Amino acid dipepetide frequency for Pithovirus sibericum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.867AlaAla: 2.867 ± 0.194
0.939AlaCys: 0.939 ± 0.082
2.009AlaAsp: 2.009 ± 0.155
3.158AlaGlu: 3.158 ± 0.152
2.511AlaPhe: 2.511 ± 0.126
2.453AlaGly: 2.453 ± 0.191
0.771AlaHis: 0.771 ± 0.075
3.399AlaIle: 3.399 ± 0.152
2.343AlaLys: 2.343 ± 0.122
4.847AlaLeu: 4.847 ± 0.185
0.866AlaMet: 0.866 ± 0.079
1.768AlaAsn: 1.768 ± 0.113
1.688AlaPro: 1.688 ± 0.15
2.125AlaGln: 2.125 ± 0.133
2.351AlaArg: 2.351 ± 0.148
4.075AlaSer: 4.075 ± 0.209
2.758AlaThr: 2.758 ± 0.26
2.955AlaVal: 2.955 ± 0.164
0.444AlaTrp: 0.444 ± 0.053
1.987AlaTyr: 1.987 ± 0.109
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.076
0.546CysCys: 0.546 ± 0.064
1.208CysAsp: 1.208 ± 0.116
1.106CysGlu: 1.106 ± 0.098
1.288CysPhe: 1.288 ± 0.097
1.237CysGly: 1.237 ± 0.117
0.502CysHis: 0.502 ± 0.058
0.844CysIle: 0.844 ± 0.095
1.063CysLys: 1.063 ± 0.128
2.438CysLeu: 2.438 ± 0.163
0.269CysMet: 0.269 ± 0.042
0.881CysAsn: 0.881 ± 0.076
1.295CysPro: 1.295 ± 0.128
1.077CysGln: 1.077 ± 0.089
1.244CysArg: 1.244 ± 0.107
2.707CysSer: 2.707 ± 0.179
0.793CysThr: 0.793 ± 0.112
0.939CysVal: 0.939 ± 0.088
0.291CysTrp: 0.291 ± 0.04
0.655CysTyr: 0.655 ± 0.073
0.0CysXaa: 0.0 ± 0.0
Asp
1.681AspAla: 1.681 ± 0.115
1.368AspCys: 1.368 ± 0.12
2.278AspAsp: 2.278 ± 0.129
4.105AspGlu: 4.105 ± 0.182
3.661AspPhe: 3.661 ± 0.17
2.845AspGly: 2.845 ± 0.443
0.699AspHis: 0.699 ± 0.068
2.947AspIle: 2.947 ± 0.142
2.554AspLys: 2.554 ± 0.142
5.618AspLeu: 5.618 ± 0.232
0.691AspMet: 0.691 ± 0.064
1.819AspAsn: 1.819 ± 0.117
2.132AspPro: 2.132 ± 0.131
2.067AspGln: 2.067 ± 0.121
2.343AspArg: 2.343 ± 0.124
3.624AspSer: 3.624 ± 0.162
1.455AspThr: 1.455 ± 0.115
2.693AspVal: 2.693 ± 0.147
1.026AspTrp: 1.026 ± 0.099
2.096AspTyr: 2.096 ± 0.123
0.0AspXaa: 0.0 ± 0.0
Glu
3.712GluAla: 3.712 ± 0.166
0.975GluCys: 0.975 ± 0.078
3.646GluAsp: 3.646 ± 0.148
6.433GluGlu: 6.433 ± 0.239
4.243GluPhe: 4.243 ± 0.226
4.359GluGly: 4.359 ± 0.185
0.924GluHis: 0.924 ± 0.078
6.972GluIle: 6.972 ± 0.262
6.797GluLys: 6.797 ± 0.311
6.135GluLeu: 6.135 ± 0.233
1.667GluMet: 1.667 ± 0.104
4.221GluAsn: 4.221 ± 0.204
1.688GluPro: 1.688 ± 0.126
3.078GluGln: 3.078 ± 0.188
4.316GluArg: 4.316 ± 0.237
4.032GluSer: 4.032 ± 0.192
3.624GluThr: 3.624 ± 0.188
4.497GluVal: 4.497 ± 0.192
1.048GluTrp: 1.048 ± 0.095
1.958GluTyr: 1.958 ± 0.127
0.0GluXaa: 0.0 ± 0.0
Phe
2.569PheAla: 2.569 ± 0.162
1.412PheCys: 1.412 ± 0.11
3.988PheAsp: 3.988 ± 0.22
4.614PheGlu: 4.614 ± 0.223
3.974PhePhe: 3.974 ± 0.23
3.006PheGly: 3.006 ± 0.149
1.426PheHis: 1.426 ± 0.11
2.991PheIle: 2.991 ± 0.148
2.147PheLys: 2.147 ± 0.129
6.775PheLeu: 6.775 ± 0.267
0.808PheMet: 0.808 ± 0.072
2.329PheAsn: 2.329 ± 0.13
3.733PhePro: 3.733 ± 0.173
2.569PheGln: 2.569 ± 0.115
3.413PheArg: 3.413 ± 0.183
6.899PheSer: 6.899 ± 0.229
2.453PheThr: 2.453 ± 0.16
3.224PheVal: 3.224 ± 0.159
1.012PheTrp: 1.012 ± 0.082
2.096PheTyr: 2.096 ± 0.142
0.0PheXaa: 0.0 ± 0.0
Gly
3.158GlyAla: 3.158 ± 0.29
1.295GlyCys: 1.295 ± 0.16
2.664GlyAsp: 2.664 ± 0.147
4.068GlyGlu: 4.068 ± 0.215
3.173GlyPhe: 3.173 ± 0.177
3.551GlyGly: 3.551 ± 0.273
0.902GlyHis: 0.902 ± 0.105
3.843GlyIle: 3.843 ± 0.193
4.461GlyLys: 4.461 ± 0.298
4.483GlyLeu: 4.483 ± 0.192
0.859GlyMet: 0.859 ± 0.095
3.712GlyAsn: 3.712 ± 0.204
3.566GlyPro: 3.566 ± 0.487
2.423GlyGln: 2.423 ± 0.139
2.933GlyArg: 2.933 ± 0.22
4.548GlySer: 4.548 ± 0.273
2.671GlyThr: 2.671 ± 0.191
3.915GlyVal: 3.915 ± 0.284
0.764GlyTrp: 0.764 ± 0.072
2.001GlyTyr: 2.001 ± 0.14
0.0GlyXaa: 0.0 ± 0.0
His
0.611HisAla: 0.611 ± 0.061
0.488HisCys: 0.488 ± 0.076
0.677HisAsp: 0.677 ± 0.077
0.866HisGlu: 0.866 ± 0.087
1.332HisPhe: 1.332 ± 0.113
0.881HisGly: 0.881 ± 0.094
0.509HisHis: 0.509 ± 0.068
0.997HisIle: 0.997 ± 0.096
1.099HisLys: 1.099 ± 0.095
2.096HisLeu: 2.096 ± 0.133
0.218HisMet: 0.218 ± 0.047
0.597HisAsn: 0.597 ± 0.062
1.019HisPro: 1.019 ± 0.084
0.735HisGln: 0.735 ± 0.079
1.019HisArg: 1.019 ± 0.092
1.506HisSer: 1.506 ± 0.099
0.56HisThr: 0.56 ± 0.068
0.589HisVal: 0.589 ± 0.064
0.196HisTrp: 0.196 ± 0.033
0.742HisTyr: 0.742 ± 0.088
0.0HisXaa: 0.0 ± 0.0
Ile
2.875IleAla: 2.875 ± 0.174
1.892IleCys: 1.892 ± 0.142
3.428IleAsp: 3.428 ± 0.179
5.545IleGlu: 5.545 ± 0.265
4.017IlePhe: 4.017 ± 0.174
3.937IleGly: 3.937 ± 0.258
1.274IleHis: 1.274 ± 0.093
3.006IleIle: 3.006 ± 0.19
2.081IleLys: 2.081 ± 0.134
8.005IleLeu: 8.005 ± 0.238
0.706IleMet: 0.706 ± 0.075
2.3IleAsn: 2.3 ± 0.134
3.821IlePro: 3.821 ± 0.172
2.947IleGln: 2.947 ± 0.16
4.039IleArg: 4.039 ± 0.169
7.074IleSer: 7.074 ± 0.286
2.467IleThr: 2.467 ± 0.154
3.682IleVal: 3.682 ± 0.185
0.946IleTrp: 0.946 ± 0.091
2.314IleTyr: 2.314 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
3.042LysAla: 3.042 ± 0.138
1.215LysCys: 1.215 ± 0.128
2.765LysAsp: 2.765 ± 0.277
4.796LysGlu: 4.796 ± 0.226
3.777LysPhe: 3.777 ± 0.216
3.428LysGly: 3.428 ± 0.186
0.888LysHis: 0.888 ± 0.088
5.334LysIle: 5.334 ± 0.233
4.905LysLys: 4.905 ± 0.308
5.269LysLeu: 5.269 ± 0.192
1.23LysMet: 1.23 ± 0.107
2.845LysAsn: 2.845 ± 0.138
1.907LysPro: 1.907 ± 0.127
1.979LysGln: 1.979 ± 0.118
2.693LysArg: 2.693 ± 0.154
3.675LysSer: 3.675 ± 0.181
2.453LysThr: 2.453 ± 0.136
3.682LysVal: 3.682 ± 0.182
1.019LysTrp: 1.019 ± 0.146
1.892LysTyr: 1.892 ± 0.114
0.0LysXaa: 0.0 ± 0.0
Leu
5.436LeuAla: 5.436 ± 0.222
1.717LeuCys: 1.717 ± 0.131
4.956LeuAsp: 4.956 ± 0.21
7.161LeuGlu: 7.161 ± 0.298
5.604LeuPhe: 5.604 ± 0.205
4.621LeuGly: 4.621 ± 0.172
1.652LeuHis: 1.652 ± 0.119
6.55LeuIle: 6.55 ± 0.229
6.2LeuLys: 6.2 ± 0.267
9.606LeuLeu: 9.606 ± 0.316
1.732LeuMet: 1.732 ± 0.113
5.138LeuAsn: 5.138 ± 0.191
5.982LeuPro: 5.982 ± 0.225
4.09LeuGln: 4.09 ± 0.197
5.327LeuArg: 5.327 ± 0.176
9.941LeuSer: 9.941 ± 0.318
5.858LeuThr: 5.858 ± 0.227
5.393LeuVal: 5.393 ± 0.197
0.961LeuTrp: 0.961 ± 0.093
2.991LeuTyr: 2.991 ± 0.173
0.0LeuXaa: 0.0 ± 0.0
Met
0.917MetAla: 0.917 ± 0.088
0.189MetCys: 0.189 ± 0.032
0.611MetAsp: 0.611 ± 0.067
1.747MetGlu: 1.747 ± 0.112
0.837MetPhe: 0.837 ± 0.075
0.982MetGly: 0.982 ± 0.109
0.16MetHis: 0.16 ± 0.035
1.135MetIle: 1.135 ± 0.086
1.295MetLys: 1.295 ± 0.1
1.244MetLeu: 1.244 ± 0.1
0.357MetMet: 0.357 ± 0.051
0.881MetAsn: 0.881 ± 0.084
0.415MetPro: 0.415 ± 0.056
0.735MetGln: 0.735 ± 0.088
0.568MetArg: 0.568 ± 0.058
1.637MetSer: 1.637 ± 0.096
0.793MetThr: 0.793 ± 0.088
1.113MetVal: 1.113 ± 0.084
0.175MetTrp: 0.175 ± 0.037
0.408MetTyr: 0.408 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
1.659AsnAla: 1.659 ± 0.108
1.244AsnCys: 1.244 ± 0.098
1.674AsnAsp: 1.674 ± 0.114
2.62AsnGlu: 2.62 ± 0.137
4.061AsnPhe: 4.061 ± 0.177
3.377AsnGly: 3.377 ± 0.324
0.815AsnHis: 0.815 ± 0.083
2.744AsnIle: 2.744 ± 0.16
2.161AsnLys: 2.161 ± 0.131
6.084AsnLeu: 6.084 ± 0.238
0.728AsnMet: 0.728 ± 0.076
1.71AsnAsn: 1.71 ± 0.111
2.715AsnPro: 2.715 ± 0.122
2.009AsnGln: 2.009 ± 0.115
2.212AsnArg: 2.212 ± 0.127
4.89AsnSer: 4.89 ± 0.208
1.383AsnThr: 1.383 ± 0.116
2.234AsnVal: 2.234 ± 0.119
0.72AsnTrp: 0.72 ± 0.065
1.725AsnTyr: 1.725 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
1.856ProAla: 1.856 ± 0.161
0.713ProCys: 0.713 ± 0.068
2.03ProAsp: 2.03 ± 0.116
4.366ProGlu: 4.366 ± 0.178
2.503ProPhe: 2.503 ± 0.138
2.336ProGly: 2.336 ± 0.141
0.764ProHis: 0.764 ± 0.073
3.493ProIle: 3.493 ± 0.173
2.591ProLys: 2.591 ± 0.186
4.352ProLeu: 4.352 ± 0.201
0.655ProMet: 0.655 ± 0.065
2.453ProAsn: 2.453 ± 0.13
2.343ProPro: 2.343 ± 0.173
2.147ProGln: 2.147 ± 0.123
2.176ProArg: 2.176 ± 0.145
4.934ProSer: 4.934 ± 0.304
3.61ProThr: 3.61 ± 0.324
2.809ProVal: 2.809 ± 0.195
0.429ProTrp: 0.429 ± 0.064
1.921ProTyr: 1.921 ± 0.113
0.0ProXaa: 0.0 ± 0.0
Gln
2.016GlnAla: 2.016 ± 0.116
0.509GlnCys: 0.509 ± 0.053
1.485GlnAsp: 1.485 ± 0.101
2.54GlnGlu: 2.54 ± 0.135
2.416GlnPhe: 2.416 ± 0.139
2.241GlnGly: 2.241 ± 0.132
0.466GlnHis: 0.466 ± 0.062
4.527GlnIle: 4.527 ± 0.206
2.642GlnLys: 2.642 ± 0.17
4.105GlnLeu: 4.105 ± 0.169
1.07GlnMet: 1.07 ± 0.106
2.351GlnAsn: 2.351 ± 0.141
1.899GlnPro: 1.899 ± 0.157
2.074GlnGln: 2.074 ± 0.163
2.067GlnArg: 2.067 ± 0.113
2.86GlnSer: 2.86 ± 0.161
2.678GlnThr: 2.678 ± 0.177
2.642GlnVal: 2.642 ± 0.145
0.568GlnTrp: 0.568 ± 0.082
1.215GlnTyr: 1.215 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
2.234ArgAla: 2.234 ± 0.135
0.815ArgCys: 0.815 ± 0.082
2.562ArgAsp: 2.562 ± 0.152
3.915ArgGlu: 3.915 ± 0.17
3.006ArgPhe: 3.006 ± 0.155
2.642ArgGly: 2.642 ± 0.198
0.917ArgHis: 0.917 ± 0.085
4.09ArgIle: 4.09 ± 0.172
4.447ArgLys: 4.447 ± 0.211
4.33ArgLeu: 4.33 ± 0.169
0.91ArgMet: 0.91 ± 0.077
3.26ArgAsn: 3.26 ± 0.148
1.878ArgPro: 1.878 ± 0.139
2.227ArgGln: 2.227 ± 0.132
3.151ArgArg: 3.151 ± 0.171
4.17ArgSer: 4.17 ± 0.222
2.729ArgThr: 2.729 ± 0.154
2.664ArgVal: 2.664 ± 0.146
0.524ArgTrp: 0.524 ± 0.066
1.994ArgTyr: 1.994 ± 0.117
0.0ArgXaa: 0.0 ± 0.0
Ser
3.966SerAla: 3.966 ± 0.137
1.819SerCys: 1.819 ± 0.127
4.476SerAsp: 4.476 ± 0.169
6.295SerGlu: 6.295 ± 0.225
5.669SerPhe: 5.669 ± 0.218
5.655SerGly: 5.655 ± 0.228
1.645SerHis: 1.645 ± 0.104
5.152SerIle: 5.152 ± 0.188
5.014SerLys: 5.014 ± 0.222
9.395SerLeu: 9.395 ± 0.327
1.295SerMet: 1.295 ± 0.1
4.032SerAsn: 4.032 ± 0.207
4.89SerPro: 4.89 ± 0.328
3.93SerGln: 3.93 ± 0.178
4.563SerArg: 4.563 ± 0.178
10.159SerSer: 10.159 ± 0.708
4.374SerThr: 4.374 ± 0.213
4.73SerVal: 4.73 ± 0.189
1.004SerTrp: 1.004 ± 0.082
2.875SerTyr: 2.875 ± 0.199
0.0SerXaa: 0.0 ± 0.0
Thr
1.936ThrAla: 1.936 ± 0.136
1.143ThrCys: 1.143 ± 0.118
1.936ThrAsp: 1.936 ± 0.13
2.947ThrGlu: 2.947 ± 0.143
2.765ThrPhe: 2.765 ± 0.153
5.88ThrGly: 5.88 ± 0.757
0.822ThrHis: 0.822 ± 0.093
2.656ThrIle: 2.656 ± 0.147
1.798ThrLys: 1.798 ± 0.129
4.643ThrLeu: 4.643 ± 0.203
0.48ThrMet: 0.48 ± 0.056
2.096ThrAsn: 2.096 ± 0.135
2.904ThrPro: 2.904 ± 0.205
1.936ThrGln: 1.936 ± 0.125
2.176ThrArg: 2.176 ± 0.135
4.541ThrSer: 4.541 ± 0.193
2.336ThrThr: 2.336 ± 0.201
2.431ThrVal: 2.431 ± 0.161
0.531ThrTrp: 0.531 ± 0.053
1.492ThrTyr: 1.492 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
2.744ValAla: 2.744 ± 0.149
1.652ValCys: 1.652 ± 0.147
3.202ValAsp: 3.202 ± 0.226
5.247ValGlu: 5.247 ± 0.205
2.911ValPhe: 2.911 ± 0.151
3.268ValGly: 3.268 ± 0.246
0.757ValHis: 0.757 ± 0.074
3.333ValIle: 3.333 ± 0.178
2.722ValLys: 2.722 ± 0.164
5.414ValLeu: 5.414 ± 0.221
0.83ValMet: 0.83 ± 0.072
2.234ValAsn: 2.234 ± 0.142
2.765ValPro: 2.765 ± 0.166
1.965ValGln: 1.965 ± 0.137
3.406ValArg: 3.406 ± 0.149
5.138ValSer: 5.138 ± 0.21
2.656ValThr: 2.656 ± 0.201
3.173ValVal: 3.173 ± 0.179
0.539ValTrp: 0.539 ± 0.052
1.819ValTyr: 1.819 ± 0.125
0.0ValXaa: 0.0 ± 0.0
Trp
0.895TrpAla: 0.895 ± 0.107
0.269TrpCys: 0.269 ± 0.043
0.473TrpAsp: 0.473 ± 0.063
0.888TrpGlu: 0.888 ± 0.084
0.662TrpPhe: 0.662 ± 0.077
0.662TrpGly: 0.662 ± 0.079
0.204TrpHis: 0.204 ± 0.044
0.728TrpIle: 0.728 ± 0.071
1.274TrpLys: 1.274 ± 0.095
1.354TrpLeu: 1.354 ± 0.157
0.298TrpMet: 0.298 ± 0.05
0.866TrpAsn: 0.866 ± 0.097
0.364TrpPro: 0.364 ± 0.051
0.488TrpGln: 0.488 ± 0.06
0.662TrpArg: 0.662 ± 0.077
0.917TrpSer: 0.917 ± 0.083
0.546TrpThr: 0.546 ± 0.064
0.764TrpVal: 0.764 ± 0.073
0.211TrpTrp: 0.211 ± 0.057
0.422TrpTyr: 0.422 ± 0.056
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.485TyrAla: 1.485 ± 0.125
0.837TyrCys: 0.837 ± 0.076
1.645TyrAsp: 1.645 ± 0.093
1.907TyrGlu: 1.907 ± 0.107
3.027TyrPhe: 3.027 ± 0.186
1.63TyrGly: 1.63 ± 0.102
0.64TyrHis: 0.64 ± 0.067
1.616TyrIle: 1.616 ± 0.109
1.201TyrLys: 1.201 ± 0.087
4.723TyrLeu: 4.723 ± 0.202
0.524TyrMet: 0.524 ± 0.061
1.274TyrAsn: 1.274 ± 0.131
1.477TyrPro: 1.477 ± 0.091
1.768TyrGln: 1.768 ± 0.11
1.805TyrArg: 1.805 ± 0.126
3.61TyrSer: 3.61 ± 0.182
1.252TyrThr: 1.252 ± 0.104
1.645TyrVal: 1.645 ± 0.115
0.539TyrTrp: 0.539 ± 0.056
1.39TyrTyr: 1.39 ± 0.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 467 proteins (137411 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski