.095 ± 0.739
6.931GlyThr: 6.931 ± 0.748
5.865GlyVal: 5.865 ± 0.641
1.303GlyTrp: 1.303 ± 0.31
2.073GlyTyr: 2.073 ± 0.319
0.0GlyXaa: 0.0 ± 0.0
His
2.31HisAla: 2.31 ± 0.307
0.237HisCys: 0.237 ± 0.184
1.54HisAsp: 1.54 ± 0.309
1.422HisGlu: 1.422 ± 0.322
0.474HisPhe: 0.474 ± 0.176
1.54HisGly: 1.54 ± 0.268
0.415HisHis: 0.415 ± 0.142
0.889HisIle: 0.889 ± 0.303
0.415HisLys: 0.415 ± 0.144
1.422HisLeu: 1.422 ± 0.331
0.237HisMet: 0.237 ± 0.108
0.533HisAsn: 0.533 ± 0.179
1.481HisPro: 1.481 ± 0.336
0.711HisGln: 0.711 ± 0.204
0.889HisArg: 0.889 ± 0.248
0.889HisSer: 0.889 ± 0.238
1.6HisThr: 1.6 ± 0.313
1.244HisVal: 1.244 ± 0.38
0.296HisTrp: 0.296 ± 0.125
0.77HisTyr: 0.77 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
5.273IleAla: 5.273 ± 0.576
0.237IleCys: 0.237 ± 0.12
4.206IleAsp: 4.206 ± 0.614
3.969IleGlu: 3.969 ± 0.463
0.829IlePhe: 0.829 ± 0.281
3.614IleGly: 3.614 ± 0.454
1.066IleHis: 1.066 ± 0.241
1.54IleIle: 1.54 ± 0.364
1.066IleLys: 1.066 ± 0.229
2.784IleLeu: 2.784 ± 0.478
0.474IleMet: 0.474 ± 0.142
1.363IleAsn: 1.363 ± 0.27
2.547IlePro: 2.547 ± 0.324
1.54IleGln: 1.54 ± 0.285
4.206IleArg: 4.206 ± 0.521
1.836IleSer: 1.836 ± 0.413
3.318IleThr: 3.318 ± 0.519
3.555IleVal: 3.555 ± 0.534
0.355IleTrp: 0.355 ± 0.142
1.185IleTyr: 1.185 ± 0.231
0.0IleXaa: 0.0 ± 0.0
Lys
3.851LysAla: 3.851 ± 0.676
0.178LysCys: 0.178 ± 0.1
1.6LysAsp: 1.6 ± 0.257
1.185LysGlu: 1.185 ± 0.292
0.948LysPhe: 0.948 ± 0.221
2.251LysGly: 2.251 ± 0.366
0.652LysHis: 0.652 ± 0.196
1.836LysIle: 1.836 ± 0.329
1.244LysLys: 1.244 ± 0.286
2.962LysLeu: 2.962 ± 0.389
0.711LysMet: 0.711 ± 0.212
0.889LysAsn: 0.889 ± 0.212
2.133LysPro: 2.133 ± 0.345
1.066LysGln: 1.066 ± 0.338
2.725LysArg: 2.725 ± 0.457
2.192LysSer: 2.192 ± 0.397
2.192LysThr: 2.192 ± 0.391
2.133LysVal: 2.133 ± 0.302
0.77LysTrp: 0.77 ± 0.214
0.355LysTyr: 0.355 ± 0.166
0.0LysXaa: 0.0 ± 0.0
Leu
10.13LeuAla: 10.13 ± 0.936
0.77LeuCys: 0.77 ± 0.26
5.569LeuAsp: 5.569 ± 0.615
4.147LeuGlu: 4.147 ± 0.4
2.666LeuPhe: 2.666 ± 0.437
6.872LeuGly: 6.872 ± 0.627
1.244LeuHis: 1.244 ± 0.317
3.258LeuIle: 3.258 ± 0.511
2.31LeuLys: 2.31 ± 0.389
5.569LeuLeu: 5.569 ± 0.634
1.718LeuMet: 1.718 ± 0.31
2.488LeuAsn: 2.488 ± 0.344
4.028LeuPro: 4.028 ± 0.499
2.192LeuGln: 2.192 ± 0.389
5.865LeuArg: 5.865 ± 0.638
4.147LeuSer: 4.147 ± 0.423
5.569LeuThr: 5.569 ± 0.561
6.339LeuVal: 6.339 ± 0.784
1.363LeuTrp: 1.363 ± 0.238
1.54LeuTyr: 1.54 ± 0.291
0.0LeuXaa: 0.0 ± 0.0
Met
3.081MetAla: 3.081 ± 0.559
0.237MetCys: 0.237 ± 0.105
0.237MetAsp: 0.237 ± 0.122
0.533MetGlu: 0.533 ± 0.185
0.474MetPhe: 0.474 ± 0.18
1.777MetGly: 1.777 ± 0.35
0.474MetHis: 0.474 ± 0.164
0.829MetIle: 0.829 ± 0.213
0.711MetLys: 0.711 ± 0.244
1.185MetLeu: 1.185 ± 0.311
0.237MetMet: 0.237 ± 0.147
0.533MetAsn: 0.533 ± 0.182
1.244MetPro: 1.244 ± 0.25
0.592MetGln: 0.592 ± 0.157
1.718MetArg: 1.718 ± 0.469
2.133MetSer: 2.133 ± 0.306
3.14MetThr: 3.14 ± 0.395
1.422MetVal: 1.422 ± 0.268
0.237MetTrp: 0.237 ± 0.148
0.474MetTyr: 0.474 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
3.14AsnAla: 3.14 ± 0.447
0.178AsnCys: 0.178 ± 0.108
1.955AsnAsp: 1.955 ± 0.342
1.244AsnGlu: 1.244 ± 0.282
0.77AsnPhe: 0.77 ± 0.419
3.081AsnGly: 3.081 ± 0.424
0.889AsnHis: 0.889 ± 0.191
1.303AsnIle: 1.303 ± 0.264
0.948AsnLys: 0.948 ± 0.243
2.488AsnLeu: 2.488 ± 0.44
0.652AsnMet: 0.652 ± 0.195
0.533AsnAsn: 0.533 ± 0.208
2.251AsnPro: 2.251 ± 0.375
0.77AsnGln: 0.77 ± 0.178
2.784AsnArg: 2.784 ± 0.436
1.718AsnSer: 1.718 ± 0.245
2.547AsnThr: 2.547 ± 0.478
2.014AsnVal: 2.014 ± 0.308
0.711AsnTrp: 0.711 ± 0.23
0.474AsnTyr: 0.474 ± 0.155
0.0AsnXaa: 0.0 ± 0.0
Pro
6.813ProAla: 6.813 ± 0.565
0.592ProCys: 0.592 ± 0.21
4.325ProAsp: 4.325 ± 0.77
3.555ProGlu: 3.555 ± 0.581
1.185ProPhe: 1.185 ± 0.276
5.273ProGly: 5.273 ± 0.543
0.77ProHis: 0.77 ± 0.191
2.133ProIle: 2.133 ± 0.395
1.54ProLys: 1.54 ± 0.294
3.258ProLeu: 3.258 ± 0.419
1.481ProMet: 1.481 ± 0.26
1.659ProAsn: 1.659 ± 0.272
2.962ProPro: 2.962 ± 0.535
1.659ProGln: 1.659 ± 0.312
3.673ProArg: 3.673 ± 0.492
3.495ProSer: 3.495 ± 0.387
4.265ProThr: 4.265 ± 0.649
3.377ProVal: 3.377 ± 0.392
1.422ProTrp: 1.422 ± 0.289
1.066ProTyr: 1.066 ± 0.26
0.0ProXaa: 0.0 ± 0.0
Gln
4.147GlnAla: 4.147 ± 0.698
0.178GlnCys: 0.178 ± 0.093
1.303GlnAsp: 1.303 ± 0.303
1.126GlnGlu: 1.126 ± 0.244
1.126GlnPhe: 1.126 ± 0.225
1.955GlnGly: 1.955 ± 0.383
0.592GlnHis: 0.592 ± 0.22
2.37GlnIle: 2.37 ± 0.364
1.126GlnLys: 1.126 ± 0.311
3.732GlnLeu: 3.732 ± 0.484
0.889GlnMet: 0.889 ± 0.21
0.829GlnAsn: 0.829 ± 0.181
1.659GlnPro: 1.659 ± 0.27
1.244GlnGln: 1.244 ± 0.299
4.147GlnArg: 4.147 ± 0.626
2.251GlnSer: 2.251 ± 0.482
1.836GlnThr: 1.836 ± 0.404
3.199GlnVal: 3.199 ± 0.417
0.829GlnTrp: 0.829 ± 0.18
0.533GlnTyr: 0.533 ± 0.199
0.0GlnXaa: 0.0 ± 0.0
Arg
8.472ArgAla: 8.472 ± 0.713
0.533ArgCys: 0.533 ± 0.169
5.095ArgAsp: 5.095 ± 0.57
4.502ArgGlu: 4.502 ± 0.64
1.955ArgPhe: 1.955 ± 0.301
5.095ArgGly: 5.095 ± 0.617
1.481ArgHis: 1.481 ± 0.423
3.851ArgIle: 3.851 ± 0.595
3.021ArgLys: 3.021 ± 0.404
6.872ArgLeu: 6.872 ± 0.582
1.836ArgMet: 1.836 ± 0.277
2.014ArgAsn: 2.014 ± 0.35
3.673ArgPro: 3.673 ± 0.683
2.903ArgGln: 2.903 ± 0.441
6.457ArgArg: 6.457 ± 0.959
3.969ArgSer: 3.969 ± 0.541
4.858ArgThr: 4.858 ± 0.571
5.569ArgVal: 5.569 ± 0.575
1.363ArgTrp: 1.363 ± 0.307
1.6ArgTyr: 1.6 ± 0.249
0.0ArgXaa: 0.0 ± 0.0
Ser
6.991SerAla: 6.991 ± 0.901
0.178SerCys: 0.178 ± 0.101
3.495SerAsp: 3.495 ± 0.433
3.199SerGlu: 3.199 ± 0.482
1.54SerPhe: 1.54 ± 0.371
6.28SerGly: 6.28 ± 0.812
0.77SerHis: 0.77 ± 0.243
2.844SerIle: 2.844 ± 0.404
1.126SerLys: 1.126 ± 0.201
3.436SerLeu: 3.436 ± 0.509
1.481SerMet: 1.481 ± 0.301
2.251SerAsn: 2.251 ± 0.341
2.31SerPro: 2.31 ± 0.384
2.725SerGln: 2.725 ± 0.705
3.436SerArg: 3.436 ± 0.577
2.903SerSer: 2.903 ± 0.488
4.976SerThr: 4.976 ± 0.504
4.206SerVal: 4.206 ± 0.508
1.244SerTrp: 1.244 ± 0.232
1.303SerTyr: 1.303 ± 0.314
0.0SerXaa: 0.0 ± 0.0
Thr
10.664ThrAla: 10.664 ± 1.008
0.415ThrCys: 0.415 ± 0.159
5.213ThrAsp: 5.213 ± 0.61
3.258ThrGlu: 3.258 ± 0.324
1.244ThrPhe: 1.244 ± 0.308
6.635ThrGly: 6.635 ± 0.735
1.718ThrHis: 1.718 ± 0.301
3.318ThrIle: 3.318 ± 0.526
2.014ThrLys: 2.014 ± 0.28
5.095ThrLeu: 5.095 ± 0.562
1.066ThrMet: 1.066 ± 0.254
1.836ThrAsn: 1.836 ± 0.498
4.858ThrPro: 4.858 ± 0.586
1.6ThrGln: 1.6 ± 0.355
4.325ThrArg: 4.325 ± 0.452
4.562ThrSer: 4.562 ± 0.64
4.976ThrThr: 4.976 ± 0.637
6.102ThrVal: 6.102 ± 0.491
1.185ThrTrp: 1.185 ± 0.234
1.422ThrTyr: 1.422 ± 0.254
0.0ThrXaa: 0.0 ± 0.0
Val
8.175ValAla: 8.175 ± 0.667
0.592ValCys: 0.592 ± 0.189
5.983ValAsp: 5.983 ± 0.554
4.265ValGlu: 4.265 ± 0.404
2.725ValPhe: 2.725 ± 0.374
5.687ValGly: 5.687 ± 0.619
1.481ValHis: 1.481 ± 0.279
4.088ValIle: 4.088 ± 0.541
1.896ValLys: 1.896 ± 0.341
5.628ValLeu: 5.628 ± 0.583
1.244ValMet: 1.244 ± 0.265
2.488ValAsn: 2.488 ± 0.461
4.739ValPro: 4.739 ± 0.548
2.844ValGln: 2.844 ± 0.436
5.095ValArg: 5.095 ± 0.572
3.969ValSer: 3.969 ± 0.603
5.509ValThr: 5.509 ± 0.484
5.213ValVal: 5.213 ± 0.605
1.007ValTrp: 1.007 ± 0.283
1.185ValTyr: 1.185 ± 0.295
0.0ValXaa: 0.0 ± 0.0
Trp
1.244TrpAla: 1.244 ± 0.26
0.296TrpCys: 0.296 ± 0.149
1.066TrpAsp: 1.066 ± 0.275
1.007TrpGlu: 1.007 ± 0.253
0.533TrpPhe: 0.533 ± 0.194
1.422TrpGly: 1.422 ± 0.318
0.415TrpHis: 0.415 ± 0.162
0.829TrpIle: 0.829 ± 0.208
0.533TrpLys: 0.533 ± 0.142
1.659TrpLeu: 1.659 ± 0.342
0.237TrpMet: 0.237 ± 0.106
0.415TrpAsn: 0.415 ± 0.161
1.007TrpPro: 1.007 ± 0.252
0.77TrpGln: 0.77 ± 0.218
2.192TrpArg: 2.192 ± 0.426
1.066TrpSer: 1.066 ± 0.259
1.363TrpThr: 1.363 ± 0.33
1.481TrpVal: 1.481 ± 0.284
0.415TrpTrp: 0.415 ± 0.143
0.474TrpTyr: 0.474 ± 0.188
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.725TyrAla: 2.725 ± 0.346
0.178TyrCys: 0.178 ± 0.099
1.422TyrAsp: 1.422 ± 0.221
0.948TyrGlu: 0.948 ± 0.232
0.474TyrPhe: 0.474 ± 0.186
2.073TyrGly: 2.073 ± 0.314
0.889TyrHis: 0.889 ± 0.271
0.533TyrIle: 0.533 ± 0.169
0.77TyrLys: 0.77 ± 0.225
1.126TyrLeu: 1.126 ± 0.208
0.178TyrMet: 0.178 ± 0.093
0.415TyrAsn: 0.415 ± 0.136
0.889TyrPro: 0.889 ± 0.207
1.007TyrGln: 1.007 ± 0.201
1.54TyrArg: 1.54 ± 0.349
1.363TyrSer: 1.363 ± 0.266
1.6TyrThr: 1.6 ± 0.213
1.836TyrVal: 1.836 ± 0.325
0.355TyrTrp: 0.355 ± 0.16
0.415TyrTyr: 0.415 ± 0.16
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (16881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski