Amino acid dipepetide frequency for Hubei tombus-like virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.338AlaAla: 4.338 ± 0.222
0.0AlaCys: 0.0 ± 0.0
4.338AlaAsp: 4.338 ± 2.113
2.169AlaGlu: 2.169 ± 1.298
1.085AlaPhe: 1.085 ± 1.393
3.254AlaGly: 3.254 ± 1.188
0.0AlaHis: 0.0 ± 0.0
3.254AlaIle: 3.254 ± 1.913
4.338AlaLys: 4.338 ± 1.672
7.592AlaLeu: 7.592 ± 3.091
2.169AlaMet: 2.169 ± 0.813
5.423AlaAsn: 5.423 ± 5.408
3.254AlaPro: 3.254 ± 1.188
1.085AlaGln: 1.085 ± 0.649
3.254AlaArg: 3.254 ± 0.853
2.169AlaSer: 2.169 ± 2.163
8.677AlaThr: 8.677 ± 3.258
5.423AlaVal: 5.423 ± 2.241
3.254AlaTrp: 3.254 ± 1.088
2.169AlaTyr: 2.169 ± 2.786
0.0AlaXaa: 0.0 ± 0.0
Cys
1.085CysAla: 1.085 ± 0.649
1.085CysCys: 1.085 ± 0.649
1.085CysAsp: 1.085 ± 0.649
0.0CysGlu: 0.0 ± 0.0
2.169CysPhe: 2.169 ± 2.163
1.085CysGly: 1.085 ± 0.649
1.085CysHis: 1.085 ± 1.393
1.085CysIle: 1.085 ± 1.393
0.0CysLys: 0.0 ± 0.0
2.169CysLeu: 2.169 ± 0.933
1.085CysMet: 1.085 ± 0.649
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
1.085CysGln: 1.085 ± 0.649
2.169CysArg: 2.169 ± 1.068
0.0CysSer: 0.0 ± 0.0
2.169CysThr: 2.169 ± 1.298
2.169CysVal: 2.169 ± 1.298
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.338AspAla: 4.338 ± 0.222
1.085AspCys: 1.085 ± 0.649
4.338AspAsp: 4.338 ± 1.438
3.254AspGlu: 3.254 ± 2.396
1.085AspPhe: 1.085 ± 0.649
8.677AspGly: 8.677 ± 1.452
0.0AspHis: 0.0 ± 0.0
3.254AspIle: 3.254 ± 1.088
1.085AspLys: 1.085 ± 0.649
5.423AspLeu: 5.423 ± 1.602
1.085AspMet: 1.085 ± 0.649
2.169AspAsn: 2.169 ± 0.933
3.254AspPro: 3.254 ± 1.188
2.169AspGln: 2.169 ± 1.298
2.169AspArg: 2.169 ± 1.298
2.169AspSer: 2.169 ± 1.068
2.169AspThr: 2.169 ± 1.298
5.423AspVal: 5.423 ± 2.351
0.0AspTrp: 0.0 ± 0.0
5.423AspTyr: 5.423 ± 0.462
0.0AspXaa: 0.0 ± 0.0
Glu
1.085GluAla: 1.085 ± 1.393
0.0GluCys: 0.0 ± 0.0
6.508GluAsp: 6.508 ± 3.205
3.254GluGlu: 3.254 ± 1.088
3.254GluPhe: 3.254 ± 2.212
4.338GluGly: 4.338 ± 1.438
2.169GluHis: 2.169 ± 1.068
0.0GluIle: 0.0 ± 0.0
4.338GluLys: 4.338 ± 2.595
6.508GluLeu: 6.508 ± 1.229
2.169GluMet: 2.169 ± 0.933
2.169GluAsn: 2.169 ± 1.298
0.0GluPro: 0.0 ± 0.0
0.0GluGln: 0.0 ± 0.0
6.508GluArg: 6.508 ± 3.205
3.254GluSer: 3.254 ± 1.088
0.0GluThr: 0.0 ± 0.0
0.0GluVal: 0.0 ± 0.0
2.169GluTrp: 2.169 ± 1.068
1.085GluTyr: 1.085 ± 1.082
0.0GluXaa: 0.0 ± 0.0
Phe
5.423PheAla: 5.423 ± 2.241
1.085PheCys: 1.085 ± 0.649
2.169PheAsp: 2.169 ± 1.068
6.508PheGlu: 6.508 ± 1.229
1.085PhePhe: 1.085 ± 1.393
4.338PheGly: 4.338 ± 1.865
0.0PheHis: 0.0 ± 0.0
2.169PheIle: 2.169 ± 1.298
2.169PheLys: 2.169 ± 0.933
1.085PheLeu: 1.085 ± 0.649
1.085PheMet: 1.085 ± 1.12
1.085PheAsn: 1.085 ± 1.393
2.169PhePro: 2.169 ± 0.933
1.085PheGln: 1.085 ± 0.649
2.169PheArg: 2.169 ± 1.068
3.254PheSer: 3.254 ± 0.853
2.169PheThr: 2.169 ± 0.933
5.423PheVal: 5.423 ± 3.476
2.169PheTrp: 2.169 ± 1.298
1.085PheTyr: 1.085 ± 0.649
0.0PheXaa: 0.0 ± 0.0
Gly
3.254GlyAla: 3.254 ± 3.245
1.085GlyCys: 1.085 ± 0.649
5.423GlyAsp: 5.423 ± 1.948
2.169GlyGlu: 2.169 ± 2.786
6.508GlyPhe: 6.508 ± 2.844
5.423GlyGly: 5.423 ± 1.12
1.085GlyHis: 1.085 ± 1.393
3.254GlyIle: 3.254 ± 1.188
3.254GlyLys: 3.254 ± 1.088
5.423GlyLeu: 5.423 ± 2.808
3.254GlyMet: 3.254 ± 1.946
3.254GlyAsn: 3.254 ± 1.188
0.0GlyPro: 0.0 ± 0.0
3.254GlyGln: 3.254 ± 0.853
7.592GlyArg: 7.592 ± 3.126
3.254GlySer: 3.254 ± 1.188
2.169GlyThr: 2.169 ± 1.499
4.338GlyVal: 4.338 ± 2.113
0.0GlyTrp: 0.0 ± 0.0
1.085GlyTyr: 1.085 ± 1.082
0.0GlyXaa: 0.0 ± 0.0
His
2.169HisAla: 2.169 ± 1.068
1.085HisCys: 1.085 ± 1.393
4.338HisAsp: 4.338 ± 2.595
2.169HisGlu: 2.169 ± 1.068
0.0HisPhe: 0.0 ± 0.0
1.085HisGly: 1.085 ± 1.393
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
2.169HisLys: 2.169 ± 1.068
3.254HisLeu: 3.254 ± 1.913
0.0HisMet: 0.0 ± 0.0
1.085HisAsn: 1.085 ± 1.393
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
5.423HisArg: 5.423 ± 2.057
1.085HisSer: 1.085 ± 0.649
3.254HisThr: 3.254 ± 1.088
1.085HisVal: 1.085 ± 0.649
0.0HisTrp: 0.0 ± 0.0
1.085HisTyr: 1.085 ± 1.393
0.0HisXaa: 0.0 ± 0.0
Ile
4.338IleAla: 4.338 ± 1.438
1.085IleCys: 1.085 ± 0.649
5.423IleAsp: 5.423 ± 2.241
2.169IleGlu: 2.169 ± 0.933
1.085IlePhe: 1.085 ± 0.649
2.169IleGly: 2.169 ± 1.298
3.254IleHis: 3.254 ± 1.088
4.338IleIle: 4.338 ± 2.595
3.254IleLys: 3.254 ± 1.946
3.254IleLeu: 3.254 ± 1.088
2.169IleMet: 2.169 ± 1.298
5.423IleAsn: 5.423 ± 2.808
2.169IlePro: 2.169 ± 1.068
3.254IleGln: 3.254 ± 1.913
3.254IleArg: 3.254 ± 2.396
2.169IleSer: 2.169 ± 1.068
1.085IleThr: 1.085 ± 1.082
1.085IleVal: 1.085 ± 0.649
0.0IleTrp: 0.0 ± 0.0
2.169IleTyr: 2.169 ± 0.933
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
1.085LysCys: 1.085 ± 0.649
5.423LysAsp: 5.423 ± 2.241
1.085LysGlu: 1.085 ± 0.649
2.169LysPhe: 2.169 ± 1.298
5.423LysGly: 5.423 ± 3.244
0.0LysHis: 0.0 ± 0.0
6.508LysIle: 6.508 ± 2.523
7.592LysLys: 7.592 ± 1.876
2.169LysLeu: 2.169 ± 1.298
0.0LysMet: 0.0 ± 0.0
4.338LysAsn: 4.338 ± 1.865
3.254LysPro: 3.254 ± 2.396
3.254LysGln: 3.254 ± 0.853
1.085LysArg: 1.085 ± 0.649
5.423LysSer: 5.423 ± 2.351
2.169LysThr: 2.169 ± 0.933
7.592LysVal: 7.592 ± 1.876
1.085LysTrp: 1.085 ± 0.649
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
5.423LeuAla: 5.423 ± 2.808
1.085LeuCys: 1.085 ± 1.082
1.085LeuAsp: 1.085 ± 1.393
0.0LeuGlu: 0.0 ± 0.0
3.254LeuPhe: 3.254 ± 1.088
5.423LeuGly: 5.423 ± 0.462
3.254LeuHis: 3.254 ± 1.946
3.254LeuIle: 3.254 ± 0.853
3.254LeuLys: 3.254 ± 1.088
2.169LeuLeu: 2.169 ± 1.499
4.338LeuMet: 4.338 ± 1.657
4.338LeuAsn: 4.338 ± 2.595
6.508LeuPro: 6.508 ± 1.229
0.0LeuGln: 0.0 ± 0.0
3.254LeuArg: 3.254 ± 0.853
11.931LeuSer: 11.931 ± 4.345
1.085LeuThr: 1.085 ± 0.649
6.508LeuVal: 6.508 ± 2.191
0.0LeuTrp: 0.0 ± 0.0
6.508LeuTyr: 6.508 ± 3.677
0.0LeuXaa: 0.0 ± 0.0
Met
3.254MetAla: 3.254 ± 0.853
3.254MetCys: 3.254 ± 1.946
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
3.254MetPhe: 3.254 ± 1.946
2.169MetGly: 2.169 ± 1.298
4.338MetHis: 4.338 ± 1.438
0.0MetIle: 0.0 ± 0.0
2.169MetLys: 2.169 ± 1.298
1.085MetLeu: 1.085 ± 1.393
0.0MetMet: 0.0 ± 0.0
3.254MetAsn: 3.254 ± 1.913
1.085MetPro: 1.085 ± 0.649
3.254MetGln: 3.254 ± 1.188
0.0MetArg: 0.0 ± 0.0
2.169MetSer: 2.169 ± 2.163
0.0MetThr: 0.0 ± 0.0
1.085MetVal: 1.085 ± 1.393
0.0MetTrp: 0.0 ± 0.0
1.085MetTyr: 1.085 ± 1.082
0.0MetXaa: 0.0 ± 0.0
Asn
5.423AsnAla: 5.423 ± 2.808
1.085AsnCys: 1.085 ± 0.649
3.254AsnAsp: 3.254 ± 0.853
2.169AsnGlu: 2.169 ± 1.298
3.254AsnPhe: 3.254 ± 1.913
1.085AsnGly: 1.085 ± 0.649
0.0AsnHis: 0.0 ± 0.0
3.254AsnIle: 3.254 ± 1.946
3.254AsnLys: 3.254 ± 1.913
4.338AsnLeu: 4.338 ± 2.964
2.169AsnMet: 2.169 ± 1.068
1.085AsnAsn: 1.085 ± 1.082
5.423AsnPro: 5.423 ± 1.12
0.0AsnGln: 0.0 ± 0.0
3.254AsnArg: 3.254 ± 0.853
6.508AsnSer: 6.508 ± 2.191
1.085AsnThr: 1.085 ± 1.082
1.085AsnVal: 1.085 ± 1.393
0.0AsnTrp: 0.0 ± 0.0
2.169AsnTyr: 2.169 ± 0.933
0.0AsnXaa: 0.0 ± 0.0
Pro
2.169ProAla: 2.169 ± 1.068
0.0ProCys: 0.0 ± 0.0
2.169ProAsp: 2.169 ± 0.933
0.0ProGlu: 0.0 ± 0.0
1.085ProPhe: 1.085 ± 1.393
1.085ProGly: 1.085 ± 1.082
3.254ProHis: 3.254 ± 0.853
4.338ProIle: 4.338 ± 1.672
1.085ProLys: 1.085 ± 0.649
4.338ProLeu: 4.338 ± 1.865
1.085ProMet: 1.085 ± 1.082
4.338ProAsn: 4.338 ± 2.136
3.254ProPro: 3.254 ± 1.088
2.169ProGln: 2.169 ± 1.298
3.254ProArg: 3.254 ± 1.946
4.338ProSer: 4.338 ± 1.672
2.169ProThr: 2.169 ± 1.499
4.338ProVal: 4.338 ± 1.438
1.085ProTrp: 1.085 ± 1.082
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
1.085GlnAla: 1.085 ± 0.649
0.0GlnCys: 0.0 ± 0.0
1.085GlnAsp: 1.085 ± 0.649
1.085GlnGlu: 1.085 ± 0.649
2.169GlnPhe: 2.169 ± 1.298
0.0GlnGly: 0.0 ± 0.0
3.254GlnHis: 3.254 ± 0.853
3.254GlnIle: 3.254 ± 1.088
1.085GlnLys: 1.085 ± 1.082
1.085GlnLeu: 1.085 ± 1.082
0.0GlnMet: 0.0 ± 0.0
1.085GlnAsn: 1.085 ± 1.082
1.085GlnPro: 1.085 ± 0.649
1.085GlnGln: 1.085 ± 0.649
2.169GlnArg: 2.169 ± 1.068
4.338GlnSer: 4.338 ± 1.438
1.085GlnThr: 1.085 ± 1.082
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
1.085GlnTyr: 1.085 ± 1.082
0.0GlnXaa: 0.0 ± 0.0
Arg
6.508ArgAla: 6.508 ± 1.104
1.085ArgCys: 1.085 ± 0.649
1.085ArgAsp: 1.085 ± 1.082
6.508ArgGlu: 6.508 ± 2.176
2.169ArgPhe: 2.169 ± 1.068
5.423ArgGly: 5.423 ± 3.476
1.085ArgHis: 1.085 ± 1.393
4.338ArgIle: 4.338 ± 1.865
4.338ArgLys: 4.338 ± 1.438
3.254ArgLeu: 3.254 ± 1.088
2.169ArgMet: 2.169 ± 1.068
2.169ArgAsn: 2.169 ± 1.298
4.338ArgPro: 4.338 ± 2.595
1.085ArgGln: 1.085 ± 1.393
5.423ArgArg: 5.423 ± 5.156
4.338ArgSer: 4.338 ± 2.136
3.254ArgThr: 3.254 ± 2.396
6.508ArgVal: 6.508 ± 3.205
0.0ArgTrp: 0.0 ± 0.0
2.169ArgTyr: 2.169 ± 1.298
0.0ArgXaa: 0.0 ± 0.0
Ser
3.254SerAla: 3.254 ± 2.212
1.085SerCys: 1.085 ± 1.393
3.254SerAsp: 3.254 ± 2.684
2.169SerGlu: 2.169 ± 1.068
6.508SerPhe: 6.508 ± 0.835
4.338SerGly: 4.338 ± 0.222
1.085SerHis: 1.085 ± 0.649
5.423SerIle: 5.423 ± 2.241
6.508SerLys: 6.508 ± 0.835
7.592SerLeu: 7.592 ± 2.935
1.085SerMet: 1.085 ± 1.082
0.0SerAsn: 0.0 ± 0.0
2.169SerPro: 2.169 ± 0.933
0.0SerGln: 0.0 ± 0.0
7.592SerArg: 7.592 ± 2.467
9.761SerSer: 9.761 ± 4.337
3.254SerThr: 3.254 ± 0.853
8.677SerVal: 8.677 ± 1.452
4.338SerTrp: 4.338 ± 0.222
3.254SerTyr: 3.254 ± 1.188
0.0SerXaa: 0.0 ± 0.0
Thr
6.508ThrAla: 6.508 ± 1.705
1.085ThrCys: 1.085 ± 0.649
2.169ThrAsp: 2.169 ± 0.933
3.254ThrGlu: 3.254 ± 0.853
2.169ThrPhe: 2.169 ± 1.068
2.169ThrGly: 2.169 ± 2.163
0.0ThrHis: 0.0 ± 0.0
1.085ThrIle: 1.085 ± 1.393
0.0ThrLys: 0.0 ± 0.0
2.169ThrLeu: 2.169 ± 1.068
3.254ThrMet: 3.254 ± 1.188
4.338ThrAsn: 4.338 ± 3.143
2.169ThrPro: 2.169 ± 1.068
1.085ThrGln: 1.085 ± 0.649
3.254ThrArg: 3.254 ± 1.088
3.254ThrSer: 3.254 ± 0.853
5.423ThrThr: 5.423 ± 3.621
5.423ThrVal: 5.423 ± 4.032
0.0ThrTrp: 0.0 ± 0.0
1.085ThrTyr: 1.085 ± 1.082
0.0ThrXaa: 0.0 ± 0.0
Val
5.423ValAla: 5.423 ± 1.602
1.085ValCys: 1.085 ± 1.082
2.169ValAsp: 2.169 ± 1.298
8.677ValGlu: 8.677 ± 2.334
2.169ValPhe: 2.169 ± 1.298
4.338ValGly: 4.338 ± 2.998
4.338ValHis: 4.338 ± 2.136
0.0ValIle: 0.0 ± 0.0
6.508ValLys: 6.508 ± 1.705
7.592ValLeu: 7.592 ± 4.541
3.254ValMet: 3.254 ± 0.853
3.254ValAsn: 3.254 ± 1.188
4.338ValPro: 4.338 ± 1.865
1.085ValGln: 1.085 ± 1.393
3.254ValArg: 3.254 ± 2.396
5.423ValSer: 5.423 ± 2.808
5.423ValThr: 5.423 ± 2.63
5.423ValVal: 5.423 ± 3.439
1.085ValTrp: 1.085 ± 0.649
2.169ValTyr: 2.169 ± 1.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
2.169TrpAsp: 2.169 ± 1.298
1.085TrpGlu: 1.085 ± 0.649
1.085TrpPhe: 1.085 ± 1.393
2.169TrpGly: 2.169 ± 1.298
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.085TrpLys: 1.085 ± 1.082
2.169TrpLeu: 2.169 ± 0.933
0.0TrpMet: 0.0 ± 0.0
1.085TrpAsn: 1.085 ± 1.393
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
2.169TrpSer: 2.169 ± 1.068
1.085TrpThr: 1.085 ± 0.649
1.085TrpVal: 1.085 ± 0.649
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.169TyrAla: 2.169 ± 1.499
2.169TyrCys: 2.169 ± 1.499
1.085TyrAsp: 1.085 ± 1.082
1.085TyrGlu: 1.085 ± 0.649
3.254TyrPhe: 3.254 ± 1.088
1.085TyrGly: 1.085 ± 1.082
1.085TyrHis: 1.085 ± 0.649
4.338TyrIle: 4.338 ± 0.222
2.169TyrLys: 2.169 ± 1.298
0.0TyrLeu: 0.0 ± 0.0
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
1.085TyrPro: 1.085 ± 1.082
1.085TyrGln: 1.085 ± 1.082
2.169TyrArg: 2.169 ± 2.163
4.338TyrSer: 4.338 ± 1.865
2.169TyrThr: 2.169 ± 1.499
4.338TyrVal: 4.338 ± 0.222
0.0TyrTrp: 0.0 ± 0.0
1.085TyrTyr: 1.085 ± 0.649
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski