Amino acid dipepetide frequency for Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.058AlaAla: 5.058 ± 0.127
0.85AlaCys: 0.85 ± 0.051
3.764AlaAsp: 3.764 ± 0.095
3.869AlaGlu: 3.869 ± 0.11
3.076AlaPhe: 3.076 ± 0.105
4.398AlaGly: 4.398 ± 0.092
1.094AlaHis: 1.094 ± 0.05
6.924AlaIle: 6.924 ± 0.14
6.45AlaLys: 6.45 ± 0.152
6.762AlaLeu: 6.762 ± 0.128
1.83AlaMet: 1.83 ± 0.068
4.093AlaAsn: 4.093 ± 0.105
1.788AlaPro: 1.788 ± 0.077
2.593AlaGln: 2.593 ± 0.079
2.425AlaArg: 2.425 ± 0.084
3.865AlaSer: 3.865 ± 0.09
3.953AlaThr: 3.953 ± 0.087
4.419AlaVal: 4.419 ± 0.1
0.639AlaTrp: 0.639 ± 0.038
2.568AlaTyr: 2.568 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.038
0.131CysCys: 0.131 ± 0.015
0.715CysAsp: 0.715 ± 0.047
0.542CysGlu: 0.542 ± 0.035
0.633CysPhe: 0.633 ± 0.034
0.93CysGly: 0.93 ± 0.049
0.234CysHis: 0.234 ± 0.023
1.021CysIle: 1.021 ± 0.047
0.666CysLys: 0.666 ± 0.041
1.092CysLeu: 1.092 ± 0.052
0.242CysMet: 0.242 ± 0.024
0.544CysAsn: 0.544 ± 0.033
0.38CysPro: 0.38 ± 0.026
0.392CysGln: 0.392 ± 0.031
0.304CysArg: 0.304 ± 0.023
0.751CysSer: 0.751 ± 0.036
0.445CysThr: 0.445 ± 0.031
0.696CysVal: 0.696 ± 0.039
0.114CysTrp: 0.114 ± 0.018
0.474CysTyr: 0.474 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
3.14AspAla: 3.14 ± 0.088
0.523AspCys: 0.523 ± 0.033
2.971AspAsp: 2.971 ± 0.089
3.308AspGlu: 3.308 ± 0.096
3.032AspPhe: 3.032 ± 0.087
3.137AspGly: 3.137 ± 0.097
0.793AspHis: 0.793 ± 0.043
5.857AspIle: 5.857 ± 0.114
5.282AspLys: 5.282 ± 0.103
4.951AspLeu: 4.951 ± 0.092
1.172AspMet: 1.172 ± 0.051
3.648AspAsn: 3.648 ± 0.094
1.579AspPro: 1.579 ± 0.06
1.579AspGln: 1.579 ± 0.054
1.877AspArg: 1.877 ± 0.075
3.77AspSer: 3.77 ± 0.093
2.695AspThr: 2.695 ± 0.071
3.277AspVal: 3.277 ± 0.085
0.533AspTrp: 0.533 ± 0.033
2.665AspTyr: 2.665 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
3.705GluAla: 3.705 ± 0.098
0.512GluCys: 0.512 ± 0.032
2.838GluAsp: 2.838 ± 0.088
3.133GluGlu: 3.133 ± 0.097
2.69GluPhe: 2.69 ± 0.074
2.452GluGly: 2.452 ± 0.075
1.117GluHis: 1.117 ± 0.05
5.33GluIle: 5.33 ± 0.113
4.995GluLys: 4.995 ± 0.12
5.855GluLeu: 5.855 ± 0.127
1.356GluMet: 1.356 ± 0.06
3.631GluAsn: 3.631 ± 0.096
1.297GluPro: 1.297 ± 0.056
2.541GluGln: 2.541 ± 0.078
1.79GluArg: 1.79 ± 0.077
3.074GluSer: 3.074 ± 0.082
2.486GluThr: 2.486 ± 0.071
3.553GluVal: 3.553 ± 0.108
0.46GluTrp: 0.46 ± 0.034
2.583GluTyr: 2.583 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
3.713PheAla: 3.713 ± 0.09
0.725PheCys: 0.725 ± 0.039
3.188PheAsp: 3.188 ± 0.088
2.901PheGlu: 2.901 ± 0.088
2.676PhePhe: 2.676 ± 0.101
3.228PheGly: 3.228 ± 0.101
0.647PheHis: 0.647 ± 0.042
4.987PheIle: 4.987 ± 0.148
3.203PheLys: 3.203 ± 0.087
4.493PheLeu: 4.493 ± 0.135
1.099PheMet: 1.099 ± 0.051
2.562PheAsn: 2.562 ± 0.082
1.274PhePro: 1.274 ± 0.058
1.067PheGln: 1.067 ± 0.052
1.432PheArg: 1.432 ± 0.051
3.909PheSer: 3.909 ± 0.113
2.359PheThr: 2.359 ± 0.079
3.239PheVal: 3.239 ± 0.104
0.468PheTrp: 0.468 ± 0.04
1.94PheTyr: 1.94 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
4.057GlyAla: 4.057 ± 0.112
0.738GlyCys: 0.738 ± 0.043
3.083GlyAsp: 3.083 ± 0.085
2.935GlyGlu: 2.935 ± 0.083
3.471GlyPhe: 3.471 ± 0.107
4.082GlyGly: 4.082 ± 0.127
1.056GlyHis: 1.056 ± 0.057
5.347GlyIle: 5.347 ± 0.115
4.219GlyLys: 4.219 ± 0.097
5.535GlyLeu: 5.535 ± 0.123
1.634GlyMet: 1.634 ± 0.057
2.57GlyAsn: 2.57 ± 0.084
1.158GlyPro: 1.158 ± 0.058
1.849GlyGln: 1.849 ± 0.071
2.037GlyArg: 2.037 ± 0.077
3.705GlySer: 3.705 ± 0.101
2.861GlyThr: 2.861 ± 0.079
4.337GlyVal: 4.337 ± 0.106
0.696GlyTrp: 0.696 ± 0.039
2.699GlyTyr: 2.699 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.025HisAla: 1.025 ± 0.047
0.205HisCys: 0.205 ± 0.023
0.867HisAsp: 0.867 ± 0.042
0.746HisGlu: 0.746 ± 0.043
0.905HisPhe: 0.905 ± 0.047
1.145HisGly: 1.145 ± 0.052
0.468HisHis: 0.468 ± 0.034
1.676HisIle: 1.676 ± 0.058
1.356HisLys: 1.356 ± 0.052
1.518HisLeu: 1.518 ± 0.053
0.346HisMet: 0.346 ± 0.023
1.206HisAsn: 1.206 ± 0.059
0.818HisPro: 0.818 ± 0.04
0.789HisGln: 0.789 ± 0.044
0.725HisArg: 0.725 ± 0.041
1.044HisSer: 1.044 ± 0.052
0.936HisThr: 0.936 ± 0.048
0.829HisVal: 0.829 ± 0.04
0.179HisTrp: 0.179 ± 0.019
0.742HisTyr: 0.742 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
7.021IleAla: 7.021 ± 0.115
1.155IleCys: 1.155 ± 0.054
5.672IleAsp: 5.672 ± 0.113
5.121IleGlu: 5.121 ± 0.109
4.824IlePhe: 4.824 ± 0.141
5.286IleGly: 5.286 ± 0.136
1.48IleHis: 1.48 ± 0.061
8.347IleIle: 8.347 ± 0.199
7.137IleLys: 7.137 ± 0.123
8.794IleLeu: 8.794 ± 0.158
1.961IleMet: 1.961 ± 0.068
5.442IleAsn: 5.442 ± 0.114
3.102IlePro: 3.102 ± 0.075
2.693IleGln: 2.693 ± 0.066
2.844IleArg: 2.844 ± 0.07
6.945IleSer: 6.945 ± 0.136
5.149IleThr: 5.149 ± 0.114
5.855IleVal: 5.855 ± 0.139
0.696IleTrp: 0.696 ± 0.037
3.416IleTyr: 3.416 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
5.267LysAla: 5.267 ± 0.119
0.597LysCys: 0.597 ± 0.042
5.052LysAsp: 5.052 ± 0.11
5.056LysGlu: 5.056 ± 0.11
3.097LysPhe: 3.097 ± 0.082
3.671LysGly: 3.671 ± 0.099
1.491LysHis: 1.491 ± 0.063
6.956LysIle: 6.956 ± 0.12
6.724LysLys: 6.724 ± 0.154
7.647LysLeu: 7.647 ± 0.147
1.818LysMet: 1.818 ± 0.063
4.961LysAsn: 4.961 ± 0.124
2.376LysPro: 2.376 ± 0.08
3.681LysGln: 3.681 ± 0.102
2.534LysArg: 2.534 ± 0.067
4.725LysSer: 4.725 ± 0.119
4.078LysThr: 4.078 ± 0.093
5.168LysVal: 5.168 ± 0.113
0.546LysTrp: 0.546 ± 0.034
3.757LysTyr: 3.757 ± 0.093
0.0LysXaa: 0.0 ± 0.0
Leu
8.0LeuAla: 8.0 ± 0.136
1.151LeuCys: 1.151 ± 0.051
5.651LeuAsp: 5.651 ± 0.122
6.414LeuGlu: 6.414 ± 0.133
4.337LeuPhe: 4.337 ± 0.126
6.06LeuGly: 6.06 ± 0.134
1.505LeuHis: 1.505 ± 0.056
7.919LeuIle: 7.919 ± 0.181
7.207LeuLys: 7.207 ± 0.146
9.241LeuLeu: 9.241 ± 0.19
2.205LeuMet: 2.205 ± 0.076
5.174LeuAsn: 5.174 ± 0.105
3.502LeuPro: 3.502 ± 0.074
3.057LeuGln: 3.057 ± 0.092
3.196LeuArg: 3.196 ± 0.094
7.16LeuSer: 7.16 ± 0.137
4.698LeuThr: 4.698 ± 0.101
6.349LeuVal: 6.349 ± 0.121
0.736LeuTrp: 0.736 ± 0.045
3.312LeuTyr: 3.312 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
1.638MetAla: 1.638 ± 0.06
0.228MetCys: 0.228 ± 0.022
0.959MetAsp: 0.959 ± 0.051
0.854MetGlu: 0.854 ± 0.048
1.214MetPhe: 1.214 ± 0.062
1.432MetGly: 1.432 ± 0.061
0.401MetHis: 0.401 ± 0.03
2.056MetIle: 2.056 ± 0.064
1.64MetLys: 1.64 ± 0.059
2.558MetLeu: 2.558 ± 0.083
0.7MetMet: 0.7 ± 0.041
1.162MetAsn: 1.162 ± 0.047
1.004MetPro: 1.004 ± 0.049
1.054MetGln: 1.054 ± 0.044
0.829MetArg: 0.829 ± 0.045
1.877MetSer: 1.877 ± 0.055
1.292MetThr: 1.292 ± 0.051
1.398MetVal: 1.398 ± 0.053
0.196MetTrp: 0.196 ± 0.023
0.801MetTyr: 0.801 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.38AsnAla: 3.38 ± 0.076
0.544AsnCys: 0.544 ± 0.034
2.929AsnAsp: 2.929 ± 0.079
2.45AsnGlu: 2.45 ± 0.067
2.851AsnPhe: 2.851 ± 0.073
2.842AsnGly: 2.842 ± 0.096
1.181AsnHis: 1.181 ± 0.049
6.709AsnIle: 6.709 ± 0.124
4.668AsnLys: 4.668 ± 0.108
5.455AsnLeu: 5.455 ± 0.121
1.271AsnMet: 1.271 ± 0.047
4.052AsnAsn: 4.052 ± 0.115
2.288AsnPro: 2.288 ± 0.067
2.364AsnGln: 2.364 ± 0.08
1.706AsnArg: 1.706 ± 0.061
3.977AsnSer: 3.977 ± 0.104
2.975AsnThr: 2.975 ± 0.084
3.192AsnVal: 3.192 ± 0.081
0.546AsnTrp: 0.546 ± 0.038
2.728AsnTyr: 2.728 ± 0.087
0.0AsnXaa: 0.0 ± 0.0
Pro
2.064ProAla: 2.064 ± 0.073
0.302ProCys: 0.302 ± 0.025
1.594ProAsp: 1.594 ± 0.062
2.132ProGlu: 2.132 ± 0.077
1.531ProPhe: 1.531 ± 0.059
1.465ProGly: 1.465 ± 0.066
0.597ProHis: 0.597 ± 0.033
2.714ProIle: 2.714 ± 0.082
2.229ProLys: 2.229 ± 0.074
2.781ProLeu: 2.781 ± 0.085
0.708ProMet: 0.708 ± 0.035
1.974ProAsn: 1.974 ± 0.072
0.685ProPro: 0.685 ± 0.037
1.33ProGln: 1.33 ± 0.053
0.989ProArg: 0.989 ± 0.048
1.961ProSer: 1.961 ± 0.062
1.832ProThr: 1.832 ± 0.064
2.149ProVal: 2.149 ± 0.067
0.278ProTrp: 0.278 ± 0.027
1.318ProTyr: 1.318 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.085GlnAla: 3.085 ± 0.096
0.242GlnCys: 0.242 ± 0.028
1.986GlnAsp: 1.986 ± 0.066
2.343GlnGlu: 2.343 ± 0.068
1.305GlnPhe: 1.305 ± 0.053
2.071GlnGly: 2.071 ± 0.062
0.681GlnHis: 0.681 ± 0.034
3.144GlnIle: 3.144 ± 0.087
3.281GlnLys: 3.281 ± 0.087
3.544GlnLeu: 3.544 ± 0.109
0.871GlnMet: 0.871 ± 0.043
2.38GlnAsn: 2.38 ± 0.074
1.029GlnPro: 1.029 ± 0.053
2.598GlnGln: 2.598 ± 0.107
1.377GlnArg: 1.377 ± 0.066
2.058GlnSer: 2.058 ± 0.065
1.851GlnThr: 1.851 ± 0.069
2.153GlnVal: 2.153 ± 0.064
0.337GlnTrp: 0.337 ± 0.029
1.4GlnTyr: 1.4 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.332ArgAla: 2.332 ± 0.074
0.308ArgCys: 0.308 ± 0.025
1.923ArgAsp: 1.923 ± 0.068
2.151ArgGlu: 2.151 ± 0.067
1.651ArgPhe: 1.651 ± 0.054
1.758ArgGly: 1.758 ± 0.062
0.614ArgHis: 0.614 ± 0.039
2.752ArgIle: 2.752 ± 0.089
2.695ArgLys: 2.695 ± 0.081
3.102ArgLeu: 3.102 ± 0.09
0.841ArgMet: 0.841 ± 0.041
1.961ArgAsn: 1.961 ± 0.062
0.942ArgPro: 0.942 ± 0.047
1.356ArgGln: 1.356 ± 0.06
1.316ArgArg: 1.316 ± 0.061
1.83ArgSer: 1.83 ± 0.067
1.347ArgThr: 1.347 ± 0.062
2.324ArgVal: 2.324 ± 0.084
0.272ArgTrp: 0.272 ± 0.028
1.497ArgTyr: 1.497 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.105SerAla: 4.105 ± 0.097
0.818SerCys: 0.818 ± 0.042
3.359SerAsp: 3.359 ± 0.074
3.348SerGlu: 3.348 ± 0.095
3.759SerPhe: 3.759 ± 0.106
4.082SerGly: 4.082 ± 0.104
1.263SerHis: 1.263 ± 0.055
6.085SerIle: 6.085 ± 0.142
5.065SerLys: 5.065 ± 0.112
7.31SerLeu: 7.31 ± 0.128
1.535SerMet: 1.535 ± 0.061
3.565SerAsn: 3.565 ± 0.101
2.043SerPro: 2.043 ± 0.064
2.927SerGln: 2.927 ± 0.089
2.09SerArg: 2.09 ± 0.065
4.746SerSer: 4.746 ± 0.124
3.209SerThr: 3.209 ± 0.078
3.907SerVal: 3.907 ± 0.115
0.626SerTrp: 0.626 ± 0.038
2.874SerTyr: 2.874 ± 0.09
0.0SerXaa: 0.0 ± 0.0
Thr
3.662ThrAla: 3.662 ± 0.09
0.477ThrCys: 0.477 ± 0.031
2.669ThrAsp: 2.669 ± 0.085
2.319ThrGlu: 2.319 ± 0.081
2.235ThrPhe: 2.235 ± 0.074
3.243ThrGly: 3.243 ± 0.095
0.926ThrHis: 0.926 ± 0.045
4.816ThrIle: 4.816 ± 0.102
4.175ThrLys: 4.175 ± 0.096
5.052ThrLeu: 5.052 ± 0.118
1.021ThrMet: 1.021 ± 0.047
3.055ThrAsn: 3.055 ± 0.083
1.885ThrPro: 1.885 ± 0.057
1.993ThrGln: 1.993 ± 0.068
1.6ThrArg: 1.6 ± 0.059
3.475ThrSer: 3.475 ± 0.079
3.123ThrThr: 3.123 ± 0.087
3.196ThrVal: 3.196 ± 0.076
0.432ThrTrp: 0.432 ± 0.031
1.765ThrTyr: 1.765 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.25ValAla: 5.25 ± 0.123
0.877ValCys: 0.877 ± 0.044
3.764ValAsp: 3.764 ± 0.097
3.684ValGlu: 3.684 ± 0.104
3.218ValPhe: 3.218 ± 0.104
3.909ValGly: 3.909 ± 0.101
0.873ValHis: 0.873 ± 0.049
5.775ValIle: 5.775 ± 0.122
4.525ValLys: 4.525 ± 0.108
5.883ValLeu: 5.883 ± 0.127
1.6ValMet: 1.6 ± 0.061
3.152ValAsn: 3.152 ± 0.079
1.858ValPro: 1.858 ± 0.074
1.444ValGln: 1.444 ± 0.045
2.087ValArg: 2.087 ± 0.085
4.424ValSer: 4.424 ± 0.108
3.441ValThr: 3.441 ± 0.084
4.776ValVal: 4.776 ± 0.129
0.487ValTrp: 0.487 ± 0.033
2.399ValTyr: 2.399 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.504TrpAla: 0.504 ± 0.033
0.108TrpCys: 0.108 ± 0.015
0.449TrpAsp: 0.449 ± 0.031
0.299TrpGlu: 0.299 ± 0.024
0.533TrpPhe: 0.533 ± 0.038
0.592TrpGly: 0.592 ± 0.041
0.234TrpHis: 0.234 ± 0.025
0.78TrpIle: 0.78 ± 0.045
0.455TrpLys: 0.455 ± 0.037
1.151TrpLeu: 1.151 ± 0.06
0.24TrpMet: 0.24 ± 0.021
0.426TrpAsn: 0.426 ± 0.033
0.205TrpPro: 0.205 ± 0.024
0.62TrpGln: 0.62 ± 0.041
0.333TrpArg: 0.333 ± 0.028
0.578TrpSer: 0.578 ± 0.038
0.308TrpThr: 0.308 ± 0.025
0.498TrpVal: 0.498 ± 0.035
0.11TrpTrp: 0.11 ± 0.014
0.32TrpTyr: 0.32 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.752TyrAla: 2.752 ± 0.079
0.477TyrCys: 0.477 ± 0.036
2.357TyrAsp: 2.357 ± 0.078
1.792TyrGlu: 1.792 ± 0.072
2.071TyrPhe: 2.071 ± 0.079
2.283TyrGly: 2.283 ± 0.08
0.869TyrHis: 0.869 ± 0.045
3.747TyrIle: 3.747 ± 0.106
3.232TyrLys: 3.232 ± 0.092
4.154TyrLeu: 4.154 ± 0.104
0.839TyrMet: 0.839 ± 0.042
2.549TyrAsn: 2.549 ± 0.075
1.421TyrPro: 1.421 ± 0.048
1.809TyrGln: 1.809 ± 0.063
1.48TyrArg: 1.48 ± 0.054
2.844TyrSer: 2.844 ± 0.085
2.079TyrThr: 2.079 ± 0.067
2.113TyrVal: 2.113 ± 0.066
0.392TyrTrp: 0.392 ± 0.032
1.708TyrTyr: 1.708 ± 0.072
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1528 proteins (474277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski