Amino acid dipepetide frequency for Leptospirillum ferriphilum (strain ML-04)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.299AlaAla: 5.299 ± 0.118	0.727AlaCys: 0.727 ± 0.036	3.259AlaAsp: 3.259 ± 0.07	4.073AlaGlu: 4.073 ± 0.081	3.488AlaPhe: 3.488 ± 0.07	6.83AlaGly: 6.83 ± 0.129	1.549AlaHis: 1.549 ± 0.049	4.533AlaIle: 4.533 ± 0.081	2.663AlaLys: 2.663 ± 0.072	9.502AlaLeu: 9.502 ± 0.156	2.048AlaMet: 2.048 ± 0.058	1.918AlaAsn: 1.918 ± 0.055	3.324AlaPro: 3.324 ± 0.061	2.18AlaGln: 2.18 ± 0.066	5.861AlaArg: 5.861 ± 0.107	5.074AlaSer: 5.074 ± 0.096	3.247AlaThr: 3.247 ± 0.067	5.169AlaVal: 5.169 ± 0.091	0.955AlaTrp: 0.955 ± 0.044	1.854AlaTyr: 1.854 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.563CysAla: 0.563 ± 0.027	0.098CysCys: 0.098 ± 0.012	0.35CysAsp: 0.35 ± 0.019	0.348CysGlu: 0.348 ± 0.025	0.353CysPhe: 0.353 ± 0.024	0.706CysGly: 0.706 ± 0.033	0.325CysHis: 0.325 ± 0.024	0.285CysIle: 0.285 ± 0.022	0.179CysLys: 0.179 ± 0.017	0.988CysLeu: 0.988 ± 0.041	0.149CysMet: 0.149 ± 0.015	0.165CysAsn: 0.165 ± 0.016	0.666CysPro: 0.666 ± 0.034	0.377CysGln: 0.377 ± 0.022	0.72CysArg: 0.72 ± 0.028	0.596CysSer: 0.596 ± 0.036	0.329CysThr: 0.329 ± 0.023	0.472CysVal: 0.472 ± 0.024	0.063CysTrp: 0.063 ± 0.01	0.201CysTyr: 0.201 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.487AspAla: 3.487 ± 0.069	0.431AspCys: 0.431 ± 0.024	1.936AspAsp: 1.936 ± 0.059	2.629AspGlu: 2.629 ± 0.067	2.359AspPhe: 2.359 ± 0.059	3.737AspGly: 3.737 ± 0.065	1.228AspHis: 1.228 ± 0.043	2.786AspIle: 2.786 ± 0.065	1.697AspLys: 1.697 ± 0.061	6.262AspLeu: 6.262 ± 0.103	1.124AspMet: 1.124 ± 0.044	1.217AspAsn: 1.217 ± 0.042	3.974AspPro: 3.974 ± 0.088	1.695AspGln: 1.695 ± 0.047	4.707AspArg: 4.707 ± 0.094	2.957AspSer: 2.957 ± 0.069	2.092AspThr: 2.092 ± 0.059	3.371AspVal: 3.371 ± 0.068	0.793AspTrp: 0.793 ± 0.038	1.205AspTyr: 1.205 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.447GluAla: 5.447 ± 0.103	0.431GluCys: 0.431 ± 0.027	3.265GluAsp: 3.265 ± 0.067	5.485GluGlu: 5.485 ± 0.12	2.052GluPhe: 2.052 ± 0.055	5.253GluGly: 5.253 ± 0.099	1.213GluHis: 1.213 ± 0.045	4.528GluIle: 4.528 ± 0.089	5.229GluLys: 5.229 ± 0.097	4.643GluLeu: 4.643 ± 0.098	1.759GluMet: 1.759 ± 0.051	2.589GluAsn: 2.589 ± 0.059	2.296GluPro: 2.296 ± 0.062	1.851GluGln: 1.851 ± 0.05	4.819GluArg: 4.819 ± 0.108	4.265GluSer: 4.265 ± 0.079	3.883GluThr: 3.883 ± 0.087	3.812GluVal: 3.812 ± 0.085	0.92GluTrp: 0.92 ± 0.035	1.27GluTyr: 1.27 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.594PheAla: 2.594 ± 0.066	0.484PheCys: 0.484 ± 0.028	2.278PheAsp: 2.278 ± 0.053	2.229PheGlu: 2.229 ± 0.06	2.751PhePhe: 2.751 ± 0.077	3.47PheGly: 3.47 ± 0.075	1.241PheHis: 1.241 ± 0.04	1.695PheIle: 1.695 ± 0.052	0.988PheLys: 0.988 ± 0.04	6.568PheLeu: 6.568 ± 0.13	0.895PheMet: 0.895 ± 0.036	1.03PheAsn: 1.03 ± 0.039	2.982PhePro: 2.982 ± 0.066	1.667PheGln: 1.667 ± 0.051	3.735PheArg: 3.735 ± 0.073	4.218PheSer: 4.218 ± 0.084	1.672PheThr: 1.672 ± 0.053	2.966PheVal: 2.966 ± 0.066	0.773PheTrp: 0.773 ± 0.032	1.316PheTyr: 1.316 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.465GlyAla: 5.465 ± 0.098	0.765GlyCys: 0.765 ± 0.032	3.742GlyAsp: 3.742 ± 0.081	5.304GlyGlu: 5.304 ± 0.088	3.939GlyPhe: 3.939 ± 0.072	6.406GlyGly: 6.406 ± 0.11	1.926GlyHis: 1.926 ± 0.06	5.743GlyIle: 5.743 ± 0.097	4.788GlyLys: 4.788 ± 0.089	7.866GlyLeu: 7.866 ± 0.116	2.4GlyMet: 2.4 ± 0.069	2.641GlyAsn: 2.641 ± 0.073	3.38GlyPro: 3.38 ± 0.071	2.753GlyGln: 2.753 ± 0.063	5.18GlyArg: 5.18 ± 0.095	5.197GlySer: 5.197 ± 0.083	4.672GlyThr: 4.672 ± 0.087	5.834GlyVal: 5.834 ± 0.104	1.227GlyTrp: 1.227 ± 0.045	2.247GlyTyr: 2.247 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.608HisAla: 1.608 ± 0.049	0.176HisCys: 0.176 ± 0.015	0.9HisAsp: 0.9 ± 0.04	1.132HisGlu: 1.132 ± 0.036	1.21HisPhe: 1.21 ± 0.041	1.594HisGly: 1.594 ± 0.045	0.731HisHis: 0.731 ± 0.031	1.104HisIle: 1.104 ± 0.042	0.705HisLys: 0.705 ± 0.034	2.83HisLeu: 2.83 ± 0.056	0.441HisMet: 0.441 ± 0.026	0.5HisAsn: 0.5 ± 0.026	1.995HisPro: 1.995 ± 0.056	0.772HisGln: 0.772 ± 0.035	1.774HisArg: 1.774 ± 0.05	1.4HisSer: 1.4 ± 0.043	0.846HisThr: 0.846 ± 0.034	1.558HisVal: 1.558 ± 0.051	0.315HisTrp: 0.315 ± 0.019	0.663HisTyr: 0.663 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.352IleAla: 4.352 ± 0.094	0.369IleCys: 0.369 ± 0.022	2.961IleAsp: 2.961 ± 0.068	3.173IleGlu: 3.173 ± 0.077	2.365IlePhe: 2.365 ± 0.062	4.355IleGly: 4.355 ± 0.083	1.424IleHis: 1.424 ± 0.047	2.101IleIle: 2.101 ± 0.054	1.616IleLys: 1.616 ± 0.062	7.686IleLeu: 7.686 ± 0.129	0.896IleMet: 0.896 ± 0.039	1.421IleAsn: 1.421 ± 0.048	3.663IlePro: 3.663 ± 0.073	2.018IleGln: 2.018 ± 0.062	5.552IleArg: 5.552 ± 0.106	3.71IleSer: 3.71 ± 0.066	2.242IleThr: 2.242 ± 0.057	3.957IleVal: 3.957 ± 0.081	0.472IleTrp: 0.472 ± 0.023	1.248IleTyr: 1.248 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.689LysAla: 3.689 ± 0.085	0.209LysCys: 0.209 ± 0.018	2.566LysAsp: 2.566 ± 0.058	3.532LysGlu: 3.532 ± 0.085	1.085LysPhe: 1.085 ± 0.036	3.731LysGly: 3.731 ± 0.077	0.702LysHis: 0.702 ± 0.033	2.913LysIle: 2.913 ± 0.06	3.795LysLys: 3.795 ± 0.085	3.091LysLeu: 3.091 ± 0.069	1.266LysMet: 1.266 ± 0.049	2.179LysAsn: 2.179 ± 0.06	2.023LysPro: 2.023 ± 0.054	1.004LysGln: 1.004 ± 0.04	2.765LysArg: 2.765 ± 0.064	2.916LysSer: 2.916 ± 0.06	3.163LysThr: 3.163 ± 0.062	2.776LysVal: 2.776 ± 0.081	0.444LysTrp: 0.444 ± 0.025	0.817LysTyr: 0.817 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	9.062LeuAla: 9.062 ± 0.141	0.821LeuCys: 0.821 ± 0.038	5.651LeuAsp: 5.651 ± 0.091	7.521LeuGlu: 7.521 ± 0.104	5.639LeuPhe: 5.639 ± 0.116	8.19LeuGly: 8.19 ± 0.122	2.314LeuHis: 2.314 ± 0.061	4.895LeuIle: 4.895 ± 0.101	4.808LeuLys: 4.808 ± 0.095	12.873LeuLeu: 12.873 ± 0.21	2.173LeuMet: 2.173 ± 0.059	2.89LeuAsn: 2.89 ± 0.063	6.946LeuPro: 6.946 ± 0.108	2.825LeuGln: 2.825 ± 0.058	6.914LeuArg: 6.914 ± 0.096	10.559LeuSer: 10.559 ± 0.13	5.487LeuThr: 5.487 ± 0.092	7.576LeuVal: 7.576 ± 0.119	1.417LeuTrp: 1.417 ± 0.062	2.783LeuTyr: 2.783 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.394MetAla: 2.394 ± 0.057	0.13MetCys: 0.13 ± 0.013	1.401MetAsp: 1.401 ± 0.041	1.886MetGlu: 1.886 ± 0.051	0.712MetPhe: 0.712 ± 0.034	2.155MetGly: 2.155 ± 0.05	0.413MetHis: 0.413 ± 0.024	1.534MetIle: 1.534 ± 0.053	1.418MetLys: 1.418 ± 0.039	1.743MetLeu: 1.743 ± 0.049	0.669MetMet: 0.669 ± 0.041	0.98MetAsn: 0.98 ± 0.035	1.083MetPro: 1.083 ± 0.039	0.572MetGln: 0.572 ± 0.031	1.241MetArg: 1.241 ± 0.039	1.615MetSer: 1.615 ± 0.049	1.743MetThr: 1.743 ± 0.048	1.727MetVal: 1.727 ± 0.048	0.183MetTrp: 0.183 ± 0.016	0.349MetTyr: 0.349 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.313AsnAla: 2.313 ± 0.057	0.233AsnCys: 0.233 ± 0.018	1.272AsnAsp: 1.272 ± 0.048	1.344AsnGlu: 1.344 ± 0.048	1.061AsnPhe: 1.061 ± 0.041	2.517AsnGly: 2.517 ± 0.073	0.711AsnHis: 0.711 ± 0.028	1.757AsnIle: 1.757 ± 0.049	0.917AsnLys: 0.917 ± 0.034	3.314AsnLeu: 3.314 ± 0.062	0.669AsnMet: 0.669 ± 0.03	0.835AsnAsn: 0.835 ± 0.036	2.64AsnPro: 2.64 ± 0.061	1.022AsnGln: 1.022 ± 0.044	2.46AsnArg: 2.46 ± 0.062	1.505AsnSer: 1.505 ± 0.055	1.429AsnThr: 1.429 ± 0.053	1.96AsnVal: 1.96 ± 0.054	0.338AsnTrp: 0.338 ± 0.018	0.662AsnTyr: 0.662 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.112ProAla: 4.112 ± 0.077	0.427ProCys: 0.427 ± 0.027	4.135ProAsp: 4.135 ± 0.103	5.214ProGlu: 5.214 ± 0.084	2.926ProPhe: 2.926 ± 0.074	5.279ProGly: 5.279 ± 0.096	1.08ProHis: 1.08 ± 0.037	2.233ProIle: 2.233 ± 0.053	1.84ProLys: 1.84 ± 0.048	5.818ProLeu: 5.818 ± 0.092	1.252ProMet: 1.252 ± 0.043	1.217ProAsn: 1.217 ± 0.039	3.493ProPro: 3.493 ± 0.098	1.411ProGln: 1.411 ± 0.043	3.008ProArg: 3.008 ± 0.069	4.359ProSer: 4.359 ± 0.082	2.125ProThr: 2.125 ± 0.061	5.5ProVal: 5.5 ± 0.092	0.722ProTrp: 0.722 ± 0.034	1.334ProTyr: 1.334 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.721GlnAla: 2.721 ± 0.064	0.198GlnCys: 0.198 ± 0.018	1.626GlnAsp: 1.626 ± 0.05	2.405GlnGlu: 2.405 ± 0.066	1.055GlnPhe: 1.055 ± 0.042	2.528GlnGly: 2.528 ± 0.057	0.491GlnHis: 0.491 ± 0.027	2.038GlnIle: 2.038 ± 0.056	2.349GlnLys: 2.349 ± 0.061	1.949GlnLeu: 1.949 ± 0.058	0.828GlnMet: 0.828 ± 0.035	1.223GlnAsn: 1.223 ± 0.041	1.175GlnPro: 1.175 ± 0.043	0.79GlnGln: 0.79 ± 0.036	1.697GlnArg: 1.697 ± 0.057	2.192GlnSer: 2.192 ± 0.061	1.945GlnThr: 1.945 ± 0.059	2.104GlnVal: 2.104 ± 0.061	0.415GlnTrp: 0.415 ± 0.026	0.685GlnTyr: 0.685 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.417ArgAla: 4.417 ± 0.095	0.423ArgCys: 0.423 ± 0.025	3.5ArgAsp: 3.5 ± 0.082	6.203ArgGlu: 6.203 ± 0.116	3.322ArgPhe: 3.322 ± 0.069	4.336ArgGly: 4.336 ± 0.071	1.672ArgHis: 1.672 ± 0.051	5.253ArgIle: 5.253 ± 0.093	4.665ArgLys: 4.665 ± 0.082	7.82ArgLeu: 7.82 ± 0.12	2.161ArgMet: 2.161 ± 0.061	2.213ArgAsn: 2.213 ± 0.056	3.371ArgPro: 3.371 ± 0.07	2.637ArgGln: 2.637 ± 0.069	4.454ArgArg: 4.454 ± 0.09	4.883ArgSer: 4.883 ± 0.094	4.114ArgThr: 4.114 ± 0.09	4.553ArgVal: 4.553 ± 0.087	1.043ArgTrp: 1.043 ± 0.043	1.878ArgTyr: 1.878 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.834SerAla: 4.834 ± 0.075	0.698SerCys: 0.698 ± 0.036	3.34SerAsp: 3.34 ± 0.061	3.924SerGlu: 3.924 ± 0.082	3.565SerPhe: 3.565 ± 0.075	7.263SerGly: 7.263 ± 0.115	1.519SerHis: 1.519 ± 0.043	3.491SerIle: 3.491 ± 0.082	1.822SerLys: 1.822 ± 0.057	9.046SerLeu: 9.046 ± 0.119	1.738SerMet: 1.738 ± 0.055	1.597SerAsn: 1.597 ± 0.059	5.025SerPro: 5.025 ± 0.1	2.013SerGln: 2.013 ± 0.049	5.919SerArg: 5.919 ± 0.096	5.525SerSer: 5.525 ± 0.13	2.976SerThr: 2.976 ± 0.076	5.17SerVal: 5.17 ± 0.09	0.956SerTrp: 0.956 ± 0.035	1.583SerTyr: 1.583 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.514ThrAla: 3.514 ± 0.069	0.385ThrCys: 0.385 ± 0.025	2.299ThrAsp: 2.299 ± 0.055	2.594ThrGlu: 2.594 ± 0.061	2.398ThrPhe: 2.398 ± 0.056	5.303ThrGly: 5.303 ± 0.084	1.131ThrHis: 1.131 ± 0.044	2.991ThrIle: 2.991 ± 0.071	1.418ThrLys: 1.418 ± 0.047	6.397ThrLeu: 6.397 ± 0.1	1.062ThrMet: 1.062 ± 0.04	1.287ThrAsn: 1.287 ± 0.048	3.294ThrPro: 3.294 ± 0.076	1.267ThrGln: 1.267 ± 0.044	3.308ThrArg: 3.308 ± 0.072	3.053ThrSer: 3.053 ± 0.08	2.489ThrThr: 2.489 ± 0.072	4.024ThrVal: 4.024 ± 0.084	0.572ThrTrp: 0.572 ± 0.029	1.202ThrTyr: 1.202 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.034ValAla: 5.034 ± 0.083	0.604ValCys: 0.604 ± 0.034	3.447ValAsp: 3.447 ± 0.068	3.857ValGlu: 3.857 ± 0.087	3.467ValPhe: 3.467 ± 0.079	4.969ValGly: 4.969 ± 0.09	1.704ValHis: 1.704 ± 0.047	3.648ValIle: 3.648 ± 0.083	2.203ValLys: 2.203 ± 0.063	8.78ValLeu: 8.78 ± 0.124	1.569ValMet: 1.569 ± 0.048	1.852ValAsn: 1.852 ± 0.053	3.95ValPro: 3.95 ± 0.075	2.116ValGln: 2.116 ± 0.06	5.785ValArg: 5.785 ± 0.097	5.591ValSer: 5.591 ± 0.096	3.756ValThr: 3.756 ± 0.075	5.3ValVal: 5.3 ± 0.105	0.868ValTrp: 0.868 ± 0.035	1.713ValTyr: 1.713 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.93TrpAla: 0.93 ± 0.04	0.112TrpCys: 0.112 ± 0.012	0.613TrpAsp: 0.613 ± 0.03	0.891TrpGlu: 0.891 ± 0.037	0.583TrpPhe: 0.583 ± 0.032	1.034TrpGly: 1.034 ± 0.046	0.261TrpHis: 0.261 ± 0.02	0.942TrpIle: 0.942 ± 0.038	0.801TrpLys: 0.801 ± 0.034	1.17TrpLeu: 1.17 ± 0.04	0.384TrpMet: 0.384 ± 0.026	0.525TrpAsn: 0.525 ± 0.027	0.616TrpPro: 0.616 ± 0.029	0.405TrpGln: 0.405 ± 0.025	0.649TrpArg: 0.649 ± 0.03	0.93TrpSer: 0.93 ± 0.036	0.761TrpThr: 0.761 ± 0.034	0.928TrpVal: 0.928 ± 0.037	0.149TrpTrp: 0.149 ± 0.016	0.278TrpTyr: 0.278 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.721TyrAla: 1.721 ± 0.054	0.211TyrCys: 0.211 ± 0.018	1.146TyrAsp: 1.146 ± 0.041	1.267TyrGlu: 1.267 ± 0.044	1.221TyrPhe: 1.221 ± 0.042	1.817TyrGly: 1.817 ± 0.055	0.617TyrHis: 0.617 ± 0.033	1.11TyrIle: 1.11 ± 0.046	0.764TyrLys: 0.764 ± 0.04	3.0TyrLeu: 3.0 ± 0.07	0.466TyrMet: 0.466 ± 0.025	0.678TyrAsn: 0.678 ± 0.032	1.591TyrPro: 1.591 ± 0.049	1.039TyrGln: 1.039 ± 0.042	2.367TyrArg: 2.367 ± 0.058	1.46TyrSer: 1.46 ± 0.049	1.018TyrThr: 1.018 ± 0.041	1.457TyrVal: 1.457 ± 0.05	0.336TyrTrp: 0.336 ± 0.021	0.754TyrTyr: 0.754 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2450 proteins (716377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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