Amino acid dipepetide frequency for Mycobacterium marinum (strain ATCC BAA-535 / M)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.149AlaAla: 21.149 ± 0.182	1.002AlaCys: 1.002 ± 0.024	7.739AlaAsp: 7.739 ± 0.065	7.103AlaGlu: 7.103 ± 0.086	3.426AlaPhe: 3.426 ± 0.05	15.109AlaGly: 15.109 ± 0.422	2.601AlaHis: 2.601 ± 0.043	5.354AlaIle: 5.354 ± 0.059	2.739AlaLys: 2.739 ± 0.053	12.581AlaLeu: 12.581 ± 0.099	2.86AlaMet: 2.86 ± 0.041	3.082AlaAsn: 3.082 ± 0.076	6.457AlaPro: 6.457 ± 0.089	4.465AlaGln: 4.465 ± 0.053	8.056AlaArg: 8.056 ± 0.089	6.444AlaSer: 6.444 ± 0.069	7.404AlaThr: 7.404 ± 0.093	10.755AlaVal: 10.755 ± 0.102	1.568AlaTrp: 1.568 ± 0.033	2.338AlaTyr: 2.338 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.119CysAla: 1.119 ± 0.03	0.104CysCys: 0.104 ± 0.008	0.563CysAsp: 0.563 ± 0.02	0.41CysGlu: 0.41 ± 0.015	0.216CysPhe: 0.216 ± 0.009	0.96CysGly: 0.96 ± 0.023	0.196CysHis: 0.196 ± 0.01	0.272CysIle: 0.272 ± 0.013	0.134CysLys: 0.134 ± 0.008	0.636CysLeu: 0.636 ± 0.021	0.136CysMet: 0.136 ± 0.008	0.186CysAsn: 0.186 ± 0.008	0.532CysPro: 0.532 ± 0.021	0.246CysGln: 0.246 ± 0.012	0.587CysArg: 0.587 ± 0.019	0.48CysSer: 0.48 ± 0.016	0.453CysThr: 0.453 ± 0.017	0.631CysVal: 0.631 ± 0.024	0.151CysTrp: 0.151 ± 0.01	0.203CysTyr: 0.203 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.893AspAla: 6.893 ± 0.088	0.445AspCys: 0.445 ± 0.016	3.422AspAsp: 3.422 ± 0.055	3.519AspGlu: 3.519 ± 0.052	1.733AspPhe: 1.733 ± 0.035	6.326AspGly: 6.326 ± 0.138	1.377AspHis: 1.377 ± 0.031	2.496AspIle: 2.496 ± 0.038	1.121AspLys: 1.121 ± 0.027	5.65AspLeu: 5.65 ± 0.077	0.933AspMet: 0.933 ± 0.025	1.248AspAsn: 1.248 ± 0.029	4.122AspPro: 4.122 ± 0.05	1.884AspGln: 1.884 ± 0.039	4.134AspArg: 4.134 ± 0.057	2.787AspSer: 2.787 ± 0.041	3.048AspThr: 3.048 ± 0.066	4.651AspVal: 4.651 ± 0.063	0.875AspTrp: 0.875 ± 0.024	1.455AspTyr: 1.455 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.637GluAla: 5.637 ± 0.074	0.407GluCys: 0.407 ± 0.015	2.157GluAsp: 2.157 ± 0.039	2.127GluGlu: 2.127 ± 0.042	1.69GluPhe: 1.69 ± 0.033	3.08GluGly: 3.08 ± 0.047	1.494GluHis: 1.494 ± 0.041	2.464GluIle: 2.464 ± 0.042	1.058GluLys: 1.058 ± 0.025	6.31GluLeu: 6.31 ± 0.071	1.018GluMet: 1.018 ± 0.02	1.012GluAsn: 1.012 ± 0.026	2.749GluPro: 2.749 ± 0.054	2.169GluGln: 2.169 ± 0.037	3.817GluArg: 3.817 ± 0.061	2.561GluSer: 2.561 ± 0.042	2.342GluThr: 2.342 ± 0.045	3.982GluVal: 3.982 ± 0.059	0.644GluTrp: 0.644 ± 0.018	1.009GluTyr: 1.009 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.815PheAla: 3.815 ± 0.048	0.331PheCys: 0.331 ± 0.014	2.304PheAsp: 2.304 ± 0.037	1.516PheGlu: 1.516 ± 0.033	1.079PhePhe: 1.079 ± 0.031	3.928PheGly: 3.928 ± 0.084	0.675PheHis: 0.675 ± 0.018	1.092PheIle: 1.092 ± 0.029	0.483PheLys: 0.483 ± 0.017	2.422PheLeu: 2.422 ± 0.044	0.514PheMet: 0.514 ± 0.021	1.008PheAsn: 1.008 ± 0.073	1.406PhePro: 1.406 ± 0.03	0.711PheGln: 0.711 ± 0.017	1.58PheArg: 1.58 ± 0.033	1.815PheSer: 1.815 ± 0.032	1.907PheThr: 1.907 ± 0.04	2.47PheVal: 2.47 ± 0.044	0.452PheTrp: 0.452 ± 0.018	0.659PheTyr: 0.659 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	13.289GlyAla: 13.289 ± 0.406	0.833GlyCys: 0.833 ± 0.023	5.721GlyAsp: 5.721 ± 0.133	4.081GlyGlu: 4.081 ± 0.056	3.396GlyPhe: 3.396 ± 0.089	15.653GlyGly: 15.653 ± 1.008	2.169GlyHis: 2.169 ± 0.042	4.397GlyIle: 4.397 ± 0.067	2.209GlyLys: 2.209 ± 0.043	9.269GlyLeu: 9.269 ± 0.109	2.17GlyMet: 2.17 ± 0.039	3.839GlyAsn: 3.839 ± 0.21	4.721GlyPro: 4.721 ± 0.055	3.424GlyGln: 3.424 ± 0.1	5.947GlyArg: 5.947 ± 0.071	6.469GlySer: 6.469 ± 0.129	6.427GlyThr: 6.427 ± 0.259	7.837GlyVal: 7.837 ± 0.102	1.773GlyTrp: 1.773 ± 0.042	2.433GlyTyr: 2.433 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.47HisAla: 2.47 ± 0.038	0.227HisCys: 0.227 ± 0.01	1.325HisAsp: 1.325 ± 0.031	0.969HisGlu: 0.969 ± 0.025	0.651HisPhe: 0.651 ± 0.018	2.208HisGly: 2.208 ± 0.033	0.797HisHis: 0.797 ± 0.066	0.846HisIle: 0.846 ± 0.023	0.365HisLys: 0.365 ± 0.015	2.107HisLeu: 2.107 ± 0.058	0.325HisMet: 0.325 ± 0.014	0.56HisAsn: 0.56 ± 0.018	1.777HisPro: 1.777 ± 0.068	0.818HisGln: 0.818 ± 0.032	1.769HisArg: 1.769 ± 0.036	1.169HisSer: 1.169 ± 0.025	1.332HisThr: 1.332 ± 0.08	1.618HisVal: 1.618 ± 0.034	0.369HisTrp: 0.369 ± 0.015	0.576HisTyr: 0.576 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.305IleAla: 6.305 ± 0.069	0.406IleCys: 0.406 ± 0.014	3.343IleAsp: 3.343 ± 0.049	2.49IleGlu: 2.49 ± 0.043	1.104IlePhe: 1.104 ± 0.029	5.077IleGly: 5.077 ± 0.091	0.805IleHis: 0.805 ± 0.025	1.46IleIle: 1.46 ± 0.029	0.893IleLys: 0.893 ± 0.024	2.955IleLeu: 2.955 ± 0.047	0.606IleMet: 0.606 ± 0.019	1.265IleAsn: 1.265 ± 0.026	2.471IlePro: 2.471 ± 0.048	0.975IleGln: 0.975 ± 0.024	2.509IleArg: 2.509 ± 0.035	2.582IleSer: 2.582 ± 0.04	2.759IleThr: 2.759 ± 0.046	3.447IleVal: 3.447 ± 0.057	0.481IleTrp: 0.481 ± 0.018	0.841IleTyr: 0.841 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.334LysAla: 2.334 ± 0.046	0.107LysCys: 0.107 ± 0.008	0.93LysAsp: 0.93 ± 0.027	0.792LysGlu: 0.792 ± 0.024	0.563LysPhe: 0.563 ± 0.017	1.42LysGly: 1.42 ± 0.034	0.449LysHis: 0.449 ± 0.017	0.942LysIle: 0.942 ± 0.024	0.569LysLys: 0.569 ± 0.025	2.067LysLeu: 2.067 ± 0.037	0.442LysMet: 0.442 ± 0.016	0.477LysAsn: 0.477 ± 0.018	1.364LysPro: 1.364 ± 0.03	0.685LysGln: 0.685 ± 0.021	1.429LysArg: 1.429 ± 0.032	1.155LysSer: 1.155 ± 0.029	1.271LysThr: 1.271 ± 0.03	1.707LysVal: 1.707 ± 0.034	0.282LysTrp: 0.282 ± 0.012	0.426LysTyr: 0.426 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.962LeuAla: 13.962 ± 0.113	0.807LeuCys: 0.807 ± 0.021	6.023LeuAsp: 6.023 ± 0.078	4.043LeuGlu: 4.043 ± 0.056	2.799LeuPhe: 2.799 ± 0.053	8.955LeuGly: 8.955 ± 0.078	2.108LeuHis: 2.108 ± 0.063	4.295LeuIle: 4.295 ± 0.058	1.612LeuLys: 1.612 ± 0.027	9.57LeuLeu: 9.57 ± 0.108	1.735LeuMet: 1.735 ± 0.034	2.312LeuAsn: 2.312 ± 0.051	5.887LeuPro: 5.887 ± 0.091	2.805LeuGln: 2.805 ± 0.044	7.173LeuArg: 7.173 ± 0.086	5.78LeuSer: 5.78 ± 0.066	6.18LeuThr: 6.18 ± 0.091	8.032LeuVal: 8.032 ± 0.082	1.234LeuTrp: 1.234 ± 0.026	1.65LeuTyr: 1.65 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.65MetAla: 2.65 ± 0.046	0.18MetCys: 0.18 ± 0.01	0.814MetAsp: 0.814 ± 0.02	0.635MetGlu: 0.635 ± 0.021	0.657MetPhe: 0.657 ± 0.021	1.541MetGly: 1.541 ± 0.034	0.416MetHis: 0.416 ± 0.014	0.867MetIle: 0.867 ± 0.023	0.419MetLys: 0.419 ± 0.018	2.058MetLeu: 2.058 ± 0.035	0.417MetMet: 0.417 ± 0.017	0.491MetAsn: 0.491 ± 0.016	1.191MetPro: 1.191 ± 0.028	0.552MetGln: 0.552 ± 0.019	1.435MetArg: 1.435 ± 0.025	1.533MetSer: 1.533 ± 0.031	1.642MetThr: 1.642 ± 0.033	1.621MetVal: 1.621 ± 0.03	0.291MetTrp: 0.291 ± 0.013	0.387MetTyr: 0.387 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.095AsnAla: 3.095 ± 0.06	0.187AsnCys: 0.187 ± 0.01	1.242AsnAsp: 1.242 ± 0.027	0.973AsnGlu: 0.973 ± 0.025	0.858AsnPhe: 0.858 ± 0.036	3.506AsnGly: 3.506 ± 0.173	0.546AsnHis: 0.546 ± 0.022	1.224AsnIle: 1.224 ± 0.065	0.439AsnLys: 0.439 ± 0.016	2.318AsnLeu: 2.318 ± 0.063	0.432AsnMet: 0.432 ± 0.017	0.745AsnAsn: 0.745 ± 0.046	1.798AsnPro: 1.798 ± 0.03	0.774AsnGln: 0.774 ± 0.022	1.563AsnArg: 1.563 ± 0.038	1.566AsnSer: 1.566 ± 0.079	1.699AsnThr: 1.699 ± 0.095	1.876AsnVal: 1.876 ± 0.066	0.388AsnTrp: 0.388 ± 0.017	0.618AsnTyr: 0.618 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.417ProAla: 7.417 ± 0.102	0.304ProCys: 0.304 ± 0.013	4.012ProAsp: 4.012 ± 0.053	3.479ProGlu: 3.479 ± 0.053	1.578ProPhe: 1.578 ± 0.035	5.841ProGly: 5.841 ± 0.063	1.262ProHis: 1.262 ± 0.043	2.397ProIle: 2.397 ± 0.046	1.187ProLys: 1.187 ± 0.025	4.931ProLeu: 4.931 ± 0.068	1.223ProMet: 1.223 ± 0.029	1.432ProAsn: 1.432 ± 0.028	3.905ProPro: 3.905 ± 0.089	1.991ProGln: 1.991 ± 0.036	3.194ProArg: 3.194 ± 0.049	3.127ProSer: 3.127 ± 0.038	3.67ProThr: 3.67 ± 0.083	4.695ProVal: 4.695 ± 0.071	0.832ProTrp: 0.832 ± 0.023	1.103ProTyr: 1.103 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.253GlnAla: 4.253 ± 0.072	0.249GlnCys: 0.249 ± 0.012	1.343GlnAsp: 1.343 ± 0.031	1.149GlnGlu: 1.149 ± 0.026	1.001GlnPhe: 1.001 ± 0.023	2.323GlnGly: 2.323 ± 0.086	0.894GlnHis: 0.894 ± 0.041	1.577GlnIle: 1.577 ± 0.03	0.549GlnLys: 0.549 ± 0.019	3.938GlnLeu: 3.938 ± 0.053	0.707GlnMet: 0.707 ± 0.023	0.685GlnAsn: 0.685 ± 0.02	2.016GlnPro: 2.016 ± 0.04	1.479GlnGln: 1.479 ± 0.032	2.892GlnArg: 2.892 ± 0.044	1.673GlnSer: 1.673 ± 0.031	1.751GlnThr: 1.751 ± 0.032	2.66GlnVal: 2.66 ± 0.044	0.562GlnTrp: 0.562 ± 0.019	0.647GlnTyr: 0.647 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.671ArgAla: 7.671 ± 0.094	0.64ArgCys: 0.64 ± 0.021	3.76ArgAsp: 3.76 ± 0.053	3.39ArgGlu: 3.39 ± 0.069	2.3ArgPhe: 2.3 ± 0.042	5.009ArgGly: 5.009 ± 0.053	1.676ArgHis: 1.676 ± 0.033	3.24ArgIle: 3.24 ± 0.044	1.418ArgLys: 1.418 ± 0.035	7.138ArgLeu: 7.138 ± 0.079	1.677ArgMet: 1.677 ± 0.031	1.595ArgAsn: 1.595 ± 0.032	3.824ArgPro: 3.824 ± 0.052	2.262ArgGln: 2.262 ± 0.043	5.963ArgArg: 5.963 ± 0.093	3.77ArgSer: 3.77 ± 0.056	3.598ArgThr: 3.598 ± 0.057	5.158ArgVal: 5.158 ± 0.064	1.254ArgTrp: 1.254 ± 0.029	1.789ArgTyr: 1.789 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.59SerAla: 7.59 ± 0.088	0.43SerCys: 0.43 ± 0.017	3.122SerAsp: 3.122 ± 0.045	2.509SerGlu: 2.509 ± 0.042	1.764SerPhe: 1.764 ± 0.048	7.117SerGly: 7.117 ± 0.156	1.037SerHis: 1.037 ± 0.021	2.23SerIle: 2.23 ± 0.034	1.058SerLys: 1.058 ± 0.028	4.979SerLeu: 4.979 ± 0.069	1.333SerMet: 1.333 ± 0.027	1.351SerAsn: 1.351 ± 0.036	3.174SerPro: 3.174 ± 0.043	1.723SerGln: 1.723 ± 0.031	3.523SerArg: 3.523 ± 0.05	3.441SerSer: 3.441 ± 0.057	3.414SerThr: 3.414 ± 0.043	4.53SerVal: 4.53 ± 0.049	0.96SerTrp: 0.96 ± 0.024	1.36SerTyr: 1.36 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	7.753ThrAla: 7.753 ± 0.074	0.39ThrCys: 0.39 ± 0.015	3.4ThrAsp: 3.4 ± 0.052	2.905ThrGlu: 2.905 ± 0.045	1.658ThrPhe: 1.658 ± 0.032	7.274ThrGly: 7.274 ± 0.253	1.24ThrHis: 1.24 ± 0.057	2.553ThrIle: 2.553 ± 0.046	1.128ThrLys: 1.128 ± 0.026	5.53ThrLeu: 5.53 ± 0.086	1.206ThrMet: 1.206 ± 0.031	1.506ThrAsn: 1.506 ± 0.052	3.743ThrPro: 3.743 ± 0.07	1.702ThrGln: 1.702 ± 0.034	3.269ThrArg: 3.269 ± 0.055	3.354ThrSer: 3.354 ± 0.048	4.12ThrThr: 4.12 ± 0.138	5.177ThrVal: 5.177 ± 0.067	0.785ThrTrp: 0.785 ± 0.023	1.224ThrTyr: 1.224 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.974ValAla: 10.974 ± 0.091	0.78ValCys: 0.78 ± 0.02	4.943ValAsp: 4.943 ± 0.065	4.013ValGlu: 4.013 ± 0.055	2.446ValPhe: 2.446 ± 0.043	7.497ValGly: 7.497 ± 0.121	1.673ValHis: 1.673 ± 0.033	3.81ValIle: 3.81 ± 0.046	1.451ValLys: 1.451 ± 0.032	8.364ValLeu: 8.364 ± 0.1	1.47ValMet: 1.47 ± 0.029	2.089ValAsn: 2.089 ± 0.037	4.384ValPro: 4.384 ± 0.067	2.176ValGln: 2.176 ± 0.039	5.25ValArg: 5.25 ± 0.072	4.824ValSer: 4.824 ± 0.048	4.904ValThr: 4.904 ± 0.062	7.822ValVal: 7.822 ± 0.098	0.979ValTrp: 0.979 ± 0.023	1.426ValTyr: 1.426 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.486TrpAla: 1.486 ± 0.027	0.15TrpCys: 0.15 ± 0.009	0.753TrpAsp: 0.753 ± 0.021	0.645TrpGlu: 0.645 ± 0.016	0.495TrpPhe: 0.495 ± 0.016	1.075TrpGly: 1.075 ± 0.026	0.355TrpHis: 0.355 ± 0.016	0.634TrpIle: 0.634 ± 0.021	0.278TrpLys: 0.278 ± 0.012	1.851TrpLeu: 1.851 ± 0.031	0.31TrpMet: 0.31 ± 0.014	0.397TrpAsn: 0.397 ± 0.017	0.811TrpPro: 0.811 ± 0.023	0.669TrpGln: 0.669 ± 0.021	1.215TrpArg: 1.215 ± 0.029	0.956TrpSer: 0.956 ± 0.021	0.829TrpThr: 0.829 ± 0.029	1.053TrpVal: 1.053 ± 0.024	0.31TrpTrp: 0.31 ± 0.015	0.299TrpTyr: 0.299 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.038	0.235TyrCys: 0.235 ± 0.011	1.206TyrAsp: 1.206 ± 0.03	0.979TyrGlu: 0.979 ± 0.024	0.753TyrPhe: 0.753 ± 0.02	2.157TyrGly: 2.157 ± 0.036	0.511TyrHis: 0.511 ± 0.019	0.625TyrIle: 0.625 ± 0.018	0.3TyrLys: 0.3 ± 0.012	2.29TyrLeu: 2.29 ± 0.039	0.281TyrMet: 0.281 ± 0.014	0.566TyrAsn: 0.566 ± 0.034	1.246TyrPro: 1.246 ± 0.029	0.839TyrGln: 0.839 ± 0.019	1.827TyrArg: 1.827 ± 0.039	1.159TyrSer: 1.159 ± 0.024	1.166TyrThr: 1.166 ± 0.034	1.552TyrVal: 1.552 ± 0.032	0.378TyrTrp: 0.378 ± 0.016	0.505TyrTyr: 0.505 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5418 proteins (1984709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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