Amino acid dipepetide frequency for Geomicrobium sp. JCM 19039

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.558AlaAla: 6.558 ± 0.107
0.641AlaCys: 0.641 ± 0.026
4.15AlaAsp: 4.15 ± 0.073
5.101AlaGlu: 5.101 ± 0.072
3.592AlaPhe: 3.592 ± 0.057
5.939AlaGly: 5.939 ± 0.083
1.709AlaHis: 1.709 ± 0.04
5.864AlaIle: 5.864 ± 0.082
3.877AlaLys: 3.877 ± 0.069
7.857AlaLeu: 7.857 ± 0.09
2.422AlaMet: 2.422 ± 0.052
2.946AlaAsn: 2.946 ± 0.053
2.555AlaPro: 2.555 ± 0.065
2.371AlaGln: 2.371 ± 0.044
3.357AlaArg: 3.357 ± 0.05
4.688AlaSer: 4.688 ± 0.071
4.136AlaThr: 4.136 ± 0.064
5.93AlaVal: 5.93 ± 0.072
0.752AlaTrp: 0.752 ± 0.028
2.494AlaTyr: 2.494 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.457CysAla: 0.457 ± 0.02
0.075CysCys: 0.075 ± 0.007
0.335CysAsp: 0.335 ± 0.017
0.434CysGlu: 0.434 ± 0.022
0.31CysPhe: 0.31 ± 0.017
0.594CysGly: 0.594 ± 0.026
0.189CysHis: 0.189 ± 0.014
0.399CysIle: 0.399 ± 0.018
0.268CysLys: 0.268 ± 0.015
0.608CysLeu: 0.608 ± 0.025
0.185CysMet: 0.185 ± 0.013
0.222CysAsn: 0.222 ± 0.014
0.303CysPro: 0.303 ± 0.019
0.198CysGln: 0.198 ± 0.014
0.29CysArg: 0.29 ± 0.016
0.478CysSer: 0.478 ± 0.022
0.381CysThr: 0.381 ± 0.019
0.398CysVal: 0.398 ± 0.02
0.076CysTrp: 0.076 ± 0.008
0.204CysTyr: 0.204 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.303AspAla: 4.303 ± 0.077
0.312AspCys: 0.312 ± 0.014
3.524AspAsp: 3.524 ± 0.077
5.693AspGlu: 5.693 ± 0.089
2.129AspPhe: 2.129 ± 0.041
4.059AspGly: 4.059 ± 0.067
1.563AspHis: 1.563 ± 0.043
3.51AspIle: 3.51 ± 0.058
1.965AspLys: 1.965 ± 0.047
5.035AspLeu: 5.035 ± 0.069
1.496AspMet: 1.496 ± 0.037
1.712AspAsn: 1.712 ± 0.039
2.291AspPro: 2.291 ± 0.046
2.442AspGln: 2.442 ± 0.051
3.052AspArg: 3.052 ± 0.056
2.498AspSer: 2.498 ± 0.048
2.827AspThr: 2.827 ± 0.056
5.111AspVal: 5.111 ± 0.076
0.776AspTrp: 0.776 ± 0.027
2.11AspTyr: 2.11 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.255GluAla: 6.255 ± 0.098
0.339GluCys: 0.339 ± 0.017
4.696GluAsp: 4.696 ± 0.078
7.621GluGlu: 7.621 ± 0.123
2.22GluPhe: 2.22 ± 0.048
4.735GluGly: 4.735 ± 0.079
1.948GluHis: 1.948 ± 0.046
4.369GluIle: 4.369 ± 0.07
4.442GluLys: 4.442 ± 0.074
6.624GluLeu: 6.624 ± 0.081
2.38GluMet: 2.38 ± 0.049
3.239GluAsn: 3.239 ± 0.06
2.472GluPro: 2.472 ± 0.051
4.42GluGln: 4.42 ± 0.073
4.995GluArg: 4.995 ± 0.077
3.793GluSer: 3.793 ± 0.064
4.204GluThr: 4.204 ± 0.063
5.224GluVal: 5.224 ± 0.076
1.0GluTrp: 1.0 ± 0.027
2.1GluTyr: 2.1 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.282PheAla: 3.282 ± 0.053
0.259PheCys: 0.259 ± 0.017
2.483PheAsp: 2.483 ± 0.053
2.686PheGlu: 2.686 ± 0.051
2.185PhePhe: 2.185 ± 0.059
3.248PheGly: 3.248 ± 0.061
1.098PheHis: 1.098 ± 0.032
3.473PheIle: 3.473 ± 0.07
1.653PheLys: 1.653 ± 0.039
4.251PheLeu: 4.251 ± 0.081
1.301PheMet: 1.301 ± 0.037
1.528PheAsn: 1.528 ± 0.036
1.561PhePro: 1.561 ± 0.04
1.769PheGln: 1.769 ± 0.038
1.67PheArg: 1.67 ± 0.042
3.045PheSer: 3.045 ± 0.049
2.837PheThr: 2.837 ± 0.05
3.282PheVal: 3.282 ± 0.065
0.433PheTrp: 0.433 ± 0.02
1.483PheTyr: 1.483 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.527GlyAla: 5.527 ± 0.088
0.558GlyCys: 0.558 ± 0.024
3.704GlyAsp: 3.704 ± 0.064
5.095GlyGlu: 5.095 ± 0.073
3.367GlyPhe: 3.367 ± 0.058
5.23GlyGly: 5.23 ± 0.083
1.544GlyHis: 1.544 ± 0.039
5.278GlyIle: 5.278 ± 0.076
3.654GlyLys: 3.654 ± 0.055
6.435GlyLeu: 6.435 ± 0.098
2.368GlyMet: 2.368 ± 0.047
2.65GlyAsn: 2.65 ± 0.051
2.039GlyPro: 2.039 ± 0.064
2.304GlyGln: 2.304 ± 0.045
2.912GlyArg: 2.912 ± 0.051
4.288GlySer: 4.288 ± 0.064
4.343GlyThr: 4.343 ± 0.068
5.636GlyVal: 5.636 ± 0.074
0.837GlyTrp: 0.837 ± 0.027
2.572GlyTyr: 2.572 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.762HisAla: 1.762 ± 0.041
0.185HisCys: 0.185 ± 0.012
1.371HisAsp: 1.371 ± 0.04
1.867HisGlu: 1.867 ± 0.046
1.139HisPhe: 1.139 ± 0.032
1.703HisGly: 1.703 ± 0.041
0.829HisHis: 0.829 ± 0.029
1.593HisIle: 1.593 ± 0.04
0.891HisLys: 0.891 ± 0.028
2.406HisLeu: 2.406 ± 0.044
0.65HisMet: 0.65 ± 0.024
0.755HisAsn: 0.755 ± 0.027
1.284HisPro: 1.284 ± 0.035
0.979HisGln: 0.979 ± 0.03
1.265HisArg: 1.265 ± 0.033
1.373HisSer: 1.373 ± 0.036
1.415HisThr: 1.415 ± 0.031
2.004HisVal: 2.004 ± 0.046
0.303HisTrp: 0.303 ± 0.018
0.983HisTyr: 0.983 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.943IleAla: 5.943 ± 0.08
0.513IleCys: 0.513 ± 0.023
4.156IleAsp: 4.156 ± 0.063
5.25IleGlu: 5.25 ± 0.081
2.672IlePhe: 2.672 ± 0.061
5.855IleGly: 5.855 ± 0.094
1.773IleHis: 1.773 ± 0.043
4.782IleIle: 4.782 ± 0.082
2.6IleLys: 2.6 ± 0.044
5.77IleLeu: 5.77 ± 0.092
1.601IleMet: 1.601 ± 0.038
2.39IleAsn: 2.39 ± 0.048
3.052IlePro: 3.052 ± 0.055
2.791IleGln: 2.791 ± 0.059
3.254IleArg: 3.254 ± 0.06
4.157IleSer: 4.157 ± 0.059
3.959IleThr: 3.959 ± 0.062
5.67IleVal: 5.67 ± 0.075
0.595IleTrp: 0.595 ± 0.025
1.97IleTyr: 1.97 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.569LysAla: 3.569 ± 0.061
0.232LysCys: 0.232 ± 0.014
2.758LysAsp: 2.758 ± 0.058
4.776LysGlu: 4.776 ± 0.075
1.147LysPhe: 1.147 ± 0.033
3.071LysGly: 3.071 ± 0.055
1.267LysHis: 1.267 ± 0.035
2.607LysIle: 2.607 ± 0.045
3.813LysLys: 3.813 ± 0.076
3.89LysLeu: 3.89 ± 0.061
1.513LysMet: 1.513 ± 0.041
2.14LysAsn: 2.14 ± 0.045
1.762LysPro: 1.762 ± 0.041
2.732LysGln: 2.732 ± 0.049
3.329LysArg: 3.329 ± 0.062
2.632LysSer: 2.632 ± 0.045
2.905LysThr: 2.905 ± 0.058
2.938LysVal: 2.938 ± 0.056
0.575LysTrp: 0.575 ± 0.023
1.32LysTyr: 1.32 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
7.482LeuAla: 7.482 ± 0.097
0.583LeuCys: 0.583 ± 0.021
5.065LeuAsp: 5.065 ± 0.075
6.382LeuGlu: 6.382 ± 0.089
4.838LeuPhe: 4.838 ± 0.09
6.287LeuGly: 6.287 ± 0.076
2.475LeuHis: 2.475 ± 0.051
6.453LeuIle: 6.453 ± 0.098
4.621LeuLys: 4.621 ± 0.077
9.931LeuLeu: 9.931 ± 0.126
2.564LeuMet: 2.564 ± 0.049
3.533LeuAsn: 3.533 ± 0.057
4.13LeuPro: 4.13 ± 0.076
4.027LeuGln: 4.027 ± 0.06
4.077LeuArg: 4.077 ± 0.074
6.565LeuSer: 6.565 ± 0.088
5.692LeuThr: 5.692 ± 0.08
6.482LeuVal: 6.482 ± 0.08
0.847LeuTrp: 0.847 ± 0.029
3.134LeuTyr: 3.134 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.134MetAla: 2.134 ± 0.041
0.155MetCys: 0.155 ± 0.012
1.645MetAsp: 1.645 ± 0.045
1.973MetGlu: 1.973 ± 0.045
1.162MetPhe: 1.162 ± 0.033
1.743MetGly: 1.743 ± 0.038
0.59MetHis: 0.59 ± 0.023
2.321MetIle: 2.321 ± 0.049
2.079MetLys: 2.079 ± 0.045
2.882MetLeu: 2.882 ± 0.053
1.059MetMet: 1.059 ± 0.03
1.773MetAsn: 1.773 ± 0.039
1.105MetPro: 1.105 ± 0.037
1.13MetGln: 1.13 ± 0.033
1.365MetArg: 1.365 ± 0.036
1.872MetSer: 1.872 ± 0.046
2.029MetThr: 2.029 ± 0.05
1.794MetVal: 1.794 ± 0.041
0.213MetTrp: 0.213 ± 0.012
0.829MetTyr: 0.829 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.787AsnAla: 2.787 ± 0.052
0.218AsnCys: 0.218 ± 0.013
2.512AsnAsp: 2.512 ± 0.05
3.388AsnGlu: 3.388 ± 0.062
1.396AsnPhe: 1.396 ± 0.04
2.818AsnGly: 2.818 ± 0.053
1.089AsnHis: 1.089 ± 0.031
2.632AsnIle: 2.632 ± 0.056
1.698AsnLys: 1.698 ± 0.039
3.114AsnLeu: 3.114 ± 0.05
1.109AsnMet: 1.109 ± 0.032
1.57AsnAsn: 1.57 ± 0.046
1.818AsnPro: 1.818 ± 0.039
1.606AsnGln: 1.606 ± 0.039
2.164AsnArg: 2.164 ± 0.051
1.748AsnSer: 1.748 ± 0.041
2.103AsnThr: 2.103 ± 0.04
3.174AsnVal: 3.174 ± 0.059
0.44AsnTrp: 0.44 ± 0.02
1.288AsnTyr: 1.288 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
2.65ProAla: 2.65 ± 0.05
0.193ProCys: 0.193 ± 0.015
2.227ProAsp: 2.227 ± 0.046
3.204ProGlu: 3.204 ± 0.05
1.995ProPhe: 1.995 ± 0.042
2.563ProGly: 2.563 ± 0.047
0.928ProHis: 0.928 ± 0.027
2.6ProIle: 2.6 ± 0.051
1.73ProLys: 1.73 ± 0.042
3.762ProLeu: 3.762 ± 0.067
1.025ProMet: 1.025 ± 0.034
1.526ProAsn: 1.526 ± 0.035
1.203ProPro: 1.203 ± 0.039
1.006ProGln: 1.006 ± 0.03
1.278ProArg: 1.278 ± 0.028
2.443ProSer: 2.443 ± 0.044
2.123ProThr: 2.123 ± 0.04
3.524ProVal: 3.524 ± 0.173
0.373ProTrp: 0.373 ± 0.021
1.38ProTyr: 1.38 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.164GlnAla: 3.164 ± 0.054
0.196GlnCys: 0.196 ± 0.012
1.807GlnAsp: 1.807 ± 0.04
2.821GlnGlu: 2.821 ± 0.054
1.709GlnPhe: 1.709 ± 0.035
2.237GlnGly: 2.237 ± 0.05
0.964GlnHis: 0.964 ± 0.034
2.442GlnIle: 2.442 ± 0.048
2.148GlnLys: 2.148 ± 0.05
4.57GlnLeu: 4.57 ± 0.067
1.39GlnMet: 1.39 ± 0.038
1.424GlnAsn: 1.424 ± 0.036
1.465GlnPro: 1.465 ± 0.034
2.118GlnGln: 2.118 ± 0.049
1.9GlnArg: 1.9 ± 0.045
2.59GlnSer: 2.59 ± 0.046
2.435GlnThr: 2.435 ± 0.049
2.626GlnVal: 2.626 ± 0.046
0.488GlnTrp: 0.488 ± 0.021
1.217GlnTyr: 1.217 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.552ArgAla: 3.552 ± 0.065
0.323ArgCys: 0.323 ± 0.017
2.516ArgAsp: 2.516 ± 0.049
3.699ArgGlu: 3.699 ± 0.062
2.191ArgPhe: 2.191 ± 0.05
2.818ArgGly: 2.818 ± 0.042
1.091ArgHis: 1.091 ± 0.031
3.287ArgIle: 3.287 ± 0.049
2.837ArgLys: 2.837 ± 0.057
4.8ArgLeu: 4.8 ± 0.065
1.67ArgMet: 1.67 ± 0.038
1.875ArgAsn: 1.875 ± 0.043
1.484ArgPro: 1.484 ± 0.04
1.818ArgGln: 1.818 ± 0.039
2.331ArgArg: 2.331 ± 0.045
2.942ArgSer: 2.942 ± 0.052
2.747ArgThr: 2.747 ± 0.048
3.474ArgVal: 3.474 ± 0.055
0.59ArgTrp: 0.59 ± 0.025
1.762ArgTyr: 1.762 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.294SerAla: 4.294 ± 0.061
0.379SerCys: 0.379 ± 0.021
3.162SerAsp: 3.162 ± 0.057
4.274SerGlu: 4.274 ± 0.064
3.253SerPhe: 3.253 ± 0.056
4.707SerGly: 4.707 ± 0.067
1.392SerHis: 1.392 ± 0.035
4.529SerIle: 4.529 ± 0.071
2.758SerLys: 2.758 ± 0.055
5.993SerLeu: 5.993 ± 0.081
1.984SerMet: 1.984 ± 0.041
2.123SerAsn: 2.123 ± 0.046
2.069SerPro: 2.069 ± 0.046
1.92SerGln: 1.92 ± 0.043
2.523SerArg: 2.523 ± 0.046
4.087SerSer: 4.087 ± 0.074
3.405SerThr: 3.405 ± 0.056
4.613SerVal: 4.613 ± 0.061
0.683SerTrp: 0.683 ± 0.026
2.106SerTyr: 2.106 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.465ThrAla: 4.465 ± 0.07
0.352ThrCys: 0.352 ± 0.018
3.255ThrAsp: 3.255 ± 0.056
3.954ThrGlu: 3.954 ± 0.064
2.845ThrPhe: 2.845 ± 0.047
4.41ThrGly: 4.41 ± 0.072
1.367ThrHis: 1.367 ± 0.036
4.484ThrIle: 4.484 ± 0.061
2.624ThrLys: 2.624 ± 0.046
5.808ThrLeu: 5.808 ± 0.079
1.647ThrMet: 1.647 ± 0.037
2.417ThrAsn: 2.417 ± 0.041
2.509ThrPro: 2.509 ± 0.053
1.421ThrGln: 1.421 ± 0.035
2.385ThrArg: 2.385 ± 0.044
3.663ThrSer: 3.663 ± 0.061
3.261ThrThr: 3.261 ± 0.057
4.742ThrVal: 4.742 ± 0.067
0.603ThrTrp: 0.603 ± 0.023
1.982ThrTyr: 1.982 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
5.736ValAla: 5.736 ± 0.087
0.591ValCys: 0.591 ± 0.022
4.401ValAsp: 4.401 ± 0.071
5.207ValGlu: 5.207 ± 0.086
3.383ValPhe: 3.383 ± 0.063
5.112ValGly: 5.112 ± 0.072
1.905ValHis: 1.905 ± 0.042
5.406ValIle: 5.406 ± 0.074
3.399ValLys: 3.399 ± 0.068
7.225ValLeu: 7.225 ± 0.096
2.167ValMet: 2.167 ± 0.046
3.176ValAsn: 3.176 ± 0.058
3.008ValPro: 3.008 ± 0.055
2.928ValGln: 2.928 ± 0.043
3.38ValArg: 3.38 ± 0.053
4.899ValSer: 4.899 ± 0.067
4.754ValThr: 4.754 ± 0.073
5.685ValVal: 5.685 ± 0.083
0.74ValTrp: 0.74 ± 0.025
2.471ValTyr: 2.471 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.645TrpAla: 0.645 ± 0.025
0.064TrpCys: 0.064 ± 0.008
0.549TrpAsp: 0.549 ± 0.024
0.696TrpGlu: 0.696 ± 0.024
0.515TrpPhe: 0.515 ± 0.026
0.729TrpGly: 0.729 ± 0.03
0.245TrpHis: 0.245 ± 0.016
0.761TrpIle: 0.761 ± 0.027
0.568TrpLys: 0.568 ± 0.022
1.27TrpLeu: 1.27 ± 0.037
0.425TrpMet: 0.425 ± 0.02
0.501TrpAsn: 0.501 ± 0.025
0.313TrpPro: 0.313 ± 0.017
0.537TrpGln: 0.537 ± 0.022
0.514TrpArg: 0.514 ± 0.021
0.655TrpSer: 0.655 ± 0.027
0.635TrpThr: 0.635 ± 0.025
0.757TrpVal: 0.757 ± 0.027
0.157TrpTrp: 0.157 ± 0.014
0.345TrpTyr: 0.345 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.371TyrAla: 2.371 ± 0.043
0.235TyrCys: 0.235 ± 0.015
2.092TyrAsp: 2.092 ± 0.041
2.955TyrGlu: 2.955 ± 0.053
1.478TyrPhe: 1.478 ± 0.036
2.486TyrGly: 2.486 ± 0.05
0.791TyrHis: 0.791 ± 0.026
1.963TyrIle: 1.963 ± 0.046
1.35TyrLys: 1.35 ± 0.038
2.939TyrLeu: 2.939 ± 0.053
0.897TyrMet: 0.897 ± 0.028
1.174TyrAsn: 1.174 ± 0.036
1.31TyrPro: 1.31 ± 0.04
1.193TyrGln: 1.193 ± 0.031
1.768TyrArg: 1.768 ± 0.045
1.837TyrSer: 1.837 ± 0.04
2.001TyrThr: 2.001 ± 0.045
2.509TyrVal: 2.509 ± 0.05
0.4TyrTrp: 0.4 ± 0.019
1.226TyrTyr: 1.226 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4361 proteins (1148845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski