Amino acid dipepetide frequency for Novosphingobium ginsenosidimutans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.25AlaAla: 20.25 ± 0.216	1.118AlaCys: 1.118 ± 0.039	7.126AlaAsp: 7.126 ± 0.099	8.541AlaGlu: 8.541 ± 0.12	4.194AlaPhe: 4.194 ± 0.075	11.86AlaGly: 11.86 ± 0.117	2.25AlaHis: 2.25 ± 0.051	6.539AlaIle: 6.539 ± 0.081	4.724AlaLys: 4.724 ± 0.072	14.675AlaLeu: 14.675 ± 0.152	3.906AlaMet: 3.906 ± 0.074	3.309AlaAsn: 3.309 ± 0.062	6.356AlaPro: 6.356 ± 0.095	4.711AlaGln: 4.711 ± 0.07	9.472AlaArg: 9.472 ± 0.129	6.409AlaSer: 6.409 ± 0.088	5.995AlaThr: 5.995 ± 0.087	8.787AlaVal: 8.787 ± 0.096	1.882AlaTrp: 1.882 ± 0.048	2.574AlaTyr: 2.574 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.039CysAla: 1.039 ± 0.037	0.089CysCys: 0.089 ± 0.008	0.582CysAsp: 0.582 ± 0.02	0.465CysGlu: 0.465 ± 0.022	0.3CysPhe: 0.3 ± 0.017	0.9CysGly: 0.9 ± 0.036	0.287CysHis: 0.287 ± 0.056	0.371CysIle: 0.371 ± 0.021	0.204CysLys: 0.204 ± 0.016	0.714CysLeu: 0.714 ± 0.032	0.152CysMet: 0.152 ± 0.013	0.238CysAsn: 0.238 ± 0.018	0.464CysPro: 0.464 ± 0.024	0.276CysGln: 0.276 ± 0.017	0.529CysArg: 0.529 ± 0.024	0.462CysSer: 0.462 ± 0.032	0.426CysThr: 0.426 ± 0.022	0.579CysVal: 0.579 ± 0.025	0.106CysTrp: 0.106 ± 0.01	0.202CysTyr: 0.202 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.806AspAla: 6.806 ± 0.09	0.553AspCys: 0.553 ± 0.031	2.807AspAsp: 2.807 ± 0.059	3.34AspGlu: 3.34 ± 0.068	2.168AspPhe: 2.168 ± 0.048	5.359AspGly: 5.359 ± 0.083	1.242AspHis: 1.242 ± 0.043	2.404AspIle: 2.404 ± 0.056	1.939AspLys: 1.939 ± 0.049	5.692AspLeu: 5.692 ± 0.081	1.243AspMet: 1.243 ± 0.033	1.354AspAsn: 1.354 ± 0.038	3.941AspPro: 3.941 ± 0.076	1.927AspGln: 1.927 ± 0.045	4.25AspArg: 4.25 ± 0.073	2.289AspSer: 2.289 ± 0.049	2.279AspThr: 2.279 ± 0.051	3.47AspVal: 3.47 ± 0.064	1.219AspTrp: 1.219 ± 0.04	1.511AspTyr: 1.511 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.371GluAla: 8.371 ± 0.116	0.38GluCys: 0.38 ± 0.023	2.801GluAsp: 2.801 ± 0.058	3.045GluGlu: 3.045 ± 0.064	1.755GluPhe: 1.755 ± 0.042	4.502GluGly: 4.502 ± 0.07	1.187GluHis: 1.187 ± 0.037	2.857GluIle: 2.857 ± 0.057	1.825GluLys: 1.825 ± 0.051	5.981GluLeu: 5.981 ± 0.096	1.381GluMet: 1.381 ± 0.039	1.374GluAsn: 1.374 ± 0.037	2.826GluPro: 2.826 ± 0.058	2.176GluGln: 2.176 ± 0.043	4.878GluArg: 4.878 ± 0.081	2.102GluSer: 2.102 ± 0.049	2.85GluThr: 2.85 ± 0.059	4.068GluVal: 4.068 ± 0.075	0.866GluTrp: 0.866 ± 0.034	1.027GluTyr: 1.027 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	5.114PheAla: 5.114 ± 0.077	0.336PheCys: 0.336 ± 0.016	2.551PheAsp: 2.551 ± 0.055	2.001PheGlu: 2.001 ± 0.038	1.266PhePhe: 1.266 ± 0.043	3.726PheGly: 3.726 ± 0.065	0.674PheHis: 0.674 ± 0.028	1.473PheIle: 1.473 ± 0.042	1.044PheLys: 1.044 ± 0.033	3.032PheLeu: 3.032 ± 0.056	0.767PheMet: 0.767 ± 0.029	1.088PheAsn: 1.088 ± 0.041	1.554PhePro: 1.554 ± 0.036	0.939PheGln: 0.939 ± 0.035	2.064PheArg: 2.064 ± 0.047	1.885PheSer: 1.885 ± 0.051	2.037PheThr: 2.037 ± 0.051	2.6PheVal: 2.6 ± 0.058	0.546PheTrp: 0.546 ± 0.024	0.919PheTyr: 0.919 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.8GlyAla: 9.8 ± 0.095	0.865GlyCys: 0.865 ± 0.029	4.51GlyAsp: 4.51 ± 0.066	5.018GlyGlu: 5.018 ± 0.077	3.698GlyPhe: 3.698 ± 0.063	8.128GlyGly: 8.128 ± 0.121	1.848GlyHis: 1.848 ± 0.05	4.381GlyIle: 4.381 ± 0.079	3.821GlyLys: 3.821 ± 0.073	9.195GlyLeu: 9.195 ± 0.1	2.494GlyMet: 2.494 ± 0.055	2.384GlyAsn: 2.384 ± 0.057	3.991GlyPro: 3.991 ± 0.056	3.477GlyGln: 3.477 ± 0.061	5.917GlyArg: 5.917 ± 0.087	4.867GlySer: 4.867 ± 0.092	5.102GlyThr: 5.102 ± 0.105	6.178GlyVal: 6.178 ± 0.075	1.789GlyTrp: 1.789 ± 0.047	2.38GlyTyr: 2.38 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.395HisAla: 2.395 ± 0.069	0.257HisCys: 0.257 ± 0.017	1.139HisAsp: 1.139 ± 0.04	0.997HisGlu: 0.997 ± 0.036	0.917HisPhe: 0.917 ± 0.032	1.986HisGly: 1.986 ± 0.045	0.558HisHis: 0.558 ± 0.026	0.823HisIle: 0.823 ± 0.034	0.465HisLys: 0.465 ± 0.023	1.906HisLeu: 1.906 ± 0.043	0.43HisMet: 0.43 ± 0.023	0.489HisAsn: 0.489 ± 0.031	1.31HisPro: 1.31 ± 0.034	0.58HisGln: 0.58 ± 0.024	1.437HisArg: 1.437 ± 0.043	0.958HisSer: 0.958 ± 0.03	0.794HisThr: 0.794 ± 0.033	1.389HisVal: 1.389 ± 0.041	0.352HisTrp: 0.352 ± 0.022	0.595HisTyr: 0.595 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.468IleAla: 7.468 ± 0.098	0.433IleCys: 0.433 ± 0.022	3.637IleAsp: 3.637 ± 0.072	3.559IleGlu: 3.559 ± 0.07	1.386IlePhe: 1.386 ± 0.04	4.861IleGly: 4.861 ± 0.072	0.912IleHis: 0.912 ± 0.027	1.804IleIle: 1.804 ± 0.043	1.451IleLys: 1.451 ± 0.04	3.559IleLeu: 3.559 ± 0.071	0.925IleMet: 0.925 ± 0.029	1.31IleAsn: 1.31 ± 0.038	2.208IlePro: 2.208 ± 0.05	1.138IleGln: 1.138 ± 0.039	2.881IleArg: 2.881 ± 0.054	2.514IleSer: 2.514 ± 0.053	2.533IleThr: 2.533 ± 0.053	3.556IleVal: 3.556 ± 0.069	0.575IleTrp: 0.575 ± 0.023	0.966IleTyr: 0.966 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.571LysAla: 4.571 ± 0.074	0.191LysCys: 0.191 ± 0.015	1.651LysAsp: 1.651 ± 0.042	1.396LysGlu: 1.396 ± 0.044	0.985LysPhe: 0.985 ± 0.031	2.926LysGly: 2.926 ± 0.062	0.614LysHis: 0.614 ± 0.025	1.492LysIle: 1.492 ± 0.041	1.089LysLys: 1.089 ± 0.04	3.731LysLeu: 3.731 ± 0.056	0.752LysMet: 0.752 ± 0.029	0.782LysAsn: 0.782 ± 0.032	2.201LysPro: 2.201 ± 0.057	1.024LysGln: 1.024 ± 0.038	2.269LysArg: 2.269 ± 0.055	1.544LysSer: 1.544 ± 0.037	1.637LysThr: 1.637 ± 0.045	2.652LysVal: 2.652 ± 0.062	0.43LysTrp: 0.43 ± 0.021	0.621LysTyr: 0.621 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.996LeuAla: 15.996 ± 0.161	0.76LeuCys: 0.76 ± 0.031	5.917LeuAsp: 5.917 ± 0.086	5.208LeuGlu: 5.208 ± 0.075	3.567LeuPhe: 3.567 ± 0.07	8.895LeuGly: 8.895 ± 0.111	1.878LeuHis: 1.878 ± 0.044	4.672LeuIle: 4.672 ± 0.07	3.33LeuLys: 3.33 ± 0.072	10.147LeuLeu: 10.147 ± 0.159	2.06LeuMet: 2.06 ± 0.049	2.431LeuAsn: 2.431 ± 0.05	5.977LeuPro: 5.977 ± 0.085	2.606LeuGln: 2.606 ± 0.049	6.92LeuArg: 6.92 ± 0.097	5.706LeuSer: 5.706 ± 0.09	5.718LeuThr: 5.718 ± 0.067	7.814LeuVal: 7.814 ± 0.102	1.293LeuTrp: 1.293 ± 0.044	1.934LeuTyr: 1.934 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.321MetAla: 3.321 ± 0.06	0.143MetCys: 0.143 ± 0.011	1.155MetAsp: 1.155 ± 0.035	1.073MetGlu: 1.073 ± 0.038	0.629MetPhe: 0.629 ± 0.026	2.01MetGly: 2.01 ± 0.05	0.465MetHis: 0.465 ± 0.025	1.199MetIle: 1.199 ± 0.033	0.894MetLys: 0.894 ± 0.031	2.545MetLeu: 2.545 ± 0.063	0.6MetMet: 0.6 ± 0.027	0.667MetAsn: 0.667 ± 0.029	1.445MetPro: 1.445 ± 0.036	0.771MetGln: 0.771 ± 0.03	1.668MetArg: 1.668 ± 0.036	1.421MetSer: 1.421 ± 0.035	1.634MetThr: 1.634 ± 0.045	1.675MetVal: 1.675 ± 0.045	0.248MetTrp: 0.248 ± 0.015	0.266MetTyr: 0.266 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.278AsnAla: 3.278 ± 0.061	0.283AsnCys: 0.283 ± 0.021	1.306AsnAsp: 1.306 ± 0.04	1.155AsnGlu: 1.155 ± 0.037	0.986AsnPhe: 0.986 ± 0.038	2.418AsnGly: 2.418 ± 0.062	0.503AsnHis: 0.503 ± 0.026	1.188AsnIle: 1.188 ± 0.039	0.698AsnLys: 0.698 ± 0.031	2.641AsnLeu: 2.641 ± 0.059	0.564AsnMet: 0.564 ± 0.024	0.674AsnAsn: 0.674 ± 0.031	1.917AsnPro: 1.917 ± 0.045	0.873AsnGln: 0.873 ± 0.033	1.944AsnArg: 1.944 ± 0.046	1.243AsnSer: 1.243 ± 0.047	1.216AsnThr: 1.216 ± 0.042	1.77AsnVal: 1.77 ± 0.041	0.431AsnTrp: 0.431 ± 0.021	0.722AsnTyr: 0.722 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	7.507ProAla: 7.507 ± 0.116	0.342ProCys: 0.342 ± 0.019	3.688ProAsp: 3.688 ± 0.064	3.832ProGlu: 3.832 ± 0.061	1.92ProPhe: 1.92 ± 0.041	5.122ProGly: 5.122 ± 0.085	1.029ProHis: 1.029 ± 0.036	2.357ProIle: 2.357 ± 0.052	1.749ProLys: 1.749 ± 0.047	5.279ProLeu: 5.279 ± 0.081	1.154ProMet: 1.154 ± 0.038	1.348ProAsn: 1.348 ± 0.035	2.771ProPro: 2.771 ± 0.078	1.938ProGln: 1.938 ± 0.045	3.162ProArg: 3.162 ± 0.057	2.509ProSer: 2.509 ± 0.056	2.416ProThr: 2.416 ± 0.058	4.49ProVal: 4.49 ± 0.074	0.734ProTrp: 0.734 ± 0.025	1.123ProTyr: 1.123 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.529GlnAla: 4.529 ± 0.076	0.253GlnCys: 0.253 ± 0.017	1.519GlnAsp: 1.519 ± 0.045	1.395GlnGlu: 1.395 ± 0.042	1.232GlnPhe: 1.232 ± 0.036	2.737GlnGly: 2.737 ± 0.049	0.718GlnHis: 0.718 ± 0.025	1.694GlnIle: 1.694 ± 0.042	0.881GlnLys: 0.881 ± 0.031	3.571GlnLeu: 3.571 ± 0.073	0.799GlnMet: 0.799 ± 0.028	0.754GlnAsn: 0.754 ± 0.031	2.015GlnPro: 2.015 ± 0.049	1.25GlnGln: 1.25 ± 0.037	2.593GlnArg: 2.593 ± 0.059	1.684GlnSer: 1.684 ± 0.043	1.626GlnThr: 1.626 ± 0.042	2.678GlnVal: 2.678 ± 0.05	0.498GlnTrp: 0.498 ± 0.023	0.589GlnTyr: 0.589 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.329ArgAla: 8.329 ± 0.108	0.529ArgCys: 0.529 ± 0.024	3.874ArgAsp: 3.874 ± 0.066	4.085ArgGlu: 4.085 ± 0.076	2.987ArgPhe: 2.987 ± 0.062	5.005ArgGly: 5.005 ± 0.076	1.554ArgHis: 1.554 ± 0.043	3.895ArgIle: 3.895 ± 0.068	2.301ArgLys: 2.301 ± 0.052	8.049ArgLeu: 8.049 ± 0.126	1.874ArgMet: 1.874 ± 0.046	1.818ArgAsn: 1.818 ± 0.044	3.534ArgPro: 3.534 ± 0.059	2.68ArgGln: 2.68 ± 0.052	5.284ArgArg: 5.284 ± 0.107	3.467ArgSer: 3.467 ± 0.058	3.248ArgThr: 3.248 ± 0.063	4.47ArgVal: 4.47 ± 0.072	1.198ArgTrp: 1.198 ± 0.04	1.768ArgTyr: 1.768 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.186SerAla: 6.186 ± 0.079	0.417SerCys: 0.417 ± 0.041	2.717SerAsp: 2.717 ± 0.049	2.671SerGlu: 2.671 ± 0.053	2.104SerPhe: 2.104 ± 0.047	5.281SerGly: 5.281 ± 0.1	0.959SerHis: 0.959 ± 0.033	2.399SerIle: 2.399 ± 0.055	1.481SerLys: 1.481 ± 0.04	5.19SerLeu: 5.19 ± 0.075	1.077SerMet: 1.077 ± 0.032	1.359SerAsn: 1.359 ± 0.04	2.826SerPro: 2.826 ± 0.06	1.61SerGln: 1.61 ± 0.041	3.413SerArg: 3.413 ± 0.056	2.543SerSer: 2.543 ± 0.074	2.5SerThr: 2.5 ± 0.071	3.4SerVal: 3.4 ± 0.063	0.747SerTrp: 0.747 ± 0.03	1.29SerTyr: 1.29 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.398ThrAla: 6.398 ± 0.093	0.441ThrCys: 0.441 ± 0.029	2.625ThrAsp: 2.625 ± 0.05	2.482ThrGlu: 2.482 ± 0.05	1.798ThrPhe: 1.798 ± 0.048	5.371ThrGly: 5.371 ± 0.081	0.883ThrHis: 0.883 ± 0.031	2.753ThrIle: 2.753 ± 0.053	1.409ThrLys: 1.409 ± 0.043	5.382ThrLeu: 5.382 ± 0.077	1.162ThrMet: 1.162 ± 0.032	1.33ThrAsn: 1.33 ± 0.051	3.118ThrPro: 3.118 ± 0.057	1.421ThrGln: 1.421 ± 0.04	3.345ThrArg: 3.345 ± 0.068	2.575ThrSer: 2.575 ± 0.07	2.624ThrThr: 2.624 ± 0.072	4.052ThrVal: 4.052 ± 0.065	0.682ThrTrp: 0.682 ± 0.026	1.086ThrTyr: 1.086 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.115ValAla: 9.115 ± 0.113	0.598ValCys: 0.598 ± 0.025	3.983ValAsp: 3.983 ± 0.065	4.282ValGlu: 4.282 ± 0.071	2.247ValPhe: 2.247 ± 0.048	5.566ValGly: 5.566 ± 0.086	1.32ValHis: 1.32 ± 0.039	3.849ValIle: 3.849 ± 0.068	2.181ValLys: 2.181 ± 0.052	7.356ValLeu: 7.356 ± 0.098	1.682ValMet: 1.682 ± 0.038	2.007ValAsn: 2.007 ± 0.048	4.134ValPro: 4.134 ± 0.07	2.123ValGln: 2.123 ± 0.048	4.789ValArg: 4.789 ± 0.074	3.941ValSer: 3.941 ± 0.067	4.448ValThr: 4.448 ± 0.069	5.38ValVal: 5.38 ± 0.086	0.992ValTrp: 0.992 ± 0.037	1.346ValTyr: 1.346 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.045	0.145TrpCys: 0.145 ± 0.011	0.779TrpAsp: 0.779 ± 0.029	0.639TrpGlu: 0.639 ± 0.021	0.614TrpPhe: 0.614 ± 0.024	1.058TrpGly: 1.058 ± 0.032	0.392TrpHis: 0.392 ± 0.019	0.716TrpIle: 0.716 ± 0.032	0.457TrpLys: 0.457 ± 0.022	2.031TrpLeu: 2.031 ± 0.058	0.37TrpMet: 0.37 ± 0.018	0.451TrpAsn: 0.451 ± 0.025	0.77TrpPro: 0.77 ± 0.028	0.778TrpGln: 0.778 ± 0.031	1.323TrpArg: 1.323 ± 0.041	0.884TrpSer: 0.884 ± 0.032	0.835TrpThr: 0.835 ± 0.029	0.898TrpVal: 0.898 ± 0.036	0.29TrpTrp: 0.29 ± 0.02	0.3TrpTyr: 0.3 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.682TyrAla: 2.682 ± 0.057	0.249TyrCys: 0.249 ± 0.015	1.426TyrAsp: 1.426 ± 0.04	1.069TyrGlu: 1.069 ± 0.033	0.862TyrPhe: 0.862 ± 0.035	2.131TyrGly: 2.131 ± 0.045	0.506TyrHis: 0.506 ± 0.025	0.815TyrIle: 0.815 ± 0.034	0.617TyrLys: 0.617 ± 0.028	2.155TyrLeu: 2.155 ± 0.055	0.432TyrMet: 0.432 ± 0.022	0.641TyrAsn: 0.641 ± 0.032	1.114TyrPro: 1.114 ± 0.037	0.719TyrGln: 0.719 ± 0.031	1.81TyrArg: 1.81 ± 0.052	1.166TyrSer: 1.166 ± 0.035	1.019TyrThr: 1.019 ± 0.035	1.431TyrVal: 1.431 ± 0.035	0.374TyrTrp: 0.374 ± 0.021	0.594TyrTyr: 0.594 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2985 proteins (950983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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