Amino acid dipepetide frequency for Streptomyces sparsogenes DSM 40356

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.29AlaAla: 22.29 ± 0.143	1.1AlaCys: 1.1 ± 0.017	8.607AlaAsp: 8.607 ± 0.06	9.292AlaGlu: 9.292 ± 0.08	3.461AlaPhe: 3.461 ± 0.036	13.505AlaGly: 13.505 ± 0.083	3.065AlaHis: 3.065 ± 0.042	3.492AlaIle: 3.492 ± 0.038	2.706AlaLys: 2.706 ± 0.043	14.983AlaLeu: 14.983 ± 0.104	2.504AlaMet: 2.504 ± 0.03	1.802AlaAsn: 1.802 ± 0.027	7.463AlaPro: 7.463 ± 0.063	3.571AlaGln: 3.571 ± 0.038	11.273AlaArg: 11.273 ± 0.085	5.625AlaSer: 5.625 ± 0.062	7.118AlaThr: 7.118 ± 0.054	12.321AlaVal: 12.321 ± 0.094	1.925AlaTrp: 1.925 ± 0.025	2.785AlaTyr: 2.785 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.135CysAla: 1.135 ± 0.021	0.097CysCys: 0.097 ± 0.007	0.486CysAsp: 0.486 ± 0.015	0.432CysGlu: 0.432 ± 0.014	0.227CysPhe: 0.227 ± 0.01	0.997CysGly: 0.997 ± 0.02	0.207CysHis: 0.207 ± 0.008	0.129CysIle: 0.129 ± 0.007	0.111CysLys: 0.111 ± 0.006	0.762CysLeu: 0.762 ± 0.017	0.125CysMet: 0.125 ± 0.006	0.123CysAsn: 0.123 ± 0.008	0.519CysPro: 0.519 ± 0.016	0.174CysGln: 0.174 ± 0.007	0.646CysArg: 0.646 ± 0.014	0.432CysSer: 0.432 ± 0.014	0.459CysThr: 0.459 ± 0.012	0.706CysVal: 0.706 ± 0.017	0.129CysTrp: 0.129 ± 0.007	0.156CysTyr: 0.156 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.639AspAla: 7.639 ± 0.06	0.409AspCys: 0.409 ± 0.013	3.46AspAsp: 3.46 ± 0.045	3.789AspGlu: 3.789 ± 0.04	1.679AspPhe: 1.679 ± 0.028	6.443AspGly: 6.443 ± 0.061	1.493AspHis: 1.493 ± 0.025	1.89AspIle: 1.89 ± 0.03	1.16AspLys: 1.16 ± 0.027	6.159AspLeu: 6.159 ± 0.051	0.782AspMet: 0.782 ± 0.018	0.91AspAsn: 0.91 ± 0.018	4.801AspPro: 4.801 ± 0.045	1.566AspGln: 1.566 ± 0.027	5.185AspArg: 5.185 ± 0.054	2.466AspSer: 2.466 ± 0.035	3.266AspThr: 3.266 ± 0.039	4.358AspVal: 4.358 ± 0.041	1.068AspTrp: 1.068 ± 0.02	1.179AspTyr: 1.179 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.836GluAla: 7.836 ± 0.076	0.39GluCys: 0.39 ± 0.013	2.904GluAsp: 2.904 ± 0.036	3.723GluGlu: 3.723 ± 0.048	1.49GluPhe: 1.49 ± 0.026	4.51GluGly: 4.51 ± 0.039	1.518GluHis: 1.518 ± 0.027	2.128GluIle: 2.128 ± 0.026	1.379GluLys: 1.379 ± 0.027	6.9GluLeu: 6.9 ± 0.059	0.834GluMet: 0.834 ± 0.015	0.911GluAsn: 0.911 ± 0.019	3.573GluPro: 3.573 ± 0.043	2.063GluGln: 2.063 ± 0.035	6.031GluArg: 6.031 ± 0.052	2.377GluSer: 2.377 ± 0.031	2.807GluThr: 2.807 ± 0.03	4.612GluVal: 4.612 ± 0.047	0.761GluTrp: 0.761 ± 0.017	1.077GluTyr: 1.077 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.659PheAla: 3.659 ± 0.042	0.252PheCys: 0.252 ± 0.009	1.956PheAsp: 1.956 ± 0.027	1.424PheGlu: 1.424 ± 0.024	0.833PhePhe: 0.833 ± 0.022	2.966PheGly: 2.966 ± 0.036	0.621PheHis: 0.621 ± 0.015	0.724PheIle: 0.724 ± 0.017	0.47PheLys: 0.47 ± 0.013	2.593PheLeu: 2.593 ± 0.037	0.377PheMet: 0.377 ± 0.012	0.54PheAsn: 0.54 ± 0.014	1.42PhePro: 1.42 ± 0.022	0.653PheGln: 0.653 ± 0.015	1.9PheArg: 1.9 ± 0.029	1.426PheSer: 1.426 ± 0.023	1.994PheThr: 1.994 ± 0.025	2.105PheVal: 2.105 ± 0.029	0.41PheTrp: 0.41 ± 0.013	0.567PheTyr: 0.567 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.604GlyAla: 11.604 ± 0.085	0.855GlyCys: 0.855 ± 0.019	5.209GlyAsp: 5.209 ± 0.051	5.413GlyGlu: 5.413 ± 0.044	2.82GlyPhe: 2.82 ± 0.035	9.448GlyGly: 9.448 ± 0.083	2.477GlyHis: 2.477 ± 0.031	3.22GlyIle: 3.22 ± 0.035	2.32GlyLys: 2.32 ± 0.037	9.557GlyLeu: 9.557 ± 0.071	1.997GlyMet: 1.997 ± 0.03	1.632GlyAsn: 1.632 ± 0.033	5.68GlyPro: 5.68 ± 0.06	2.675GlyGln: 2.675 ± 0.033	8.43GlyArg: 8.43 ± 0.066	5.22GlySer: 5.22 ± 0.05	6.009GlyThr: 6.009 ± 0.06	7.539GlyVal: 7.539 ± 0.055	1.716GlyTrp: 1.716 ± 0.029	2.32GlyTyr: 2.32 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.737HisAla: 2.737 ± 0.033	0.216HisCys: 0.216 ± 0.009	1.351HisAsp: 1.351 ± 0.023	1.193HisGlu: 1.193 ± 0.024	0.66HisPhe: 0.66 ± 0.016	2.505HisGly: 2.505 ± 0.032	0.765HisHis: 0.765 ± 0.018	0.735HisIle: 0.735 ± 0.017	0.344HisLys: 0.344 ± 0.012	2.551HisLeu: 2.551 ± 0.033	0.316HisMet: 0.316 ± 0.009	0.373HisAsn: 0.373 ± 0.013	1.992HisPro: 1.992 ± 0.03	0.692HisGln: 0.692 ± 0.017	2.227HisArg: 2.227 ± 0.033	1.011HisSer: 1.011 ± 0.021	1.427HisThr: 1.427 ± 0.024	1.585HisVal: 1.585 ± 0.023	0.386HisTrp: 0.386 ± 0.013	0.505HisTyr: 0.505 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.766IleAla: 4.766 ± 0.043	0.279IleCys: 0.279 ± 0.01	2.173IleAsp: 2.173 ± 0.031	1.944IleGlu: 1.944 ± 0.028	0.671IlePhe: 0.671 ± 0.018	3.435IleGly: 3.435 ± 0.046	0.629IleHis: 0.629 ± 0.016	0.789IleIle: 0.789 ± 0.019	0.722IleLys: 0.722 ± 0.019	2.247IleLeu: 2.247 ± 0.035	0.425IleMet: 0.425 ± 0.014	0.685IleAsn: 0.685 ± 0.019	1.749IlePro: 1.749 ± 0.023	0.654IleGln: 0.654 ± 0.016	2.288IleArg: 2.288 ± 0.03	1.687IleSer: 1.687 ± 0.023	2.215IleThr: 2.215 ± 0.032	2.459IleVal: 2.459 ± 0.03	0.362IleTrp: 0.362 ± 0.012	0.512IleTyr: 0.512 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.823LysAla: 2.823 ± 0.046	0.105LysCys: 0.105 ± 0.006	1.25LysAsp: 1.25 ± 0.025	1.111LysGlu: 1.111 ± 0.026	0.416LysPhe: 0.416 ± 0.014	1.725LysGly: 1.725 ± 0.031	0.416LysHis: 0.416 ± 0.011	0.783LysIle: 0.783 ± 0.019	0.823LysLys: 0.823 ± 0.026	1.901LysLeu: 1.901 ± 0.031	0.316LysMet: 0.316 ± 0.011	0.481LysAsn: 0.481 ± 0.017	1.31LysPro: 1.31 ± 0.024	0.638LysGln: 0.638 ± 0.021	1.478LysArg: 1.478 ± 0.028	1.077LysSer: 1.077 ± 0.022	1.229LysThr: 1.229 ± 0.025	1.756LysVal: 1.756 ± 0.031	0.262LysTrp: 0.262 ± 0.01	0.424LysTyr: 0.424 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.596LeuAla: 15.596 ± 0.11	0.896LeuCys: 0.896 ± 0.02	6.756LeuAsp: 6.756 ± 0.057	4.902LeuGlu: 4.902 ± 0.049	2.61LeuPhe: 2.61 ± 0.031	9.375LeuGly: 9.375 ± 0.071	2.282LeuHis: 2.282 ± 0.027	3.265LeuIle: 3.265 ± 0.047	1.841LeuLys: 1.841 ± 0.03	11.303LeuLeu: 11.303 ± 0.095	1.612LeuMet: 1.612 ± 0.026	1.546LeuAsn: 1.546 ± 0.028	6.636LeuPro: 6.636 ± 0.055	1.939LeuGln: 1.939 ± 0.026	9.379LeuArg: 9.379 ± 0.078	5.33LeuSer: 5.33 ± 0.045	6.845LeuThr: 6.845 ± 0.056	8.526LeuVal: 8.526 ± 0.064	1.309LeuTrp: 1.309 ± 0.022	1.868LeuTyr: 1.868 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.299MetAla: 2.299 ± 0.034	0.125MetCys: 0.125 ± 0.007	0.893MetAsp: 0.893 ± 0.018	0.727MetGlu: 0.727 ± 0.016	0.435MetPhe: 0.435 ± 0.013	1.301MetGly: 1.301 ± 0.023	0.325MetHis: 0.325 ± 0.011	0.62MetIle: 0.62 ± 0.016	0.395MetLys: 0.395 ± 0.016	1.652MetLeu: 1.652 ± 0.027	0.287MetMet: 0.287 ± 0.01	0.394MetAsn: 0.394 ± 0.013	1.059MetPro: 1.059 ± 0.021	0.368MetGln: 0.368 ± 0.012	1.439MetArg: 1.439 ± 0.026	1.221MetSer: 1.221 ± 0.021	1.451MetThr: 1.451 ± 0.023	1.319MetVal: 1.319 ± 0.025	0.216MetTrp: 0.216 ± 0.009	0.331MetTyr: 0.331 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.041AsnAla: 2.041 ± 0.027	0.165AsnCys: 0.165 ± 0.007	0.894AsnAsp: 0.894 ± 0.02	0.752AsnGlu: 0.752 ± 0.019	0.457AsnPhe: 0.457 ± 0.013	1.679AsnGly: 1.679 ± 0.032	0.4AsnHis: 0.4 ± 0.012	0.606AsnIle: 0.606 ± 0.016	0.389AsnLys: 0.389 ± 0.013	1.577AsnLeu: 1.577 ± 0.026	0.276AsnMet: 0.276 ± 0.011	0.394AsnAsn: 0.394 ± 0.013	1.273AsnPro: 1.273 ± 0.023	0.493AsnGln: 0.493 ± 0.014	1.199AsnArg: 1.199 ± 0.019	0.85AsnSer: 0.85 ± 0.019	1.07AsnThr: 1.07 ± 0.025	1.226AsnVal: 1.226 ± 0.024	0.264AsnTrp: 0.264 ± 0.01	0.404AsnTyr: 0.404 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.152ProAla: 9.152 ± 0.078	0.375ProCys: 0.375 ± 0.013	4.754ProAsp: 4.754 ± 0.044	4.452ProGlu: 4.452 ± 0.046	1.525ProPhe: 1.525 ± 0.025	7.232ProGly: 7.232 ± 0.064	1.513ProHis: 1.513 ± 0.025	1.31ProIle: 1.31 ± 0.022	1.139ProLys: 1.139 ± 0.022	5.63ProLeu: 5.63 ± 0.051	0.98ProMet: 0.98 ± 0.02	0.838ProAsn: 0.838 ± 0.019	3.815ProPro: 3.815 ± 0.051	1.611ProGln: 1.611 ± 0.027	4.441ProArg: 4.441 ± 0.044	3.127ProSer: 3.127 ± 0.041	3.221ProThr: 3.221 ± 0.036	5.269ProVal: 5.269 ± 0.044	0.961ProTrp: 0.961 ± 0.019	1.409ProTyr: 1.409 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.667GlnAla: 3.667 ± 0.042	0.158GlnCys: 0.158 ± 0.008	1.379GlnAsp: 1.379 ± 0.026	1.404GlnGlu: 1.404 ± 0.028	0.614GlnPhe: 0.614 ± 0.015	2.251GlnGly: 2.251 ± 0.028	0.62GlnHis: 0.62 ± 0.015	0.983GlnIle: 0.983 ± 0.019	0.545GlnLys: 0.545 ± 0.02	2.801GlnLeu: 2.801 ± 0.031	0.462GlnMet: 0.462 ± 0.014	0.436GlnAsn: 0.436 ± 0.015	1.633GlnPro: 1.633 ± 0.03	1.124GlnGln: 1.124 ± 0.03	2.397GlnArg: 2.397 ± 0.032	1.142GlnSer: 1.142 ± 0.023	1.234GlnThr: 1.234 ± 0.024	2.227GlnVal: 2.227 ± 0.031	0.464GlnTrp: 0.464 ± 0.012	0.539GlnTyr: 0.539 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.864ArgAla: 10.864 ± 0.077	0.676ArgCys: 0.676 ± 0.017	4.513ArgAsp: 4.513 ± 0.05	5.153ArgGlu: 5.153 ± 0.052	2.432ArgPhe: 2.432 ± 0.028	6.403ArgGly: 6.403 ± 0.062	2.345ArgHis: 2.345 ± 0.03	3.201ArgIle: 3.201 ± 0.035	1.614ArgLys: 1.614 ± 0.027	9.677ArgLeu: 9.677 ± 0.066	1.762ArgMet: 1.762 ± 0.026	1.272ArgAsn: 1.272 ± 0.025	5.544ArgPro: 5.544 ± 0.054	2.42ArgGln: 2.42 ± 0.029	8.606ArgArg: 8.606 ± 0.08	3.894ArgSer: 3.894 ± 0.042	5.253ArgThr: 5.253 ± 0.046	6.188ArgVal: 6.188 ± 0.048	1.488ArgTrp: 1.488 ± 0.027	1.905ArgTyr: 1.905 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.61SerAla: 6.61 ± 0.057	0.417SerCys: 0.417 ± 0.012	2.538SerAsp: 2.538 ± 0.032	2.304SerGlu: 2.304 ± 0.029	1.51SerPhe: 1.51 ± 0.023	5.912SerGly: 5.912 ± 0.062	1.023SerHis: 1.023 ± 0.02	1.33SerIle: 1.33 ± 0.022	0.976SerLys: 0.976 ± 0.022	4.722SerLeu: 4.722 ± 0.047	0.986SerMet: 0.986 ± 0.018	0.819SerAsn: 0.819 ± 0.019	3.192SerPro: 3.192 ± 0.035	1.194SerGln: 1.194 ± 0.022	3.697SerArg: 3.697 ± 0.039	2.721SerSer: 2.721 ± 0.036	2.727SerThr: 2.727 ± 0.036	3.953SerVal: 3.953 ± 0.041	0.891SerTrp: 0.891 ± 0.017	1.18SerTyr: 1.18 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.934ThrAla: 8.934 ± 0.068	0.416ThrCys: 0.416 ± 0.012	3.509ThrAsp: 3.509 ± 0.038	3.14ThrGlu: 3.14 ± 0.037	1.521ThrPhe: 1.521 ± 0.028	6.643ThrGly: 6.643 ± 0.052	1.212ThrHis: 1.212 ± 0.026	1.643ThrIle: 1.643 ± 0.028	1.064ThrLys: 1.064 ± 0.021	5.594ThrLeu: 5.594 ± 0.041	0.917ThrMet: 0.917 ± 0.019	0.936ThrAsn: 0.936 ± 0.019	4.106ThrPro: 4.106 ± 0.046	1.197ThrGln: 1.197 ± 0.023	3.973ThrArg: 3.973 ± 0.037	3.009ThrSer: 3.009 ± 0.037	3.744ThrThr: 3.744 ± 0.045	5.808ThrVal: 5.808 ± 0.055	0.903ThrTrp: 0.903 ± 0.022	1.264ThrTyr: 1.264 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.748ValAla: 10.748 ± 0.077	0.771ValCys: 0.771 ± 0.016	4.728ValAsp: 4.728 ± 0.046	4.658ValGlu: 4.658 ± 0.047	2.406ValPhe: 2.406 ± 0.031	6.455ValGly: 6.455 ± 0.055	1.891ValHis: 1.891 ± 0.025	2.826ValIle: 2.826 ± 0.038	1.589ValLys: 1.589 ± 0.031	9.267ValLeu: 9.267 ± 0.074	1.376ValMet: 1.376 ± 0.023	1.541ValAsn: 1.541 ± 0.027	5.06ValPro: 5.06 ± 0.047	1.845ValGln: 1.845 ± 0.024	7.217ValArg: 7.217 ± 0.046	4.203ValSer: 4.203 ± 0.042	5.261ValThr: 5.261 ± 0.053	7.828ValVal: 7.828 ± 0.071	1.148ValTrp: 1.148 ± 0.024	1.551ValTyr: 1.551 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.684TrpAla: 1.684 ± 0.029	0.173TrpCys: 0.173 ± 0.008	0.862TrpAsp: 0.862 ± 0.02	0.758TrpGlu: 0.758 ± 0.016	0.494TrpPhe: 0.494 ± 0.014	1.083TrpGly: 1.083 ± 0.019	0.372TrpHis: 0.372 ± 0.013	0.537TrpIle: 0.537 ± 0.013	0.352TrpLys: 0.352 ± 0.013	1.825TrpLeu: 1.825 ± 0.026	0.271TrpMet: 0.271 ± 0.01	0.38TrpAsn: 0.38 ± 0.012	0.821TrpPro: 0.821 ± 0.021	0.57TrpGln: 0.57 ± 0.015	1.471TrpArg: 1.471 ± 0.023	0.953TrpSer: 0.953 ± 0.022	1.047TrpThr: 1.047 ± 0.02	1.002TrpVal: 1.002 ± 0.021	0.347TrpTrp: 0.347 ± 0.012	0.381TrpTyr: 0.381 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.802TyrAla: 2.802 ± 0.034	0.175TyrCys: 0.175 ± 0.008	1.477TyrAsp: 1.477 ± 0.031	1.257TyrGlu: 1.257 ± 0.024	0.627TyrPhe: 0.627 ± 0.014	2.273TyrGly: 2.273 ± 0.032	0.398TyrHis: 0.398 ± 0.012	0.479TyrIle: 0.479 ± 0.013	0.385TyrLys: 0.385 ± 0.014	2.114TyrLeu: 2.114 ± 0.031	0.253TyrMet: 0.253 ± 0.01	0.397TyrAsn: 0.397 ± 0.013	1.109TyrPro: 1.109 ± 0.019	0.632TyrGln: 0.632 ± 0.018	1.933TyrArg: 1.933 ± 0.03	0.93TyrSer: 0.93 ± 0.02	1.155TyrThr: 1.155 ± 0.022	1.584TyrVal: 1.584 ± 0.03	0.375TyrTrp: 0.375 ± 0.012	0.453TyrTyr: 0.453 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8678 proteins (2800111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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