Amino acid dipepetide frequency for Chryseobacterium lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.047AlaAla: 5.047 ± 0.115
0.553AlaCys: 0.553 ± 0.032
3.609AlaAsp: 3.609 ± 0.072
5.036AlaGlu: 5.036 ± 0.105
3.277AlaPhe: 3.277 ± 0.067
4.835AlaGly: 4.835 ± 0.104
1.195AlaHis: 1.195 ± 0.042
4.535AlaIle: 4.535 ± 0.114
4.602AlaLys: 4.602 ± 0.101
6.051AlaLeu: 6.051 ± 0.117
1.779AlaMet: 1.779 ± 0.054
3.202AlaAsn: 3.202 ± 0.082
2.081AlaPro: 2.081 ± 0.072
2.746AlaGln: 2.746 ± 0.075
2.309AlaArg: 2.309 ± 0.06
3.931AlaSer: 3.931 ± 0.094
3.682AlaThr: 3.682 ± 0.115
4.633AlaVal: 4.633 ± 0.091
0.544AlaTrp: 0.544 ± 0.029
2.258AlaTyr: 2.258 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.476CysAla: 0.476 ± 0.032
0.113CysCys: 0.113 ± 0.014
0.379CysAsp: 0.379 ± 0.022
0.466CysGlu: 0.466 ± 0.03
0.377CysPhe: 0.377 ± 0.022
0.658CysGly: 0.658 ± 0.035
0.188CysHis: 0.188 ± 0.019
0.61CysIle: 0.61 ± 0.028
0.405CysLys: 0.405 ± 0.029
0.559CysLeu: 0.559 ± 0.028
0.154CysMet: 0.154 ± 0.016
0.385CysAsn: 0.385 ± 0.025
0.362CysPro: 0.362 ± 0.027
0.207CysGln: 0.207 ± 0.019
0.304CysArg: 0.304 ± 0.022
0.529CysSer: 0.529 ± 0.032
0.429CysThr: 0.429 ± 0.026
0.389CysVal: 0.389 ± 0.025
0.067CysTrp: 0.067 ± 0.013
0.276CysTyr: 0.276 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.519AspAla: 3.519 ± 0.079
0.337AspCys: 0.337 ± 0.028
2.528AspAsp: 2.528 ± 0.071
3.97AspGlu: 3.97 ± 0.087
3.708AspPhe: 3.708 ± 0.073
3.257AspGly: 3.257 ± 0.079
1.062AspHis: 1.062 ± 0.042
3.861AspIle: 3.861 ± 0.077
3.421AspLys: 3.421 ± 0.086
4.95AspLeu: 4.95 ± 0.098
1.111AspMet: 1.111 ± 0.037
2.343AspAsn: 2.343 ± 0.064
1.936AspPro: 1.936 ± 0.049
1.799AspGln: 1.799 ± 0.045
2.071AspArg: 2.071 ± 0.06
2.737AspSer: 2.737 ± 0.069
2.343AspThr: 2.343 ± 0.061
3.196AspVal: 3.196 ± 0.073
0.685AspTrp: 0.685 ± 0.035
2.447AspTyr: 2.447 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
4.127GluAla: 4.127 ± 0.09
0.358GluCys: 0.358 ± 0.025
3.258GluAsp: 3.258 ± 0.091
5.675GluGlu: 5.675 ± 0.131
3.264GluPhe: 3.264 ± 0.076
3.737GluGly: 3.737 ± 0.072
1.161GluHis: 1.161 ± 0.045
6.242GluIle: 6.242 ± 0.113
6.825GluLys: 6.825 ± 0.125
5.926GluLeu: 5.926 ± 0.112
2.006GluMet: 2.006 ± 0.062
5.059GluAsn: 5.059 ± 0.095
1.632GluPro: 1.632 ± 0.05
2.545GluGln: 2.545 ± 0.067
2.762GluArg: 2.762 ± 0.071
3.268GluSer: 3.268 ± 0.072
3.905GluThr: 3.905 ± 0.071
4.382GluVal: 4.382 ± 0.089
0.671GluTrp: 0.671 ± 0.035
2.559GluTyr: 2.559 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.369PheAla: 3.369 ± 0.074
0.477PheCys: 0.477 ± 0.027
3.008PheAsp: 3.008 ± 0.07
3.28PheGlu: 3.28 ± 0.065
3.084PhePhe: 3.084 ± 0.082
3.793PheGly: 3.793 ± 0.098
1.077PheHis: 1.077 ± 0.04
3.997PheIle: 3.997 ± 0.096
2.98PheLys: 2.98 ± 0.078
5.04PheLeu: 5.04 ± 0.109
1.331PheMet: 1.331 ± 0.047
2.736PheAsn: 2.736 ± 0.071
2.034PhePro: 2.034 ± 0.058
1.868PheGln: 1.868 ± 0.057
2.251PheArg: 2.251 ± 0.057
4.263PheSer: 4.263 ± 0.088
3.231PheThr: 3.231 ± 0.069
3.011PheVal: 3.011 ± 0.066
0.671PheTrp: 0.671 ± 0.032
2.245PheTyr: 2.245 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
4.204GlyAla: 4.204 ± 0.104
0.587GlyCys: 0.587 ± 0.039
3.05GlyAsp: 3.05 ± 0.068
3.694GlyGlu: 3.694 ± 0.076
3.686GlyPhe: 3.686 ± 0.078
4.483GlyGly: 4.483 ± 0.103
1.13GlyHis: 1.13 ± 0.044
5.624GlyIle: 5.624 ± 0.106
5.493GlyLys: 5.493 ± 0.102
5.466GlyLeu: 5.466 ± 0.101
1.85GlyMet: 1.85 ± 0.052
4.062GlyAsn: 4.062 ± 0.103
1.318GlyPro: 1.318 ± 0.045
1.977GlyGln: 1.977 ± 0.052
2.269GlyArg: 2.269 ± 0.065
4.044GlySer: 4.044 ± 0.093
4.302GlyThr: 4.302 ± 0.133
3.945GlyVal: 3.945 ± 0.082
0.728GlyTrp: 0.728 ± 0.037
2.814GlyTyr: 2.814 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.039
0.2HisCys: 0.2 ± 0.019
0.926HisAsp: 0.926 ± 0.035
1.148HisGlu: 1.148 ± 0.04
1.305HisPhe: 1.305 ± 0.049
1.09HisGly: 1.09 ± 0.041
0.617HisHis: 0.617 ± 0.036
1.397HisIle: 1.397 ± 0.044
1.124HisLys: 1.124 ± 0.045
1.996HisLeu: 1.996 ± 0.064
0.313HisMet: 0.313 ± 0.022
0.917HisAsn: 0.917 ± 0.035
1.032HisPro: 1.032 ± 0.042
0.957HisGln: 0.957 ± 0.041
0.812HisArg: 0.812 ± 0.038
1.246HisSer: 1.246 ± 0.044
1.009HisThr: 1.009 ± 0.038
0.837HisVal: 0.837 ± 0.041
0.229HisTrp: 0.229 ± 0.018
0.927HisTyr: 0.927 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.39IleAla: 5.39 ± 0.102
0.604IleCys: 0.604 ± 0.031
4.108IleAsp: 4.108 ± 0.076
4.834IleGlu: 4.834 ± 0.089
4.035IlePhe: 4.035 ± 0.089
4.854IleGly: 4.854 ± 0.095
1.486IleHis: 1.486 ± 0.043
5.897IleIle: 5.897 ± 0.134
4.989IleLys: 4.989 ± 0.084
7.307IleLeu: 7.307 ± 0.128
1.578IleMet: 1.578 ± 0.048
4.023IleAsn: 4.023 ± 0.086
3.471IlePro: 3.471 ± 0.075
2.929IleGln: 2.929 ± 0.06
3.008IleArg: 3.008 ± 0.07
5.936IleSer: 5.936 ± 0.086
4.637IleThr: 4.637 ± 0.09
4.347IleVal: 4.347 ± 0.097
0.679IleTrp: 0.679 ± 0.032
2.583IleTyr: 2.583 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.675LysAla: 4.675 ± 0.093
0.368LysCys: 0.368 ± 0.022
4.028LysAsp: 4.028 ± 0.1
5.747LysGlu: 5.747 ± 0.124
3.173LysPhe: 3.173 ± 0.082
4.153LysGly: 4.153 ± 0.089
1.196LysHis: 1.196 ± 0.043
6.839LysIle: 6.839 ± 0.107
6.832LysLys: 6.832 ± 0.148
6.01LysLeu: 6.01 ± 0.108
2.381LysMet: 2.381 ± 0.066
5.399LysAsn: 5.399 ± 0.111
2.621LysPro: 2.621 ± 0.066
2.395LysGln: 2.395 ± 0.061
2.619LysArg: 2.619 ± 0.076
4.309LysSer: 4.309 ± 0.088
4.429LysThr: 4.429 ± 0.085
4.328LysVal: 4.328 ± 0.092
0.675LysTrp: 0.675 ± 0.034
2.845LysTyr: 2.845 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
5.816LeuAla: 5.816 ± 0.099
0.637LeuCys: 0.637 ± 0.037
4.555LeuAsp: 4.555 ± 0.093
5.992LeuGlu: 5.992 ± 0.123
4.752LeuPhe: 4.752 ± 0.104
5.724LeuGly: 5.724 ± 0.107
1.808LeuHis: 1.808 ± 0.051
6.453LeuIle: 6.453 ± 0.114
7.407LeuLys: 7.407 ± 0.11
8.498LeuLeu: 8.498 ± 0.144
2.539LeuMet: 2.539 ± 0.063
5.382LeuAsn: 5.382 ± 0.091
3.782LeuPro: 3.782 ± 0.086
3.774LeuGln: 3.774 ± 0.086
3.449LeuArg: 3.449 ± 0.074
6.394LeuSer: 6.394 ± 0.091
4.866LeuThr: 4.866 ± 0.1
4.851LeuVal: 4.851 ± 0.087
0.797LeuTrp: 0.797 ± 0.032
3.148LeuTyr: 3.148 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.785MetAla: 1.785 ± 0.05
0.119MetCys: 0.119 ± 0.014
1.314MetAsp: 1.314 ± 0.047
1.759MetGlu: 1.759 ± 0.046
0.991MetPhe: 0.991 ± 0.04
1.567MetGly: 1.567 ± 0.05
0.429MetHis: 0.429 ± 0.026
1.919MetIle: 1.919 ± 0.058
2.677MetLys: 2.677 ± 0.066
2.164MetLeu: 2.164 ± 0.057
0.958MetMet: 0.958 ± 0.045
1.733MetAsn: 1.733 ± 0.055
0.961MetPro: 0.961 ± 0.034
0.896MetGln: 0.896 ± 0.034
0.989MetArg: 0.989 ± 0.038
1.541MetSer: 1.541 ± 0.047
1.372MetThr: 1.372 ± 0.045
1.598MetVal: 1.598 ± 0.048
0.193MetTrp: 0.193 ± 0.017
0.762MetTyr: 0.762 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.946AsnAla: 3.946 ± 0.084
0.418AsnCys: 0.418 ± 0.026
2.671AsnAsp: 2.671 ± 0.065
3.437AsnGlu: 3.437 ± 0.07
3.319AsnPhe: 3.319 ± 0.074
3.919AsnGly: 3.919 ± 0.078
1.105AsnHis: 1.105 ± 0.04
4.664AsnIle: 4.664 ± 0.092
3.677AsnLys: 3.677 ± 0.091
5.302AsnLeu: 5.302 ± 0.097
1.367AsnMet: 1.367 ± 0.045
3.301AsnAsn: 3.301 ± 0.109
2.907AsnPro: 2.907 ± 0.07
2.055AsnGln: 2.055 ± 0.065
2.286AsnArg: 2.286 ± 0.063
3.524AsnSer: 3.524 ± 0.085
3.408AsnThr: 3.408 ± 0.093
3.316AsnVal: 3.316 ± 0.078
0.713AsnTrp: 0.713 ± 0.032
2.668AsnTyr: 2.668 ± 0.072
0.0AsnXaa: 0.0 ± 0.0
Pro
2.637ProAla: 2.637 ± 0.076
0.243ProCys: 0.243 ± 0.018
2.163ProAsp: 2.163 ± 0.06
3.665ProGlu: 3.665 ± 0.084
1.977ProPhe: 1.977 ± 0.063
2.258ProGly: 2.258 ± 0.063
0.716ProHis: 0.716 ± 0.033
2.168ProIle: 2.168 ± 0.055
2.476ProLys: 2.476 ± 0.067
2.987ProLeu: 2.987 ± 0.069
0.875ProMet: 0.875 ± 0.038
1.983ProAsn: 1.983 ± 0.061
1.026ProPro: 1.026 ± 0.051
1.41ProGln: 1.41 ± 0.041
1.118ProArg: 1.118 ± 0.036
2.231ProSer: 2.231 ± 0.061
1.952ProThr: 1.952 ± 0.072
3.12ProVal: 3.12 ± 0.071
0.317ProTrp: 0.317 ± 0.021
1.492ProTyr: 1.492 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.076GlnAla: 2.076 ± 0.061
0.2GlnCys: 0.2 ± 0.018
1.716GlnAsp: 1.716 ± 0.049
2.654GlnGlu: 2.654 ± 0.072
1.728GlnPhe: 1.728 ± 0.053
2.014GlnGly: 2.014 ± 0.06
0.892GlnHis: 0.892 ± 0.037
2.914GlnIle: 2.914 ± 0.056
3.389GlnLys: 3.389 ± 0.077
3.638GlnLeu: 3.638 ± 0.081
1.056GlnMet: 1.056 ± 0.035
2.672GlnAsn: 2.672 ± 0.08
1.345GlnPro: 1.345 ± 0.043
1.9GlnGln: 1.9 ± 0.067
1.482GlnArg: 1.482 ± 0.051
1.898GlnSer: 1.898 ± 0.061
2.007GlnThr: 2.007 ± 0.061
1.986GlnVal: 1.986 ± 0.054
0.396GlnTrp: 0.396 ± 0.024
1.69GlnTyr: 1.69 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.074ArgAla: 2.074 ± 0.06
0.238ArgCys: 0.238 ± 0.017
1.809ArgAsp: 1.809 ± 0.058
2.681ArgGlu: 2.681 ± 0.075
2.122ArgPhe: 2.122 ± 0.063
1.965ArgGly: 1.965 ± 0.062
0.763ArgHis: 0.763 ± 0.036
3.274ArgIle: 3.274 ± 0.069
3.441ArgLys: 3.441 ± 0.072
3.27ArgLeu: 3.27 ± 0.065
1.152ArgMet: 1.152 ± 0.043
2.757ArgAsn: 2.757 ± 0.069
1.219ArgPro: 1.219 ± 0.051
1.289ArgGln: 1.289 ± 0.043
1.636ArgArg: 1.636 ± 0.06
2.011ArgSer: 2.011 ± 0.052
2.075ArgThr: 2.075 ± 0.055
2.051ArgVal: 2.051 ± 0.052
0.391ArgTrp: 0.391 ± 0.025
1.56ArgTyr: 1.56 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.285SerAla: 4.285 ± 0.097
0.617SerCys: 0.617 ± 0.034
3.239SerAsp: 3.239 ± 0.064
4.678SerGlu: 4.678 ± 0.096
3.495SerPhe: 3.495 ± 0.065
5.079SerGly: 5.079 ± 0.115
1.156SerHis: 1.156 ± 0.045
4.194SerIle: 4.194 ± 0.077
4.18SerLys: 4.18 ± 0.078
5.65SerLeu: 5.65 ± 0.105
1.384SerMet: 1.384 ± 0.045
3.055SerAsn: 3.055 ± 0.076
2.3SerPro: 2.3 ± 0.073
2.362SerGln: 2.362 ± 0.066
2.386SerArg: 2.386 ± 0.06
3.979SerSer: 3.979 ± 0.111
3.372SerThr: 3.372 ± 0.108
4.316SerVal: 4.316 ± 0.099
0.678SerTrp: 0.678 ± 0.039
2.512SerTyr: 2.512 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.361ThrAla: 4.361 ± 0.11
0.348ThrCys: 0.348 ± 0.022
3.049ThrAsp: 3.049 ± 0.065
3.839ThrGlu: 3.839 ± 0.075
2.89ThrPhe: 2.89 ± 0.074
4.49ThrGly: 4.49 ± 0.142
1.039ThrHis: 1.039 ± 0.039
4.006ThrIle: 4.006 ± 0.085
3.41ThrLys: 3.41 ± 0.075
5.205ThrLeu: 5.205 ± 0.084
1.163ThrMet: 1.163 ± 0.041
2.696ThrAsn: 2.696 ± 0.085
2.573ThrPro: 2.573 ± 0.088
2.143ThrGln: 2.143 ± 0.063
1.723ThrArg: 1.723 ± 0.044
3.499ThrSer: 3.499 ± 0.095
3.445ThrThr: 3.445 ± 0.128
4.188ThrVal: 4.188 ± 0.104
0.51ThrTrp: 0.51 ± 0.03
2.04ThrTyr: 2.04 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
4.092ValAla: 4.092 ± 0.09
0.504ValCys: 0.504 ± 0.027
3.008ValAsp: 3.008 ± 0.076
3.781ValGlu: 3.781 ± 0.081
3.423ValPhe: 3.423 ± 0.069
3.621ValGly: 3.621 ± 0.084
1.056ValHis: 1.056 ± 0.034
4.651ValIle: 4.651 ± 0.093
4.428ValLys: 4.428 ± 0.09
5.805ValLeu: 5.805 ± 0.102
1.631ValMet: 1.631 ± 0.049
3.397ValAsn: 3.397 ± 0.068
2.473ValPro: 2.473 ± 0.07
2.177ValGln: 2.177 ± 0.055
2.146ValArg: 2.146 ± 0.064
4.418ValSer: 4.418 ± 0.068
3.438ValThr: 3.438 ± 0.097
3.843ValVal: 3.843 ± 0.081
0.594ValTrp: 0.594 ± 0.027
2.447ValTyr: 2.447 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.62TrpAla: 0.62 ± 0.031
0.093TrpCys: 0.093 ± 0.012
0.594TrpAsp: 0.594 ± 0.031
0.645TrpGlu: 0.645 ± 0.033
0.587TrpPhe: 0.587 ± 0.026
0.602TrpGly: 0.602 ± 0.032
0.185TrpHis: 0.185 ± 0.017
0.756TrpIle: 0.756 ± 0.032
0.866TrpLys: 0.866 ± 0.034
0.899TrpLeu: 0.899 ± 0.036
0.357TrpMet: 0.357 ± 0.026
0.722TrpAsn: 0.722 ± 0.033
0.212TrpPro: 0.212 ± 0.018
0.432TrpGln: 0.432 ± 0.022
0.361TrpArg: 0.361 ± 0.023
0.565TrpSer: 0.565 ± 0.029
0.518TrpThr: 0.518 ± 0.036
0.59TrpVal: 0.59 ± 0.037
0.127TrpTrp: 0.127 ± 0.015
0.395TrpTyr: 0.395 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.307TyrAla: 2.307 ± 0.05
0.318TyrCys: 0.318 ± 0.022
2.27TyrAsp: 2.27 ± 0.054
2.384TyrGlu: 2.384 ± 0.063
2.553TyrPhe: 2.553 ± 0.065
2.628TyrGly: 2.628 ± 0.06
0.917TyrHis: 0.917 ± 0.035
2.692TyrIle: 2.692 ± 0.067
2.402TyrLys: 2.402 ± 0.057
3.9TyrLeu: 3.9 ± 0.082
0.739TyrMet: 0.739 ± 0.033
2.184TyrAsn: 2.184 ± 0.067
1.527TyrPro: 1.527 ± 0.044
1.792TyrGln: 1.792 ± 0.056
1.796TyrArg: 1.796 ± 0.053
2.593TyrSer: 2.593 ± 0.067
2.197TyrThr: 2.197 ± 0.074
2.004TyrVal: 2.004 ± 0.056
0.463TyrTrp: 0.463 ± 0.026
1.895TyrTyr: 1.895 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2165 proteins (706491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski