Amino acid dipepetide frequency for Canid alphaherpesvirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.778AlaAla: 2.778 ± 0.391
0.814AlaCys: 0.814 ± 0.139
1.571AlaAsp: 1.571 ± 0.193
1.543AlaGlu: 1.543 ± 0.163
2.189AlaPhe: 2.189 ± 0.32
1.571AlaGly: 1.571 ± 0.263
0.617AlaHis: 0.617 ± 0.129
4.209AlaIle: 4.209 ± 0.403
2.385AlaLys: 2.385 ± 0.261
5.023AlaLeu: 5.023 ± 0.402
1.066AlaMet: 1.066 ± 0.184
2.245AlaAsn: 2.245 ± 0.242
1.852AlaPro: 1.852 ± 0.231
1.431AlaGln: 1.431 ± 0.245
2.245AlaArg: 2.245 ± 0.281
4.349AlaSer: 4.349 ± 0.352
2.497AlaThr: 2.497 ± 0.204
2.582AlaVal: 2.582 ± 0.245
0.365AlaTrp: 0.365 ± 0.116
1.768AlaTyr: 1.768 ± 0.222
0.0AlaXaa: 0.0 ± 0.0
Cys
0.87CysAla: 0.87 ± 0.119
0.449CysCys: 0.449 ± 0.109
1.207CysAsp: 1.207 ± 0.181
0.898CysGlu: 0.898 ± 0.186
0.982CysPhe: 0.982 ± 0.172
0.842CysGly: 0.842 ± 0.122
0.533CysHis: 0.533 ± 0.123
1.656CysIle: 1.656 ± 0.238
0.926CysLys: 0.926 ± 0.184
1.88CysLeu: 1.88 ± 0.241
0.449CysMet: 0.449 ± 0.085
1.431CysAsn: 1.431 ± 0.238
0.73CysPro: 0.73 ± 0.151
0.421CysGln: 0.421 ± 0.105
0.617CysArg: 0.617 ± 0.133
1.319CysSer: 1.319 ± 0.221
1.263CysThr: 1.263 ± 0.201
1.038CysVal: 1.038 ± 0.141
0.224CysTrp: 0.224 ± 0.081
0.842CysTyr: 0.842 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
2.273AspAla: 2.273 ± 0.295
0.898AspCys: 0.898 ± 0.165
3.48AspAsp: 3.48 ± 0.507
3.957AspGlu: 3.957 ± 0.332
2.301AspPhe: 2.301 ± 0.223
2.497AspGly: 2.497 ± 0.259
1.01AspHis: 1.01 ± 0.164
4.995AspIle: 4.995 ± 0.387
2.806AspLys: 2.806 ± 0.336
4.939AspLeu: 4.939 ± 0.295
0.87AspMet: 0.87 ± 0.136
2.862AspAsn: 2.862 ± 0.276
2.161AspPro: 2.161 ± 0.355
1.235AspGln: 1.235 ± 0.156
2.189AspArg: 2.189 ± 0.322
4.798AspSer: 4.798 ± 0.361
2.89AspThr: 2.89 ± 0.274
2.946AspVal: 2.946 ± 0.358
0.73AspTrp: 0.73 ± 0.155
2.273AspTyr: 2.273 ± 0.244
0.0AspXaa: 0.0 ± 0.0
Glu
2.862GluAla: 2.862 ± 0.257
1.066GluCys: 1.066 ± 0.201
4.125GluAsp: 4.125 ± 0.382
4.406GluGlu: 4.406 ± 0.513
2.105GluPhe: 2.105 ± 0.295
2.02GluGly: 2.02 ± 0.238
0.87GluHis: 0.87 ± 0.144
4.209GluIle: 4.209 ± 0.369
3.648GluLys: 3.648 ± 0.378
5.921GluLeu: 5.921 ± 0.384
1.122GluMet: 1.122 ± 0.2
5.247GluAsn: 5.247 ± 0.491
2.048GluPro: 2.048 ± 0.296
1.319GluGln: 1.319 ± 0.179
1.936GluArg: 1.936 ± 0.186
6.005GluSer: 6.005 ± 0.547
3.62GluThr: 3.62 ± 0.259
2.918GluVal: 2.918 ± 0.33
0.505GluTrp: 0.505 ± 0.109
1.992GluTyr: 1.992 ± 0.209
0.0GluXaa: 0.0 ± 0.0
Phe
1.656PheAla: 1.656 ± 0.185
1.01PheCys: 1.01 ± 0.144
3.283PheAsp: 3.283 ± 0.305
2.469PheGlu: 2.469 ± 0.218
3.002PhePhe: 3.002 ± 0.381
2.554PheGly: 2.554 ± 0.31
0.842PheHis: 0.842 ± 0.178
5.079PheIle: 5.079 ± 0.459
3.508PheLys: 3.508 ± 0.431
4.574PheLeu: 4.574 ± 0.411
1.179PheMet: 1.179 ± 0.254
3.62PheAsn: 3.62 ± 0.302
1.599PhePro: 1.599 ± 0.273
1.515PheGln: 1.515 ± 0.192
1.571PheArg: 1.571 ± 0.226
4.49PheSer: 4.49 ± 0.39
2.554PheThr: 2.554 ± 0.222
2.525PheVal: 2.525 ± 0.231
0.421PheTrp: 0.421 ± 0.115
2.329PheTyr: 2.329 ± 0.276
0.0PheXaa: 0.0 ± 0.0
Gly
2.385GlyAla: 2.385 ± 0.328
0.926GlyCys: 0.926 ± 0.168
2.497GlyAsp: 2.497 ± 0.286
2.778GlyGlu: 2.778 ± 0.244
2.666GlyPhe: 2.666 ± 0.269
2.189GlyGly: 2.189 ± 0.352
0.702GlyHis: 0.702 ± 0.156
3.255GlyIle: 3.255 ± 0.266
2.329GlyLys: 2.329 ± 0.299
4.321GlyLeu: 4.321 ± 0.368
0.73GlyMet: 0.73 ± 0.131
2.61GlyAsn: 2.61 ± 0.318
1.796GlyPro: 1.796 ± 0.23
1.319GlyGln: 1.319 ± 0.177
1.992GlyArg: 1.992 ± 0.306
3.395GlySer: 3.395 ± 0.366
2.525GlyThr: 2.525 ± 0.333
2.806GlyVal: 2.806 ± 0.29
0.449GlyTrp: 0.449 ± 0.113
1.656GlyTyr: 1.656 ± 0.219
0.0GlyXaa: 0.0 ± 0.0
His
1.066HisAla: 1.066 ± 0.165
0.309HisCys: 0.309 ± 0.099
0.561HisAsp: 0.561 ± 0.126
1.01HisGlu: 1.01 ± 0.203
0.898HisPhe: 0.898 ± 0.17
1.235HisGly: 1.235 ± 0.188
0.589HisHis: 0.589 ± 0.124
1.628HisIle: 1.628 ± 0.205
1.094HisLys: 1.094 ± 0.148
1.768HisLeu: 1.768 ± 0.232
0.477HisMet: 0.477 ± 0.119
0.786HisAsn: 0.786 ± 0.154
1.515HisPro: 1.515 ± 0.237
0.898HisGln: 0.898 ± 0.184
0.758HisArg: 0.758 ± 0.139
1.319HisSer: 1.319 ± 0.183
1.066HisThr: 1.066 ± 0.16
0.982HisVal: 0.982 ± 0.187
0.028HisTrp: 0.028 ± 0.029
0.449HisTyr: 0.449 ± 0.111
0.0HisXaa: 0.0 ± 0.0
Ile
3.676IleAla: 3.676 ± 0.389
1.543IleCys: 1.543 ± 0.229
4.49IleAsp: 4.49 ± 0.387
4.658IleGlu: 4.658 ± 0.504
4.209IlePhe: 4.209 ± 0.413
3.311IleGly: 3.311 ± 0.3
1.319IleHis: 1.319 ± 0.164
7.268IleIle: 7.268 ± 0.565
5.865IleLys: 5.865 ± 0.476
8.615IleLeu: 8.615 ± 0.58
1.459IleMet: 1.459 ± 0.178
6.903IleAsn: 6.903 ± 0.704
4.406IlePro: 4.406 ± 0.357
3.536IleGln: 3.536 ± 0.357
2.974IleArg: 2.974 ± 0.272
8.587IleSer: 8.587 ± 0.676
5.332IleThr: 5.332 ± 0.469
3.872IleVal: 3.872 ± 0.334
0.73IleTrp: 0.73 ± 0.124
3.48IleTyr: 3.48 ± 0.286
0.0IleXaa: 0.0 ± 0.0
Lys
2.273LysAla: 2.273 ± 0.333
1.066LysCys: 1.066 ± 0.147
2.918LysAsp: 2.918 ± 0.359
2.862LysGlu: 2.862 ± 0.269
3.255LysPhe: 3.255 ± 0.39
2.413LysGly: 2.413 ± 0.254
1.179LysHis: 1.179 ± 0.178
4.995LysIle: 4.995 ± 0.366
4.49LysLys: 4.49 ± 0.354
6.005LysLeu: 6.005 ± 0.562
1.543LysMet: 1.543 ± 0.248
6.033LysAsn: 6.033 ± 0.452
3.48LysPro: 3.48 ± 0.352
2.469LysGln: 2.469 ± 0.268
3.48LysArg: 3.48 ± 0.258
5.332LysSer: 5.332 ± 0.513
4.209LysThr: 4.209 ± 0.278
2.834LysVal: 2.834 ± 0.408
0.561LysTrp: 0.561 ± 0.129
2.357LysTyr: 2.357 ± 0.281
0.0LysXaa: 0.0 ± 0.0
Leu
4.574LeuAla: 4.574 ± 0.454
1.88LeuCys: 1.88 ± 0.269
4.209LeuAsp: 4.209 ± 0.425
6.033LeuGlu: 6.033 ± 0.392
5.247LeuPhe: 5.247 ± 0.443
3.957LeuGly: 3.957 ± 0.33
2.048LeuHis: 2.048 ± 0.19
7.829LeuIle: 7.829 ± 0.55
6.286LeuLys: 6.286 ± 0.461
9.625LeuLeu: 9.625 ± 0.587
1.992LeuMet: 1.992 ± 0.183
7.408LeuAsn: 7.408 ± 0.479
4.321LeuPro: 4.321 ± 0.331
3.002LeuGln: 3.002 ± 0.264
4.041LeuArg: 4.041 ± 0.372
9.709LeuSer: 9.709 ± 0.603
5.416LeuThr: 5.416 ± 0.377
4.293LeuVal: 4.293 ± 0.336
1.094LeuTrp: 1.094 ± 0.184
3.648LeuTyr: 3.648 ± 0.309
0.0LeuXaa: 0.0 ± 0.0
Met
1.235MetAla: 1.235 ± 0.188
0.561MetCys: 0.561 ± 0.098
1.431MetAsp: 1.431 ± 0.194
1.852MetGlu: 1.852 ± 0.223
1.375MetPhe: 1.375 ± 0.188
0.982MetGly: 0.982 ± 0.155
0.224MetHis: 0.224 ± 0.071
1.459MetIle: 1.459 ± 0.237
1.094MetLys: 1.094 ± 0.167
2.048MetLeu: 2.048 ± 0.212
0.645MetMet: 0.645 ± 0.128
0.814MetAsn: 0.814 ± 0.137
0.645MetPro: 0.645 ± 0.151
0.477MetGln: 0.477 ± 0.107
0.926MetArg: 0.926 ± 0.16
1.88MetSer: 1.88 ± 0.234
0.786MetThr: 0.786 ± 0.132
1.094MetVal: 1.094 ± 0.163
0.112MetTrp: 0.112 ± 0.066
0.673MetTyr: 0.673 ± 0.129
0.0MetXaa: 0.0 ± 0.0
Asn
1.992AsnAla: 1.992 ± 0.239
1.375AsnCys: 1.375 ± 0.19
3.508AsnAsp: 3.508 ± 0.33
3.732AsnGlu: 3.732 ± 0.379
3.508AsnPhe: 3.508 ± 0.274
3.648AsnGly: 3.648 ± 0.394
1.403AsnHis: 1.403 ± 0.182
6.875AsnIle: 6.875 ± 0.618
4.041AsnLys: 4.041 ± 0.386
6.931AsnLeu: 6.931 ± 0.573
1.403AsnMet: 1.403 ± 0.177
5.724AsnAsn: 5.724 ± 0.483
3.648AsnPro: 3.648 ± 0.288
3.115AsnGln: 3.115 ± 0.318
2.525AsnArg: 2.525 ± 0.253
6.229AsnSer: 6.229 ± 0.502
4.574AsnThr: 4.574 ± 0.391
4.153AsnVal: 4.153 ± 0.318
0.561AsnTrp: 0.561 ± 0.107
3.087AsnTyr: 3.087 ± 0.297
0.0AsnXaa: 0.0 ± 0.0
Pro
1.656ProAla: 1.656 ± 0.246
0.702ProCys: 0.702 ± 0.119
1.88ProAsp: 1.88 ± 0.25
3.704ProGlu: 3.704 ± 0.432
1.992ProPhe: 1.992 ± 0.222
2.161ProGly: 2.161 ± 0.214
0.898ProHis: 0.898 ± 0.166
4.153ProIle: 4.153 ± 0.316
3.059ProLys: 3.059 ± 0.301
4.041ProLeu: 4.041 ± 0.432
1.066ProMet: 1.066 ± 0.192
2.778ProAsn: 2.778 ± 0.277
3.451ProPro: 3.451 ± 0.436
1.403ProGln: 1.403 ± 0.208
2.076ProArg: 2.076 ± 0.355
4.798ProSer: 4.798 ± 0.378
2.862ProThr: 2.862 ± 0.264
2.582ProVal: 2.582 ± 0.409
0.449ProTrp: 0.449 ± 0.123
1.656ProTyr: 1.656 ± 0.197
0.0ProXaa: 0.0 ± 0.0
Gln
1.515GlnAla: 1.515 ± 0.176
0.477GlnCys: 0.477 ± 0.116
1.291GlnAsp: 1.291 ± 0.221
1.487GlnGlu: 1.487 ± 0.219
1.684GlnPhe: 1.684 ± 0.26
1.235GlnGly: 1.235 ± 0.185
1.066GlnHis: 1.066 ± 0.251
2.357GlnIle: 2.357 ± 0.255
2.076GlnLys: 2.076 ± 0.267
3.031GlnLeu: 3.031 ± 0.315
0.533GlnMet: 0.533 ± 0.121
2.273GlnAsn: 2.273 ± 0.21
2.076GlnPro: 2.076 ± 0.27
1.487GlnGln: 1.487 ± 0.224
2.076GlnArg: 2.076 ± 0.251
3.311GlnSer: 3.311 ± 0.392
2.329GlnThr: 2.329 ± 0.267
1.375GlnVal: 1.375 ± 0.245
0.196GlnTrp: 0.196 ± 0.078
0.87GlnTyr: 0.87 ± 0.182
0.0GlnXaa: 0.0 ± 0.0
Arg
2.133ArgAla: 2.133 ± 0.258
0.954ArgCys: 0.954 ± 0.168
2.076ArgAsp: 2.076 ± 0.223
2.525ArgGlu: 2.525 ± 0.286
2.048ArgPhe: 2.048 ± 0.285
2.161ArgGly: 2.161 ± 0.27
0.842ArgHis: 0.842 ± 0.141
2.918ArgIle: 2.918 ± 0.286
3.059ArgLys: 3.059 ± 0.373
4.377ArgLeu: 4.377 ± 0.319
0.617ArgMet: 0.617 ± 0.113
2.273ArgAsn: 2.273 ± 0.316
1.908ArgPro: 1.908 ± 0.28
1.431ArgGln: 1.431 ± 0.215
3.227ArgArg: 3.227 ± 0.401
3.536ArgSer: 3.536 ± 0.388
2.105ArgThr: 2.105 ± 0.278
2.722ArgVal: 2.722 ± 0.236
0.309ArgTrp: 0.309 ± 0.114
1.431ArgTyr: 1.431 ± 0.214
0.0ArgXaa: 0.0 ± 0.0
Ser
3.564SerAla: 3.564 ± 0.375
1.319SerCys: 1.319 ± 0.164
5.079SerAsp: 5.079 ± 0.501
6.145SerGlu: 6.145 ± 0.585
4.041SerPhe: 4.041 ± 0.387
4.349SerGly: 4.349 ± 0.376
1.824SerHis: 1.824 ± 0.241
8.39SerIle: 8.39 ± 0.584
6.903SerLys: 6.903 ± 0.574
9.709SerLeu: 9.709 ± 0.516
1.656SerMet: 1.656 ± 0.197
6.314SerAsn: 6.314 ± 0.424
3.816SerPro: 3.816 ± 0.383
2.946SerGln: 2.946 ± 0.32
3.536SerArg: 3.536 ± 0.493
10.888SerSer: 10.888 ± 1.072
6.145SerThr: 6.145 ± 0.417
4.939SerVal: 4.939 ± 0.384
0.926SerTrp: 0.926 ± 0.172
3.199SerTyr: 3.199 ± 0.267
0.0SerXaa: 0.0 ± 0.0
Thr
2.61ThrAla: 2.61 ± 0.237
1.066ThrCys: 1.066 ± 0.189
2.806ThrAsp: 2.806 ± 0.263
2.974ThrGlu: 2.974 ± 0.338
2.778ThrPhe: 2.778 ± 0.239
2.189ThrGly: 2.189 ± 0.265
1.179ThrHis: 1.179 ± 0.166
6.117ThrIle: 6.117 ± 0.493
3.48ThrLys: 3.48 ± 0.273
5.107ThrLeu: 5.107 ± 0.41
1.15ThrMet: 1.15 ± 0.181
4.462ThrAsn: 4.462 ± 0.378
3.592ThrPro: 3.592 ± 0.375
2.189ThrGln: 2.189 ± 0.237
2.638ThrArg: 2.638 ± 0.299
6.258ThrSer: 6.258 ± 0.414
4.377ThrThr: 4.377 ± 0.331
3.143ThrVal: 3.143 ± 0.32
0.505ThrTrp: 0.505 ± 0.15
2.133ThrTyr: 2.133 ± 0.231
0.0ThrXaa: 0.0 ± 0.0
Val
2.189ValAla: 2.189 ± 0.281
1.122ValCys: 1.122 ± 0.207
2.638ValAsp: 2.638 ± 0.287
2.413ValGlu: 2.413 ± 0.19
3.171ValPhe: 3.171 ± 0.274
1.628ValGly: 1.628 ± 0.22
0.645ValHis: 0.645 ± 0.163
4.855ValIle: 4.855 ± 0.381
3.171ValLys: 3.171 ± 0.41
4.855ValLeu: 4.855 ± 0.454
1.122ValMet: 1.122 ± 0.185
4.406ValAsn: 4.406 ± 0.424
2.525ValPro: 2.525 ± 0.33
1.235ValGln: 1.235 ± 0.167
1.936ValArg: 1.936 ± 0.266
5.051ValSer: 5.051 ± 0.32
3.002ValThr: 3.002 ± 0.291
2.469ValVal: 2.469 ± 0.24
0.281ValTrp: 0.281 ± 0.073
2.666ValTyr: 2.666 ± 0.319
0.0ValXaa: 0.0 ± 0.0
Trp
0.393TrpAla: 0.393 ± 0.088
0.224TrpCys: 0.224 ± 0.07
0.673TrpAsp: 0.673 ± 0.096
0.393TrpGlu: 0.393 ± 0.107
0.421TrpPhe: 0.421 ± 0.122
0.477TrpGly: 0.477 ± 0.112
0.084TrpHis: 0.084 ± 0.037
0.589TrpIle: 0.589 ± 0.11
0.533TrpLys: 0.533 ± 0.132
0.645TrpLeu: 0.645 ± 0.125
0.224TrpMet: 0.224 ± 0.075
0.645TrpAsn: 0.645 ± 0.123
0.449TrpPro: 0.449 ± 0.124
0.253TrpGln: 0.253 ± 0.086
0.393TrpArg: 0.393 ± 0.087
0.87TrpSer: 0.87 ± 0.141
0.702TrpThr: 0.702 ± 0.147
0.561TrpVal: 0.561 ± 0.131
0.14TrpTrp: 0.14 ± 0.056
0.337TrpTyr: 0.337 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.403TyrAla: 1.403 ± 0.207
0.814TyrCys: 0.814 ± 0.138
2.385TyrAsp: 2.385 ± 0.198
2.105TyrGlu: 2.105 ± 0.258
1.908TyrPhe: 1.908 ± 0.244
1.908TyrGly: 1.908 ± 0.203
0.561TyrHis: 0.561 ± 0.104
3.395TyrIle: 3.395 ± 0.356
3.031TyrLys: 3.031 ± 0.4
3.199TyrLeu: 3.199 ± 0.345
0.982TyrMet: 0.982 ± 0.176
3.199TyrAsn: 3.199 ± 0.297
1.347TyrPro: 1.347 ± 0.202
1.066TyrGln: 1.066 ± 0.205
1.515TyrArg: 1.515 ± 0.188
3.564TyrSer: 3.564 ± 0.277
2.497TyrThr: 2.497 ± 0.28
1.543TyrVal: 1.543 ± 0.214
0.421TyrTrp: 0.421 ± 0.113
1.347TyrTyr: 1.347 ± 0.23
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (35638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski