Amino acid dipepetide frequency for Candidatus Accumulibacter aalborgensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.212AlaAla: 16.212 ± 0.16	1.414AlaCys: 1.414 ± 0.031	6.718AlaAsp: 6.718 ± 0.08	7.034AlaGlu: 7.034 ± 0.092	3.957AlaPhe: 3.957 ± 0.057	10.187AlaGly: 10.187 ± 0.11	2.475AlaHis: 2.475 ± 0.046	5.785AlaIle: 5.785 ± 0.073	3.49AlaLys: 3.49 ± 0.07	13.762AlaLeu: 13.762 ± 0.125	2.919AlaMet: 2.919 ± 0.045	3.221AlaAsn: 3.221 ± 0.056	4.953AlaPro: 4.953 ± 0.072	4.499AlaGln: 4.499 ± 0.077	8.94AlaArg: 8.94 ± 0.091	6.669AlaSer: 6.669 ± 0.102	5.991AlaThr: 5.991 ± 0.082	8.516AlaVal: 8.516 ± 0.082	1.669AlaTrp: 1.669 ± 0.035	2.491AlaTyr: 2.491 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.242CysAla: 1.242 ± 0.032	0.176CysCys: 0.176 ± 0.012	0.586CysAsp: 0.586 ± 0.021	0.575CysGlu: 0.575 ± 0.02	0.405CysPhe: 0.405 ± 0.017	1.071CysGly: 1.071 ± 0.029	0.343CysHis: 0.343 ± 0.019	0.404CysIle: 0.404 ± 0.014	0.252CysLys: 0.252 ± 0.012	1.095CysLeu: 1.095 ± 0.029	0.188CysMet: 0.188 ± 0.011	0.26CysAsn: 0.26 ± 0.015	0.586CysPro: 0.586 ± 0.024	0.349CysGln: 0.349 ± 0.015	0.898CysArg: 0.898 ± 0.025	0.663CysSer: 0.663 ± 0.024	0.504CysThr: 0.504 ± 0.025	0.696CysVal: 0.696 ± 0.022	0.179CysTrp: 0.179 ± 0.01	0.276CysTyr: 0.276 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.417AspAla: 6.417 ± 0.077	0.588AspCys: 0.588 ± 0.022	3.194AspAsp: 3.194 ± 0.051	3.586AspGlu: 3.586 ± 0.05	2.344AspPhe: 2.344 ± 0.043	4.755AspGly: 4.755 ± 0.066	1.259AspHis: 1.259 ± 0.031	2.451AspIle: 2.451 ± 0.046	1.718AspLys: 1.718 ± 0.04	6.061AspLeu: 6.061 ± 0.062	0.966AspMet: 0.966 ± 0.029	1.291AspAsn: 1.291 ± 0.034	3.088AspPro: 3.088 ± 0.053	1.955AspGln: 1.955 ± 0.039	3.884AspArg: 3.884 ± 0.051	2.836AspSer: 2.836 ± 0.051	2.368AspThr: 2.368 ± 0.045	3.568AspVal: 3.568 ± 0.052	0.996AspTrp: 0.996 ± 0.029	1.544AspTyr: 1.544 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.747GluAla: 6.747 ± 0.089	0.496GluCys: 0.496 ± 0.019	2.287GluAsp: 2.287 ± 0.036	2.83GluGlu: 2.83 ± 0.06	1.946GluPhe: 1.946 ± 0.041	3.507GluGly: 3.507 ± 0.049	1.377GluHis: 1.377 ± 0.035	3.214GluIle: 3.214 ± 0.052	2.254GluLys: 2.254 ± 0.046	6.098GluLeu: 6.098 ± 0.078	1.459GluMet: 1.459 ± 0.034	1.527GluAsn: 1.527 ± 0.038	2.2GluPro: 2.2 ± 0.04	2.647GluGln: 2.647 ± 0.046	4.857GluArg: 4.857 ± 0.068	2.816GluSer: 2.816 ± 0.046	2.874GluThr: 2.874 ± 0.048	4.234GluVal: 4.234 ± 0.065	0.809GluTrp: 0.809 ± 0.026	1.22GluTyr: 1.22 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.587PheAla: 4.587 ± 0.053	0.449PheCys: 0.449 ± 0.017	2.512PheAsp: 2.512 ± 0.046	1.953PheGlu: 1.953 ± 0.038	1.605PhePhe: 1.605 ± 0.041	3.307PheGly: 3.307 ± 0.059	0.759PheHis: 0.759 ± 0.028	1.562PheIle: 1.562 ± 0.032	1.058PheLys: 1.058 ± 0.027	3.625PheLeu: 3.625 ± 0.068	0.734PheMet: 0.734 ± 0.02	1.077PheAsn: 1.077 ± 0.031	1.673PhePro: 1.673 ± 0.036	1.069PheGln: 1.069 ± 0.025	2.263PheArg: 2.263 ± 0.043	2.48PheSer: 2.48 ± 0.044	1.791PheThr: 1.791 ± 0.038	2.841PheVal: 2.841 ± 0.05	0.525PheTrp: 0.525 ± 0.022	0.958PheTyr: 0.958 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.796GlyAla: 7.796 ± 0.085	0.993GlyCys: 0.993 ± 0.028	4.318GlyAsp: 4.318 ± 0.067	4.783GlyGlu: 4.783 ± 0.06	3.228GlyPhe: 3.228 ± 0.053	6.503GlyGly: 6.503 ± 0.088	1.856GlyHis: 1.856 ± 0.036	4.108GlyIle: 4.108 ± 0.057	3.414GlyLys: 3.414 ± 0.056	8.219GlyLeu: 8.219 ± 0.097	2.064GlyMet: 2.064 ± 0.038	2.346GlyAsn: 2.346 ± 0.06	2.645GlyPro: 2.645 ± 0.045	3.285GlyGln: 3.285 ± 0.053	5.766GlyArg: 5.766 ± 0.06	4.899GlySer: 4.899 ± 0.074	3.993GlyThr: 3.993 ± 0.068	5.96GlyVal: 5.96 ± 0.076	1.249GlyTrp: 1.249 ± 0.031	2.215GlyTyr: 2.215 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.531HisAla: 2.531 ± 0.044	0.32HisCys: 0.32 ± 0.014	1.278HisAsp: 1.278 ± 0.031	1.178HisGlu: 1.178 ± 0.031	1.017HisPhe: 1.017 ± 0.029	1.949HisGly: 1.949 ± 0.041	0.669HisHis: 0.669 ± 0.023	0.875HisIle: 0.875 ± 0.028	0.553HisLys: 0.553 ± 0.02	2.587HisLeu: 2.587 ± 0.046	0.394HisMet: 0.394 ± 0.02	0.512HisAsn: 0.512 ± 0.018	1.456HisPro: 1.456 ± 0.033	0.878HisGln: 0.878 ± 0.025	1.73HisArg: 1.73 ± 0.037	1.258HisSer: 1.258 ± 0.033	0.92HisThr: 0.92 ± 0.026	1.375HisVal: 1.375 ± 0.031	0.328HisTrp: 0.328 ± 0.016	0.679HisTyr: 0.679 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.218IleAla: 6.218 ± 0.059	0.491IleCys: 0.491 ± 0.017	3.446IleAsp: 3.446 ± 0.051	3.384IleGlu: 3.384 ± 0.052	1.541IlePhe: 1.541 ± 0.036	4.372IleGly: 4.372 ± 0.058	0.975IleHis: 0.975 ± 0.026	2.004IleIle: 2.004 ± 0.047	1.588IleLys: 1.588 ± 0.042	4.096IleLeu: 4.096 ± 0.057	0.779IleMet: 0.779 ± 0.025	1.53IleAsn: 1.53 ± 0.033	2.224IlePro: 2.224 ± 0.047	1.257IleGln: 1.257 ± 0.029	3.118IleArg: 3.118 ± 0.046	2.742IleSer: 2.742 ± 0.049	2.468IleThr: 2.468 ± 0.048	3.827IleVal: 3.827 ± 0.059	0.506IleTrp: 0.506 ± 0.024	1.081IleTyr: 1.081 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.727LysAla: 3.727 ± 0.063	0.211LysCys: 0.211 ± 0.014	1.609LysAsp: 1.609 ± 0.042	1.641LysGlu: 1.641 ± 0.044	0.862LysPhe: 0.862 ± 0.024	2.321LysGly: 2.321 ± 0.045	0.675LysHis: 0.675 ± 0.02	1.577LysIle: 1.577 ± 0.036	1.318LysLys: 1.318 ± 0.039	3.498LysLeu: 3.498 ± 0.055	0.777LysMet: 0.777 ± 0.026	0.937LysAsn: 0.937 ± 0.027	1.912LysPro: 1.912 ± 0.048	1.22LysGln: 1.22 ± 0.035	2.393LysArg: 2.393 ± 0.045	1.773LysSer: 1.773 ± 0.039	1.875LysThr: 1.875 ± 0.039	2.382LysVal: 2.382 ± 0.044	0.353LysTrp: 0.353 ± 0.014	0.672LysTyr: 0.672 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.602LeuAla: 15.602 ± 0.153	1.216LeuCys: 1.216 ± 0.029	6.209LeuAsp: 6.209 ± 0.063	5.371LeuGlu: 5.371 ± 0.069	3.828LeuPhe: 3.828 ± 0.074	8.196LeuGly: 8.196 ± 0.093	2.344LeuHis: 2.344 ± 0.045	5.161LeuIle: 5.161 ± 0.068	3.569LeuLys: 3.569 ± 0.054	12.839LeuLeu: 12.839 ± 0.17	2.157LeuMet: 2.157 ± 0.042	2.663LeuAsn: 2.663 ± 0.047	6.561LeuPro: 6.561 ± 0.083	3.8LeuGln: 3.8 ± 0.06	8.135LeuArg: 8.135 ± 0.086	6.527LeuSer: 6.527 ± 0.075	5.734LeuThr: 5.734 ± 0.085	7.687LeuVal: 7.687 ± 0.085	1.379LeuTrp: 1.379 ± 0.034	2.218LeuTyr: 2.218 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.718MetAla: 2.718 ± 0.047	0.146MetCys: 0.146 ± 0.01	0.942MetAsp: 0.942 ± 0.028	0.917MetGlu: 0.917 ± 0.027	0.707MetPhe: 0.707 ± 0.024	1.455MetGly: 1.455 ± 0.037	0.48MetHis: 0.48 ± 0.017	1.134MetIle: 1.134 ± 0.028	0.932MetLys: 0.932 ± 0.03	2.427MetLeu: 2.427 ± 0.041	0.535MetMet: 0.535 ± 0.023	0.852MetAsn: 0.852 ± 0.026	1.261MetPro: 1.261 ± 0.027	0.863MetGln: 0.863 ± 0.027	1.555MetArg: 1.555 ± 0.038	1.453MetSer: 1.453 ± 0.029	1.445MetThr: 1.445 ± 0.033	1.562MetVal: 1.562 ± 0.034	0.18MetTrp: 0.18 ± 0.01	0.327MetTyr: 0.327 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.004AsnAla: 3.004 ± 0.049	0.293AsnCys: 0.293 ± 0.015	1.48AsnAsp: 1.48 ± 0.037	1.343AsnGlu: 1.343 ± 0.034	0.983AsnPhe: 0.983 ± 0.025	2.32AsnGly: 2.32 ± 0.049	0.564AsnHis: 0.564 ± 0.016	1.224AsnIle: 1.224 ± 0.037	0.782AsnLys: 0.782 ± 0.024	2.744AsnLeu: 2.744 ± 0.048	0.501AsnMet: 0.501 ± 0.018	0.781AsnAsn: 0.781 ± 0.033	1.863AsnPro: 1.863 ± 0.039	0.902AsnGln: 0.902 ± 0.024	1.984AsnArg: 1.984 ± 0.038	1.427AsnSer: 1.427 ± 0.035	1.372AsnThr: 1.372 ± 0.038	1.907AsnVal: 1.907 ± 0.042	0.456AsnTrp: 0.456 ± 0.018	0.712AsnTyr: 0.712 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.654ProAla: 6.654 ± 0.089	0.487ProCys: 0.487 ± 0.018	3.154ProAsp: 3.154 ± 0.059	3.336ProGlu: 3.336 ± 0.053	1.774ProPhe: 1.774 ± 0.038	4.248ProGly: 4.248 ± 0.061	0.984ProHis: 0.984 ± 0.031	2.064ProIle: 2.064 ± 0.042	1.365ProLys: 1.365 ± 0.035	5.406ProLeu: 5.406 ± 0.067	1.133ProMet: 1.133 ± 0.03	1.242ProAsn: 1.242 ± 0.036	2.778ProPro: 2.778 ± 0.06	1.839ProGln: 1.839 ± 0.033	3.058ProArg: 3.058 ± 0.046	2.602ProSer: 2.602 ± 0.044	2.589ProThr: 2.589 ± 0.054	3.964ProVal: 3.964 ± 0.067	0.731ProTrp: 0.731 ± 0.023	1.128ProTyr: 1.128 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.873GlnAla: 4.873 ± 0.071	0.312GlnCys: 0.312 ± 0.014	1.507GlnAsp: 1.507 ± 0.035	1.817GlnGlu: 1.817 ± 0.038	1.212GlnPhe: 1.212 ± 0.029	2.751GlnGly: 2.751 ± 0.047	0.953GlnHis: 0.953 ± 0.03	1.971GlnIle: 1.971 ± 0.039	1.211GlnLys: 1.211 ± 0.03	3.958GlnLeu: 3.958 ± 0.061	0.944GlnMet: 0.944 ± 0.032	0.901GlnAsn: 0.901 ± 0.025	2.076GlnPro: 2.076 ± 0.037	1.824GlnGln: 1.824 ± 0.044	3.389GlnArg: 3.389 ± 0.052	2.009GlnSer: 2.009 ± 0.041	1.844GlnThr: 1.844 ± 0.036	2.867GlnVal: 2.867 ± 0.042	0.53GlnTrp: 0.53 ± 0.022	0.737GlnTyr: 0.737 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.246ArgAla: 7.246 ± 0.088	0.814ArgCys: 0.814 ± 0.027	3.828ArgAsp: 3.828 ± 0.055	4.428ArgGlu: 4.428 ± 0.068	3.086ArgPhe: 3.086 ± 0.049	4.61ArgGly: 4.61 ± 0.05	2.033ArgHis: 2.033 ± 0.039	3.865ArgIle: 3.865 ± 0.065	2.289ArgLys: 2.289 ± 0.045	9.193ArgLeu: 9.193 ± 0.073	1.8ArgMet: 1.8 ± 0.037	1.893ArgAsn: 1.893 ± 0.035	3.427ArgPro: 3.427 ± 0.051	3.62ArgGln: 3.62 ± 0.054	6.176ArgArg: 6.176 ± 0.083	4.125ArgSer: 4.125 ± 0.058	3.151ArgThr: 3.151 ± 0.053	5.159ArgVal: 5.159 ± 0.066	1.162ArgTrp: 1.162 ± 0.027	1.998ArgTyr: 1.998 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.696SerAla: 6.696 ± 0.086	0.583SerCys: 0.583 ± 0.022	2.976SerAsp: 2.976 ± 0.048	3.15SerGlu: 3.15 ± 0.051	2.194SerPhe: 2.194 ± 0.039	5.51SerGly: 5.51 ± 0.071	1.23SerHis: 1.23 ± 0.029	2.586SerIle: 2.586 ± 0.052	1.51SerLys: 1.51 ± 0.037	6.373SerLeu: 6.373 ± 0.076	1.223SerMet: 1.223 ± 0.03	1.365SerAsn: 1.365 ± 0.034	3.156SerPro: 3.156 ± 0.049	1.929SerGln: 1.929 ± 0.035	3.985SerArg: 3.985 ± 0.053	3.416SerSer: 3.416 ± 0.066	2.915SerThr: 2.915 ± 0.054	4.036SerVal: 4.036 ± 0.057	0.764SerTrp: 0.764 ± 0.024	1.366SerTyr: 1.366 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.81ThrAla: 5.81 ± 0.081	0.488ThrCys: 0.488 ± 0.031	2.534ThrAsp: 2.534 ± 0.048	2.225ThrGlu: 2.225 ± 0.046	1.737ThrPhe: 1.737 ± 0.038	4.392ThrGly: 4.392 ± 0.075	1.084ThrHis: 1.084 ± 0.027	2.495ThrIle: 2.495 ± 0.048	1.095ThrLys: 1.095 ± 0.031	6.384ThrLeu: 6.384 ± 0.075	1.039ThrMet: 1.039 ± 0.026	1.183ThrAsn: 1.183 ± 0.031	3.22ThrPro: 3.22 ± 0.051	1.67ThrGln: 1.67 ± 0.035	3.468ThrArg: 3.468 ± 0.054	2.716ThrSer: 2.716 ± 0.055	2.855ThrThr: 2.855 ± 0.074	4.096ThrVal: 4.096 ± 0.065	0.657ThrTrp: 0.657 ± 0.024	1.123ThrTyr: 1.123 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.061ValAla: 9.061 ± 0.093	0.819ValCys: 0.819 ± 0.025	4.397ValAsp: 4.397 ± 0.056	4.114ValGlu: 4.114 ± 0.051	2.879ValPhe: 2.879 ± 0.045	5.487ValGly: 5.487 ± 0.061	1.462ValHis: 1.462 ± 0.036	3.739ValIle: 3.739 ± 0.051	2.303ValLys: 2.303 ± 0.049	8.031ValLeu: 8.031 ± 0.089	1.586ValMet: 1.586 ± 0.036	2.024ValAsn: 2.024 ± 0.043	3.503ValPro: 3.503 ± 0.051	2.234ValGln: 2.234 ± 0.042	4.968ValArg: 4.968 ± 0.062	4.409ValSer: 4.409 ± 0.061	3.836ValThr: 3.836 ± 0.065	6.122ValVal: 6.122 ± 0.086	0.934ValTrp: 0.934 ± 0.025	1.502ValTyr: 1.502 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.201TrpAla: 1.201 ± 0.033	0.167TrpCys: 0.167 ± 0.012	0.579TrpAsp: 0.579 ± 0.022	0.629TrpGlu: 0.629 ± 0.022	0.534TrpPhe: 0.534 ± 0.022	0.798TrpGly: 0.798 ± 0.022	0.348TrpHis: 0.348 ± 0.016	0.643TrpIle: 0.643 ± 0.022	0.439TrpLys: 0.439 ± 0.018	2.073TrpLeu: 2.073 ± 0.046	0.328TrpMet: 0.328 ± 0.016	0.419TrpAsn: 0.419 ± 0.018	0.711TrpPro: 0.711 ± 0.023	0.857TrpGln: 0.857 ± 0.024	1.302TrpArg: 1.302 ± 0.03	0.874TrpSer: 0.874 ± 0.028	0.624TrpThr: 0.624 ± 0.025	0.929TrpVal: 0.929 ± 0.029	0.248TrpTrp: 0.248 ± 0.015	0.314TrpTyr: 0.314 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.559TyrAla: 2.559 ± 0.043	0.288TyrCys: 0.288 ± 0.015	1.315TyrAsp: 1.315 ± 0.047	1.103TyrGlu: 1.103 ± 0.03	0.989TyrPhe: 0.989 ± 0.029	1.901TyrGly: 1.901 ± 0.039	0.615TyrHis: 0.615 ± 0.021	0.787TyrIle: 0.787 ± 0.024	0.592TyrLys: 0.592 ± 0.02	2.728TyrLeu: 2.728 ± 0.045	0.364TyrMet: 0.364 ± 0.017	0.62TyrAsn: 0.62 ± 0.023	1.242TyrPro: 1.242 ± 0.027	0.989TyrGln: 0.989 ± 0.028	2.033TyrArg: 2.033 ± 0.04	1.269TyrSer: 1.269 ± 0.031	1.122TyrThr: 1.122 ± 0.035	1.68TyrVal: 1.68 ± 0.037	0.363TyrTrp: 0.363 ± 0.017	0.679TyrTyr: 0.679 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4556 proteins (1422198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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