Amino acid dipepetide frequency for Halolamina sp. CBA1230

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.864AlaAla: 14.864 ± 0.186	0.693AlaCys: 0.693 ± 0.028	9.9AlaAsp: 9.9 ± 0.111	9.537AlaGlu: 9.537 ± 0.127	4.336AlaPhe: 4.336 ± 0.076	10.32AlaGly: 10.32 ± 0.117	1.753AlaHis: 1.753 ± 0.045	4.428AlaIle: 4.428 ± 0.075	1.772AlaLys: 1.772 ± 0.043	10.482AlaLeu: 10.482 ± 0.144	2.161AlaMet: 2.161 ± 0.051	2.327AlaAsn: 2.327 ± 0.053	4.176AlaPro: 4.176 ± 0.075	2.081AlaGln: 2.081 ± 0.047	5.985AlaArg: 5.985 ± 0.081	5.415AlaSer: 5.415 ± 0.087	6.822AlaThr: 6.822 ± 0.094	11.435AlaVal: 11.435 ± 0.152	1.197AlaTrp: 1.197 ± 0.043	2.841AlaTyr: 2.841 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.559CysAla: 0.559 ± 0.026	0.089CysCys: 0.089 ± 0.011	0.543CysAsp: 0.543 ± 0.025	0.57CysGlu: 0.57 ± 0.027	0.209CysPhe: 0.209 ± 0.015	0.892CysGly: 0.892 ± 0.038	0.176CysHis: 0.176 ± 0.015	0.23CysIle: 0.23 ± 0.016	0.128CysLys: 0.128 ± 0.012	0.534CysLeu: 0.534 ± 0.022	0.075CysMet: 0.075 ± 0.009	0.163CysAsn: 0.163 ± 0.014	0.571CysPro: 0.571 ± 0.027	0.16CysGln: 0.16 ± 0.013	0.462CysArg: 0.462 ± 0.026	0.42CysSer: 0.42 ± 0.021	0.387CysThr: 0.387 ± 0.021	0.446CysVal: 0.446 ± 0.021	0.091CysTrp: 0.091 ± 0.008	0.197CysTyr: 0.197 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	11.05AspAla: 11.05 ± 0.132	0.718AspCys: 0.718 ± 0.03	8.038AspAsp: 8.038 ± 0.118	8.307AspGlu: 8.307 ± 0.121	1.577AspPhe: 1.577 ± 0.047	8.127AspGly: 8.127 ± 0.117	1.896AspHis: 1.896 ± 0.042	2.677AspIle: 2.677 ± 0.058	0.863AspLys: 0.863 ± 0.036	6.956AspLeu: 6.956 ± 0.108	1.134AspMet: 1.134 ± 0.037	1.223AspAsn: 1.223 ± 0.04	4.646AspPro: 4.646 ± 0.081	1.682AspGln: 1.682 ± 0.047	6.427AspArg: 6.427 ± 0.083	3.702AspSer: 3.702 ± 0.067	4.277AspThr: 4.277 ± 0.081	7.26AspVal: 7.26 ± 0.104	1.078AspTrp: 1.078 ± 0.037	1.816AspTyr: 1.816 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	9.16GluAla: 9.16 ± 0.13	0.524GluCys: 0.524 ± 0.023	5.518GluAsp: 5.518 ± 0.088	8.204GluGlu: 8.204 ± 0.161	3.2GluPhe: 3.2 ± 0.066	6.029GluGly: 6.029 ± 0.095	2.053GluHis: 2.053 ± 0.047	4.018GluIle: 4.018 ± 0.078	1.915GluLys: 1.915 ± 0.054	8.277GluLeu: 8.277 ± 0.12	2.041GluMet: 2.041 ± 0.047	2.631GluAsn: 2.631 ± 0.059	4.217GluPro: 4.217 ± 0.081	3.111GluGln: 3.111 ± 0.065	7.729GluArg: 7.729 ± 0.105	5.236GluSer: 5.236 ± 0.084	6.284GluThr: 6.284 ± 0.099	5.621GluVal: 5.621 ± 0.077	1.202GluTrp: 1.202 ± 0.034	2.992GluTyr: 2.992 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.832PheAla: 3.832 ± 0.067	0.248PheCys: 0.248 ± 0.016	3.373PheAsp: 3.373 ± 0.061	3.107PheGlu: 3.107 ± 0.066	0.956PhePhe: 0.956 ± 0.034	3.152PheGly: 3.152 ± 0.062	0.664PheHis: 0.664 ± 0.027	0.82PheIle: 0.82 ± 0.028	0.441PheLys: 0.441 ± 0.025	2.814PheLeu: 2.814 ± 0.062	0.463PheMet: 0.463 ± 0.024	0.66PheAsn: 0.66 ± 0.029	1.376PhePro: 1.376 ± 0.037	0.759PheGln: 0.759 ± 0.029	1.818PheArg: 1.818 ± 0.041	1.748PheSer: 1.748 ± 0.046	1.953PheThr: 1.953 ± 0.048	3.315PheVal: 3.315 ± 0.067	0.405PheTrp: 0.405 ± 0.024	0.791PheTyr: 0.791 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.498GlyAla: 8.498 ± 0.14	0.676GlyCys: 0.676 ± 0.027	7.058GlyAsp: 7.058 ± 0.103	8.055GlyGlu: 8.055 ± 0.118	3.106GlyPhe: 3.106 ± 0.062	7.707GlyGly: 7.707 ± 0.125	1.65GlyHis: 1.65 ± 0.047	3.91GlyIle: 3.91 ± 0.063	1.769GlyLys: 1.769 ± 0.047	7.271GlyLeu: 7.271 ± 0.103	1.748GlyMet: 1.748 ± 0.041	2.019GlyAsn: 2.019 ± 0.057	3.327GlyPro: 3.327 ± 0.054	2.019GlyGln: 2.019 ± 0.051	4.812GlyArg: 4.812 ± 0.077	5.067GlySer: 5.067 ± 0.081	5.819GlyThr: 5.819 ± 0.083	8.211GlyVal: 8.211 ± 0.102	1.203GlyTrp: 1.203 ± 0.033	2.74GlyTyr: 2.74 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.038HisAla: 2.038 ± 0.048	0.171HisCys: 0.171 ± 0.016	1.812HisAsp: 1.812 ± 0.047	1.865HisGlu: 1.865 ± 0.045	0.466HisPhe: 0.466 ± 0.024	1.905HisGly: 1.905 ± 0.051	0.52HisHis: 0.52 ± 0.024	0.634HisIle: 0.634 ± 0.029	0.329HisLys: 0.329 ± 0.018	1.689HisLeu: 1.689 ± 0.045	0.244HisMet: 0.244 ± 0.018	0.418HisAsn: 0.418 ± 0.021	1.278HisPro: 1.278 ± 0.037	0.449HisGln: 0.449 ± 0.021	1.383HisArg: 1.383 ± 0.04	0.892HisSer: 0.892 ± 0.026	1.031HisThr: 1.031 ± 0.034	1.863HisVal: 1.863 ± 0.048	0.235HisTrp: 0.235 ± 0.014	0.595HisTyr: 0.595 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.444IleAla: 4.444 ± 0.075	0.242IleCys: 0.242 ± 0.017	3.823IleAsp: 3.823 ± 0.069	4.074IleGlu: 4.074 ± 0.072	0.764IlePhe: 0.764 ± 0.028	3.437IleGly: 3.437 ± 0.069	0.825IleHis: 0.825 ± 0.031	1.006IleIle: 1.006 ± 0.044	0.633IleLys: 0.633 ± 0.029	2.539IleLeu: 2.539 ± 0.061	0.434IleMet: 0.434 ± 0.021	0.847IleAsn: 0.847 ± 0.033	1.974IlePro: 1.974 ± 0.046	1.064IleGln: 1.064 ± 0.034	2.444IleArg: 2.444 ± 0.054	1.958IleSer: 1.958 ± 0.052	2.197IleThr: 2.197 ± 0.051	3.602IleVal: 3.602 ± 0.064	0.318IleTrp: 0.318 ± 0.019	0.807IleTyr: 0.807 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.733LysAla: 1.733 ± 0.047	0.121LysCys: 0.121 ± 0.013	0.948LysAsp: 0.948 ± 0.036	1.533LysGlu: 1.533 ± 0.047	0.522LysPhe: 0.522 ± 0.025	1.303LysGly: 1.303 ± 0.045	0.494LysHis: 0.494 ± 0.028	0.726LysIle: 0.726 ± 0.028	0.508LysLys: 0.508 ± 0.027	1.733LysLeu: 1.733 ± 0.047	0.359LysMet: 0.359 ± 0.02	0.525LysAsn: 0.525 ± 0.027	0.872LysPro: 0.872 ± 0.03	0.778LysGln: 0.778 ± 0.032	1.547LysArg: 1.547 ± 0.045	1.033LysSer: 1.033 ± 0.039	1.168LysThr: 1.168 ± 0.039	1.128LysVal: 1.128 ± 0.041	0.223LysTrp: 0.223 ± 0.015	0.534LysTyr: 0.534 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.257LeuAla: 11.257 ± 0.15	0.557LeuCys: 0.557 ± 0.026	7.685LeuAsp: 7.685 ± 0.106	6.091LeuGlu: 6.091 ± 0.092	3.165LeuPhe: 3.165 ± 0.074	7.925LeuGly: 7.925 ± 0.121	1.61LeuHis: 1.61 ± 0.042	2.958LeuIle: 2.958 ± 0.061	1.557LeuLys: 1.557 ± 0.051	9.236LeuLeu: 9.236 ± 0.163	1.187LeuMet: 1.187 ± 0.038	1.894LeuAsn: 1.894 ± 0.046	4.478LeuPro: 4.478 ± 0.072	2.174LeuGln: 2.174 ± 0.049	5.874LeuArg: 5.874 ± 0.088	5.797LeuSer: 5.797 ± 0.087	5.386LeuThr: 5.386 ± 0.09	7.92LeuVal: 7.92 ± 0.116	0.956LeuTrp: 0.956 ± 0.037	2.226LeuTyr: 2.226 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.786MetAla: 1.786 ± 0.045	0.081MetCys: 0.081 ± 0.01	1.21MetAsp: 1.21 ± 0.044	1.213MetGlu: 1.213 ± 0.038	0.484MetPhe: 0.484 ± 0.025	1.414MetGly: 1.414 ± 0.046	0.303MetHis: 0.303 ± 0.018	0.58MetIle: 0.58 ± 0.026	0.391MetLys: 0.391 ± 0.02	1.497MetLeu: 1.497 ± 0.039	0.287MetMet: 0.287 ± 0.017	0.54MetAsn: 0.54 ± 0.023	0.839MetPro: 0.839 ± 0.032	0.519MetGln: 0.519 ± 0.027	1.041MetArg: 1.041 ± 0.033	1.541MetSer: 1.541 ± 0.039	1.279MetThr: 1.279 ± 0.035	1.245MetVal: 1.245 ± 0.037	0.169MetTrp: 0.169 ± 0.013	0.344MetTyr: 0.344 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.553AsnAla: 2.553 ± 0.055	0.229AsnCys: 0.229 ± 0.017	1.689AsnAsp: 1.689 ± 0.046	1.879AsnGlu: 1.879 ± 0.049	0.603AsnPhe: 0.603 ± 0.028	2.009AsnGly: 2.009 ± 0.055	0.511AsnHis: 0.511 ± 0.024	0.799AsnIle: 0.799 ± 0.032	0.422AsnLys: 0.422 ± 0.024	1.825AsnLeu: 1.825 ± 0.052	0.38AsnMet: 0.38 ± 0.022	0.581AsnAsn: 0.581 ± 0.025	1.534AsnPro: 1.534 ± 0.041	0.63AsnGln: 0.63 ± 0.03	1.597AsnArg: 1.597 ± 0.044	1.012AsnSer: 1.012 ± 0.034	1.363AsnThr: 1.363 ± 0.044	2.316AsnVal: 2.316 ± 0.059	0.331AsnTrp: 0.331 ± 0.018	0.693AsnTyr: 0.693 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.012ProAla: 5.012 ± 0.084	0.249ProCys: 0.249 ± 0.015	4.891ProAsp: 4.891 ± 0.075	5.317ProGlu: 5.317 ± 0.068	1.604ProPhe: 1.604 ± 0.04	3.973ProGly: 3.973 ± 0.08	0.847ProHis: 0.847 ± 0.032	1.84ProIle: 1.84 ± 0.05	0.808ProLys: 0.808 ± 0.03	3.62ProLeu: 3.62 ± 0.07	0.789ProMet: 0.789 ± 0.027	1.132ProAsn: 1.132 ± 0.033	2.29ProPro: 2.29 ± 0.053	0.965ProGln: 0.965 ± 0.032	2.353ProArg: 2.353 ± 0.046	2.65ProSer: 2.65 ± 0.056	3.319ProThr: 3.319 ± 0.071	4.113ProVal: 4.113 ± 0.067	0.509ProTrp: 0.509 ± 0.024	1.156ProTyr: 1.156 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.49GlnAla: 2.49 ± 0.049	0.181GlnCys: 0.181 ± 0.013	1.36GlnAsp: 1.36 ± 0.042	1.889GlnGlu: 1.889 ± 0.05	1.204GlnPhe: 1.204 ± 0.034	1.708GlnGly: 1.708 ± 0.048	0.577GlnHis: 0.577 ± 0.021	1.018GlnIle: 1.018 ± 0.032	0.573GlnLys: 0.573 ± 0.028	2.316GlnLeu: 2.316 ± 0.054	0.421GlnMet: 0.421 ± 0.022	0.663GlnAsn: 0.663 ± 0.03	1.207GlnPro: 1.207 ± 0.039	1.167GlnGln: 1.167 ± 0.046	2.071GlnArg: 2.071 ± 0.05	1.66GlnSer: 1.66 ± 0.049	1.418GlnThr: 1.418 ± 0.041	1.855GlnVal: 1.855 ± 0.045	0.356GlnTrp: 0.356 ± 0.018	0.881GlnTyr: 0.881 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.297ArgAla: 6.297 ± 0.079	0.457ArgCys: 0.457 ± 0.024	4.904ArgAsp: 4.904 ± 0.074	7.296ArgGlu: 7.296 ± 0.125	2.31ArgPhe: 2.31 ± 0.049	4.6ArgGly: 4.6 ± 0.071	1.261ArgHis: 1.261 ± 0.037	2.816ArgIle: 2.816 ± 0.054	1.454ArgLys: 1.454 ± 0.052	6.229ArgLeu: 6.229 ± 0.082	1.262ArgMet: 1.262 ± 0.04	1.724ArgAsn: 1.724 ± 0.046	2.455ArgPro: 2.455 ± 0.052	1.807ArgGln: 1.807 ± 0.045	4.899ArgArg: 4.899 ± 0.082	3.517ArgSer: 3.517 ± 0.058	3.832ArgThr: 3.832 ± 0.06	5.281ArgVal: 5.281 ± 0.083	0.792ArgTrp: 0.792 ± 0.031	1.97ArgTyr: 1.97 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.264SerAla: 5.264 ± 0.083	0.335SerCys: 0.335 ± 0.02	4.02SerAsp: 4.02 ± 0.074	4.531SerGlu: 4.531 ± 0.085	1.923SerPhe: 1.923 ± 0.044	5.185SerGly: 5.185 ± 0.074	1.032SerHis: 1.032 ± 0.031	2.315SerIle: 2.315 ± 0.059	1.153SerLys: 1.153 ± 0.037	5.062SerLeu: 5.062 ± 0.076	1.04SerMet: 1.04 ± 0.03	1.248SerAsn: 1.248 ± 0.039	2.748SerPro: 2.748 ± 0.05	1.333SerGln: 1.333 ± 0.037	3.309SerArg: 3.309 ± 0.056	2.883SerSer: 2.883 ± 0.074	3.523SerThr: 3.523 ± 0.072	5.148SerVal: 5.148 ± 0.077	0.644SerTrp: 0.644 ± 0.029	1.431SerTyr: 1.431 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.123ThrAla: 7.123 ± 0.098	0.346ThrCys: 0.346 ± 0.019	5.098ThrAsp: 5.098 ± 0.081	4.877ThrGlu: 4.877 ± 0.077	2.164ThrPhe: 2.164 ± 0.05	5.565ThrGly: 5.565 ± 0.073	1.158ThrHis: 1.158 ± 0.037	2.525ThrIle: 2.525 ± 0.05	0.989ThrLys: 0.989 ± 0.036	5.883ThrLeu: 5.883 ± 0.088	0.969ThrMet: 0.969 ± 0.026	1.412ThrAsn: 1.412 ± 0.043	3.517ThrPro: 3.517 ± 0.068	1.331ThrGln: 1.331 ± 0.042	3.09ThrArg: 3.09 ± 0.059	2.702ThrSer: 2.702 ± 0.061	4.224ThrThr: 4.224 ± 0.083	7.137ThrVal: 7.137 ± 0.108	0.629ThrTrp: 0.629 ± 0.028	1.595ThrTyr: 1.595 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.733ValAla: 10.733 ± 0.154	0.627ValCys: 0.627 ± 0.028	8.199ValAsp: 8.199 ± 0.105	8.124ValGlu: 8.124 ± 0.104	2.883ValPhe: 2.883 ± 0.053	8.135ValGly: 8.135 ± 0.099	1.633ValHis: 1.633 ± 0.046	2.976ValIle: 2.976 ± 0.063	1.359ValLys: 1.359 ± 0.044	8.05ValLeu: 8.05 ± 0.113	1.214ValMet: 1.214 ± 0.037	1.98ValAsn: 1.98 ± 0.049	4.265ValPro: 4.265 ± 0.063	1.885ValGln: 1.885 ± 0.044	5.456ValArg: 5.456 ± 0.089	4.973ValSer: 4.973 ± 0.077	5.834ValThr: 5.834 ± 0.095	9.099ValVal: 9.099 ± 0.123	0.826ValTrp: 0.826 ± 0.031	2.096ValTyr: 2.096 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.062TrpAla: 1.062 ± 0.034	0.106TrpCys: 0.106 ± 0.012	0.744TrpAsp: 0.744 ± 0.032	0.927TrpGlu: 0.927 ± 0.034	0.434TrpPhe: 0.434 ± 0.022	0.89TrpGly: 0.89 ± 0.035	0.232TrpHis: 0.232 ± 0.015	0.451TrpIle: 0.451 ± 0.021	0.291TrpLys: 0.291 ± 0.019	1.345TrpLeu: 1.345 ± 0.044	0.218TrpMet: 0.218 ± 0.015	0.365TrpAsn: 0.365 ± 0.02	0.451TrpPro: 0.451 ± 0.023	0.395TrpGln: 0.395 ± 0.021	0.901TrpArg: 0.901 ± 0.029	0.66TrpSer: 0.66 ± 0.034	0.76TrpThr: 0.76 ± 0.031	0.914TrpVal: 0.914 ± 0.03	0.226TrpTrp: 0.226 ± 0.016	0.37TrpTyr: 0.37 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.771TyrAla: 2.771 ± 0.06	0.251TyrCys: 0.251 ± 0.016	2.64TyrAsp: 2.64 ± 0.058	2.567TyrGlu: 2.567 ± 0.058	0.787TyrPhe: 0.787 ± 0.028	2.389TyrGly: 2.389 ± 0.052	0.622TyrHis: 0.622 ± 0.028	0.702TyrIle: 0.702 ± 0.025	0.433TyrLys: 0.433 ± 0.02	2.576TyrLeu: 2.576 ± 0.056	0.336TyrMet: 0.336 ± 0.019	0.603TyrAsn: 0.603 ± 0.031	1.218TyrPro: 1.218 ± 0.036	0.71TyrGln: 0.71 ± 0.028	1.965TyrArg: 1.965 ± 0.044	1.259TyrSer: 1.259 ± 0.037	1.459TyrThr: 1.459 ± 0.045	2.439TyrVal: 2.439 ± 0.052	0.349TyrTrp: 0.349 ± 0.02	0.869TyrTyr: 0.869 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3470 proteins (987246 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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