Amino acid dipepetide frequency for Winogradskyella sp. KYW1333

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.08AlaAla: 3.08 ± 0.087	0.527AlaCys: 0.527 ± 0.029	3.265AlaAsp: 3.265 ± 0.076	3.737AlaGlu: 3.737 ± 0.083	3.28AlaPhe: 3.28 ± 0.063	3.877AlaGly: 3.877 ± 0.086	1.048AlaHis: 1.048 ± 0.036	5.344AlaIle: 5.344 ± 0.097	4.467AlaLys: 4.467 ± 0.091	5.856AlaLeu: 5.856 ± 0.084	1.513AlaMet: 1.513 ± 0.04	3.545AlaAsn: 3.545 ± 0.069	1.71AlaPro: 1.71 ± 0.048	2.214AlaGln: 2.214 ± 0.049	1.966AlaArg: 1.966 ± 0.05	4.189AlaSer: 4.189 ± 0.077	3.492AlaThr: 3.492 ± 0.076	3.836AlaVal: 3.836 ± 0.083	0.601AlaTrp: 0.601 ± 0.026	2.352AlaTyr: 2.352 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.441CysAla: 0.441 ± 0.025	0.101CysCys: 0.101 ± 0.011	0.493CysAsp: 0.493 ± 0.035	0.494CysGlu: 0.494 ± 0.024	0.434CysPhe: 0.434 ± 0.024	0.649CysGly: 0.649 ± 0.034	0.18CysHis: 0.18 ± 0.018	0.648CysIle: 0.648 ± 0.032	0.476CysLys: 0.476 ± 0.022	0.664CysLeu: 0.664 ± 0.028	0.133CysMet: 0.133 ± 0.013	0.434CysAsn: 0.434 ± 0.022	0.311CysPro: 0.311 ± 0.026	0.218CysGln: 0.218 ± 0.017	0.171CysArg: 0.171 ± 0.014	0.546CysSer: 0.546 ± 0.026	0.379CysThr: 0.379 ± 0.024	0.44CysVal: 0.44 ± 0.023	0.059CysTrp: 0.059 ± 0.009	0.281CysTyr: 0.281 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.871AspAla: 3.871 ± 0.074	0.437AspCys: 0.437 ± 0.025	3.435AspAsp: 3.435 ± 0.077	4.042AspGlu: 4.042 ± 0.085	3.723AspPhe: 3.723 ± 0.074	4.082AspGly: 4.082 ± 0.091	0.876AspHis: 0.876 ± 0.032	5.19AspIle: 5.19 ± 0.074	4.27AspLys: 4.27 ± 0.087	5.468AspLeu: 5.468 ± 0.084	1.163AspMet: 1.163 ± 0.039	3.824AspAsn: 3.824 ± 0.08	1.774AspPro: 1.774 ± 0.053	1.554AspGln: 1.554 ± 0.05	1.931AspArg: 1.931 ± 0.043	3.523AspSer: 3.523 ± 0.09	3.006AspThr: 3.006 ± 0.059	3.931AspVal: 3.931 ± 0.07	0.763AspTrp: 0.763 ± 0.031	3.023AspTyr: 3.023 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.286GluAla: 4.286 ± 0.086	0.373GluCys: 0.373 ± 0.026	4.111GluAsp: 4.111 ± 0.08	4.811GluGlu: 4.811 ± 0.099	3.202GluPhe: 3.202 ± 0.063	3.725GluGly: 3.725 ± 0.074	1.079GluHis: 1.079 ± 0.036	5.535GluIle: 5.535 ± 0.082	4.989GluLys: 4.989 ± 0.093	6.176GluLeu: 6.176 ± 0.101	1.44GluMet: 1.44 ± 0.049	4.539GluAsn: 4.539 ± 0.08	1.642GluPro: 1.642 ± 0.043	2.176GluGln: 2.176 ± 0.056	2.571GluArg: 2.571 ± 0.063	3.673GluSer: 3.673 ± 0.067	3.67GluThr: 3.67 ± 0.067	4.332GluVal: 4.332 ± 0.087	0.663GluTrp: 0.663 ± 0.024	2.401GluTyr: 2.401 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.879PheAla: 2.879 ± 0.055	0.436PheCys: 0.436 ± 0.025	3.421PheAsp: 3.421 ± 0.074	3.532PheGlu: 3.532 ± 0.065	2.664PhePhe: 2.664 ± 0.075	3.861PheGly: 3.861 ± 0.079	0.792PheHis: 0.792 ± 0.028	4.234PheIle: 4.234 ± 0.093	4.003PheLys: 4.003 ± 0.078	4.402PheLeu: 4.402 ± 0.098	1.154PheMet: 1.154 ± 0.035	3.782PheAsn: 3.782 ± 0.082	1.625PhePro: 1.625 ± 0.046	1.503PheGln: 1.503 ± 0.043	1.634PheArg: 1.634 ± 0.051	4.011PheSer: 4.011 ± 0.082	3.08PheThr: 3.08 ± 0.069	3.064PheVal: 3.064 ± 0.064	0.579PheTrp: 0.579 ± 0.03	2.117PheTyr: 2.117 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	3.979GlyAla: 3.979 ± 0.077	0.591GlyCys: 0.591 ± 0.039	3.785GlyAsp: 3.785 ± 0.089	3.789GlyGlu: 3.789 ± 0.067	3.76GlyPhe: 3.76 ± 0.08	4.641GlyGly: 4.641 ± 0.102	1.176GlyHis: 1.176 ± 0.038	5.503GlyIle: 5.503 ± 0.093	4.567GlyLys: 4.567 ± 0.094	5.989GlyLeu: 5.989 ± 0.086	1.525GlyMet: 1.525 ± 0.045	3.889GlyAsn: 3.889 ± 0.087	1.485GlyPro: 1.485 ± 0.051	1.957GlyGln: 1.957 ± 0.046	2.233GlyArg: 2.233 ± 0.062	3.997GlySer: 3.997 ± 0.08	3.926GlyThr: 3.926 ± 0.098	4.177GlyVal: 4.177 ± 0.077	0.801GlyTrp: 0.801 ± 0.038	2.792GlyTyr: 2.792 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.905HisAla: 0.905 ± 0.031	0.165HisCys: 0.165 ± 0.013	0.832HisAsp: 0.832 ± 0.036	0.928HisGlu: 0.928 ± 0.036	1.092HisPhe: 1.092 ± 0.035	1.061HisGly: 1.061 ± 0.04	0.443HisHis: 0.443 ± 0.022	1.417HisIle: 1.417 ± 0.046	1.243HisLys: 1.243 ± 0.041	1.64HisLeu: 1.64 ± 0.045	0.349HisMet: 0.349 ± 0.02	1.085HisAsn: 1.085 ± 0.038	0.832HisPro: 0.832 ± 0.035	0.637HisGln: 0.637 ± 0.029	0.665HisArg: 0.665 ± 0.031	1.025HisSer: 1.025 ± 0.041	0.842HisThr: 0.842 ± 0.028	0.962HisVal: 0.962 ± 0.032	0.2HisTrp: 0.2 ± 0.013	0.8HisTyr: 0.8 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.44IleAla: 5.44 ± 0.096	0.707IleCys: 0.707 ± 0.032	5.459IleAsp: 5.459 ± 0.084	5.975IleGlu: 5.975 ± 0.094	3.787IlePhe: 3.787 ± 0.081	5.222IleGly: 5.222 ± 0.086	1.256IleHis: 1.256 ± 0.042	6.63IleIle: 6.63 ± 0.124	6.064IleLys: 6.064 ± 0.096	7.26IleLeu: 7.26 ± 0.127	1.41IleMet: 1.41 ± 0.04	5.462IleAsn: 5.462 ± 0.08	3.227IlePro: 3.227 ± 0.059	2.335IleGln: 2.335 ± 0.048	2.572IleArg: 2.572 ± 0.057	6.057IleSer: 6.057 ± 0.089	4.753IleThr: 4.753 ± 0.091	5.062IleVal: 5.062 ± 0.091	0.732IleTrp: 0.732 ± 0.032	3.029IleTyr: 3.029 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	4.635LysAla: 4.635 ± 0.094	0.316LysCys: 0.316 ± 0.022	4.556LysAsp: 4.556 ± 0.08	5.364LysGlu: 5.364 ± 0.106	3.007LysPhe: 3.007 ± 0.072	4.398LysGly: 4.398 ± 0.079	1.425LysHis: 1.425 ± 0.043	5.822LysIle: 5.822 ± 0.101	6.031LysLys: 6.031 ± 0.101	6.606LysLeu: 6.606 ± 0.098	1.827LysMet: 1.827 ± 0.047	4.801LysAsn: 4.801 ± 0.088	2.46LysPro: 2.46 ± 0.062	2.625LysGln: 2.625 ± 0.062	3.092LysArg: 3.092 ± 0.067	4.977LysSer: 4.977 ± 0.087	4.395LysThr: 4.395 ± 0.078	4.638LysVal: 4.638 ± 0.08	0.783LysTrp: 0.783 ± 0.029	3.029LysTyr: 3.029 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	5.336LeuAla: 5.336 ± 0.09	0.68LeuCys: 0.68 ± 0.03	5.532LeuAsp: 5.532 ± 0.088	5.821LeuGlu: 5.821 ± 0.085	4.889LeuPhe: 4.889 ± 0.1	5.788LeuGly: 5.788 ± 0.096	1.505LeuHis: 1.505 ± 0.052	7.313LeuIle: 7.313 ± 0.114	7.771LeuLys: 7.771 ± 0.115	8.243LeuLeu: 8.243 ± 0.139	2.076LeuMet: 2.076 ± 0.054	6.29LeuAsn: 6.29 ± 0.101	3.39LeuPro: 3.39 ± 0.071	2.83LeuGln: 2.83 ± 0.055	3.323LeuArg: 3.323 ± 0.069	6.516LeuSer: 6.516 ± 0.093	4.908LeuThr: 4.908 ± 0.086	5.453LeuVal: 5.453 ± 0.083	0.777LeuTrp: 0.777 ± 0.036	3.151LeuTyr: 3.151 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.562MetAla: 1.562 ± 0.046	0.135MetCys: 0.135 ± 0.013	1.199MetAsp: 1.199 ± 0.035	1.186MetGlu: 1.186 ± 0.037	0.886MetPhe: 0.886 ± 0.034	1.29MetGly: 1.29 ± 0.042	0.44MetHis: 0.44 ± 0.024	1.589MetIle: 1.589 ± 0.045	1.982MetLys: 1.982 ± 0.042	1.932MetLeu: 1.932 ± 0.051	0.551MetMet: 0.551 ± 0.03	1.266MetAsn: 1.266 ± 0.03	0.831MetPro: 0.831 ± 0.035	0.77MetGln: 0.77 ± 0.031	0.907MetArg: 0.907 ± 0.039	1.448MetSer: 1.448 ± 0.046	1.205MetThr: 1.205 ± 0.04	1.345MetVal: 1.345 ± 0.039	0.166MetTrp: 0.166 ± 0.015	0.729MetTyr: 0.729 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.841AsnAla: 3.841 ± 0.076	0.525AsnCys: 0.525 ± 0.027	3.907AsnAsp: 3.907 ± 0.077	4.047AsnGlu: 4.047 ± 0.077	3.288AsnPhe: 3.288 ± 0.078	4.275AsnGly: 4.275 ± 0.089	1.093AsnHis: 1.093 ± 0.037	5.193AsnIle: 5.193 ± 0.093	4.547AsnLys: 4.547 ± 0.083	5.613AsnLeu: 5.613 ± 0.089	1.306AsnMet: 1.306 ± 0.035	4.45AsnAsn: 4.45 ± 0.09	2.803AsnPro: 2.803 ± 0.068	2.322AsnGln: 2.322 ± 0.058	2.318AsnArg: 2.318 ± 0.063	4.453AsnSer: 4.453 ± 0.095	3.879AsnThr: 3.879 ± 0.09	3.729AsnVal: 3.729 ± 0.077	0.827AsnTrp: 0.827 ± 0.036	3.106AsnTyr: 3.106 ± 0.063	0.001AsnXaa: 0.001 ± 0.001
Pro	1.629ProAla: 1.629 ± 0.041	0.209ProCys: 0.209 ± 0.016	2.068ProAsp: 2.068 ± 0.047	2.725ProGlu: 2.725 ± 0.057	1.904ProPhe: 1.904 ± 0.048	1.904ProGly: 1.904 ± 0.058	0.571ProHis: 0.571 ± 0.024	2.848ProIle: 2.848 ± 0.062	2.361ProLys: 2.361 ± 0.054	2.906ProLeu: 2.906 ± 0.058	0.721ProMet: 0.721 ± 0.028	2.5ProAsn: 2.5 ± 0.065	0.815ProPro: 0.815 ± 0.033	1.069ProGln: 1.069 ± 0.038	0.947ProArg: 0.947 ± 0.031	2.158ProSer: 2.158 ± 0.052	1.868ProThr: 1.868 ± 0.056	2.187ProVal: 2.187 ± 0.059	0.328ProTrp: 0.328 ± 0.021	1.462ProTyr: 1.462 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.826GlnAla: 1.826 ± 0.049	0.192GlnCys: 0.192 ± 0.014	1.699GlnAsp: 1.699 ± 0.043	2.01GlnGlu: 2.01 ± 0.062	1.694GlnPhe: 1.694 ± 0.05	1.754GlnGly: 1.754 ± 0.046	0.533GlnHis: 0.533 ± 0.025	2.672GlnIle: 2.672 ± 0.047	2.446GlnLys: 2.446 ± 0.065	3.485GlnLeu: 3.485 ± 0.07	0.733GlnMet: 0.733 ± 0.031	2.108GlnAsn: 2.108 ± 0.056	1.081GlnPro: 1.081 ± 0.04	1.19GlnGln: 1.19 ± 0.043	1.231GlnArg: 1.231 ± 0.039	1.898GlnSer: 1.898 ± 0.055	1.767GlnThr: 1.767 ± 0.047	1.858GlnVal: 1.858 ± 0.047	0.347GlnTrp: 0.347 ± 0.019	1.323GlnTyr: 1.323 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.185ArgAla: 2.185 ± 0.055	0.199ArgCys: 0.199 ± 0.015	1.926ArgAsp: 1.926 ± 0.054	2.135ArgGlu: 2.135 ± 0.058	2.005ArgPhe: 2.005 ± 0.047	2.023ArgGly: 2.023 ± 0.057	0.655ArgHis: 0.655 ± 0.025	2.935ArgIle: 2.935 ± 0.061	2.601ArgLys: 2.601 ± 0.06	3.429ArgLeu: 3.429 ± 0.058	0.813ArgMet: 0.813 ± 0.029	2.221ArgAsn: 2.221 ± 0.056	1.191ArgPro: 1.191 ± 0.042	1.206ArgGln: 1.206 ± 0.044	1.462ArgArg: 1.462 ± 0.047	2.023ArgSer: 2.023 ± 0.057	1.855ArgThr: 1.855 ± 0.052	2.121ArgVal: 2.121 ± 0.051	0.368ArgTrp: 0.368 ± 0.021	1.584ArgTyr: 1.584 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.771SerAla: 3.771 ± 0.071	0.636SerCys: 0.636 ± 0.029	3.885SerAsp: 3.885 ± 0.072	4.277SerGlu: 4.277 ± 0.079	3.808SerPhe: 3.808 ± 0.074	4.739SerGly: 4.739 ± 0.073	1.106SerHis: 1.106 ± 0.038	5.701SerIle: 5.701 ± 0.093	5.059SerLys: 5.059 ± 0.085	5.968SerLeu: 5.968 ± 0.103	1.302SerMet: 1.302 ± 0.036	4.369SerAsn: 4.369 ± 0.08	2.038SerPro: 2.038 ± 0.049	2.15SerGln: 2.15 ± 0.056	2.151SerArg: 2.151 ± 0.064	4.432SerSer: 4.432 ± 0.094	3.758SerThr: 3.758 ± 0.087	4.032SerVal: 4.032 ± 0.077	0.676SerTrp: 0.676 ± 0.031	2.775SerTyr: 2.775 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.293ThrAla: 3.293 ± 0.073	0.384ThrCys: 0.384 ± 0.027	3.329ThrAsp: 3.329 ± 0.055	3.505ThrGlu: 3.505 ± 0.061	3.012ThrPhe: 3.012 ± 0.059	4.039ThrGly: 4.039 ± 0.1	0.957ThrHis: 0.957 ± 0.035	5.068ThrIle: 5.068 ± 0.087	3.765ThrLys: 3.765 ± 0.071	5.139ThrLeu: 5.139 ± 0.077	1.038ThrMet: 1.038 ± 0.031	3.518ThrAsn: 3.518 ± 0.083	2.204ThrPro: 2.204 ± 0.061	1.651ThrGln: 1.651 ± 0.047	1.718ThrArg: 1.718 ± 0.049	3.944ThrSer: 3.944 ± 0.088	3.451ThrThr: 3.451 ± 0.082	3.723ThrVal: 3.723 ± 0.083	0.572ThrTrp: 0.572 ± 0.03	2.459ThrTyr: 2.459 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.026ValAla: 4.026 ± 0.081	0.506ValCys: 0.506 ± 0.027	3.803ValAsp: 3.803 ± 0.072	4.041ValGlu: 4.041 ± 0.082	3.33ValPhe: 3.33 ± 0.075	3.885ValGly: 3.885 ± 0.08	0.967ValHis: 0.967 ± 0.036	5.231ValIle: 5.231 ± 0.086	4.369ValLys: 4.369 ± 0.086	5.887ValLeu: 5.887 ± 0.085	1.32ValMet: 1.32 ± 0.042	3.778ValAsn: 3.778 ± 0.067	2.048ValPro: 2.048 ± 0.057	1.641ValGln: 1.641 ± 0.049	1.995ValArg: 1.995 ± 0.049	4.326ValSer: 4.326 ± 0.074	3.607ValThr: 3.607 ± 0.073	4.297ValVal: 4.297 ± 0.084	0.59ValTrp: 0.59 ± 0.026	2.381ValTyr: 2.381 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.578TrpAla: 0.578 ± 0.027	0.092TrpCys: 0.092 ± 0.01	0.668TrpAsp: 0.668 ± 0.03	0.661TrpGlu: 0.661 ± 0.029	0.582TrpPhe: 0.582 ± 0.028	0.62TrpGly: 0.62 ± 0.035	0.233TrpHis: 0.233 ± 0.015	0.749TrpIle: 0.749 ± 0.028	0.698TrpLys: 0.698 ± 0.033	0.996TrpLeu: 0.996 ± 0.032	0.286TrpMet: 0.286 ± 0.019	0.694TrpAsn: 0.694 ± 0.034	0.245TrpPro: 0.245 ± 0.019	0.409TrpGln: 0.409 ± 0.022	0.434TrpArg: 0.434 ± 0.024	0.706TrpSer: 0.706 ± 0.031	0.579TrpThr: 0.579 ± 0.034	0.589TrpVal: 0.589 ± 0.03	0.152TrpTrp: 0.152 ± 0.013	0.482TrpTyr: 0.482 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.336TyrAla: 2.336 ± 0.055	0.338TyrCys: 0.338 ± 0.021	2.513TyrAsp: 2.513 ± 0.057	2.315TyrGlu: 2.315 ± 0.052	2.423TyrPhe: 2.423 ± 0.061	2.73TyrGly: 2.73 ± 0.056	0.789TyrHis: 0.789 ± 0.033	2.818TyrIle: 2.818 ± 0.059	3.078TyrLys: 3.078 ± 0.07	3.934TyrLeu: 3.934 ± 0.069	0.758TyrMet: 0.758 ± 0.031	2.971TyrAsn: 2.971 ± 0.064	1.468TyrPro: 1.468 ± 0.042	1.389TyrGln: 1.389 ± 0.044	1.616TyrArg: 1.616 ± 0.035	2.731TyrSer: 2.731 ± 0.062	2.349TyrThr: 2.349 ± 0.069	2.254TyrVal: 2.254 ± 0.058	0.468TyrTrp: 0.468 ± 0.027	1.915TyrTyr: 1.915 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2480 proteins (859683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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