Amino acid dipepetide frequency for Wenzhou tombus-like virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.486AlaAla: 9.486 ± 2.674
1.581AlaCys: 1.581 ± 1.946
2.372AlaAsp: 2.372 ± 1.077
2.372AlaGlu: 2.372 ± 0.606
3.162AlaPhe: 3.162 ± 1.466
9.486AlaGly: 9.486 ± 5.477
0.791AlaHis: 0.791 ± 0.542
0.791AlaIle: 0.791 ± 0.653
3.953AlaLys: 3.953 ± 2.931
9.486AlaLeu: 9.486 ± 1.131
2.372AlaMet: 2.372 ± 0.499
3.953AlaAsn: 3.953 ± 1.93
5.534AlaPro: 5.534 ± 0.94
1.581AlaGln: 1.581 ± 1.085
3.162AlaArg: 3.162 ± 1.578
4.743AlaSer: 4.743 ± 1.429
5.534AlaThr: 5.534 ± 2.515
11.858AlaVal: 11.858 ± 3.029
0.791AlaTrp: 0.791 ± 0.653
4.743AlaTyr: 4.743 ± 2.154
0.0AlaXaa: 0.0 ± 0.0
Cys
2.372CysAla: 2.372 ± 1.077
0.0CysCys: 0.0 ± 0.0
0.791CysAsp: 0.791 ± 0.973
0.0CysGlu: 0.0 ± 0.0
0.791CysPhe: 0.791 ± 0.653
3.162CysGly: 3.162 ± 0.909
0.0CysHis: 0.0 ± 0.0
3.162CysIle: 3.162 ± 0.909
0.791CysLys: 0.791 ± 0.653
1.581CysLeu: 1.581 ± 0.417
0.0CysMet: 0.0 ± 0.0
0.791CysAsn: 0.791 ± 0.973
0.791CysPro: 0.791 ± 0.973
0.791CysGln: 0.791 ± 0.653
0.791CysArg: 0.791 ± 0.542
0.0CysSer: 0.0 ± 0.0
0.791CysThr: 0.791 ± 0.653
1.581CysVal: 1.581 ± 1.305
1.581CysTrp: 1.581 ± 0.871
0.791CysTyr: 0.791 ± 0.542
0.0CysXaa: 0.0 ± 0.0
Asp
5.534AspAla: 5.534 ± 0.719
3.162AspCys: 3.162 ± 1.991
1.581AspAsp: 1.581 ± 0.417
2.372AspGlu: 2.372 ± 0.952
1.581AspPhe: 1.581 ± 0.417
5.534AspGly: 5.534 ± 1.4
0.0AspHis: 0.0 ± 0.0
0.791AspIle: 0.791 ± 0.653
1.581AspLys: 1.581 ± 1.085
2.372AspLeu: 2.372 ± 0.952
1.581AspMet: 1.581 ± 1.305
2.372AspAsn: 2.372 ± 1.627
2.372AspPro: 2.372 ± 0.952
0.791AspGln: 0.791 ± 0.973
1.581AspArg: 1.581 ± 0.871
5.534AspSer: 5.534 ± 0.719
3.162AspThr: 3.162 ± 1.578
2.372AspVal: 2.372 ± 0.952
0.0AspTrp: 0.0 ± 0.0
1.581AspTyr: 1.581 ± 1.085
0.0AspXaa: 0.0 ± 0.0
Glu
5.534GluAla: 5.534 ± 3.273
0.791GluCys: 0.791 ± 0.653
0.0GluAsp: 0.0 ± 0.0
3.953GluGlu: 3.953 ± 1.462
5.534GluPhe: 5.534 ± 1.409
3.162GluGly: 3.162 ± 0.909
2.372GluHis: 2.372 ± 1.958
1.581GluIle: 1.581 ± 1.085
2.372GluLys: 2.372 ± 1.958
3.162GluLeu: 3.162 ± 0.909
0.791GluMet: 0.791 ± 0.973
1.581GluAsn: 1.581 ± 0.871
1.581GluPro: 1.581 ± 1.305
2.372GluGln: 2.372 ± 1.915
3.162GluArg: 3.162 ± 1.566
1.581GluSer: 1.581 ± 0.417
0.0GluThr: 0.0 ± 0.0
3.953GluVal: 3.953 ± 1.351
1.581GluTrp: 1.581 ± 1.305
0.791GluTyr: 0.791 ± 0.653
0.0GluXaa: 0.0 ± 0.0
Phe
5.534PheAla: 5.534 ± 2.781
0.791PheCys: 0.791 ± 0.653
3.162PheAsp: 3.162 ± 1.578
1.581PheGlu: 1.581 ± 0.417
0.0PhePhe: 0.0 ± 0.0
0.791PheGly: 0.791 ± 0.973
0.791PheHis: 0.791 ± 0.653
0.791PheIle: 0.791 ± 0.542
0.0PheLys: 0.0 ± 0.0
2.372PheLeu: 2.372 ± 0.606
2.372PheMet: 2.372 ± 0.714
3.162PheAsn: 3.162 ± 0.471
0.0PhePro: 0.0 ± 0.0
2.372PheGln: 2.372 ± 0.606
3.953PheArg: 3.953 ± 1.317
3.953PheSer: 3.953 ± 0.368
1.581PheThr: 1.581 ± 1.085
3.953PheVal: 3.953 ± 1.625
0.0PheTrp: 0.0 ± 0.0
2.372PheTyr: 2.372 ± 0.952
0.0PheXaa: 0.0 ± 0.0
Gly
4.743GlyAla: 4.743 ± 2.154
2.372GlyCys: 2.372 ± 1.077
7.905GlyAsp: 7.905 ± 3.471
3.162GlyGlu: 3.162 ± 0.834
1.581GlyPhe: 1.581 ± 1.305
2.372GlyGly: 2.372 ± 1.077
0.791GlyHis: 0.791 ± 0.653
3.162GlyIle: 3.162 ± 1.578
5.534GlyLys: 5.534 ± 2.523
9.486GlyLeu: 9.486 ± 2.721
1.581GlyMet: 1.581 ± 0.417
5.534GlyAsn: 5.534 ± 0.719
5.534GlyPro: 5.534 ± 0.719
0.791GlyGln: 0.791 ± 0.542
3.953GlyArg: 3.953 ± 1.317
3.953GlySer: 3.953 ± 1.93
7.905GlyThr: 7.905 ± 4.52
4.743GlyVal: 4.743 ± 1.302
1.581GlyTrp: 1.581 ± 0.417
3.162GlyTyr: 3.162 ± 0.471
0.0GlyXaa: 0.0 ± 0.0
His
0.791HisAla: 0.791 ± 0.653
0.0HisCys: 0.0 ± 0.0
0.791HisAsp: 0.791 ± 0.542
0.0HisGlu: 0.0 ± 0.0
1.581HisPhe: 1.581 ± 0.417
2.372HisGly: 2.372 ± 0.952
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
0.791HisLeu: 0.791 ± 0.542
1.581HisMet: 1.581 ± 1.049
0.791HisAsn: 0.791 ± 0.542
0.791HisPro: 0.791 ± 0.542
0.0HisGln: 0.0 ± 0.0
2.372HisArg: 2.372 ± 1.451
3.953HisSer: 3.953 ± 1.717
0.791HisThr: 0.791 ± 0.542
2.372HisVal: 2.372 ± 1.958
0.0HisTrp: 0.0 ± 0.0
0.791HisTyr: 0.791 ± 0.973
0.0HisXaa: 0.0 ± 0.0
Ile
3.162IleAla: 3.162 ± 1.566
0.0IleCys: 0.0 ± 0.0
2.372IleAsp: 2.372 ± 0.714
3.162IleGlu: 3.162 ± 1.991
3.953IlePhe: 3.953 ± 1.717
2.372IleGly: 2.372 ± 1.627
0.791IleHis: 0.791 ± 0.653
1.581IleIle: 1.581 ± 1.049
2.372IleLys: 2.372 ± 1.451
1.581IleLeu: 1.581 ± 0.417
2.372IleMet: 2.372 ± 1.958
0.0IleAsn: 0.0 ± 0.0
1.581IlePro: 1.581 ± 0.417
0.791IleGln: 0.791 ± 0.653
0.791IleArg: 0.791 ± 0.542
2.372IleSer: 2.372 ± 0.952
4.743IleThr: 4.743 ± 1.429
2.372IleVal: 2.372 ± 1.077
0.0IleTrp: 0.0 ± 0.0
2.372IleTyr: 2.372 ± 1.958
0.0IleXaa: 0.0 ± 0.0
Lys
4.743LysAla: 4.743 ± 2.902
0.0LysCys: 0.0 ± 0.0
2.372LysAsp: 2.372 ± 0.606
1.581LysGlu: 1.581 ± 1.049
1.581LysPhe: 1.581 ± 1.049
4.743LysGly: 4.743 ± 3.916
0.791LysHis: 0.791 ± 0.542
3.162LysIle: 3.162 ± 1.578
1.581LysLys: 1.581 ± 1.049
3.953LysLeu: 3.953 ± 1.462
0.0LysMet: 0.0 ± 0.0
3.162LysAsn: 3.162 ± 1.743
0.791LysPro: 0.791 ± 0.542
1.581LysGln: 1.581 ± 1.085
6.324LysArg: 6.324 ± 0.437
0.791LysSer: 0.791 ± 0.542
1.581LysThr: 1.581 ± 1.085
1.581LysVal: 1.581 ± 1.305
1.581LysTrp: 1.581 ± 1.305
2.372LysTyr: 2.372 ± 0.714
0.0LysXaa: 0.0 ± 0.0
Leu
10.277LeuAla: 10.277 ± 3.498
3.162LeuCys: 3.162 ± 0.471
6.324LeuAsp: 6.324 ± 1.668
4.743LeuGlu: 4.743 ± 1.918
0.0LeuPhe: 0.0 ± 0.0
3.953LeuGly: 3.953 ± 1.317
0.0LeuHis: 0.0 ± 0.0
2.372LeuIle: 2.372 ± 1.627
3.162LeuLys: 3.162 ± 0.834
3.953LeuLeu: 3.953 ± 2.536
1.581LeuMet: 1.581 ± 0.417
3.162LeuAsn: 3.162 ± 0.834
6.324LeuPro: 6.324 ± 2.35
0.791LeuGln: 0.791 ± 0.653
2.372LeuArg: 2.372 ± 1.958
3.953LeuSer: 3.953 ± 0.815
3.953LeuThr: 3.953 ± 1.036
14.229LeuVal: 14.229 ± 1.658
0.791LeuTrp: 0.791 ± 0.542
2.372LeuTyr: 2.372 ± 1.627
0.0LeuXaa: 0.0 ± 0.0
Met
1.581MetAla: 1.581 ± 0.871
1.581MetCys: 1.581 ± 0.417
0.791MetAsp: 0.791 ± 0.542
0.791MetGlu: 0.791 ± 0.653
1.581MetPhe: 1.581 ± 0.417
2.372MetGly: 2.372 ± 1.627
1.581MetHis: 1.581 ± 1.305
0.0MetIle: 0.0 ± 0.0
1.581MetLys: 1.581 ± 0.417
1.581MetLeu: 1.581 ± 1.049
0.791MetMet: 0.791 ± 0.973
1.581MetAsn: 1.581 ± 1.049
0.0MetPro: 0.0 ± 0.0
0.791MetGln: 0.791 ± 0.653
3.162MetArg: 3.162 ± 2.61
0.791MetSer: 0.791 ± 0.542
2.372MetThr: 2.372 ± 0.606
3.162MetVal: 3.162 ± 0.909
0.791MetTrp: 0.791 ± 0.542
2.372MetTyr: 2.372 ± 1.958
0.0MetXaa: 0.0 ± 0.0
Asn
1.581AsnAla: 1.581 ± 1.085
1.581AsnCys: 1.581 ± 1.049
2.372AsnAsp: 2.372 ± 1.077
1.581AsnGlu: 1.581 ± 1.946
0.791AsnPhe: 0.791 ± 0.973
7.115AsnGly: 7.115 ± 2.143
2.372AsnHis: 2.372 ± 0.606
3.162AsnIle: 3.162 ± 0.834
3.162AsnLys: 3.162 ± 1.566
6.324AsnLeu: 6.324 ± 1.864
2.372AsnMet: 2.372 ± 1.038
3.162AsnAsn: 3.162 ± 0.909
0.791AsnPro: 0.791 ± 0.542
1.581AsnGln: 1.581 ± 0.871
2.372AsnArg: 2.372 ± 0.606
1.581AsnSer: 1.581 ± 0.871
3.953AsnThr: 3.953 ± 1.462
3.953AsnVal: 3.953 ± 1.883
0.0AsnTrp: 0.0 ± 0.0
1.581AsnTyr: 1.581 ± 1.085
0.0AsnXaa: 0.0 ± 0.0
Pro
3.162ProAla: 3.162 ± 0.471
0.0ProCys: 0.0 ± 0.0
2.372ProAsp: 2.372 ± 1.451
2.372ProGlu: 2.372 ± 0.952
0.0ProPhe: 0.0 ± 0.0
3.162ProGly: 3.162 ± 1.198
0.791ProHis: 0.791 ± 0.542
2.372ProIle: 2.372 ± 1.958
0.791ProLys: 0.791 ± 0.542
7.905ProLeu: 7.905 ± 3.86
0.0ProMet: 0.0 ± 0.0
2.372ProAsn: 2.372 ± 0.606
3.953ProPro: 3.953 ± 1.717
1.581ProGln: 1.581 ± 0.871
3.162ProArg: 3.162 ± 0.909
0.791ProSer: 0.791 ± 0.653
2.372ProThr: 2.372 ± 0.606
5.534ProVal: 5.534 ± 1.896
0.0ProTrp: 0.0 ± 0.0
1.581ProTyr: 1.581 ± 0.417
0.0ProXaa: 0.0 ± 0.0
Gln
3.162GlnAla: 3.162 ± 0.471
0.0GlnCys: 0.0 ± 0.0
1.581GlnAsp: 1.581 ± 1.049
1.581GlnGlu: 1.581 ± 1.049
1.581GlnPhe: 1.581 ± 1.049
1.581GlnGly: 1.581 ± 1.085
0.791GlnHis: 0.791 ± 0.973
2.372GlnIle: 2.372 ± 1.766
1.581GlnLys: 1.581 ± 0.871
0.791GlnLeu: 0.791 ± 0.542
1.581GlnMet: 1.581 ± 1.305
0.791GlnAsn: 0.791 ± 0.542
2.372GlnPro: 2.372 ± 0.952
1.581GlnGln: 1.581 ± 0.417
3.953GlnArg: 3.953 ± 1.93
2.372GlnSer: 2.372 ± 0.952
2.372GlnThr: 2.372 ± 1.627
3.162GlnVal: 3.162 ± 1.198
0.0GlnTrp: 0.0 ± 0.0
0.791GlnTyr: 0.791 ± 0.542
0.0GlnXaa: 0.0 ± 0.0
Arg
1.581ArgAla: 1.581 ± 1.085
1.581ArgCys: 1.581 ± 1.305
0.0ArgAsp: 0.0 ± 0.0
3.953ArgGlu: 3.953 ± 0.368
3.953ArgPhe: 3.953 ± 1.351
7.905ArgGly: 7.905 ± 1.811
1.581ArgHis: 1.581 ± 0.417
4.743ArgIle: 4.743 ± 0.18
4.743ArgLys: 4.743 ± 0.18
3.953ArgLeu: 3.953 ± 1.717
3.162ArgMet: 3.162 ± 1.991
3.953ArgAsn: 3.953 ± 1.625
2.372ArgPro: 2.372 ± 1.451
0.791ArgGln: 0.791 ± 0.542
4.743ArgArg: 4.743 ± 0.949
4.743ArgSer: 4.743 ± 0.949
2.372ArgThr: 2.372 ± 0.714
3.162ArgVal: 3.162 ± 1.743
3.162ArgTrp: 3.162 ± 1.566
0.791ArgTyr: 0.791 ± 0.973
0.0ArgXaa: 0.0 ± 0.0
Ser
7.905SerAla: 7.905 ± 0.835
0.0SerCys: 0.0 ± 0.0
2.372SerAsp: 2.372 ± 0.952
2.372SerGlu: 2.372 ± 1.451
2.372SerPhe: 2.372 ± 0.714
4.743SerGly: 4.743 ± 0.949
1.581SerHis: 1.581 ± 1.085
2.372SerIle: 2.372 ± 0.714
2.372SerLys: 2.372 ± 0.952
5.534SerLeu: 5.534 ± 1.409
0.0SerMet: 0.0 ± 0.0
4.743SerAsn: 4.743 ± 1.337
1.581SerPro: 1.581 ± 0.417
3.953SerGln: 3.953 ± 0.815
2.372SerArg: 2.372 ± 1.627
7.905SerSer: 7.905 ± 2.603
5.534SerThr: 5.534 ± 1.821
4.743SerVal: 4.743 ± 2.247
1.581SerTrp: 1.581 ± 1.305
3.162SerTyr: 3.162 ± 1.198
0.0SerXaa: 0.0 ± 0.0
Thr
7.115ThrAla: 7.115 ± 2.884
1.581ThrCys: 1.581 ± 1.085
0.791ThrAsp: 0.791 ± 0.653
0.791ThrGlu: 0.791 ± 0.542
2.372ThrPhe: 2.372 ± 0.714
4.743ThrGly: 4.743 ± 2.247
0.791ThrHis: 0.791 ± 0.973
3.162ThrIle: 3.162 ± 1.991
2.372ThrLys: 2.372 ± 1.627
3.953ThrLeu: 3.953 ± 2.711
1.581ThrMet: 1.581 ± 1.085
3.162ThrAsn: 3.162 ± 1.466
2.372ThrPro: 2.372 ± 0.952
2.372ThrGln: 2.372 ± 0.714
5.534ThrArg: 5.534 ± 1.529
7.115ThrSer: 7.115 ± 0.847
7.115ThrThr: 7.115 ± 3.857
5.534ThrVal: 5.534 ± 0.502
0.0ThrTrp: 0.0 ± 0.0
3.162ThrTyr: 3.162 ± 1.578
0.0ThrXaa: 0.0 ± 0.0
Val
7.905ValAla: 7.905 ± 1.354
1.581ValCys: 1.581 ± 0.871
5.534ValAsp: 5.534 ± 0.719
7.115ValGlu: 7.115 ± 1.775
4.743ValPhe: 4.743 ± 2.074
7.115ValGly: 7.115 ± 0.537
1.581ValHis: 1.581 ± 0.417
1.581ValIle: 1.581 ± 1.085
3.953ValLys: 3.953 ± 2.219
4.743ValLeu: 4.743 ± 0.18
3.162ValMet: 3.162 ± 0.834
5.534ValAsn: 5.534 ± 2.166
2.372ValPro: 2.372 ± 1.766
3.953ValGln: 3.953 ± 0.815
4.743ValArg: 4.743 ± 3.508
7.115ValSer: 7.115 ± 2.105
4.743ValThr: 4.743 ± 1.302
5.534ValVal: 5.534 ± 2.667
1.581ValTrp: 1.581 ± 1.085
3.953ValTyr: 3.953 ± 1.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.791TrpAla: 0.791 ± 0.973
0.0TrpCys: 0.0 ± 0.0
1.581TrpAsp: 1.581 ± 0.417
1.581TrpGlu: 1.581 ± 1.049
0.791TrpPhe: 0.791 ± 0.653
0.791TrpGly: 0.791 ± 0.653
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.791TrpLeu: 0.791 ± 0.542
1.581TrpMet: 1.581 ± 1.175
0.0TrpAsn: 0.0 ± 0.0
0.791TrpPro: 0.791 ± 0.542
1.581TrpGln: 1.581 ± 0.417
0.791TrpArg: 0.791 ± 0.542
1.581TrpSer: 1.581 ± 1.085
0.0TrpThr: 0.0 ± 0.0
1.581TrpVal: 1.581 ± 1.305
0.0TrpTrp: 0.0 ± 0.0
0.791TrpTyr: 0.791 ± 0.973
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.581TyrAla: 1.581 ± 0.417
0.791TyrCys: 0.791 ± 0.653
0.791TyrAsp: 0.791 ± 0.542
0.791TyrGlu: 0.791 ± 0.542
1.581TyrPhe: 1.581 ± 1.085
2.372TyrGly: 2.372 ± 0.952
2.372TyrHis: 2.372 ± 1.627
1.581TyrIle: 1.581 ± 0.417
2.372TyrLys: 2.372 ± 1.451
3.162TyrLeu: 3.162 ± 0.834
0.0TyrMet: 0.0 ± 0.0
1.581TyrAsn: 1.581 ± 0.417
2.372TyrPro: 2.372 ± 1.627
3.953TyrGln: 3.953 ± 0.815
3.953TyrArg: 3.953 ± 2.536
2.372TyrSer: 2.372 ± 0.714
4.743TyrThr: 4.743 ± 1.903
3.162TyrVal: 3.162 ± 0.471
0.0TyrTrp: 0.0 ± 0.0
2.372TyrTyr: 2.372 ± 0.714
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski