Amino acid dipepetide frequency for Ruegeria phage Tedan

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.211AlaAla: 10.211 ± 1.209
1.211AlaCys: 1.211 ± 0.268
6.421AlaAsp: 6.421 ± 0.504
6.947AlaGlu: 6.947 ± 0.835
3.526AlaPhe: 3.526 ± 0.442
8.211AlaGly: 8.211 ± 0.755
1.684AlaHis: 1.684 ± 0.335
5.316AlaIle: 5.316 ± 0.524
3.684AlaLys: 3.684 ± 0.612
8.895AlaLeu: 8.895 ± 0.661
2.316AlaMet: 2.316 ± 0.357
4.053AlaAsn: 4.053 ± 0.564
3.737AlaPro: 3.737 ± 0.367
3.947AlaGln: 3.947 ± 0.401
6.474AlaArg: 6.474 ± 0.595
4.842AlaSer: 4.842 ± 0.583
5.737AlaThr: 5.737 ± 0.6
5.947AlaVal: 5.947 ± 0.48
1.684AlaTrp: 1.684 ± 0.35
1.895AlaTyr: 1.895 ± 0.29
0.0AlaXaa: 0.0 ± 0.0
Cys
0.842CysAla: 0.842 ± 0.192
0.158CysCys: 0.158 ± 0.09
0.684CysAsp: 0.684 ± 0.242
0.421CysGlu: 0.421 ± 0.189
0.421CysPhe: 0.421 ± 0.141
0.526CysGly: 0.526 ± 0.153
0.158CysHis: 0.158 ± 0.104
0.316CysIle: 0.316 ± 0.113
0.526CysLys: 0.526 ± 0.149
1.0CysLeu: 1.0 ± 0.197
0.105CysMet: 0.105 ± 0.063
0.105CysAsn: 0.105 ± 0.066
0.632CysPro: 0.632 ± 0.209
0.421CysGln: 0.421 ± 0.146
0.842CysArg: 0.842 ± 0.19
0.474CysSer: 0.474 ± 0.122
0.579CysThr: 0.579 ± 0.196
0.579CysVal: 0.579 ± 0.18
0.158CysTrp: 0.158 ± 0.096
0.263CysTyr: 0.263 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
6.158AspAla: 6.158 ± 0.472
0.789AspCys: 0.789 ± 0.253
5.158AspAsp: 5.158 ± 0.578
4.947AspGlu: 4.947 ± 0.646
2.789AspPhe: 2.789 ± 0.393
5.632AspGly: 5.632 ± 0.503
1.421AspHis: 1.421 ± 0.265
3.211AspIle: 3.211 ± 0.359
2.105AspLys: 2.105 ± 0.316
7.579AspLeu: 7.579 ± 0.54
2.0AspMet: 2.0 ± 0.348
2.526AspAsn: 2.526 ± 0.469
4.579AspPro: 4.579 ± 0.485
2.316AspGln: 2.316 ± 0.353
4.421AspArg: 4.421 ± 0.449
3.0AspSer: 3.0 ± 0.426
4.158AspThr: 4.158 ± 0.558
4.842AspVal: 4.842 ± 0.458
1.474AspTrp: 1.474 ± 0.423
1.421AspTyr: 1.421 ± 0.268
0.0AspXaa: 0.0 ± 0.0
Glu
7.684GluAla: 7.684 ± 0.725
0.263GluCys: 0.263 ± 0.104
5.105GluAsp: 5.105 ± 0.586
4.737GluGlu: 4.737 ± 0.85
2.789GluPhe: 2.789 ± 0.431
4.579GluGly: 4.579 ± 0.438
0.895GluHis: 0.895 ± 0.185
3.684GluIle: 3.684 ± 0.393
3.105GluLys: 3.105 ± 0.458
6.263GluLeu: 6.263 ± 0.736
2.053GluMet: 2.053 ± 0.337
3.158GluAsn: 3.158 ± 0.42
1.632GluPro: 1.632 ± 0.331
2.895GluGln: 2.895 ± 0.427
4.421GluArg: 4.421 ± 0.593
2.211GluSer: 2.211 ± 0.319
4.105GluThr: 4.105 ± 0.511
4.158GluVal: 4.158 ± 0.463
1.368GluTrp: 1.368 ± 0.352
1.368GluTyr: 1.368 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
3.263PheAla: 3.263 ± 0.477
0.211PheCys: 0.211 ± 0.104
3.737PheAsp: 3.737 ± 0.444
2.842PheGlu: 2.842 ± 0.315
1.263PhePhe: 1.263 ± 0.235
2.632PheGly: 2.632 ± 0.433
0.526PheHis: 0.526 ± 0.155
1.474PheIle: 1.474 ± 0.266
1.632PheLys: 1.632 ± 0.266
3.105PheLeu: 3.105 ± 0.452
0.632PheMet: 0.632 ± 0.166
1.632PheAsn: 1.632 ± 0.277
2.0PhePro: 2.0 ± 0.319
1.053PheGln: 1.053 ± 0.258
2.263PheArg: 2.263 ± 0.278
2.368PheSer: 2.368 ± 0.368
3.421PheThr: 3.421 ± 0.584
2.421PheVal: 2.421 ± 0.34
0.263PheTrp: 0.263 ± 0.099
1.053PheTyr: 1.053 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
6.579GlyAla: 6.579 ± 0.671
0.474GlyCys: 0.474 ± 0.163
5.737GlyAsp: 5.737 ± 0.54
5.737GlyGlu: 5.737 ± 0.561
2.895GlyPhe: 2.895 ± 0.401
6.947GlyGly: 6.947 ± 0.785
1.684GlyHis: 1.684 ± 0.308
3.0GlyIle: 3.0 ± 0.319
3.105GlyLys: 3.105 ± 0.491
5.632GlyLeu: 5.632 ± 0.548
2.053GlyMet: 2.053 ± 0.381
3.632GlyAsn: 3.632 ± 0.436
2.263GlyPro: 2.263 ± 0.343
2.842GlyGln: 2.842 ± 0.441
4.368GlyArg: 4.368 ± 0.404
5.316GlySer: 5.316 ± 0.589
6.0GlyThr: 6.0 ± 0.721
5.632GlyVal: 5.632 ± 0.473
1.526GlyTrp: 1.526 ± 0.281
2.211GlyTyr: 2.211 ± 0.3
0.0GlyXaa: 0.0 ± 0.0
His
1.632HisAla: 1.632 ± 0.289
0.053HisCys: 0.053 ± 0.063
1.421HisAsp: 1.421 ± 0.312
1.421HisGlu: 1.421 ± 0.317
0.737HisPhe: 0.737 ± 0.154
1.789HisGly: 1.789 ± 0.282
0.316HisHis: 0.316 ± 0.123
0.789HisIle: 0.789 ± 0.236
0.947HisLys: 0.947 ± 0.226
1.0HisLeu: 1.0 ± 0.224
0.421HisMet: 0.421 ± 0.151
0.263HisAsn: 0.263 ± 0.107
0.632HisPro: 0.632 ± 0.215
0.947HisGln: 0.947 ± 0.224
1.211HisArg: 1.211 ± 0.238
0.842HisSer: 0.842 ± 0.238
1.053HisThr: 1.053 ± 0.221
1.526HisVal: 1.526 ± 0.287
0.211HisTrp: 0.211 ± 0.106
0.526HisTyr: 0.526 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
4.526IleAla: 4.526 ± 0.539
0.526IleCys: 0.526 ± 0.147
3.316IleAsp: 3.316 ± 0.395
3.368IleGlu: 3.368 ± 0.474
1.632IlePhe: 1.632 ± 0.324
3.211IleGly: 3.211 ± 0.387
0.842IleHis: 0.842 ± 0.191
2.316IleIle: 2.316 ± 0.351
1.947IleLys: 1.947 ± 0.295
3.684IleLeu: 3.684 ± 0.374
1.053IleMet: 1.053 ± 0.248
2.0IleAsn: 2.0 ± 0.331
2.684IlePro: 2.684 ± 0.409
2.211IleGln: 2.211 ± 0.354
2.737IleArg: 2.737 ± 0.391
2.737IleSer: 2.737 ± 0.506
2.895IleThr: 2.895 ± 0.413
3.421IleVal: 3.421 ± 0.376
0.895IleTrp: 0.895 ± 0.211
1.579IleTyr: 1.579 ± 0.261
0.0IleXaa: 0.0 ± 0.0
Lys
5.421LysAla: 5.421 ± 0.841
0.263LysCys: 0.263 ± 0.121
2.579LysAsp: 2.579 ± 0.531
2.368LysGlu: 2.368 ± 0.416
1.421LysPhe: 1.421 ± 0.286
3.211LysGly: 3.211 ± 0.593
0.842LysHis: 0.842 ± 0.219
1.895LysIle: 1.895 ± 0.305
2.474LysLys: 2.474 ± 0.587
3.211LysLeu: 3.211 ± 0.456
1.737LysMet: 1.737 ± 0.351
0.789LysAsn: 0.789 ± 0.205
2.053LysPro: 2.053 ± 0.494
1.842LysGln: 1.842 ± 0.419
2.421LysArg: 2.421 ± 0.4
2.368LysSer: 2.368 ± 0.404
2.842LysThr: 2.842 ± 0.396
2.789LysVal: 2.789 ± 0.363
0.579LysTrp: 0.579 ± 0.189
1.053LysTyr: 1.053 ± 0.245
0.0LysXaa: 0.0 ± 0.0
Leu
8.474LeuAla: 8.474 ± 0.584
0.737LeuCys: 0.737 ± 0.198
6.474LeuAsp: 6.474 ± 0.612
5.474LeuGlu: 5.474 ± 0.654
2.789LeuPhe: 2.789 ± 0.35
7.053LeuGly: 7.053 ± 0.571
1.842LeuHis: 1.842 ± 0.443
3.842LeuIle: 3.842 ± 0.44
3.895LeuLys: 3.895 ± 0.636
6.895LeuLeu: 6.895 ± 0.589
2.368LeuMet: 2.368 ± 0.389
3.842LeuAsn: 3.842 ± 0.387
4.105LeuPro: 4.105 ± 0.403
2.684LeuGln: 2.684 ± 0.385
4.737LeuArg: 4.737 ± 0.549
4.684LeuSer: 4.684 ± 0.523
7.158LeuThr: 7.158 ± 0.684
5.421LeuVal: 5.421 ± 0.613
1.947LeuTrp: 1.947 ± 0.35
2.053LeuTyr: 2.053 ± 0.301
0.0LeuXaa: 0.0 ± 0.0
Met
2.632MetAla: 2.632 ± 0.418
0.211MetCys: 0.211 ± 0.097
1.789MetAsp: 1.789 ± 0.317
1.474MetGlu: 1.474 ± 0.338
0.632MetPhe: 0.632 ± 0.184
1.947MetGly: 1.947 ± 0.356
0.368MetHis: 0.368 ± 0.157
1.368MetIle: 1.368 ± 0.242
1.211MetLys: 1.211 ± 0.207
1.947MetLeu: 1.947 ± 0.385
0.316MetMet: 0.316 ± 0.128
0.737MetAsn: 0.737 ± 0.194
1.263MetPro: 1.263 ± 0.282
1.263MetGln: 1.263 ± 0.302
1.316MetArg: 1.316 ± 0.28
1.684MetSer: 1.684 ± 0.303
2.474MetThr: 2.474 ± 0.362
1.474MetVal: 1.474 ± 0.195
0.263MetTrp: 0.263 ± 0.1
0.789MetTyr: 0.789 ± 0.238
0.0MetXaa: 0.0 ± 0.0
Asn
3.895AsnAla: 3.895 ± 0.469
0.316AsnCys: 0.316 ± 0.136
2.105AsnAsp: 2.105 ± 0.278
2.263AsnGlu: 2.263 ± 0.308
1.684AsnPhe: 1.684 ± 0.25
4.0AsnGly: 4.0 ± 0.465
0.579AsnHis: 0.579 ± 0.221
1.632AsnIle: 1.632 ± 0.335
1.0AsnLys: 1.0 ± 0.277
3.368AsnLeu: 3.368 ± 0.502
0.842AsnMet: 0.842 ± 0.194
2.0AsnAsn: 2.0 ± 0.447
2.474AsnPro: 2.474 ± 0.286
1.789AsnGln: 1.789 ± 0.374
3.0AsnArg: 3.0 ± 0.322
2.474AsnSer: 2.474 ± 0.362
3.263AsnThr: 3.263 ± 0.565
2.421AsnVal: 2.421 ± 0.355
1.0AsnTrp: 1.0 ± 0.204
0.895AsnTyr: 0.895 ± 0.252
0.0AsnXaa: 0.0 ± 0.0
Pro
4.684ProAla: 4.684 ± 0.504
0.474ProCys: 0.474 ± 0.159
3.263ProAsp: 3.263 ± 0.345
3.526ProGlu: 3.526 ± 0.519
1.632ProPhe: 1.632 ± 0.268
3.632ProGly: 3.632 ± 0.455
0.895ProHis: 0.895 ± 0.276
2.053ProIle: 2.053 ± 0.327
2.211ProLys: 2.211 ± 0.471
4.579ProLeu: 4.579 ± 0.408
0.842ProMet: 0.842 ± 0.199
1.895ProAsn: 1.895 ± 0.29
1.947ProPro: 1.947 ± 0.336
1.316ProGln: 1.316 ± 0.272
2.632ProArg: 2.632 ± 0.367
3.316ProSer: 3.316 ± 0.485
2.737ProThr: 2.737 ± 0.376
3.0ProVal: 3.0 ± 0.458
0.526ProTrp: 0.526 ± 0.19
1.105ProTyr: 1.105 ± 0.234
0.0ProXaa: 0.0 ± 0.0
Gln
4.211GlnAla: 4.211 ± 0.459
0.316GlnCys: 0.316 ± 0.116
2.474GlnAsp: 2.474 ± 0.361
2.421GlnGlu: 2.421 ± 0.469
1.316GlnPhe: 1.316 ± 0.28
2.263GlnGly: 2.263 ± 0.371
0.526GlnHis: 0.526 ± 0.15
2.211GlnIle: 2.211 ± 0.388
1.684GlnLys: 1.684 ± 0.311
3.474GlnLeu: 3.474 ± 0.451
1.105GlnMet: 1.105 ± 0.287
1.947GlnAsn: 1.947 ± 0.299
1.737GlnPro: 1.737 ± 0.349
1.316GlnGln: 1.316 ± 0.29
2.421GlnArg: 2.421 ± 0.357
1.684GlnSer: 1.684 ± 0.325
2.263GlnThr: 2.263 ± 0.401
3.105GlnVal: 3.105 ± 0.418
0.947GlnTrp: 0.947 ± 0.197
0.842GlnTyr: 0.842 ± 0.205
0.0GlnXaa: 0.0 ± 0.0
Arg
5.684ArgAla: 5.684 ± 0.758
0.789ArgCys: 0.789 ± 0.225
4.0ArgAsp: 4.0 ± 0.5
3.789ArgGlu: 3.789 ± 0.443
2.474ArgPhe: 2.474 ± 0.478
4.263ArgGly: 4.263 ± 0.534
0.842ArgHis: 0.842 ± 0.185
3.684ArgIle: 3.684 ± 0.461
2.947ArgLys: 2.947 ± 0.457
5.368ArgLeu: 5.368 ± 0.47
1.895ArgMet: 1.895 ± 0.308
2.316ArgAsn: 2.316 ± 0.314
3.684ArgPro: 3.684 ± 0.529
2.316ArgGln: 2.316 ± 0.419
5.632ArgArg: 5.632 ± 0.752
3.211ArgSer: 3.211 ± 0.424
3.632ArgThr: 3.632 ± 0.389
4.105ArgVal: 4.105 ± 0.421
1.053ArgTrp: 1.053 ± 0.235
1.789ArgTyr: 1.789 ± 0.373
0.0ArgXaa: 0.0 ± 0.0
Ser
5.842SerAla: 5.842 ± 0.558
0.737SerCys: 0.737 ± 0.197
3.421SerAsp: 3.421 ± 0.408
3.263SerGlu: 3.263 ± 0.419
2.211SerPhe: 2.211 ± 0.358
4.842SerGly: 4.842 ± 0.651
1.0SerHis: 1.0 ± 0.213
2.579SerIle: 2.579 ± 0.364
2.211SerLys: 2.211 ± 0.384
4.842SerLeu: 4.842 ± 0.468
1.684SerMet: 1.684 ± 0.31
2.053SerAsn: 2.053 ± 0.389
1.842SerPro: 1.842 ± 0.374
2.0SerGln: 2.0 ± 0.276
3.105SerArg: 3.105 ± 0.412
3.316SerSer: 3.316 ± 0.4
3.316SerThr: 3.316 ± 0.34
4.158SerVal: 4.158 ± 0.514
0.947SerTrp: 0.947 ± 0.225
1.368SerTyr: 1.368 ± 0.291
0.0SerXaa: 0.0 ± 0.0
Thr
6.263ThrAla: 6.263 ± 0.794
0.368ThrCys: 0.368 ± 0.143
4.526ThrAsp: 4.526 ± 0.59
4.105ThrGlu: 4.105 ± 0.48
3.158ThrPhe: 3.158 ± 0.469
5.737ThrGly: 5.737 ± 0.629
1.0ThrHis: 1.0 ± 0.251
3.579ThrIle: 3.579 ± 0.513
2.053ThrLys: 2.053 ± 0.304
6.632ThrLeu: 6.632 ± 0.974
1.211ThrMet: 1.211 ± 0.234
3.579ThrAsn: 3.579 ± 0.665
4.211ThrPro: 4.211 ± 0.551
2.263ThrGln: 2.263 ± 0.353
3.579ThrArg: 3.579 ± 0.411
3.368ThrSer: 3.368 ± 0.503
5.263ThrThr: 5.263 ± 0.99
5.0ThrVal: 5.0 ± 0.607
1.158ThrTrp: 1.158 ± 0.253
1.737ThrTyr: 1.737 ± 0.289
0.0ThrXaa: 0.0 ± 0.0
Val
6.0ValAla: 6.0 ± 0.569
0.632ValCys: 0.632 ± 0.183
5.421ValAsp: 5.421 ± 0.487
5.053ValGlu: 5.053 ± 0.548
2.842ValPhe: 2.842 ± 0.397
4.316ValGly: 4.316 ± 0.49
1.421ValHis: 1.421 ± 0.225
2.895ValIle: 2.895 ± 0.349
3.579ValLys: 3.579 ± 0.51
5.158ValLeu: 5.158 ± 0.504
1.368ValMet: 1.368 ± 0.271
3.0ValAsn: 3.0 ± 0.486
2.632ValPro: 2.632 ± 0.366
2.684ValGln: 2.684 ± 0.327
4.211ValArg: 4.211 ± 0.448
4.526ValSer: 4.526 ± 0.603
5.316ValThr: 5.316 ± 0.777
4.421ValVal: 4.421 ± 0.506
1.0ValTrp: 1.0 ± 0.229
1.316ValTyr: 1.316 ± 0.254
0.0ValXaa: 0.0 ± 0.0
Trp
1.053TrpAla: 1.053 ± 0.258
0.158TrpCys: 0.158 ± 0.085
1.316TrpAsp: 1.316 ± 0.257
1.105TrpGlu: 1.105 ± 0.221
0.789TrpPhe: 0.789 ± 0.224
1.053TrpGly: 1.053 ± 0.265
0.368TrpHis: 0.368 ± 0.131
0.737TrpIle: 0.737 ± 0.21
0.895TrpLys: 0.895 ± 0.215
2.0TrpLeu: 2.0 ± 0.322
0.421TrpMet: 0.421 ± 0.119
0.789TrpAsn: 0.789 ± 0.203
0.684TrpPro: 0.684 ± 0.208
0.789TrpGln: 0.789 ± 0.183
1.053TrpArg: 1.053 ± 0.204
0.895TrpSer: 0.895 ± 0.214
1.316TrpThr: 1.316 ± 0.246
1.526TrpVal: 1.526 ± 0.278
0.368TrpTrp: 0.368 ± 0.125
0.474TrpTyr: 0.474 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.684TyrAla: 1.684 ± 0.291
0.526TyrCys: 0.526 ± 0.168
1.579TyrAsp: 1.579 ± 0.278
1.211TyrGlu: 1.211 ± 0.272
0.789TyrPhe: 0.789 ± 0.182
1.842TyrGly: 1.842 ± 0.334
0.526TyrHis: 0.526 ± 0.156
1.0TyrIle: 1.0 ± 0.192
0.947TyrLys: 0.947 ± 0.22
1.842TyrLeu: 1.842 ± 0.296
0.684TyrMet: 0.684 ± 0.175
0.684TyrAsn: 0.684 ± 0.217
1.474TyrPro: 1.474 ± 0.317
1.368TyrGln: 1.368 ± 0.29
2.632TyrArg: 2.632 ± 0.349
1.421TyrSer: 1.421 ± 0.253
1.263TyrThr: 1.263 ± 0.232
1.842TyrVal: 1.842 ± 0.302
0.421TyrTrp: 0.421 ± 0.161
0.684TyrTyr: 0.684 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (19001 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski