Amino acid dipepetide frequency for Hydrogenophaga sp. BA0156

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.25AlaAla: 19.25 ± 0.209
1.327AlaCys: 1.327 ± 0.036
6.77AlaAsp: 6.77 ± 0.08
7.015AlaGlu: 7.015 ± 0.09
4.362AlaPhe: 4.362 ± 0.059
10.984AlaGly: 10.984 ± 0.11
3.103AlaHis: 3.103 ± 0.051
5.061AlaIle: 5.061 ± 0.065
3.309AlaLys: 3.309 ± 0.071
17.401AlaLeu: 17.401 ± 0.179
3.529AlaMet: 3.529 ± 0.055
2.698AlaAsn: 2.698 ± 0.047
7.304AlaPro: 7.304 ± 0.11
6.509AlaGln: 6.509 ± 0.083
10.614AlaArg: 10.614 ± 0.121
6.487AlaSer: 6.487 ± 0.076
6.098AlaThr: 6.098 ± 0.07
9.735AlaVal: 9.735 ± 0.092
2.299AlaTrp: 2.299 ± 0.052
2.412AlaTyr: 2.412 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.199CysAla: 1.199 ± 0.036
0.124CysCys: 0.124 ± 0.01
0.507CysAsp: 0.507 ± 0.02
0.543CysGlu: 0.543 ± 0.021
0.295CysPhe: 0.295 ± 0.014
0.962CysGly: 0.962 ± 0.027
0.269CysHis: 0.269 ± 0.015
0.348CysIle: 0.348 ± 0.015
0.19CysLys: 0.19 ± 0.012
0.85CysLeu: 0.85 ± 0.025
0.192CysMet: 0.192 ± 0.012
0.203CysAsn: 0.203 ± 0.013
0.501CysPro: 0.501 ± 0.022
0.249CysGln: 0.249 ± 0.013
0.589CysArg: 0.589 ± 0.022
0.44CysSer: 0.44 ± 0.019
0.492CysThr: 0.492 ± 0.02
0.693CysVal: 0.693 ± 0.026
0.117CysTrp: 0.117 ± 0.01
0.153CysTyr: 0.153 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.484AspAla: 7.484 ± 0.085
0.405AspCys: 0.405 ± 0.02
2.673AspAsp: 2.673 ± 0.045
3.212AspGlu: 3.212 ± 0.051
1.831AspPhe: 1.831 ± 0.041
4.552AspGly: 4.552 ± 0.072
1.21AspHis: 1.21 ± 0.032
2.107AspIle: 2.107 ± 0.039
1.502AspLys: 1.502 ± 0.036
5.252AspLeu: 5.252 ± 0.066
1.085AspMet: 1.085 ± 0.029
1.144AspAsn: 1.144 ± 0.033
3.164AspPro: 3.164 ± 0.048
1.53AspGln: 1.53 ± 0.031
3.417AspArg: 3.417 ± 0.048
2.064AspSer: 2.064 ± 0.044
2.665AspThr: 2.665 ± 0.047
3.694AspVal: 3.694 ± 0.055
0.96AspTrp: 0.96 ± 0.024
1.149AspTyr: 1.149 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.75GluAla: 7.75 ± 0.105
0.37GluCys: 0.37 ± 0.014
2.149GluAsp: 2.149 ± 0.042
2.096GluGlu: 2.096 ± 0.047
1.551GluPhe: 1.551 ± 0.036
3.979GluGly: 3.979 ± 0.051
1.475GluHis: 1.475 ± 0.032
2.276GluIle: 2.276 ± 0.049
1.6GluLys: 1.6 ± 0.041
6.021GluLeu: 6.021 ± 0.073
1.073GluMet: 1.073 ± 0.031
1.088GluAsn: 1.088 ± 0.029
2.861GluPro: 2.861 ± 0.05
2.621GluGln: 2.621 ± 0.046
5.474GluArg: 5.474 ± 0.076
2.207GluSer: 2.207 ± 0.041
2.282GluThr: 2.282 ± 0.036
4.01GluVal: 4.01 ± 0.055
0.718GluTrp: 0.718 ± 0.022
0.883GluTyr: 0.883 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.192PheAla: 4.192 ± 0.057
0.375PheCys: 0.375 ± 0.019
2.418PheAsp: 2.418 ± 0.041
2.151PheGlu: 2.151 ± 0.036
1.279PhePhe: 1.279 ± 0.033
3.33PheGly: 3.33 ± 0.053
0.751PheHis: 0.751 ± 0.021
1.332PheIle: 1.332 ± 0.03
1.059PheLys: 1.059 ± 0.03
2.807PheLeu: 2.807 ± 0.052
0.799PheMet: 0.799 ± 0.024
1.093PheAsn: 1.093 ± 0.027
1.414PhePro: 1.414 ± 0.033
1.03PheGln: 1.03 ± 0.029
1.803PheArg: 1.803 ± 0.031
1.849PheSer: 1.849 ± 0.031
1.894PheThr: 1.894 ± 0.04
2.774PheVal: 2.774 ± 0.05
0.482PheTrp: 0.482 ± 0.02
0.811PheTyr: 0.811 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.836GlyAla: 9.836 ± 0.111
0.84GlyCys: 0.84 ± 0.027
3.937GlyAsp: 3.937 ± 0.065
4.731GlyGlu: 4.731 ± 0.065
3.405GlyPhe: 3.405 ± 0.055
6.995GlyGly: 6.995 ± 0.096
2.137GlyHis: 2.137 ± 0.039
3.542GlyIle: 3.542 ± 0.064
2.701GlyLys: 2.701 ± 0.054
10.039GlyLeu: 10.039 ± 0.106
2.256GlyMet: 2.256 ± 0.046
1.938GlyAsn: 1.938 ± 0.045
3.601GlyPro: 3.601 ± 0.058
3.606GlyGln: 3.606 ± 0.066
5.978GlyArg: 5.978 ± 0.083
4.356GlySer: 4.356 ± 0.06
4.153GlyThr: 4.153 ± 0.049
6.97GlyVal: 6.97 ± 0.062
1.612GlyTrp: 1.612 ± 0.042
2.068GlyTyr: 2.068 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
3.218HisAla: 3.218 ± 0.053
0.297HisCys: 0.297 ± 0.016
1.236HisAsp: 1.236 ± 0.032
1.256HisGlu: 1.256 ± 0.03
0.866HisPhe: 0.866 ± 0.025
2.34HisGly: 2.34 ± 0.046
0.701HisHis: 0.701 ± 0.026
0.906HisIle: 0.906 ± 0.023
0.559HisLys: 0.559 ± 0.022
2.488HisLeu: 2.488 ± 0.043
0.487HisMet: 0.487 ± 0.018
0.511HisAsn: 0.511 ± 0.019
1.595HisPro: 1.595 ± 0.037
0.8HisGln: 0.8 ± 0.025
1.781HisArg: 1.781 ± 0.036
0.999HisSer: 0.999 ± 0.027
1.256HisThr: 1.256 ± 0.03
1.631HisVal: 1.631 ± 0.037
0.485HisTrp: 0.485 ± 0.022
0.555HisTyr: 0.555 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.952IleAla: 5.952 ± 0.069
0.325IleCys: 0.325 ± 0.016
2.955IleAsp: 2.955 ± 0.04
3.084IleGlu: 3.084 ± 0.052
1.036IlePhe: 1.036 ± 0.028
3.931IleGly: 3.931 ± 0.062
0.788IleHis: 0.788 ± 0.023
1.07IleIle: 1.07 ± 0.032
1.242IleLys: 1.242 ± 0.029
2.674IleLeu: 2.674 ± 0.049
0.612IleMet: 0.612 ± 0.02
1.243IleAsn: 1.243 ± 0.03
1.757IlePro: 1.757 ± 0.035
1.172IleGln: 1.172 ± 0.031
2.34IleArg: 2.34 ± 0.047
1.758IleSer: 1.758 ± 0.043
2.282IleThr: 2.282 ± 0.041
3.239IleVal: 3.239 ± 0.053
0.412IleTrp: 0.412 ± 0.017
0.78IleTyr: 0.78 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.013LysAla: 4.013 ± 0.057
0.141LysCys: 0.141 ± 0.01
1.389LysAsp: 1.389 ± 0.036
1.258LysGlu: 1.258 ± 0.036
0.791LysPhe: 0.791 ± 0.026
2.289LysGly: 2.289 ± 0.039
0.592LysHis: 0.592 ± 0.018
1.117LysIle: 1.117 ± 0.028
1.154LysLys: 1.154 ± 0.042
2.946LysLeu: 2.946 ± 0.055
0.622LysMet: 0.622 ± 0.025
0.754LysAsn: 0.754 ± 0.026
1.865LysPro: 1.865 ± 0.04
1.004LysGln: 1.004 ± 0.033
2.071LysArg: 2.071 ± 0.041
1.399LysSer: 1.399 ± 0.036
1.691LysThr: 1.691 ± 0.034
2.169LysVal: 2.169 ± 0.052
0.295LysTrp: 0.295 ± 0.014
0.521LysTyr: 0.521 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
16.008LeuAla: 16.008 ± 0.16
1.066LeuCys: 1.066 ± 0.032
6.014LeuAsp: 6.014 ± 0.078
4.995LeuGlu: 4.995 ± 0.061
3.441LeuPhe: 3.441 ± 0.055
9.392LeuGly: 9.392 ± 0.102
2.564LeuHis: 2.564 ± 0.047
4.278LeuIle: 4.278 ± 0.067
3.383LeuLys: 3.383 ± 0.053
12.259LeuLeu: 12.259 ± 0.128
2.612LeuMet: 2.612 ± 0.05
2.687LeuAsn: 2.687 ± 0.044
6.634LeuPro: 6.634 ± 0.078
4.938LeuGln: 4.938 ± 0.068
8.92LeuArg: 8.92 ± 0.108
6.095LeuSer: 6.095 ± 0.077
5.188LeuThr: 5.188 ± 0.075
8.286LeuVal: 8.286 ± 0.078
1.539LeuTrp: 1.539 ± 0.036
1.931LeuTyr: 1.931 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.161MetAla: 3.161 ± 0.055
0.158MetCys: 0.158 ± 0.012
1.102MetAsp: 1.102 ± 0.028
0.898MetGlu: 0.898 ± 0.029
0.617MetPhe: 0.617 ± 0.022
2.01MetGly: 2.01 ± 0.046
0.522MetHis: 0.522 ± 0.02
0.779MetIle: 0.779 ± 0.026
0.971MetLys: 0.971 ± 0.03
2.376MetLeu: 2.376 ± 0.044
0.474MetMet: 0.474 ± 0.02
0.851MetAsn: 0.851 ± 0.026
1.455MetPro: 1.455 ± 0.035
0.982MetGln: 0.982 ± 0.026
1.653MetArg: 1.653 ± 0.036
1.483MetSer: 1.483 ± 0.034
1.304MetThr: 1.304 ± 0.031
1.62MetVal: 1.62 ± 0.035
0.19MetTrp: 0.19 ± 0.011
0.307MetTyr: 0.307 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.334AsnAla: 3.334 ± 0.051
0.219AsnCys: 0.219 ± 0.012
1.21AsnAsp: 1.21 ± 0.036
1.141AsnGlu: 1.141 ± 0.03
0.781AsnPhe: 0.781 ± 0.024
2.159AsnGly: 2.159 ± 0.037
0.527AsnHis: 0.527 ± 0.019
1.043AsnIle: 1.043 ± 0.026
0.668AsnLys: 0.668 ± 0.022
2.468AsnLeu: 2.468 ± 0.045
0.487AsnMet: 0.487 ± 0.021
0.649AsnAsn: 0.649 ± 0.022
1.848AsnPro: 1.848 ± 0.039
0.831AsnGln: 0.831 ± 0.026
1.637AsnArg: 1.637 ± 0.037
0.964AsnSer: 0.964 ± 0.027
1.39AsnThr: 1.39 ± 0.037
1.74AsnVal: 1.74 ± 0.044
0.365AsnTrp: 0.365 ± 0.015
0.499AsnTyr: 0.499 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.332ProAla: 8.332 ± 0.114
0.359ProCys: 0.359 ± 0.017
3.177ProAsp: 3.177 ± 0.044
3.583ProGlu: 3.583 ± 0.049
1.818ProPhe: 1.818 ± 0.032
5.087ProGly: 5.087 ± 0.064
1.284ProHis: 1.284 ± 0.032
1.746ProIle: 1.746 ± 0.034
1.32ProLys: 1.32 ± 0.032
5.978ProLeu: 5.978 ± 0.072
1.29ProMet: 1.29 ± 0.031
1.246ProAsn: 1.246 ± 0.033
3.052ProPro: 3.052 ± 0.069
2.213ProGln: 2.213 ± 0.038
3.609ProArg: 3.609 ± 0.059
2.607ProSer: 2.607 ± 0.044
2.664ProThr: 2.664 ± 0.045
4.591ProVal: 4.591 ± 0.06
0.931ProTrp: 0.931 ± 0.024
1.016ProTyr: 1.016 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
6.584GlnAla: 6.584 ± 0.087
0.295GlnCys: 0.295 ± 0.014
1.561GlnAsp: 1.561 ± 0.036
1.429GlnGlu: 1.429 ± 0.036
1.059GlnPhe: 1.059 ± 0.025
3.427GlnGly: 3.427 ± 0.056
1.011GlnHis: 1.011 ± 0.026
1.587GlnIle: 1.587 ± 0.04
0.996GlnLys: 0.996 ± 0.03
4.18GlnLeu: 4.18 ± 0.072
0.926GlnMet: 0.926 ± 0.028
0.842GlnAsn: 0.842 ± 0.027
2.378GlnPro: 2.378 ± 0.046
2.036GlnGln: 2.036 ± 0.046
4.341GlnArg: 4.341 ± 0.072
1.772GlnSer: 1.772 ± 0.04
1.987GlnThr: 1.987 ± 0.036
3.076GlnVal: 3.076 ± 0.055
0.727GlnTrp: 0.727 ± 0.024
0.68GlnTyr: 0.68 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.339ArgAla: 9.339 ± 0.103
0.646ArgCys: 0.646 ± 0.023
3.696ArgAsp: 3.696 ± 0.054
4.983ArgGlu: 4.983 ± 0.071
2.956ArgPhe: 2.956 ± 0.051
5.241ArgGly: 5.241 ± 0.058
2.151ArgHis: 2.151 ± 0.038
3.27ArgIle: 3.27 ± 0.057
1.808ArgLys: 1.808 ± 0.043
9.297ArgLeu: 9.297 ± 0.099
1.81ArgMet: 1.81 ± 0.039
1.656ArgAsn: 1.656 ± 0.032
3.745ArgPro: 3.745 ± 0.056
3.166ArgGln: 3.166 ± 0.064
5.805ArgArg: 5.805 ± 0.081
3.616ArgSer: 3.616 ± 0.049
3.308ArgThr: 3.308 ± 0.051
5.764ArgVal: 5.764 ± 0.071
1.524ArgTrp: 1.524 ± 0.041
1.731ArgTyr: 1.731 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.531SerAla: 6.531 ± 0.076
0.367SerCys: 0.367 ± 0.016
2.389SerAsp: 2.389 ± 0.044
2.314SerGlu: 2.314 ± 0.044
1.756SerPhe: 1.756 ± 0.044
4.817SerGly: 4.817 ± 0.066
1.122SerHis: 1.122 ± 0.03
1.904SerIle: 1.904 ± 0.042
1.246SerLys: 1.246 ± 0.036
5.399SerLeu: 5.399 ± 0.071
1.075SerMet: 1.075 ± 0.028
1.222SerAsn: 1.222 ± 0.035
2.874SerPro: 2.874 ± 0.048
1.713SerGln: 1.713 ± 0.037
3.333SerArg: 3.333 ± 0.052
2.534SerSer: 2.534 ± 0.051
2.585SerThr: 2.585 ± 0.038
3.701SerVal: 3.701 ± 0.058
0.676SerTrp: 0.676 ± 0.022
1.051SerTyr: 1.051 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.102ThrAla: 6.102 ± 0.07
0.375ThrCys: 0.375 ± 0.019
2.315ThrAsp: 2.315 ± 0.041
2.464ThrGlu: 2.464 ± 0.047
1.544ThrPhe: 1.544 ± 0.033
4.582ThrGly: 4.582 ± 0.068
1.143ThrHis: 1.143 ± 0.031
1.757ThrIle: 1.757 ± 0.034
1.097ThrLys: 1.097 ± 0.03
6.351ThrLeu: 6.351 ± 0.07
0.891ThrMet: 0.891 ± 0.025
1.092ThrAsn: 1.092 ± 0.033
3.781ThrPro: 3.781 ± 0.051
1.867ThrGln: 1.867 ± 0.04
3.326ThrArg: 3.326 ± 0.041
2.243ThrSer: 2.243 ± 0.042
2.539ThrThr: 2.539 ± 0.046
4.278ThrVal: 4.278 ± 0.069
0.669ThrTrp: 0.669 ± 0.024
0.947ThrTyr: 0.947 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.826ValAla: 9.826 ± 0.096
0.803ValCys: 0.803 ± 0.022
3.965ValAsp: 3.965 ± 0.059
3.746ValGlu: 3.746 ± 0.048
2.908ValPhe: 2.908 ± 0.053
5.673ValGly: 5.673 ± 0.06
1.769ValHis: 1.769 ± 0.032
3.244ValIle: 3.244 ± 0.054
2.39ValLys: 2.39 ± 0.044
8.833ValLeu: 8.833 ± 0.089
1.889ValMet: 1.889 ± 0.04
2.135ValAsn: 2.135 ± 0.044
4.199ValPro: 4.199 ± 0.057
3.118ValGln: 3.118 ± 0.059
5.67ValArg: 5.67 ± 0.068
3.96ValSer: 3.96 ± 0.061
3.731ValThr: 3.731 ± 0.058
6.631ValVal: 6.631 ± 0.077
1.15ValTrp: 1.15 ± 0.033
1.567ValTyr: 1.567 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.688TrpAla: 1.688 ± 0.043
0.203TrpCys: 0.203 ± 0.012
0.645TrpAsp: 0.645 ± 0.021
0.506TrpGlu: 0.506 ± 0.02
0.567TrpPhe: 0.567 ± 0.021
1.069TrpGly: 1.069 ± 0.029
0.414TrpHis: 0.414 ± 0.019
0.652TrpIle: 0.652 ± 0.023
0.373TrpLys: 0.373 ± 0.017
2.353TrpLeu: 2.353 ± 0.056
0.426TrpMet: 0.426 ± 0.018
0.396TrpAsn: 0.396 ± 0.016
0.89TrpPro: 0.89 ± 0.029
0.756TrpGln: 0.756 ± 0.026
1.533TrpArg: 1.533 ± 0.038
0.823TrpSer: 0.823 ± 0.023
0.752TrpThr: 0.752 ± 0.028
1.141TrpVal: 1.141 ± 0.031
0.352TrpTrp: 0.352 ± 0.02
0.268TrpTyr: 0.268 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.469TyrAla: 2.469 ± 0.046
0.219TyrCys: 0.219 ± 0.012
0.992TyrAsp: 0.992 ± 0.027
1.08TyrGlu: 1.08 ± 0.032
0.783TyrPhe: 0.783 ± 0.024
1.882TyrGly: 1.882 ± 0.037
0.433TyrHis: 0.433 ± 0.017
0.631TyrIle: 0.631 ± 0.021
0.516TyrLys: 0.516 ± 0.02
2.256TyrLeu: 2.256 ± 0.039
0.377TyrMet: 0.377 ± 0.015
0.511TyrAsn: 0.511 ± 0.019
0.988TyrPro: 0.988 ± 0.029
0.755TyrGln: 0.755 ± 0.024
1.616TyrArg: 1.616 ± 0.035
0.953TyrSer: 0.953 ± 0.027
1.099TyrThr: 1.099 ± 0.03
1.465TyrVal: 1.465 ± 0.035
0.304TyrTrp: 0.304 ± 0.017
0.46TyrTyr: 0.46 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4261 proteins (1407824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski