Amino acid dipepetide frequency for Candidatus Rhodobacter lobularis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.171AlaAla: 17.171 ± 0.153	1.145AlaCys: 1.145 ± 0.032	6.871AlaAsp: 6.871 ± 0.076	8.723AlaGlu: 8.723 ± 0.101	4.441AlaPhe: 4.441 ± 0.06	10.71AlaGly: 10.71 ± 0.096	2.442AlaHis: 2.442 ± 0.044	5.761AlaIle: 5.761 ± 0.066	4.015AlaLys: 4.015 ± 0.065	13.873AlaLeu: 13.873 ± 0.122	3.928AlaMet: 3.928 ± 0.054	2.808AlaAsn: 2.808 ± 0.044	6.129AlaPro: 6.129 ± 0.076	5.015AlaGln: 5.015 ± 0.071	8.674AlaArg: 8.674 ± 0.092	5.753AlaSer: 5.753 ± 0.058	5.9AlaThr: 5.9 ± 0.081	8.56AlaVal: 8.56 ± 0.089	1.659AlaTrp: 1.659 ± 0.036	2.649AlaTyr: 2.649 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.173CysAla: 1.173 ± 0.029	0.119CysCys: 0.119 ± 0.009	0.613CysAsp: 0.613 ± 0.022	0.49CysGlu: 0.49 ± 0.018	0.362CysPhe: 0.362 ± 0.015	1.036CysGly: 1.036 ± 0.029	0.277CysHis: 0.277 ± 0.014	0.428CysIle: 0.428 ± 0.017	0.253CysLys: 0.253 ± 0.013	0.927CysLeu: 0.927 ± 0.026	0.2CysMet: 0.2 ± 0.011	0.228CysAsn: 0.228 ± 0.012	0.51CysPro: 0.51 ± 0.02	0.269CysGln: 0.269 ± 0.014	0.532CysArg: 0.532 ± 0.02	0.47CysSer: 0.47 ± 0.017	0.486CysThr: 0.486 ± 0.019	0.675CysVal: 0.675 ± 0.022	0.13CysTrp: 0.13 ± 0.009	0.249CysTyr: 0.249 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.489AspAla: 7.489 ± 0.072	0.571AspCys: 0.571 ± 0.021	3.138AspAsp: 3.138 ± 0.07	3.403AspGlu: 3.403 ± 0.052	2.327AspPhe: 2.327 ± 0.043	5.548AspGly: 5.548 ± 0.074	1.355AspHis: 1.355 ± 0.036	3.097AspIle: 3.097 ± 0.046	1.644AspLys: 1.644 ± 0.034	6.189AspLeu: 6.189 ± 0.07	1.627AspMet: 1.627 ± 0.038	1.273AspAsn: 1.273 ± 0.034	3.716AspPro: 3.716 ± 0.06	1.999AspGln: 1.999 ± 0.04	4.008AspArg: 4.008 ± 0.06	2.068AspSer: 2.068 ± 0.043	2.764AspThr: 2.764 ± 0.059	4.229AspVal: 4.229 ± 0.058	1.227AspTrp: 1.227 ± 0.031	1.597AspTyr: 1.597 ± 0.034	0.001AspXaa: 0.001 ± 0.001
Glu	8.501GluAla: 8.501 ± 0.102	0.399GluCys: 0.399 ± 0.017	3.336GluAsp: 3.336 ± 0.053	3.445GluGlu: 3.445 ± 0.065	1.978GluPhe: 1.978 ± 0.04	4.681GluGly: 4.681 ± 0.06	1.279GluHis: 1.279 ± 0.029	3.912GluIle: 3.912 ± 0.063	1.954GluLys: 1.954 ± 0.045	5.365GluLeu: 5.365 ± 0.073	1.917GluMet: 1.917 ± 0.037	1.796GluAsn: 1.796 ± 0.035	2.738GluPro: 2.738 ± 0.042	1.988GluGln: 1.988 ± 0.038	4.296GluArg: 4.296 ± 0.063	2.156GluSer: 2.156 ± 0.04	3.765GluThr: 3.765 ± 0.052	4.386GluVal: 4.386 ± 0.051	0.753GluTrp: 0.753 ± 0.024	1.097GluTyr: 1.097 ± 0.026	0.001GluXaa: 0.001 ± 0.001
Phe	4.619PheAla: 4.619 ± 0.052	0.446PheCys: 0.446 ± 0.02	2.879PheAsp: 2.879 ± 0.045	2.418PheGlu: 2.418 ± 0.04	1.532PhePhe: 1.532 ± 0.041	3.807PheGly: 3.807 ± 0.059	0.745PheHis: 0.745 ± 0.025	1.672PheIle: 1.672 ± 0.032	0.986PheLys: 0.986 ± 0.03	3.557PheLeu: 3.557 ± 0.058	0.906PheMet: 0.906 ± 0.027	1.086PheAsn: 1.086 ± 0.026	1.644PhePro: 1.644 ± 0.033	1.242PheGln: 1.242 ± 0.032	2.113PheArg: 2.113 ± 0.043	2.106PheSer: 2.106 ± 0.039	2.105PheThr: 2.105 ± 0.043	2.825PheVal: 2.825 ± 0.046	0.662PheTrp: 0.662 ± 0.024	0.966PheTyr: 0.966 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.936GlyAla: 10.936 ± 0.119	0.967GlyCys: 0.967 ± 0.027	4.908GlyAsp: 4.908 ± 0.071	4.689GlyGlu: 4.689 ± 0.056	3.865GlyPhe: 3.865 ± 0.055	7.705GlyGly: 7.705 ± 0.115	2.022GlyHis: 2.022 ± 0.039	4.304GlyIle: 4.304 ± 0.059	3.06GlyLys: 3.06 ± 0.055	9.323GlyLeu: 9.323 ± 0.079	2.628GlyMet: 2.628 ± 0.048	2.249GlyAsn: 2.249 ± 0.063	3.776GlyPro: 3.776 ± 0.051	3.227GlyGln: 3.227 ± 0.051	5.457GlyArg: 5.457 ± 0.073	4.23GlySer: 4.23 ± 0.06	4.582GlyThr: 4.582 ± 0.073	6.518GlyVal: 6.518 ± 0.064	1.559GlyTrp: 1.559 ± 0.034	2.47GlyTyr: 2.47 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.365HisAla: 2.365 ± 0.041	0.27HisCys: 0.27 ± 0.015	1.216HisAsp: 1.216 ± 0.035	1.063HisGlu: 1.063 ± 0.025	0.846HisPhe: 0.846 ± 0.025	2.012HisGly: 2.012 ± 0.04	0.594HisHis: 0.594 ± 0.024	1.021HisIle: 1.021 ± 0.027	0.54HisLys: 0.54 ± 0.021	2.034HisLeu: 2.034 ± 0.04	0.596HisMet: 0.596 ± 0.021	0.508HisAsn: 0.508 ± 0.02	1.38HisPro: 1.38 ± 0.033	0.695HisGln: 0.695 ± 0.021	1.366HisArg: 1.366 ± 0.029	1.01HisSer: 1.01 ± 0.028	0.803HisThr: 0.803 ± 0.025	1.498HisVal: 1.498 ± 0.031	0.377HisTrp: 0.377 ± 0.014	0.543HisTyr: 0.543 ± 0.02	0.001HisXaa: 0.001 ± 0.001
Ile	6.937IleAla: 6.937 ± 0.075	0.649IleCys: 0.649 ± 0.02	3.303IleAsp: 3.303 ± 0.055	3.476IleGlu: 3.476 ± 0.05	1.806IlePhe: 1.806 ± 0.04	4.869IleGly: 4.869 ± 0.059	0.872IleHis: 0.872 ± 0.023	2.181IleIle: 2.181 ± 0.048	1.525IleLys: 1.525 ± 0.038	4.677IleLeu: 4.677 ± 0.064	1.044IleMet: 1.044 ± 0.027	1.434IleAsn: 1.434 ± 0.037	2.287IlePro: 2.287 ± 0.043	1.399IleGln: 1.399 ± 0.029	2.962IleArg: 2.962 ± 0.047	2.915IleSer: 2.915 ± 0.048	2.89IleThr: 2.89 ± 0.044	3.49IleVal: 3.49 ± 0.054	0.78IleTrp: 0.78 ± 0.024	1.218IleTyr: 1.218 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.813LysAla: 3.813 ± 0.065	0.197LysCys: 0.197 ± 0.012	1.78LysAsp: 1.78 ± 0.037	1.618LysGlu: 1.618 ± 0.035	0.963LysPhe: 0.963 ± 0.025	2.613LysGly: 2.613 ± 0.051	0.643LysHis: 0.643 ± 0.022	1.721LysIle: 1.721 ± 0.038	1.147LysLys: 1.147 ± 0.035	2.982LysLeu: 2.982 ± 0.047	0.855LysMet: 0.855 ± 0.027	0.83LysAsn: 0.83 ± 0.025	1.816LysPro: 1.816 ± 0.041	0.903LysGln: 0.903 ± 0.03	2.188LysArg: 2.188 ± 0.046	1.782LysSer: 1.782 ± 0.039	1.903LysThr: 1.903 ± 0.034	2.185LysVal: 2.185 ± 0.044	0.393LysTrp: 0.393 ± 0.017	0.648LysTyr: 0.648 ± 0.021	0.001LysXaa: 0.001 ± 0.001
Leu	12.895LeuAla: 12.895 ± 0.107	0.991LeuCys: 0.991 ± 0.027	5.928LeuAsp: 5.928 ± 0.075	5.566LeuGlu: 5.566 ± 0.071	3.568LeuPhe: 3.568 ± 0.056	8.874LeuGly: 8.874 ± 0.102	1.785LeuHis: 1.785 ± 0.042	4.99LeuIle: 4.99 ± 0.059	3.025LeuLys: 3.025 ± 0.046	8.637LeuLeu: 8.637 ± 0.105	2.587LeuMet: 2.587 ± 0.049	2.748LeuAsn: 2.748 ± 0.053	5.339LeuPro: 5.339 ± 0.061	2.888LeuGln: 2.888 ± 0.049	6.849LeuArg: 6.849 ± 0.077	6.308LeuSer: 6.308 ± 0.07	5.562LeuThr: 5.562 ± 0.068	6.984LeuVal: 6.984 ± 0.069	1.324LeuTrp: 1.324 ± 0.034	2.001LeuTyr: 2.001 ± 0.039	0.001LeuXaa: 0.001 ± 0.001
Met	3.595MetAla: 3.595 ± 0.055	0.211MetCys: 0.211 ± 0.012	1.422MetAsp: 1.422 ± 0.035	1.271MetGlu: 1.271 ± 0.033	0.864MetPhe: 0.864 ± 0.023	2.348MetGly: 2.348 ± 0.039	0.484MetHis: 0.484 ± 0.019	1.491MetIle: 1.491 ± 0.032	0.925MetLys: 0.925 ± 0.024	2.647MetLeu: 2.647 ± 0.043	0.739MetMet: 0.739 ± 0.023	0.855MetAsn: 0.855 ± 0.026	1.501MetPro: 1.501 ± 0.039	1.045MetGln: 1.045 ± 0.03	2.066MetArg: 2.066 ± 0.039	1.829MetSer: 1.829 ± 0.034	1.903MetThr: 1.903 ± 0.034	1.923MetVal: 1.923 ± 0.039	0.281MetTrp: 0.281 ± 0.014	0.37MetTyr: 0.37 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	3.436AsnAla: 3.436 ± 0.053	0.3AsnCys: 0.3 ± 0.014	1.504AsnAsp: 1.504 ± 0.048	1.231AsnGlu: 1.231 ± 0.03	1.047AsnPhe: 1.047 ± 0.025	2.527AsnGly: 2.527 ± 0.059	0.554AsnHis: 0.554 ± 0.022	1.397AsnIle: 1.397 ± 0.033	0.721AsnLys: 0.721 ± 0.022	2.521AsnLeu: 2.521 ± 0.046	0.718AsnMet: 0.718 ± 0.022	0.737AsnAsn: 0.737 ± 0.028	1.812AsnPro: 1.812 ± 0.033	0.834AsnGln: 0.834 ± 0.026	1.706AsnArg: 1.706 ± 0.035	1.266AsnSer: 1.266 ± 0.033	1.336AsnThr: 1.336 ± 0.035	1.918AsnVal: 1.918 ± 0.036	0.487AsnTrp: 0.487 ± 0.02	0.68AsnTyr: 0.68 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.485ProAla: 5.485 ± 0.077	0.395ProCys: 0.395 ± 0.017	3.701ProAsp: 3.701 ± 0.05	4.211ProGlu: 4.211 ± 0.065	1.993ProPhe: 1.993 ± 0.039	4.687ProGly: 4.687 ± 0.061	1.131ProHis: 1.131 ± 0.028	2.322ProIle: 2.322 ± 0.037	1.761ProLys: 1.761 ± 0.037	4.474ProLeu: 4.474 ± 0.058	1.355ProMet: 1.355 ± 0.034	1.51ProAsn: 1.51 ± 0.032	2.201ProPro: 2.201 ± 0.049	1.723ProGln: 1.723 ± 0.035	2.792ProArg: 2.792 ± 0.046	2.578ProSer: 2.578 ± 0.043	2.394ProThr: 2.394 ± 0.043	3.965ProVal: 3.965 ± 0.055	0.693ProTrp: 0.693 ± 0.025	1.156ProTyr: 1.156 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.335GlnAla: 4.335 ± 0.064	0.222GlnCys: 0.222 ± 0.013	1.926GlnAsp: 1.926 ± 0.033	1.896GlnGlu: 1.896 ± 0.037	1.206GlnPhe: 1.206 ± 0.029	2.863GlnGly: 2.863 ± 0.05	0.661GlnHis: 0.661 ± 0.022	2.1GlnIle: 2.1 ± 0.033	1.067GlnLys: 1.067 ± 0.026	2.847GlnLeu: 2.847 ± 0.049	1.127GlnMet: 1.127 ± 0.027	1.002GlnAsn: 1.002 ± 0.027	1.595GlnPro: 1.595 ± 0.032	1.177GlnGln: 1.177 ± 0.036	2.372GlnArg: 2.372 ± 0.049	1.889GlnSer: 1.889 ± 0.038	1.771GlnThr: 1.771 ± 0.037	2.601GlnVal: 2.601 ± 0.046	0.407GlnTrp: 0.407 ± 0.017	0.601GlnTyr: 0.601 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.456ArgAla: 8.456 ± 0.083	0.524ArgCys: 0.524 ± 0.023	4.121ArgAsp: 4.121 ± 0.056	3.635ArgGlu: 3.635 ± 0.062	2.694ArgPhe: 2.694 ± 0.047	4.769ArgGly: 4.769 ± 0.059	1.474ArgHis: 1.474 ± 0.032	3.445ArgIle: 3.445 ± 0.049	2.022ArgLys: 2.022 ± 0.044	6.99ArgLeu: 6.99 ± 0.087	1.888ArgMet: 1.888 ± 0.033	1.715ArgAsn: 1.715 ± 0.04	3.137ArgPro: 3.137 ± 0.05	2.236ArgGln: 2.236 ± 0.04	4.834ArgArg: 4.834 ± 0.07	3.155ArgSer: 3.155 ± 0.044	2.69ArgThr: 2.69 ± 0.049	4.787ArgVal: 4.787 ± 0.068	0.978ArgTrp: 0.978 ± 0.027	1.546ArgTyr: 1.546 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.042SerAla: 6.042 ± 0.065	0.438SerCys: 0.438 ± 0.02	3.16SerAsp: 3.16 ± 0.048	2.876SerGlu: 2.876 ± 0.045	2.365SerPhe: 2.365 ± 0.041	5.316SerGly: 5.316 ± 0.068	1.023SerHis: 1.023 ± 0.031	2.431SerIle: 2.431 ± 0.047	1.654SerLys: 1.654 ± 0.04	4.757SerLeu: 4.757 ± 0.064	1.373SerMet: 1.373 ± 0.033	1.468SerAsn: 1.468 ± 0.035	2.395SerPro: 2.395 ± 0.044	1.632SerGln: 1.632 ± 0.037	2.927SerArg: 2.927 ± 0.048	2.538SerSer: 2.538 ± 0.056	2.483SerThr: 2.483 ± 0.046	3.779SerVal: 3.779 ± 0.054	0.72SerTrp: 0.72 ± 0.022	1.385SerTyr: 1.385 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.982ThrAla: 5.982 ± 0.073	0.51ThrCys: 0.51 ± 0.025	2.881ThrAsp: 2.881 ± 0.048	3.121ThrGlu: 3.121 ± 0.05	1.936ThrPhe: 1.936 ± 0.037	5.266ThrGly: 5.266 ± 0.067	1.115ThrHis: 1.115 ± 0.028	2.673ThrIle: 2.673 ± 0.051	1.576ThrLys: 1.576 ± 0.034	5.552ThrLeu: 5.552 ± 0.069	1.279ThrMet: 1.279 ± 0.029	1.322ThrAsn: 1.322 ± 0.031	3.157ThrPro: 3.157 ± 0.05	1.757ThrGln: 1.757 ± 0.038	3.241ThrArg: 3.241 ± 0.049	2.531ThrSer: 2.531 ± 0.043	2.634ThrThr: 2.634 ± 0.051	3.966ThrVal: 3.966 ± 0.066	0.741ThrTrp: 0.741 ± 0.022	1.257ThrTyr: 1.257 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.859ValAla: 8.859 ± 0.088	0.658ValCys: 0.658 ± 0.02	4.161ValAsp: 4.161 ± 0.056	4.6ValGlu: 4.6 ± 0.065	2.908ValPhe: 2.908 ± 0.048	5.528ValGly: 5.528 ± 0.059	1.335ValHis: 1.335 ± 0.031	4.121ValIle: 4.121 ± 0.054	2.079ValLys: 2.079 ± 0.04	7.5ValLeu: 7.5 ± 0.078	2.081ValMet: 2.081 ± 0.045	2.099ValAsn: 2.099 ± 0.039	3.576ValPro: 3.576 ± 0.049	2.19ValGln: 2.19 ± 0.04	3.978ValArg: 3.978 ± 0.06	4.215ValSer: 4.215 ± 0.06	4.594ValThr: 4.594 ± 0.067	5.628ValVal: 5.628 ± 0.065	0.977ValTrp: 0.977 ± 0.027	1.489ValTyr: 1.489 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.526TrpAla: 1.526 ± 0.039	0.144TrpCys: 0.144 ± 0.01	0.853TrpAsp: 0.853 ± 0.028	0.725TrpGlu: 0.725 ± 0.023	0.604TrpPhe: 0.604 ± 0.024	1.156TrpGly: 1.156 ± 0.029	0.363TrpHis: 0.363 ± 0.018	0.699TrpIle: 0.699 ± 0.022	0.426TrpLys: 0.426 ± 0.017	1.72TrpLeu: 1.72 ± 0.04	0.415TrpMet: 0.415 ± 0.018	0.456TrpAsn: 0.456 ± 0.018	0.74TrpPro: 0.74 ± 0.022	0.631TrpGln: 0.631 ± 0.022	1.141TrpArg: 1.141 ± 0.028	0.814TrpSer: 0.814 ± 0.022	0.771TrpThr: 0.771 ± 0.022	1.061TrpVal: 1.061 ± 0.031	0.26TrpTrp: 0.26 ± 0.015	0.31TrpTyr: 0.31 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.612TyrAla: 2.612 ± 0.047	0.269TyrCys: 0.269 ± 0.014	1.569TyrAsp: 1.569 ± 0.035	1.283TyrGlu: 1.283 ± 0.032	1.012TyrPhe: 1.012 ± 0.029	2.159TyrGly: 2.159 ± 0.043	0.587TyrHis: 0.587 ± 0.019	0.948TyrIle: 0.948 ± 0.027	0.599TyrLys: 0.599 ± 0.02	2.276TyrLeu: 2.276 ± 0.044	0.505TyrMet: 0.505 ± 0.02	0.608TyrAsn: 0.608 ± 0.02	1.077TyrPro: 1.077 ± 0.029	0.816TyrGln: 0.816 ± 0.025	1.595TyrArg: 1.595 ± 0.04	1.147TyrSer: 1.147 ± 0.027	1.163TyrThr: 1.163 ± 0.033	1.596TyrVal: 1.596 ± 0.033	0.409TyrTrp: 0.409 ± 0.018	0.601TyrTyr: 0.601 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4763 proteins (1428562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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