Amino acid dipepetide frequency for Nitrosospira lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.072AlaAla: 12.072 ± 0.169	1.011AlaCys: 1.011 ± 0.035	5.266AlaAsp: 5.266 ± 0.077	6.095AlaGlu: 6.095 ± 0.093	3.585AlaPhe: 3.585 ± 0.07	8.745AlaGly: 8.745 ± 0.126	2.317AlaHis: 2.317 ± 0.05	5.875AlaIle: 5.875 ± 0.084	3.895AlaLys: 3.895 ± 0.078	11.044AlaLeu: 11.044 ± 0.131	2.796AlaMet: 2.796 ± 0.06	3.166AlaAsn: 3.166 ± 0.066	3.95AlaPro: 3.95 ± 0.076	3.909AlaGln: 3.909 ± 0.079	6.746AlaArg: 6.746 ± 0.091	5.822AlaSer: 5.822 ± 0.09	5.005AlaThr: 5.005 ± 0.083	7.049AlaVal: 7.049 ± 0.091	1.357AlaTrp: 1.357 ± 0.042	2.517AlaTyr: 2.517 ± 0.052	0.001AlaXaa: 0.001 ± 0.001
Cys	0.962CysAla: 0.962 ± 0.036	0.129CysCys: 0.129 ± 0.012	0.519CysAsp: 0.519 ± 0.025	0.513CysGlu: 0.513 ± 0.028	0.362CysPhe: 0.362 ± 0.02	0.965CysGly: 0.965 ± 0.036	0.34CysHis: 0.34 ± 0.023	0.514CysIle: 0.514 ± 0.026	0.311CysLys: 0.311 ± 0.02	0.849CysLeu: 0.849 ± 0.027	0.208CysMet: 0.208 ± 0.014	0.324CysAsn: 0.324 ± 0.018	0.472CysPro: 0.472 ± 0.025	0.272CysGln: 0.272 ± 0.016	0.649CysArg: 0.649 ± 0.027	0.519CysSer: 0.519 ± 0.024	0.446CysThr: 0.446 ± 0.02	0.625CysVal: 0.625 ± 0.026	0.112CysTrp: 0.112 ± 0.01	0.287CysTyr: 0.287 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.328AspAla: 5.328 ± 0.087	0.491AspCys: 0.491 ± 0.024	2.596AspAsp: 2.596 ± 0.059	3.426AspGlu: 3.426 ± 0.078	2.241AspPhe: 2.241 ± 0.054	4.035AspGly: 4.035 ± 0.075	1.238AspHis: 1.238 ± 0.047	3.328AspIle: 3.328 ± 0.065	2.287AspLys: 2.287 ± 0.057	5.22AspLeu: 5.22 ± 0.09	1.298AspMet: 1.298 ± 0.037	1.698AspAsn: 1.698 ± 0.045	2.718AspPro: 2.718 ± 0.064	1.693AspGln: 1.693 ± 0.048	3.01AspArg: 3.01 ± 0.067	2.975AspSer: 2.975 ± 0.059	2.692AspThr: 2.692 ± 0.052	3.518AspVal: 3.518 ± 0.068	0.851AspTrp: 0.851 ± 0.034	1.715AspTyr: 1.715 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.062GluAla: 6.062 ± 0.096	0.473GluCys: 0.473 ± 0.024	2.549GluAsp: 2.549 ± 0.059	3.349GluGlu: 3.349 ± 0.08	2.251GluPhe: 2.251 ± 0.048	3.676GluGly: 3.676 ± 0.067	1.348GluHis: 1.348 ± 0.046	4.223GluIle: 4.223 ± 0.078	3.186GluLys: 3.186 ± 0.073	6.209GluLeu: 6.209 ± 0.094	1.693GluMet: 1.693 ± 0.041	2.174GluAsn: 2.174 ± 0.052	2.416GluPro: 2.416 ± 0.054	2.695GluGln: 2.695 ± 0.065	4.25GluArg: 4.25 ± 0.083	3.261GluSer: 3.261 ± 0.059	3.201GluThr: 3.201 ± 0.061	3.874GluVal: 3.874 ± 0.076	0.766GluTrp: 0.766 ± 0.031	1.551GluTyr: 1.551 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.63PheAla: 3.63 ± 0.06	0.413PheCys: 0.413 ± 0.02	2.447PheAsp: 2.447 ± 0.06	2.262PheGlu: 2.262 ± 0.049	1.689PhePhe: 1.689 ± 0.052	3.223PheGly: 3.223 ± 0.066	0.9PheHis: 0.9 ± 0.033	2.175PheIle: 2.175 ± 0.054	1.342PheLys: 1.342 ± 0.039	3.554PheLeu: 3.554 ± 0.081	0.941PheMet: 0.941 ± 0.034	1.489PheAsn: 1.489 ± 0.043	1.807PhePro: 1.807 ± 0.048	1.273PheGln: 1.273 ± 0.032	2.202PheArg: 2.202 ± 0.054	2.696PheSer: 2.696 ± 0.058	2.16PheThr: 2.16 ± 0.054	2.503PheVal: 2.503 ± 0.06	0.542PheTrp: 0.542 ± 0.032	1.167PheTyr: 1.167 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.955GlyAla: 6.955 ± 0.124	0.848GlyCys: 0.848 ± 0.034	3.828GlyAsp: 3.828 ± 0.071	4.616GlyGlu: 4.616 ± 0.074	3.237GlyPhe: 3.237 ± 0.069	6.472GlyGly: 6.472 ± 0.116	1.864GlyHis: 1.864 ± 0.048	5.258GlyIle: 5.258 ± 0.089	4.231GlyLys: 4.231 ± 0.062	7.865GlyLeu: 7.865 ± 0.103	2.432GlyMet: 2.432 ± 0.057	2.889GlyAsn: 2.889 ± 0.064	2.398GlyPro: 2.398 ± 0.062	2.719GlyGln: 2.719 ± 0.062	4.554GlyArg: 4.554 ± 0.072	4.667GlySer: 4.667 ± 0.089	4.242GlyThr: 4.242 ± 0.086	5.613GlyVal: 5.613 ± 0.089	1.174GlyTrp: 1.174 ± 0.041	2.581GlyTyr: 2.581 ± 0.077	0.0GlyXaa: 0.0 ± 0.0
His	2.432HisAla: 2.432 ± 0.046	0.286HisCys: 0.286 ± 0.018	1.328HisAsp: 1.328 ± 0.039	1.367HisGlu: 1.367 ± 0.04	0.976HisPhe: 0.976 ± 0.039	2.031HisGly: 2.031 ± 0.047	0.779HisHis: 0.779 ± 0.032	1.343HisIle: 1.343 ± 0.042	0.809HisLys: 0.809 ± 0.03	2.313HisLeu: 2.313 ± 0.049	0.58HisMet: 0.58 ± 0.024	0.761HisAsn: 0.761 ± 0.028	1.535HisPro: 1.535 ± 0.045	0.858HisGln: 0.858 ± 0.031	1.495HisArg: 1.495 ± 0.044	1.274HisSer: 1.274 ± 0.039	1.145HisThr: 1.145 ± 0.035	1.509HisVal: 1.509 ± 0.038	0.343HisTrp: 0.343 ± 0.019	0.805HisTyr: 0.805 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.572IleAla: 6.572 ± 0.083	0.566IleCys: 0.566 ± 0.026	3.396IleAsp: 3.396 ± 0.067	3.913IleGlu: 3.913 ± 0.063	2.203IlePhe: 2.203 ± 0.051	4.772IleGly: 4.772 ± 0.076	1.356IleHis: 1.356 ± 0.038	3.23IleIle: 3.23 ± 0.066	2.623IleLys: 2.623 ± 0.054	5.494IleLeu: 5.494 ± 0.086	1.279IleMet: 1.279 ± 0.033	2.189IleAsn: 2.189 ± 0.051	3.036IlePro: 3.036 ± 0.066	1.934IleGln: 1.934 ± 0.046	3.525IleArg: 3.525 ± 0.061	3.877IleSer: 3.877 ± 0.064	3.387IleThr: 3.387 ± 0.067	3.911IleVal: 3.911 ± 0.073	0.613IleTrp: 0.613 ± 0.03	1.6IleTyr: 1.6 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.01LysAla: 4.01 ± 0.082	0.286LysCys: 0.286 ± 0.02	2.045LysAsp: 2.045 ± 0.055	2.518LysGlu: 2.518 ± 0.059	1.388LysPhe: 1.388 ± 0.044	2.722LysGly: 2.722 ± 0.068	0.978LysHis: 0.978 ± 0.031	2.712LysIle: 2.712 ± 0.055	2.297LysLys: 2.297 ± 0.07	4.411LysLeu: 4.411 ± 0.073	1.162LysMet: 1.162 ± 0.04	1.696LysAsn: 1.696 ± 0.049	2.344LysPro: 2.344 ± 0.06	1.797LysGln: 1.797 ± 0.042	2.767LysArg: 2.767 ± 0.054	2.463LysSer: 2.463 ± 0.058	2.516LysThr: 2.516 ± 0.055	2.683LysVal: 2.683 ± 0.057	0.511LysTrp: 0.511 ± 0.027	0.971LysTyr: 0.971 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.644LeuAla: 11.644 ± 0.159	0.986LeuCys: 0.986 ± 0.032	5.836LeuAsp: 5.836 ± 0.094	5.979LeuGlu: 5.979 ± 0.08	3.801LeuPhe: 3.801 ± 0.074	7.737LeuGly: 7.737 ± 0.106	2.406LeuHis: 2.406 ± 0.057	5.731LeuIle: 5.731 ± 0.103	4.571LeuLys: 4.571 ± 0.07	11.234LeuLeu: 11.234 ± 0.18	2.555LeuMet: 2.555 ± 0.058	3.527LeuAsn: 3.527 ± 0.069	5.732LeuPro: 5.732 ± 0.085	3.612LeuGln: 3.612 ± 0.071	7.067LeuArg: 7.067 ± 0.109	6.558LeuSer: 6.558 ± 0.091	5.686LeuThr: 5.686 ± 0.078	6.602LeuVal: 6.602 ± 0.088	1.171LeuTrp: 1.171 ± 0.039	2.376LeuTyr: 2.376 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.611MetAla: 2.611 ± 0.052	0.152MetCys: 0.152 ± 0.013	1.299MetAsp: 1.299 ± 0.037	1.52MetGlu: 1.52 ± 0.04	0.752MetPhe: 0.752 ± 0.031	1.89MetGly: 1.89 ± 0.05	0.63MetHis: 0.63 ± 0.027	1.391MetIle: 1.391 ± 0.049	1.314MetLys: 1.314 ± 0.039	2.894MetLeu: 2.894 ± 0.065	0.657MetMet: 0.657 ± 0.028	1.048MetAsn: 1.048 ± 0.033	1.524MetPro: 1.524 ± 0.042	1.119MetGln: 1.119 ± 0.037	1.788MetArg: 1.788 ± 0.041	1.629MetSer: 1.629 ± 0.051	1.442MetThr: 1.442 ± 0.04	1.706MetVal: 1.706 ± 0.038	0.206MetTrp: 0.206 ± 0.016	0.395MetTyr: 0.395 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.341AsnAla: 3.341 ± 0.064	0.337AsnCys: 0.337 ± 0.022	1.656AsnAsp: 1.656 ± 0.05	1.847AsnGlu: 1.847 ± 0.045	1.415AsnPhe: 1.415 ± 0.043	2.755AsnGly: 2.755 ± 0.058	0.779AsnHis: 0.779 ± 0.029	2.147AsnIle: 2.147 ± 0.054	1.277AsnLys: 1.277 ± 0.042	3.736AsnLeu: 3.736 ± 0.066	0.777AsnMet: 0.777 ± 0.028	1.283AsnAsn: 1.283 ± 0.047	2.243AsnPro: 2.243 ± 0.051	1.269AsnGln: 1.269 ± 0.036	2.201AsnArg: 2.201 ± 0.056	1.835AsnSer: 1.835 ± 0.047	1.777AsnThr: 1.777 ± 0.046	2.256AsnVal: 2.256 ± 0.054	0.536AsnTrp: 0.536 ± 0.027	1.017AsnTyr: 1.017 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.184ProAla: 5.184 ± 0.087	0.392ProCys: 0.392 ± 0.026	3.261ProAsp: 3.261 ± 0.071	3.48ProGlu: 3.48 ± 0.065	1.806ProPhe: 1.806 ± 0.051	4.264ProGly: 4.264 ± 0.075	1.145ProHis: 1.145 ± 0.038	2.386ProIle: 2.386 ± 0.049	1.659ProLys: 1.659 ± 0.043	4.75ProLeu: 4.75 ± 0.076	1.128ProMet: 1.128 ± 0.032	1.472ProAsn: 1.472 ± 0.045	2.456ProPro: 2.456 ± 0.072	1.865ProGln: 1.865 ± 0.052	2.446ProArg: 2.446 ± 0.05	2.583ProSer: 2.583 ± 0.062	2.009ProThr: 2.009 ± 0.048	4.061ProVal: 4.061 ± 0.071	0.628ProTrp: 0.628 ± 0.031	1.289ProTyr: 1.289 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.161GlnAla: 4.161 ± 0.073	0.268GlnCys: 0.268 ± 0.017	1.681GlnAsp: 1.681 ± 0.046	2.052GlnGlu: 2.052 ± 0.051	1.339GlnPhe: 1.339 ± 0.036	2.764GlnGly: 2.764 ± 0.063	0.919GlnHis: 0.919 ± 0.034	2.335GlnIle: 2.335 ± 0.05	1.64GlnLys: 1.64 ± 0.045	3.983GlnLeu: 3.983 ± 0.071	0.963GlnMet: 0.963 ± 0.032	1.196GlnAsn: 1.196 ± 0.032	1.845GlnPro: 1.845 ± 0.046	1.662GlnGln: 1.662 ± 0.048	2.575GlnArg: 2.575 ± 0.054	2.093GlnSer: 2.093 ± 0.05	1.859GlnThr: 1.859 ± 0.049	2.593GlnVal: 2.593 ± 0.064	0.5GlnTrp: 0.5 ± 0.026	0.987GlnTyr: 0.987 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.621ArgAla: 5.621 ± 0.087	0.569ArgCys: 0.569 ± 0.027	3.46ArgAsp: 3.46 ± 0.067	4.199ArgGlu: 4.199 ± 0.075	2.799ArgPhe: 2.799 ± 0.066	4.092ArgGly: 4.092 ± 0.071	1.725ArgHis: 1.725 ± 0.047	4.186ArgIle: 4.186 ± 0.072	2.745ArgLys: 2.745 ± 0.062	7.019ArgLeu: 7.019 ± 0.105	1.795ArgMet: 1.795 ± 0.04	2.462ArgAsn: 2.462 ± 0.058	2.648ArgPro: 2.648 ± 0.052	2.83ArgGln: 2.83 ± 0.061	4.21ArgArg: 4.21 ± 0.08	3.377ArgSer: 3.377 ± 0.059	2.912ArgThr: 2.912 ± 0.063	4.242ArgVal: 4.242 ± 0.071	0.821ArgTrp: 0.821 ± 0.028	2.139ArgTyr: 2.139 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.69SerAla: 5.69 ± 0.085	0.534SerCys: 0.534 ± 0.029	2.815SerAsp: 2.815 ± 0.058	3.043SerGlu: 3.043 ± 0.06	2.275SerPhe: 2.275 ± 0.053	5.87SerGly: 5.87 ± 0.09	1.458SerHis: 1.458 ± 0.039	3.404SerIle: 3.404 ± 0.065	2.063SerLys: 2.063 ± 0.048	6.206SerLeu: 6.206 ± 0.089	1.594SerMet: 1.594 ± 0.051	1.88SerAsn: 1.88 ± 0.052	2.958SerPro: 2.958 ± 0.061	2.1SerGln: 2.1 ± 0.048	3.848SerArg: 3.848 ± 0.064	3.571SerSer: 3.571 ± 0.068	3.008SerThr: 3.008 ± 0.061	4.07SerVal: 4.07 ± 0.061	0.773SerTrp: 0.773 ± 0.03	1.565SerTyr: 1.565 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.298ThrAla: 5.298 ± 0.086	0.506ThrCys: 0.506 ± 0.025	2.662ThrAsp: 2.662 ± 0.053	2.736ThrGlu: 2.736 ± 0.06	1.87ThrPhe: 1.87 ± 0.044	4.981ThrGly: 4.981 ± 0.081	1.267ThrHis: 1.267 ± 0.039	2.83ThrIle: 2.83 ± 0.059	1.616ThrLys: 1.616 ± 0.049	6.137ThrLeu: 6.137 ± 0.091	1.21ThrMet: 1.21 ± 0.035	1.463ThrAsn: 1.463 ± 0.042	2.944ThrPro: 2.944 ± 0.057	1.855ThrGln: 1.855 ± 0.049	3.189ThrArg: 3.189 ± 0.064	2.995ThrSer: 2.995 ± 0.069	2.669ThrThr: 2.669 ± 0.065	3.834ThrVal: 3.834 ± 0.065	0.654ThrTrp: 0.654 ± 0.031	1.374ThrTyr: 1.374 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.035ValAla: 7.035 ± 0.107	0.666ValCys: 0.666 ± 0.025	3.667ValAsp: 3.667 ± 0.071	4.2ValGlu: 4.2 ± 0.077	2.637ValPhe: 2.637 ± 0.063	4.394ValGly: 4.394 ± 0.073	1.416ValHis: 1.416 ± 0.041	4.306ValIle: 4.306 ± 0.066	2.952ValLys: 2.952 ± 0.062	7.187ValLeu: 7.187 ± 0.109	1.995ValMet: 1.995 ± 0.048	2.465ValAsn: 2.465 ± 0.062	3.297ValPro: 3.297 ± 0.073	2.177ValGln: 2.177 ± 0.058	4.302ValArg: 4.302 ± 0.071	4.213ValSer: 4.213 ± 0.071	3.99ValThr: 3.99 ± 0.072	5.183ValVal: 5.183 ± 0.079	0.805ValTrp: 0.805 ± 0.032	1.613ValTyr: 1.613 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.948TrpAla: 0.948 ± 0.033	0.126TrpCys: 0.126 ± 0.011	0.642TrpAsp: 0.642 ± 0.03	0.689TrpGlu: 0.689 ± 0.029	0.503TrpPhe: 0.503 ± 0.025	0.863TrpGly: 0.863 ± 0.036	0.386TrpHis: 0.386 ± 0.02	0.819TrpIle: 0.819 ± 0.031	0.568TrpLys: 0.568 ± 0.025	1.726TrpLeu: 1.726 ± 0.056	0.384TrpMet: 0.384 ± 0.02	0.503TrpAsn: 0.503 ± 0.023	0.492TrpPro: 0.492 ± 0.022	0.642TrpGln: 0.642 ± 0.025	1.005TrpArg: 1.005 ± 0.037	0.703TrpSer: 0.703 ± 0.027	0.576TrpThr: 0.576 ± 0.026	0.88TrpVal: 0.88 ± 0.035	0.233TrpTrp: 0.233 ± 0.024	0.337TrpTyr: 0.337 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.667TyrAla: 2.667 ± 0.06	0.34TyrCys: 0.34 ± 0.02	1.407TyrAsp: 1.407 ± 0.04	1.402TyrGlu: 1.402 ± 0.039	1.284TyrPhe: 1.284 ± 0.038	2.191TyrGly: 2.191 ± 0.059	0.717TyrHis: 0.717 ± 0.03	1.283TyrIle: 1.283 ± 0.037	0.892TyrLys: 0.892 ± 0.031	2.979TyrLeu: 2.979 ± 0.063	0.521TyrMet: 0.521 ± 0.028	0.799TyrAsn: 0.799 ± 0.03	1.447TyrPro: 1.447 ± 0.04	1.136TyrGln: 1.136 ± 0.033	2.022TyrArg: 2.022 ± 0.047	1.612TyrSer: 1.612 ± 0.037	1.369TyrThr: 1.369 ± 0.038	1.789TyrVal: 1.789 ± 0.044	0.43TyrTrp: 0.43 ± 0.024	0.84TyrTyr: 0.84 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2855 proteins (913826 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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