Amino acid dipepetide frequency for Angustibacter sp. Root456

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.027AlaAla: 22.027 ± 0.238	1.045AlaCys: 1.045 ± 0.035	8.756AlaAsp: 8.756 ± 0.102	7.478AlaGlu: 7.478 ± 0.101	3.524AlaPhe: 3.524 ± 0.068	12.759AlaGly: 12.759 ± 0.127	2.833AlaHis: 2.833 ± 0.054	3.846AlaIle: 3.846 ± 0.067	2.383AlaLys: 2.383 ± 0.068	15.308AlaLeu: 15.308 ± 0.171	2.722AlaMet: 2.722 ± 0.05	1.802AlaAsn: 1.802 ± 0.046	6.585AlaPro: 6.585 ± 0.098	4.496AlaGln: 4.496 ± 0.06	10.825AlaArg: 10.825 ± 0.121	7.091AlaSer: 7.091 ± 0.084	7.727AlaThr: 7.727 ± 0.101	14.028AlaVal: 14.028 ± 0.141	1.971AlaTrp: 1.971 ± 0.048	2.399AlaTyr: 2.399 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.032	0.09CysCys: 0.09 ± 0.01	0.5CysAsp: 0.5 ± 0.018	0.349CysGlu: 0.349 ± 0.019	0.194CysPhe: 0.194 ± 0.015	0.889CysGly: 0.889 ± 0.029	0.18CysHis: 0.18 ± 0.013	0.178CysIle: 0.178 ± 0.012	0.086CysLys: 0.086 ± 0.009	0.632CysLeu: 0.632 ± 0.024	0.096CysMet: 0.096 ± 0.009	0.102CysAsn: 0.102 ± 0.009	0.471CysPro: 0.471 ± 0.023	0.162CysGln: 0.162 ± 0.012	0.542CysArg: 0.542 ± 0.023	0.463CysSer: 0.463 ± 0.022	0.494CysThr: 0.494 ± 0.022	0.647CysVal: 0.647 ± 0.023	0.114CysTrp: 0.114 ± 0.009	0.139CysTyr: 0.139 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.891AspAla: 8.891 ± 0.097	0.373AspCys: 0.373 ± 0.018	5.464AspAsp: 5.464 ± 0.077	4.004AspGlu: 4.004 ± 0.068	1.377AspPhe: 1.377 ± 0.035	6.446AspGly: 6.446 ± 0.083	1.525AspHis: 1.525 ± 0.037	1.449AspIle: 1.449 ± 0.039	0.847AspLys: 0.847 ± 0.029	7.137AspLeu: 7.137 ± 0.085	0.675AspMet: 0.675 ± 0.021	0.746AspAsn: 0.746 ± 0.028	4.266AspPro: 4.266 ± 0.063	1.677AspGln: 1.677 ± 0.041	4.51AspArg: 4.51 ± 0.07	2.277AspSer: 2.277 ± 0.045	2.705AspThr: 2.705 ± 0.056	7.363AspVal: 7.363 ± 0.09	0.843AspTrp: 0.843 ± 0.027	1.065AspTyr: 1.065 ± 0.033	0.001AspXaa: 0.001 ± 0.001
Glu	6.811GluAla: 6.811 ± 0.092	0.337GluCys: 0.337 ± 0.018	2.041GluAsp: 2.041 ± 0.044	2.215GluGlu: 2.215 ± 0.048	1.174GluPhe: 1.174 ± 0.032	3.848GluGly: 3.848 ± 0.062	1.732GluHis: 1.732 ± 0.038	1.74GluIle: 1.74 ± 0.046	0.902GluLys: 0.902 ± 0.031	6.478GluLeu: 6.478 ± 0.096	0.786GluMet: 0.786 ± 0.026	0.709GluAsn: 0.709 ± 0.029	3.159GluPro: 3.159 ± 0.065	2.641GluGln: 2.641 ± 0.051	5.786GluArg: 5.786 ± 0.09	2.341GluSer: 2.341 ± 0.049	2.292GluThr: 2.292 ± 0.055	5.177GluVal: 5.177 ± 0.082	0.663GluTrp: 0.663 ± 0.022	0.877GluTyr: 0.877 ± 0.028	0.001GluXaa: 0.001 ± 0.001
Phe	3.578PheAla: 3.578 ± 0.063	0.236PheCys: 0.236 ± 0.014	1.926PheAsp: 1.926 ± 0.042	1.354PheGlu: 1.354 ± 0.034	0.811PhePhe: 0.811 ± 0.031	2.862PheGly: 2.862 ± 0.061	0.491PheHis: 0.491 ± 0.022	0.678PheIle: 0.678 ± 0.026	0.393PheLys: 0.393 ± 0.021	2.198PheLeu: 2.198 ± 0.048	0.37PheMet: 0.37 ± 0.018	0.491PheAsn: 0.491 ± 0.023	1.109PhePro: 1.109 ± 0.032	0.579PheGln: 0.579 ± 0.024	1.566PheArg: 1.566 ± 0.04	1.438PheSer: 1.438 ± 0.037	1.743PheThr: 1.743 ± 0.042	2.753PheVal: 2.753 ± 0.051	0.382PheTrp: 0.382 ± 0.019	0.52PheTyr: 0.52 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.214GlyAla: 11.214 ± 0.108	0.776GlyCys: 0.776 ± 0.028	5.258GlyAsp: 5.258 ± 0.081	4.815GlyGlu: 4.815 ± 0.072	2.768GlyPhe: 2.768 ± 0.051	8.13GlyGly: 8.13 ± 0.094	2.263GlyHis: 2.263 ± 0.046	3.015GlyIle: 3.015 ± 0.052	1.838GlyLys: 1.838 ± 0.056	9.698GlyLeu: 9.698 ± 0.111	1.684GlyMet: 1.684 ± 0.041	1.359GlyAsn: 1.359 ± 0.039	4.513GlyPro: 4.513 ± 0.07	2.826GlyGln: 2.826 ± 0.056	7.788GlyArg: 7.788 ± 0.091	5.337GlySer: 5.337 ± 0.084	5.36GlyThr: 5.36 ± 0.079	8.62GlyVal: 8.62 ± 0.081	1.781GlyTrp: 1.781 ± 0.045	2.052GlyTyr: 2.052 ± 0.043	0.004GlyXaa: 0.004 ± 0.002
His	2.711HisAla: 2.711 ± 0.051	0.175HisCys: 0.175 ± 0.013	1.673HisAsp: 1.673 ± 0.042	1.386HisGlu: 1.386 ± 0.032	0.515HisPhe: 0.515 ± 0.023	2.37HisGly: 2.37 ± 0.046	0.708HisHis: 0.708 ± 0.028	0.4HisIle: 0.4 ± 0.018	0.24HisLys: 0.24 ± 0.014	2.628HisLeu: 2.628 ± 0.053	0.294HisMet: 0.294 ± 0.014	0.299HisAsn: 0.299 ± 0.016	1.636HisPro: 1.636 ± 0.04	0.679HisGln: 0.679 ± 0.024	2.055HisArg: 2.055 ± 0.043	0.917HisSer: 0.917 ± 0.031	1.055HisThr: 1.055 ± 0.027	2.308HisVal: 2.308 ± 0.045	0.325HisTrp: 0.325 ± 0.016	0.431HisTyr: 0.431 ± 0.021	0.001HisXaa: 0.001 ± 0.001
Ile	4.459IleAla: 4.459 ± 0.064	0.248IleCys: 0.248 ± 0.015	2.24IleAsp: 2.24 ± 0.051	1.993IleGlu: 1.993 ± 0.046	0.608IlePhe: 0.608 ± 0.026	3.173IleGly: 3.173 ± 0.066	0.488IleHis: 0.488 ± 0.019	0.847IleIle: 0.847 ± 0.037	0.61IleLys: 0.61 ± 0.029	1.868IleLeu: 1.868 ± 0.051	0.382IleMet: 0.382 ± 0.019	0.588IleAsn: 0.588 ± 0.025	1.266IlePro: 1.266 ± 0.039	0.637IleGln: 0.637 ± 0.028	1.634IleArg: 1.634 ± 0.041	1.478IleSer: 1.478 ± 0.037	1.985IleThr: 1.985 ± 0.046	2.783IleVal: 2.783 ± 0.051	0.339IleTrp: 0.339 ± 0.017	0.511IleTyr: 0.511 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.324LysAla: 2.324 ± 0.065	0.08LysCys: 0.08 ± 0.01	0.985LysAsp: 0.985 ± 0.032	0.69LysGlu: 0.69 ± 0.029	0.346LysPhe: 0.346 ± 0.02	1.459LysGly: 1.459 ± 0.047	0.362LysHis: 0.362 ± 0.019	0.672LysIle: 0.672 ± 0.027	0.548LysLys: 0.548 ± 0.036	1.411LysLeu: 1.411 ± 0.039	0.282LysMet: 0.282 ± 0.015	0.373LysAsn: 0.373 ± 0.02	0.992LysPro: 0.992 ± 0.037	0.583LysGln: 0.583 ± 0.029	1.132LysArg: 1.132 ± 0.037	0.901LysSer: 0.901 ± 0.032	1.015LysThr: 1.015 ± 0.036	1.723LysVal: 1.723 ± 0.047	0.18LysTrp: 0.18 ± 0.013	0.354LysTyr: 0.354 ± 0.018	0.001LysXaa: 0.001 ± 0.001
Leu	16.702LeuAla: 16.702 ± 0.17	0.672LeuCys: 0.672 ± 0.025	7.343LeuAsp: 7.343 ± 0.1	4.997LeuGlu: 4.997 ± 0.085	2.24LeuPhe: 2.24 ± 0.046	9.652LeuGly: 9.652 ± 0.1	2.307LeuHis: 2.307 ± 0.051	2.477LeuIle: 2.477 ± 0.051	1.645LeuLys: 1.645 ± 0.041	11.648LeuLeu: 11.648 ± 0.142	1.603LeuMet: 1.603 ± 0.038	1.385LeuAsn: 1.385 ± 0.037	6.119LeuPro: 6.119 ± 0.08	2.84LeuGln: 2.84 ± 0.055	8.877LeuArg: 8.877 ± 0.103	5.529LeuSer: 5.529 ± 0.073	6.464LeuThr: 6.464 ± 0.065	11.245LeuVal: 11.245 ± 0.121	1.159LeuTrp: 1.159 ± 0.031	1.551LeuTyr: 1.551 ± 0.041	0.003LeuXaa: 0.003 ± 0.002
Met	2.184MetAla: 2.184 ± 0.046	0.103MetCys: 0.103 ± 0.009	0.766MetAsp: 0.766 ± 0.022	0.574MetGlu: 0.574 ± 0.024	0.378MetPhe: 0.378 ± 0.021	1.347MetGly: 1.347 ± 0.038	0.346MetHis: 0.346 ± 0.017	0.477MetIle: 0.477 ± 0.022	0.341MetLys: 0.341 ± 0.02	1.65MetLeu: 1.65 ± 0.04	0.277MetMet: 0.277 ± 0.015	0.301MetAsn: 0.301 ± 0.016	1.044MetPro: 1.044 ± 0.027	0.487MetGln: 0.487 ± 0.023	1.448MetArg: 1.448 ± 0.031	1.421MetSer: 1.421 ± 0.038	1.514MetThr: 1.514 ± 0.037	1.427MetVal: 1.427 ± 0.033	0.172MetTrp: 0.172 ± 0.013	0.278MetTyr: 0.278 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.066AsnAla: 2.066 ± 0.048	0.126AsnCys: 0.126 ± 0.011	0.93AsnAsp: 0.93 ± 0.032	0.625AsnGlu: 0.625 ± 0.024	0.393AsnPhe: 0.393 ± 0.018	1.382AsnGly: 1.382 ± 0.046	0.336AsnHis: 0.336 ± 0.017	0.471AsnIle: 0.471 ± 0.023	0.272AsnLys: 0.272 ± 0.02	1.599AsnLeu: 1.599 ± 0.039	0.201AsnMet: 0.201 ± 0.014	0.316AsnAsn: 0.316 ± 0.019	1.119AsnPro: 1.119 ± 0.032	0.442AsnGln: 0.442 ± 0.023	1.029AsnArg: 1.029 ± 0.028	0.717AsnSer: 0.717 ± 0.027	0.797AsnThr: 0.797 ± 0.029	1.463AsnVal: 1.463 ± 0.033	0.193AsnTrp: 0.193 ± 0.014	0.331AsnTyr: 0.331 ± 0.019	0.001AsnXaa: 0.001 ± 0.001
Pro	7.6ProAla: 7.6 ± 0.089	0.306ProCys: 0.306 ± 0.017	4.392ProAsp: 4.392 ± 0.066	3.255ProGlu: 3.255 ± 0.06	1.513ProPhe: 1.513 ± 0.035	5.479ProGly: 5.479 ± 0.073	1.292ProHis: 1.292 ± 0.035	1.34ProIle: 1.34 ± 0.04	0.859ProLys: 0.859 ± 0.033	5.104ProLeu: 5.104 ± 0.077	1.009ProMet: 1.009 ± 0.034	0.762ProAsn: 0.762 ± 0.025	2.986ProPro: 2.986 ± 0.066	1.977ProGln: 1.977 ± 0.047	3.879ProArg: 3.879 ± 0.065	3.439ProSer: 3.439 ± 0.06	3.47ProThr: 3.47 ± 0.065	5.416ProVal: 5.416 ± 0.069	0.977ProTrp: 0.977 ± 0.03	1.085ProTyr: 1.085 ± 0.034	0.003ProXaa: 0.003 ± 0.001
Gln	4.317GlnAla: 4.317 ± 0.074	0.185GlnCys: 0.185 ± 0.013	1.294GlnAsp: 1.294 ± 0.033	1.167GlnGlu: 1.167 ± 0.034	0.675GlnPhe: 0.675 ± 0.023	2.243GlnGly: 2.243 ± 0.052	0.835GlnHis: 0.835 ± 0.027	1.047GlnIle: 1.047 ± 0.035	0.463GlnLys: 0.463 ± 0.023	3.634GlnLeu: 3.634 ± 0.059	0.5GlnMet: 0.5 ± 0.02	0.419GlnAsn: 0.419 ± 0.02	2.045GlnPro: 2.045 ± 0.049	1.469GlnGln: 1.469 ± 0.039	3.09GlnArg: 3.09 ± 0.06	1.375GlnSer: 1.375 ± 0.038	1.499GlnThr: 1.499 ± 0.042	3.51GlnVal: 3.51 ± 0.052	0.497GlnTrp: 0.497 ± 0.021	0.591GlnTyr: 0.591 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.36ArgAla: 10.36 ± 0.122	0.604ArgCys: 0.604 ± 0.022	4.751ArgAsp: 4.751 ± 0.068	4.862ArgGlu: 4.862 ± 0.075	2.25ArgPhe: 2.25 ± 0.043	6.098ArgGly: 6.098 ± 0.077	1.952ArgHis: 1.952 ± 0.035	2.467ArgIle: 2.467 ± 0.048	1.131ArgLys: 1.131 ± 0.036	9.462ArgLeu: 9.462 ± 0.109	1.612ArgMet: 1.612 ± 0.036	1.043ArgAsn: 1.043 ± 0.033	4.684ArgPro: 4.684 ± 0.075	2.5ArgGln: 2.5 ± 0.045	8.443ArgArg: 8.443 ± 0.12	4.529ArgSer: 4.529 ± 0.067	4.786ArgThr: 4.786 ± 0.063	6.878ArgVal: 6.878 ± 0.088	1.656ArgTrp: 1.656 ± 0.043	1.721ArgTyr: 1.721 ± 0.04	0.003ArgXaa: 0.003 ± 0.002
Ser	7.263SerAla: 7.263 ± 0.089	0.379SerCys: 0.379 ± 0.021	3.075SerAsp: 3.075 ± 0.052	2.327SerGlu: 2.327 ± 0.051	1.525SerPhe: 1.525 ± 0.04	5.688SerGly: 5.688 ± 0.077	1.067SerHis: 1.067 ± 0.032	1.496SerIle: 1.496 ± 0.042	0.846SerLys: 0.846 ± 0.033	5.186SerLeu: 5.186 ± 0.067	1.157SerMet: 1.157 ± 0.031	0.885SerAsn: 0.885 ± 0.026	3.037SerPro: 3.037 ± 0.054	1.558SerGln: 1.558 ± 0.039	4.088SerArg: 4.088 ± 0.06	3.428SerSer: 3.428 ± 0.084	3.531SerThr: 3.531 ± 0.068	4.713SerVal: 4.713 ± 0.067	0.939SerTrp: 0.939 ± 0.032	1.105SerTyr: 1.105 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.98ThrAla: 7.98 ± 0.098	0.449ThrCys: 0.449 ± 0.024	3.363ThrAsp: 3.363 ± 0.055	2.46ThrGlu: 2.46 ± 0.045	1.74ThrPhe: 1.74 ± 0.044	5.855ThrGly: 5.855 ± 0.088	1.17ThrHis: 1.17 ± 0.035	1.849ThrIle: 1.849 ± 0.047	1.0ThrLys: 1.0 ± 0.036	5.624ThrLeu: 5.624 ± 0.065	0.952ThrMet: 0.952 ± 0.031	0.983ThrAsn: 0.983 ± 0.031	3.777ThrPro: 3.777 ± 0.068	1.51ThrGln: 1.51 ± 0.041	3.896ThrArg: 3.896 ± 0.048	3.769ThrSer: 3.769 ± 0.066	4.147ThrThr: 4.147 ± 0.072	5.803ThrVal: 5.803 ± 0.076	1.011ThrTrp: 1.011 ± 0.033	1.273ThrTyr: 1.273 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	14.001ValAla: 14.001 ± 0.144	0.718ValCys: 0.718 ± 0.025	6.694ValAsp: 6.694 ± 0.077	5.625ValGlu: 5.625 ± 0.079	2.424ValPhe: 2.424 ± 0.05	8.455ValGly: 8.455 ± 0.087	2.16ValHis: 2.16 ± 0.046	2.923ValIle: 2.923 ± 0.058	1.49ValLys: 1.49 ± 0.037	11.225ValLeu: 11.225 ± 0.11	1.484ValMet: 1.484 ± 0.037	1.602ValAsn: 1.602 ± 0.039	5.561ValPro: 5.561 ± 0.08	2.667ValGln: 2.667 ± 0.052	8.212ValArg: 8.212 ± 0.091	4.996ValSer: 4.996 ± 0.071	6.134ValThr: 6.134 ± 0.082	12.76ValVal: 12.76 ± 0.149	1.202ValTrp: 1.202 ± 0.033	1.482ValTyr: 1.482 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.778TrpAla: 1.778 ± 0.038	0.145TrpCys: 0.145 ± 0.01	0.857TrpAsp: 0.857 ± 0.028	0.509TrpGlu: 0.509 ± 0.02	0.49TrpPhe: 0.49 ± 0.021	1.068TrpGly: 1.068 ± 0.03	0.406TrpHis: 0.406 ± 0.018	0.393TrpIle: 0.393 ± 0.019	0.247TrpLys: 0.247 ± 0.016	1.862TrpLeu: 1.862 ± 0.042	0.263TrpMet: 0.263 ± 0.018	0.315TrpAsn: 0.315 ± 0.016	0.835TrpPro: 0.835 ± 0.027	0.6TrpGln: 0.6 ± 0.025	1.421TrpArg: 1.421 ± 0.033	0.943TrpSer: 0.943 ± 0.032	0.915TrpThr: 0.915 ± 0.035	1.329TrpVal: 1.329 ± 0.035	0.451TrpTrp: 0.451 ± 0.022	0.293TrpTyr: 0.293 ± 0.015	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.449TyrAla: 2.449 ± 0.053	0.165TyrCys: 0.165 ± 0.011	1.333TyrAsp: 1.333 ± 0.035	1.023TyrGlu: 1.023 ± 0.032	0.538TyrPhe: 0.538 ± 0.025	1.893TyrGly: 1.893 ± 0.042	0.35TyrHis: 0.35 ± 0.018	0.371TyrIle: 0.371 ± 0.019	0.272TyrLys: 0.272 ± 0.015	2.106TyrLeu: 2.106 ± 0.048	0.185TyrMet: 0.185 ± 0.012	0.332TyrAsn: 0.332 ± 0.02	0.936TyrPro: 0.936 ± 0.029	0.525TyrGln: 0.525 ± 0.023	1.569TyrArg: 1.569 ± 0.045	0.902TyrSer: 0.902 ± 0.027	0.976TyrThr: 0.976 ± 0.035	1.866TyrVal: 1.866 ± 0.041	0.264TyrTrp: 0.264 ± 0.014	0.392TyrTyr: 0.392 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 3495 proteins (1130590 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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