Amino acid dipepetide frequency for Variovorax paradoxus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.268AlaAla: 19.268 ± 0.138
1.339AlaCys: 1.339 ± 0.028
6.551AlaAsp: 6.551 ± 0.054
6.992AlaGlu: 6.992 ± 0.062
4.303AlaPhe: 4.303 ± 0.047
11.532AlaGly: 11.532 ± 0.097
2.706AlaHis: 2.706 ± 0.044
5.483AlaIle: 5.483 ± 0.055
3.895AlaLys: 3.895 ± 0.054
15.227AlaLeu: 15.227 ± 0.101
3.743AlaMet: 3.743 ± 0.041
2.882AlaAsn: 2.882 ± 0.043
6.794AlaPro: 6.794 ± 0.072
5.653AlaGln: 5.653 ± 0.062
9.427AlaArg: 9.427 ± 0.079
7.286AlaSer: 7.286 ± 0.067
6.204AlaThr: 6.204 ± 0.056
9.498AlaVal: 9.498 ± 0.067
1.956AlaTrp: 1.956 ± 0.035
2.481AlaTyr: 2.481 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.21CysAla: 1.21 ± 0.025
0.125CysCys: 0.125 ± 0.008
0.53CysAsp: 0.53 ± 0.016
0.536CysGlu: 0.536 ± 0.016
0.319CysPhe: 0.319 ± 0.013
0.976CysGly: 0.976 ± 0.022
0.245CysHis: 0.245 ± 0.011
0.422CysIle: 0.422 ± 0.015
0.229CysLys: 0.229 ± 0.011
0.787CysLeu: 0.787 ± 0.02
0.225CysMet: 0.225 ± 0.008
0.236CysAsn: 0.236 ± 0.01
0.429CysPro: 0.429 ± 0.015
0.231CysGln: 0.231 ± 0.01
0.585CysArg: 0.585 ± 0.016
0.51CysSer: 0.51 ± 0.014
0.51CysThr: 0.51 ± 0.017
0.696CysVal: 0.696 ± 0.017
0.124CysTrp: 0.124 ± 0.008
0.188CysTyr: 0.188 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.49AspAla: 7.49 ± 0.064
0.445AspCys: 0.445 ± 0.015
2.55AspAsp: 2.55 ± 0.035
3.016AspGlu: 3.016 ± 0.04
2.066AspPhe: 2.066 ± 0.032
4.53AspGly: 4.53 ± 0.049
1.102AspHis: 1.102 ± 0.019
2.321AspIle: 2.321 ± 0.035
1.536AspLys: 1.536 ± 0.034
5.107AspLeu: 5.107 ± 0.061
1.212AspMet: 1.212 ± 0.024
1.183AspAsn: 1.183 ± 0.026
2.907AspPro: 2.907 ± 0.042
1.421AspGln: 1.421 ± 0.024
3.342AspArg: 3.342 ± 0.046
2.187AspSer: 2.187 ± 0.034
2.438AspThr: 2.438 ± 0.037
3.921AspVal: 3.921 ± 0.041
0.864AspTrp: 0.864 ± 0.021
1.323AspTyr: 1.323 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
7.182GluAla: 7.182 ± 0.068
0.396GluCys: 0.396 ± 0.015
2.147GluAsp: 2.147 ± 0.036
2.561GluGlu: 2.561 ± 0.039
1.751GluPhe: 1.751 ± 0.032
3.951GluGly: 3.951 ± 0.048
1.286GluHis: 1.286 ± 0.022
2.594GluIle: 2.594 ± 0.04
1.854GluLys: 1.854 ± 0.036
5.803GluLeu: 5.803 ± 0.06
1.274GluMet: 1.274 ± 0.026
1.224GluAsn: 1.224 ± 0.024
2.658GluPro: 2.658 ± 0.04
2.267GluGln: 2.267 ± 0.034
4.735GluArg: 4.735 ± 0.055
2.624GluSer: 2.624 ± 0.035
2.538GluThr: 2.538 ± 0.037
3.94GluVal: 3.94 ± 0.051
0.764GluTrp: 0.764 ± 0.021
0.959GluTyr: 0.959 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
4.503PheAla: 4.503 ± 0.049
0.369PheCys: 0.369 ± 0.013
2.568PheAsp: 2.568 ± 0.035
2.151PheGlu: 2.151 ± 0.036
1.355PhePhe: 1.355 ± 0.032
3.558PheGly: 3.558 ± 0.043
0.757PheHis: 0.757 ± 0.021
1.503PheIle: 1.503 ± 0.027
1.154PheLys: 1.154 ± 0.022
2.979PheLeu: 2.979 ± 0.04
0.832PheMet: 0.832 ± 0.019
1.08PheAsn: 1.08 ± 0.022
1.564PhePro: 1.564 ± 0.024
0.98PheGln: 0.98 ± 0.02
1.979PheArg: 1.979 ± 0.03
2.204PheSer: 2.204 ± 0.031
1.849PheThr: 1.849 ± 0.029
2.807PheVal: 2.807 ± 0.035
0.528PheTrp: 0.528 ± 0.017
0.802PheTyr: 0.802 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
9.993GlyAla: 9.993 ± 0.093
0.895GlyCys: 0.895 ± 0.02
3.94GlyAsp: 3.94 ± 0.052
4.475GlyGlu: 4.475 ± 0.052
3.391GlyPhe: 3.391 ± 0.05
7.445GlyGly: 7.445 ± 0.113
1.962GlyHis: 1.962 ± 0.031
4.258GlyIle: 4.258 ± 0.047
3.281GlyLys: 3.281 ± 0.048
8.871GlyLeu: 8.871 ± 0.073
2.336GlyMet: 2.336 ± 0.035
2.243GlyAsn: 2.243 ± 0.038
3.291GlyPro: 3.291 ± 0.04
3.134GlyGln: 3.134 ± 0.038
5.757GlyArg: 5.757 ± 0.05
4.873GlySer: 4.873 ± 0.061
4.798GlyThr: 4.798 ± 0.07
6.566GlyVal: 6.566 ± 0.055
1.498GlyTrp: 1.498 ± 0.028
2.357GlyTyr: 2.357 ± 0.031
0.0GlyXaa: 0.0 ± 0.0
His
3.033HisAla: 3.033 ± 0.04
0.262HisCys: 0.262 ± 0.012
1.174HisAsp: 1.174 ± 0.026
1.151HisGlu: 1.151 ± 0.024
0.862HisPhe: 0.862 ± 0.02
2.167HisGly: 2.167 ± 0.036
0.603HisHis: 0.603 ± 0.02
0.911HisIle: 0.911 ± 0.019
0.55HisLys: 0.55 ± 0.018
2.17HisLeu: 2.17 ± 0.038
0.506HisMet: 0.506 ± 0.015
0.479HisAsn: 0.479 ± 0.014
1.491HisPro: 1.491 ± 0.026
0.631HisGln: 0.631 ± 0.017
1.543HisArg: 1.543 ± 0.029
1.01HisSer: 1.01 ± 0.025
1.012HisThr: 1.012 ± 0.021
1.68HisVal: 1.68 ± 0.03
0.393HisTrp: 0.393 ± 0.015
0.586HisTyr: 0.586 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.599IleAla: 6.599 ± 0.058
0.4IleCys: 0.4 ± 0.015
3.197IleAsp: 3.197 ± 0.037
3.151IleGlu: 3.151 ± 0.042
1.277IlePhe: 1.277 ± 0.024
4.483IleGly: 4.483 ± 0.055
0.824IleHis: 0.824 ± 0.018
1.319IleIle: 1.319 ± 0.032
1.366IleLys: 1.366 ± 0.029
3.068IleLeu: 3.068 ± 0.046
0.686IleMet: 0.686 ± 0.019
1.267IleAsn: 1.267 ± 0.023
2.025IlePro: 2.025 ± 0.03
1.199IleGln: 1.199 ± 0.025
2.679IleArg: 2.679 ± 0.034
2.338IleSer: 2.338 ± 0.033
2.263IleThr: 2.263 ± 0.036
3.706IleVal: 3.706 ± 0.048
0.467IleTrp: 0.467 ± 0.017
0.961IleTyr: 0.961 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
4.197LysAla: 4.197 ± 0.052
0.162LysCys: 0.162 ± 0.009
1.582LysAsp: 1.582 ± 0.03
1.51LysGlu: 1.51 ± 0.032
0.934LysPhe: 0.934 ± 0.019
2.389LysGly: 2.389 ± 0.035
0.615LysHis: 0.615 ± 0.017
1.437LysIle: 1.437 ± 0.029
1.384LysLys: 1.384 ± 0.037
3.504LysLeu: 3.504 ± 0.048
0.755LysMet: 0.755 ± 0.02
0.891LysAsn: 0.891 ± 0.024
2.082LysPro: 2.082 ± 0.036
1.111LysGln: 1.111 ± 0.024
2.147LysArg: 2.147 ± 0.031
1.732LysSer: 1.732 ± 0.031
1.895LysThr: 1.895 ± 0.038
2.47LysVal: 2.47 ± 0.041
0.359LysTrp: 0.359 ± 0.013
0.628LysTyr: 0.628 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.234LeuAla: 15.234 ± 0.098
1.027LeuCys: 1.027 ± 0.022
5.697LeuAsp: 5.697 ± 0.054
4.992LeuGlu: 4.992 ± 0.058
3.494LeuPhe: 3.494 ± 0.047
8.91LeuGly: 8.91 ± 0.079
2.35LeuHis: 2.35 ± 0.033
4.148LeuIle: 4.148 ± 0.048
3.418LeuLys: 3.418 ± 0.042
11.019LeuLeu: 11.019 ± 0.098
2.508LeuMet: 2.508 ± 0.035
2.52LeuAsn: 2.52 ± 0.035
6.215LeuPro: 6.215 ± 0.062
3.961LeuGln: 3.961 ± 0.042
7.89LeuArg: 7.89 ± 0.079
6.067LeuSer: 6.067 ± 0.051
4.937LeuThr: 4.937 ± 0.044
8.099LeuVal: 8.099 ± 0.081
1.294LeuTrp: 1.294 ± 0.028
1.966LeuTyr: 1.966 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
3.182MetAla: 3.182 ± 0.043
0.194MetCys: 0.194 ± 0.01
1.023MetAsp: 1.023 ± 0.022
1.027MetGlu: 1.027 ± 0.023
0.751MetPhe: 0.751 ± 0.018
1.851MetGly: 1.851 ± 0.029
0.557MetHis: 0.557 ± 0.016
0.937MetIle: 0.937 ± 0.019
1.082MetLys: 1.082 ± 0.023
2.78MetLeu: 2.78 ± 0.042
0.546MetMet: 0.546 ± 0.018
0.869MetAsn: 0.869 ± 0.02
1.646MetPro: 1.646 ± 0.031
1.066MetGln: 1.066 ± 0.022
1.835MetArg: 1.835 ± 0.029
1.618MetSer: 1.618 ± 0.027
1.593MetThr: 1.593 ± 0.026
1.785MetVal: 1.785 ± 0.032
0.216MetTrp: 0.216 ± 0.009
0.376MetTyr: 0.376 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.317AsnAla: 3.317 ± 0.038
0.25AsnCys: 0.25 ± 0.012
1.255AsnAsp: 1.255 ± 0.024
1.22AsnGlu: 1.22 ± 0.023
0.925AsnPhe: 0.925 ± 0.022
2.265AsnGly: 2.265 ± 0.042
0.49AsnHis: 0.49 ± 0.013
1.216AsnIle: 1.216 ± 0.024
0.807AsnLys: 0.807 ± 0.02
2.484AsnLeu: 2.484 ± 0.028
0.545AsnMet: 0.545 ± 0.016
0.732AsnAsn: 0.732 ± 0.022
1.791AsnPro: 1.791 ± 0.029
0.783AsnGln: 0.783 ± 0.019
1.57AsnArg: 1.57 ± 0.025
1.206AsnSer: 1.206 ± 0.027
1.357AsnThr: 1.357 ± 0.031
1.905AsnVal: 1.905 ± 0.031
0.398AsnTrp: 0.398 ± 0.015
0.645AsnTyr: 0.645 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.718ProAla: 7.718 ± 0.078
0.356ProCys: 0.356 ± 0.014
3.059ProAsp: 3.059 ± 0.039
3.31ProGlu: 3.31 ± 0.04
1.871ProPhe: 1.871 ± 0.027
4.844ProGly: 4.844 ± 0.044
1.177ProHis: 1.177 ± 0.024
2.031ProIle: 2.031 ± 0.031
1.555ProLys: 1.555 ± 0.032
5.327ProLeu: 5.327 ± 0.054
1.421ProMet: 1.421 ± 0.03
1.303ProAsn: 1.303 ± 0.026
3.028ProPro: 3.028 ± 0.055
2.053ProGln: 2.053 ± 0.031
3.21ProArg: 3.21 ± 0.041
3.056ProSer: 3.056 ± 0.042
2.591ProThr: 2.591 ± 0.035
4.453ProVal: 4.453 ± 0.045
0.808ProTrp: 0.808 ± 0.019
1.241ProTyr: 1.241 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
5.136GlnAla: 5.136 ± 0.052
0.279GlnCys: 0.279 ± 0.01
1.399GlnAsp: 1.399 ± 0.022
1.503GlnGlu: 1.503 ± 0.03
1.181GlnPhe: 1.181 ± 0.024
2.823GlnGly: 2.823 ± 0.037
0.84GlnHis: 0.84 ± 0.02
1.651GlnIle: 1.651 ± 0.026
1.1GlnLys: 1.1 ± 0.025
4.099GlnLeu: 4.099 ± 0.05
0.951GlnMet: 0.951 ± 0.021
0.813GlnAsn: 0.813 ± 0.018
2.249GlnPro: 2.249 ± 0.031
1.915GlnGln: 1.915 ± 0.055
3.207GlnArg: 3.207 ± 0.045
1.853GlnSer: 1.853 ± 0.033
1.716GlnThr: 1.716 ± 0.028
2.827GlnVal: 2.827 ± 0.037
0.65GlnTrp: 0.65 ± 0.018
0.711GlnTyr: 0.711 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
8.318ArgAla: 8.318 ± 0.07
0.63ArgCys: 0.63 ± 0.018
3.46ArgAsp: 3.46 ± 0.041
4.251ArgGlu: 4.251 ± 0.047
2.774ArgPhe: 2.774 ± 0.036
4.88ArgGly: 4.88 ± 0.055
1.902ArgHis: 1.902 ± 0.032
3.667ArgIle: 3.667 ± 0.045
2.161ArgLys: 2.161 ± 0.032
7.775ArgLeu: 7.775 ± 0.077
2.045ArgMet: 2.045 ± 0.033
1.836ArgAsn: 1.836 ± 0.032
3.381ArgPro: 3.381 ± 0.039
2.709ArgGln: 2.709 ± 0.039
5.296ArgArg: 5.296 ± 0.054
3.796ArgSer: 3.796 ± 0.046
3.514ArgThr: 3.514 ± 0.042
5.119ArgVal: 5.119 ± 0.051
1.188ArgTrp: 1.188 ± 0.022
1.812ArgTyr: 1.812 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.741SerAla: 6.741 ± 0.06
0.459SerCys: 0.459 ± 0.015
2.565SerAsp: 2.565 ± 0.034
2.53SerGlu: 2.53 ± 0.031
2.276SerPhe: 2.276 ± 0.032
5.379SerGly: 5.379 ± 0.065
1.191SerHis: 1.191 ± 0.023
2.407SerIle: 2.407 ± 0.032
1.58SerLys: 1.58 ± 0.029
5.711SerLeu: 5.711 ± 0.052
1.456SerMet: 1.456 ± 0.027
1.416SerAsn: 1.416 ± 0.027
3.072SerPro: 3.072 ± 0.042
1.821SerGln: 1.821 ± 0.032
3.605SerArg: 3.605 ± 0.043
3.242SerSer: 3.242 ± 0.046
2.949SerThr: 2.949 ± 0.04
4.021SerVal: 4.021 ± 0.045
0.759SerTrp: 0.759 ± 0.021
1.298SerTyr: 1.298 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
6.158ThrAla: 6.158 ± 0.06
0.38ThrCys: 0.38 ± 0.014
2.468ThrAsp: 2.468 ± 0.036
2.302ThrGlu: 2.302 ± 0.032
1.678ThrPhe: 1.678 ± 0.032
4.679ThrGly: 4.679 ± 0.056
1.166ThrHis: 1.166 ± 0.025
2.094ThrIle: 2.094 ± 0.034
1.202ThrLys: 1.202 ± 0.03
6.139ThrLeu: 6.139 ± 0.056
1.136ThrMet: 1.136 ± 0.023
1.134ThrAsn: 1.134 ± 0.029
3.541ThrPro: 3.541 ± 0.039
1.808ThrGln: 1.808 ± 0.027
3.398ThrArg: 3.398 ± 0.035
2.702ThrSer: 2.702 ± 0.036
2.798ThrThr: 2.798 ± 0.044
4.356ThrVal: 4.356 ± 0.043
0.668ThrTrp: 0.668 ± 0.019
1.01ThrTyr: 1.01 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
9.953ValAla: 9.953 ± 0.078
0.746ValCys: 0.746 ± 0.019
3.968ValAsp: 3.968 ± 0.044
4.104ValGlu: 4.104 ± 0.053
2.815ValPhe: 2.815 ± 0.04
5.716ValGly: 5.716 ± 0.069
1.625ValHis: 1.625 ± 0.029
3.4ValIle: 3.4 ± 0.046
2.424ValLys: 2.424 ± 0.039
8.646ValLeu: 8.646 ± 0.08
1.92ValMet: 1.92 ± 0.028
2.054ValAsn: 2.054 ± 0.034
4.376ValPro: 4.376 ± 0.042
2.729ValGln: 2.729 ± 0.039
5.346ValArg: 5.346 ± 0.053
4.218ValSer: 4.218 ± 0.041
3.945ValThr: 3.945 ± 0.052
6.426ValVal: 6.426 ± 0.062
0.957ValTrp: 0.957 ± 0.026
1.513ValTyr: 1.513 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.369TrpAla: 1.369 ± 0.027
0.157TrpCys: 0.157 ± 0.009
0.594TrpAsp: 0.594 ± 0.017
0.549TrpGlu: 0.549 ± 0.017
0.569TrpPhe: 0.569 ± 0.018
0.986TrpGly: 0.986 ± 0.024
0.396TrpHis: 0.396 ± 0.013
0.705TrpIle: 0.705 ± 0.018
0.497TrpLys: 0.497 ± 0.015
2.012TrpLeu: 2.012 ± 0.037
0.417TrpMet: 0.417 ± 0.014
0.453TrpAsn: 0.453 ± 0.013
0.746TrpPro: 0.746 ± 0.018
0.704TrpGln: 0.704 ± 0.018
1.269TrpArg: 1.269 ± 0.025
0.82TrpSer: 0.82 ± 0.022
0.744TrpThr: 0.744 ± 0.02
0.962TrpVal: 0.962 ± 0.021
0.259TrpTrp: 0.259 ± 0.011
0.29TrpTyr: 0.29 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.618TyrAla: 2.618 ± 0.036
0.241TyrCys: 0.241 ± 0.011
1.234TyrAsp: 1.234 ± 0.029
1.176TyrGlu: 1.176 ± 0.026
0.931TyrPhe: 0.931 ± 0.02
2.002TyrGly: 2.002 ± 0.029
0.418TyrHis: 0.418 ± 0.015
0.774TyrIle: 0.774 ± 0.021
0.708TyrLys: 0.708 ± 0.02
2.238TyrLeu: 2.238 ± 0.034
0.417TyrMet: 0.417 ± 0.015
0.545TyrAsn: 0.545 ± 0.017
1.126TyrPro: 1.126 ± 0.023
0.728TyrGln: 0.728 ± 0.019
1.697TyrArg: 1.697 ± 0.03
1.137TyrSer: 1.137 ± 0.023
1.17TyrThr: 1.17 ± 0.026
1.644TyrVal: 1.644 ± 0.025
0.346TyrTrp: 0.346 ± 0.014
0.551TyrTyr: 0.551 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6788 proteins (2201532 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski