Amino acid dipepetide frequency for Hafnia phage vB_HpaM_yong1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.189AlaAla: 10.189 ± 0.94
1.057AlaCys: 1.057 ± 0.275
5.66AlaAsp: 5.66 ± 0.756
6.566AlaGlu: 6.566 ± 0.746
3.245AlaPhe: 3.245 ± 0.5
6.943AlaGly: 6.943 ± 0.77
0.906AlaHis: 0.906 ± 0.227
5.509AlaIle: 5.509 ± 0.594
5.736AlaLys: 5.736 ± 0.616
7.094AlaLeu: 7.094 ± 0.797
3.396AlaMet: 3.396 ± 0.468
3.698AlaAsn: 3.698 ± 0.517
2.792AlaPro: 2.792 ± 0.43
3.925AlaGln: 3.925 ± 0.646
3.245AlaArg: 3.245 ± 0.429
5.358AlaSer: 5.358 ± 0.846
4.377AlaThr: 4.377 ± 0.588
5.736AlaVal: 5.736 ± 0.557
1.585AlaTrp: 1.585 ± 0.358
2.566AlaTyr: 2.566 ± 0.419
0.0AlaXaa: 0.0 ± 0.0
Cys
0.906CysAla: 0.906 ± 0.25
0.0CysCys: 0.0 ± 0.0
0.377CysAsp: 0.377 ± 0.161
0.981CysGlu: 0.981 ± 0.288
0.075CysPhe: 0.075 ± 0.074
0.906CysGly: 0.906 ± 0.261
0.302CysHis: 0.302 ± 0.153
0.377CysIle: 0.377 ± 0.15
0.679CysLys: 0.679 ± 0.228
0.906CysLeu: 0.906 ± 0.247
0.226CysMet: 0.226 ± 0.134
0.453CysAsn: 0.453 ± 0.181
0.679CysPro: 0.679 ± 0.202
0.302CysGln: 0.302 ± 0.134
0.83CysArg: 0.83 ± 0.231
0.604CysSer: 0.604 ± 0.254
0.453CysThr: 0.453 ± 0.186
0.604CysVal: 0.604 ± 0.226
0.075CysTrp: 0.075 ± 0.084
0.453CysTyr: 0.453 ± 0.185
0.0CysXaa: 0.0 ± 0.0
Asp
5.811AspAla: 5.811 ± 0.569
0.453AspCys: 0.453 ± 0.2
4.075AspAsp: 4.075 ± 0.525
4.075AspGlu: 4.075 ± 0.564
2.264AspPhe: 2.264 ± 0.362
5.358AspGly: 5.358 ± 0.677
0.528AspHis: 0.528 ± 0.21
4.151AspIle: 4.151 ± 0.573
3.698AspLys: 3.698 ± 0.573
4.604AspLeu: 4.604 ± 0.492
1.434AspMet: 1.434 ± 0.309
3.472AspAsn: 3.472 ± 0.543
1.509AspPro: 1.509 ± 0.346
1.66AspGln: 1.66 ± 0.361
2.34AspArg: 2.34 ± 0.401
4.151AspSer: 4.151 ± 0.482
3.321AspThr: 3.321 ± 0.457
4.679AspVal: 4.679 ± 0.651
1.208AspTrp: 1.208 ± 0.271
2.038AspTyr: 2.038 ± 0.403
0.0AspXaa: 0.0 ± 0.0
Glu
5.66GluAla: 5.66 ± 0.789
0.906GluCys: 0.906 ± 0.254
2.868GluAsp: 2.868 ± 0.479
3.623GluGlu: 3.623 ± 0.595
2.264GluPhe: 2.264 ± 0.335
3.321GluGly: 3.321 ± 0.544
1.66GluHis: 1.66 ± 0.391
4.151GluIle: 4.151 ± 0.533
4.0GluLys: 4.0 ± 0.74
7.019GluLeu: 7.019 ± 0.687
2.038GluMet: 2.038 ± 0.35
2.868GluAsn: 2.868 ± 0.372
2.415GluPro: 2.415 ± 0.409
2.943GluGln: 2.943 ± 0.455
3.849GluArg: 3.849 ± 0.69
3.17GluSer: 3.17 ± 0.426
2.113GluThr: 2.113 ± 0.399
3.623GluVal: 3.623 ± 0.452
1.358GluTrp: 1.358 ± 0.33
1.887GluTyr: 1.887 ± 0.452
0.0GluXaa: 0.0 ± 0.0
Phe
3.17PheAla: 3.17 ± 0.426
0.226PheCys: 0.226 ± 0.145
2.642PheAsp: 2.642 ± 0.466
2.038PheGlu: 2.038 ± 0.347
0.981PhePhe: 0.981 ± 0.259
2.792PheGly: 2.792 ± 0.472
0.679PheHis: 0.679 ± 0.242
1.962PheIle: 1.962 ± 0.398
1.736PheLys: 1.736 ± 0.266
2.113PheLeu: 2.113 ± 0.488
1.358PheMet: 1.358 ± 0.319
1.736PheAsn: 1.736 ± 0.381
1.585PhePro: 1.585 ± 0.34
0.83PheGln: 0.83 ± 0.285
1.585PheArg: 1.585 ± 0.351
2.34PheSer: 2.34 ± 0.458
2.792PheThr: 2.792 ± 0.407
1.962PheVal: 1.962 ± 0.373
0.453PheTrp: 0.453 ± 0.152
0.83PheTyr: 0.83 ± 0.211
0.0PheXaa: 0.0 ± 0.0
Gly
5.585GlyAla: 5.585 ± 0.698
0.755GlyCys: 0.755 ± 0.265
5.736GlyAsp: 5.736 ± 1.023
4.755GlyGlu: 4.755 ± 0.532
3.094GlyPhe: 3.094 ± 0.563
5.509GlyGly: 5.509 ± 0.974
1.283GlyHis: 1.283 ± 0.28
5.208GlyIle: 5.208 ± 0.631
5.887GlyLys: 5.887 ± 0.619
5.283GlyLeu: 5.283 ± 0.95
3.245GlyMet: 3.245 ± 0.531
3.019GlyAsn: 3.019 ± 0.442
1.132GlyPro: 1.132 ± 0.303
2.566GlyGln: 2.566 ± 0.523
3.698GlyArg: 3.698 ± 0.504
3.472GlySer: 3.472 ± 0.562
3.396GlyThr: 3.396 ± 0.444
5.962GlyVal: 5.962 ± 0.628
1.585GlyTrp: 1.585 ± 0.329
2.264GlyTyr: 2.264 ± 0.333
0.0GlyXaa: 0.0 ± 0.0
His
1.434HisAla: 1.434 ± 0.296
0.151HisCys: 0.151 ± 0.103
0.906HisAsp: 0.906 ± 0.26
0.981HisGlu: 0.981 ± 0.31
0.604HisPhe: 0.604 ± 0.195
0.83HisGly: 0.83 ± 0.234
0.453HisHis: 0.453 ± 0.192
0.679HisIle: 0.679 ± 0.213
1.132HisLys: 1.132 ± 0.288
1.66HisLeu: 1.66 ± 0.378
0.302HisMet: 0.302 ± 0.154
0.151HisAsn: 0.151 ± 0.104
0.604HisPro: 0.604 ± 0.249
1.132HisGln: 1.132 ± 0.308
1.057HisArg: 1.057 ± 0.254
1.132HisSer: 1.132 ± 0.372
0.302HisThr: 0.302 ± 0.125
0.981HisVal: 0.981 ± 0.294
0.528HisTrp: 0.528 ± 0.234
0.679HisTyr: 0.679 ± 0.198
0.0HisXaa: 0.0 ± 0.0
Ile
4.906IleAla: 4.906 ± 0.675
0.981IleCys: 0.981 ± 0.282
4.453IleAsp: 4.453 ± 0.45
4.453IleGlu: 4.453 ± 0.506
1.509IlePhe: 1.509 ± 0.273
6.113IleGly: 6.113 ± 0.722
0.679IleHis: 0.679 ± 0.179
2.868IleIle: 2.868 ± 0.52
4.679IleLys: 4.679 ± 0.568
3.17IleLeu: 3.17 ± 0.393
1.585IleMet: 1.585 ± 0.392
3.17IleAsn: 3.17 ± 0.377
3.019IlePro: 3.019 ± 0.405
2.491IleGln: 2.491 ± 0.385
3.623IleArg: 3.623 ± 0.586
5.434IleSer: 5.434 ± 0.596
4.755IleThr: 4.755 ± 0.768
3.623IleVal: 3.623 ± 0.567
0.604IleTrp: 0.604 ± 0.186
1.509IleTyr: 1.509 ± 0.35
0.0IleXaa: 0.0 ± 0.0
Lys
6.642LysAla: 6.642 ± 0.731
0.453LysCys: 0.453 ± 0.166
3.396LysAsp: 3.396 ± 0.514
3.774LysGlu: 3.774 ± 0.591
2.189LysPhe: 2.189 ± 0.453
4.226LysGly: 4.226 ± 0.563
1.887LysHis: 1.887 ± 0.333
4.0LysIle: 4.0 ± 0.679
3.623LysLys: 3.623 ± 0.563
4.755LysLeu: 4.755 ± 0.564
1.887LysMet: 1.887 ± 0.487
3.472LysAsn: 3.472 ± 0.488
2.943LysPro: 2.943 ± 0.494
3.094LysGln: 3.094 ± 0.421
3.396LysArg: 3.396 ± 0.565
3.623LysSer: 3.623 ± 0.419
3.094LysThr: 3.094 ± 0.557
3.094LysVal: 3.094 ± 0.421
0.83LysTrp: 0.83 ± 0.259
1.962LysTyr: 1.962 ± 0.369
0.0LysXaa: 0.0 ± 0.0
Leu
5.811LeuAla: 5.811 ± 0.706
0.679LeuCys: 0.679 ± 0.214
4.679LeuAsp: 4.679 ± 0.526
4.302LeuGlu: 4.302 ± 0.628
2.566LeuPhe: 2.566 ± 0.468
5.057LeuGly: 5.057 ± 0.698
0.83LeuHis: 0.83 ± 0.231
5.811LeuIle: 5.811 ± 0.63
5.358LeuLys: 5.358 ± 0.834
5.962LeuLeu: 5.962 ± 0.63
1.509LeuMet: 1.509 ± 0.328
5.358LeuAsn: 5.358 ± 0.854
3.925LeuPro: 3.925 ± 0.578
3.396LeuGln: 3.396 ± 0.489
4.226LeuArg: 4.226 ± 0.617
6.868LeuSer: 6.868 ± 0.787
4.377LeuThr: 4.377 ± 0.6
4.151LeuVal: 4.151 ± 0.577
1.208LeuTrp: 1.208 ± 0.283
2.038LeuTyr: 2.038 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
3.094MetAla: 3.094 ± 0.389
0.604MetCys: 0.604 ± 0.216
1.358MetAsp: 1.358 ± 0.299
0.981MetGlu: 0.981 ± 0.258
0.377MetPhe: 0.377 ± 0.145
2.189MetGly: 2.189 ± 0.455
0.302MetHis: 0.302 ± 0.136
1.585MetIle: 1.585 ± 0.32
2.264MetLys: 2.264 ± 0.38
1.887MetLeu: 1.887 ± 0.391
0.83MetMet: 0.83 ± 0.318
1.736MetAsn: 1.736 ± 0.374
1.283MetPro: 1.283 ± 0.279
0.981MetGln: 0.981 ± 0.28
1.811MetArg: 1.811 ± 0.482
2.038MetSer: 2.038 ± 0.326
3.396MetThr: 3.396 ± 0.48
1.132MetVal: 1.132 ± 0.265
0.453MetTrp: 0.453 ± 0.199
0.453MetTyr: 0.453 ± 0.168
0.0MetXaa: 0.0 ± 0.0
Asn
4.83AsnAla: 4.83 ± 0.763
0.302AsnCys: 0.302 ± 0.139
2.491AsnAsp: 2.491 ± 0.407
2.491AsnGlu: 2.491 ± 0.468
1.434AsnPhe: 1.434 ± 0.314
4.679AsnGly: 4.679 ± 0.603
0.679AsnHis: 0.679 ± 0.198
3.623AsnIle: 3.623 ± 0.558
3.321AsnLys: 3.321 ± 0.419
4.528AsnLeu: 4.528 ± 0.563
1.057AsnMet: 1.057 ± 0.262
2.264AsnAsn: 2.264 ± 0.38
2.792AsnPro: 2.792 ± 0.573
1.962AsnGln: 1.962 ± 0.38
1.887AsnArg: 1.887 ± 0.366
2.415AsnSer: 2.415 ± 0.473
3.245AsnThr: 3.245 ± 0.54
3.094AsnVal: 3.094 ± 0.609
1.208AsnTrp: 1.208 ± 0.269
1.132AsnTyr: 1.132 ± 0.209
0.0AsnXaa: 0.0 ± 0.0
Pro
3.094ProAla: 3.094 ± 0.572
0.453ProCys: 0.453 ± 0.21
3.774ProAsp: 3.774 ± 0.498
3.925ProGlu: 3.925 ± 0.555
1.811ProPhe: 1.811 ± 0.352
1.057ProGly: 1.057 ± 0.271
0.302ProHis: 0.302 ± 0.153
2.566ProIle: 2.566 ± 0.366
2.34ProLys: 2.34 ± 0.395
3.547ProLeu: 3.547 ± 0.596
0.83ProMet: 0.83 ± 0.211
2.038ProAsn: 2.038 ± 0.321
1.132ProPro: 1.132 ± 0.306
1.585ProGln: 1.585 ± 0.363
1.509ProArg: 1.509 ± 0.321
2.113ProSer: 2.113 ± 0.415
3.094ProThr: 3.094 ± 0.504
3.547ProVal: 3.547 ± 0.661
0.528ProTrp: 0.528 ± 0.245
1.208ProTyr: 1.208 ± 0.261
0.0ProXaa: 0.0 ± 0.0
Gln
3.774GlnAla: 3.774 ± 0.48
0.528GlnCys: 0.528 ± 0.194
1.736GlnAsp: 1.736 ± 0.346
1.66GlnGlu: 1.66 ± 0.384
2.113GlnPhe: 2.113 ± 0.413
2.415GlnGly: 2.415 ± 0.471
1.132GlnHis: 1.132 ± 0.284
1.962GlnIle: 1.962 ± 0.352
2.491GlnLys: 2.491 ± 0.402
3.396GlnLeu: 3.396 ± 0.445
1.132GlnMet: 1.132 ± 0.311
2.34GlnAsn: 2.34 ± 0.408
2.566GlnPro: 2.566 ± 0.532
2.113GlnGln: 2.113 ± 0.438
2.038GlnArg: 2.038 ± 0.41
3.623GlnSer: 3.623 ± 0.433
2.566GlnThr: 2.566 ± 0.432
2.264GlnVal: 2.264 ± 0.403
0.906GlnTrp: 0.906 ± 0.231
0.906GlnTyr: 0.906 ± 0.216
0.0GlnXaa: 0.0 ± 0.0
Arg
5.057ArgAla: 5.057 ± 0.56
0.604ArgCys: 0.604 ± 0.17
3.472ArgAsp: 3.472 ± 0.536
3.547ArgGlu: 3.547 ± 0.518
1.509ArgPhe: 1.509 ± 0.313
3.623ArgGly: 3.623 ± 0.546
1.057ArgHis: 1.057 ± 0.255
3.321ArgIle: 3.321 ± 0.58
3.094ArgLys: 3.094 ± 0.498
4.679ArgLeu: 4.679 ± 0.622
1.509ArgMet: 1.509 ± 0.316
2.415ArgAsn: 2.415 ± 0.428
2.038ArgPro: 2.038 ± 0.33
2.943ArgGln: 2.943 ± 0.352
4.453ArgArg: 4.453 ± 0.697
2.491ArgSer: 2.491 ± 0.388
2.415ArgThr: 2.415 ± 0.451
2.717ArgVal: 2.717 ± 0.478
1.057ArgTrp: 1.057 ± 0.335
2.113ArgTyr: 2.113 ± 0.351
0.0ArgXaa: 0.0 ± 0.0
Ser
5.811SerAla: 5.811 ± 0.664
0.528SerCys: 0.528 ± 0.195
3.774SerAsp: 3.774 ± 0.501
3.849SerGlu: 3.849 ± 0.563
2.566SerPhe: 2.566 ± 0.444
4.906SerGly: 4.906 ± 0.493
0.755SerHis: 0.755 ± 0.271
4.226SerIle: 4.226 ± 0.559
3.472SerLys: 3.472 ± 0.528
5.811SerLeu: 5.811 ± 0.62
2.113SerMet: 2.113 ± 0.388
3.396SerAsn: 3.396 ± 0.516
3.094SerPro: 3.094 ± 0.428
3.17SerGln: 3.17 ± 0.633
3.547SerArg: 3.547 ± 0.444
3.321SerSer: 3.321 ± 0.505
3.698SerThr: 3.698 ± 0.501
4.302SerVal: 4.302 ± 0.559
1.057SerTrp: 1.057 ± 0.288
1.887SerTyr: 1.887 ± 0.325
0.0SerXaa: 0.0 ± 0.0
Thr
5.283ThrAla: 5.283 ± 0.583
0.377ThrCys: 0.377 ± 0.176
3.094ThrAsp: 3.094 ± 0.429
3.245ThrGlu: 3.245 ± 0.51
1.811ThrPhe: 1.811 ± 0.385
5.358ThrGly: 5.358 ± 0.76
0.83ThrHis: 0.83 ± 0.214
4.679ThrIle: 4.679 ± 0.75
2.491ThrLys: 2.491 ± 0.436
3.547ThrLeu: 3.547 ± 0.478
1.887ThrMet: 1.887 ± 0.396
2.868ThrAsn: 2.868 ± 0.538
2.491ThrPro: 2.491 ± 0.41
2.189ThrGln: 2.189 ± 0.474
3.321ThrArg: 3.321 ± 0.54
4.151ThrSer: 4.151 ± 0.631
3.849ThrThr: 3.849 ± 0.542
4.679ThrVal: 4.679 ± 0.811
1.283ThrTrp: 1.283 ± 0.319
2.264ThrTyr: 2.264 ± 0.404
0.0ThrXaa: 0.0 ± 0.0
Val
5.358ValAla: 5.358 ± 0.496
0.604ValCys: 0.604 ± 0.23
3.698ValAsp: 3.698 ± 0.601
4.755ValGlu: 4.755 ± 0.494
1.887ValPhe: 1.887 ± 0.39
4.151ValGly: 4.151 ± 0.427
0.604ValHis: 0.604 ± 0.222
4.0ValIle: 4.0 ± 0.44
3.094ValLys: 3.094 ± 0.479
4.453ValLeu: 4.453 ± 0.462
0.981ValMet: 0.981 ± 0.234
3.019ValAsn: 3.019 ± 0.493
2.642ValPro: 2.642 ± 0.557
2.113ValGln: 2.113 ± 0.335
3.472ValArg: 3.472 ± 0.522
5.434ValSer: 5.434 ± 0.643
5.585ValThr: 5.585 ± 0.945
5.132ValVal: 5.132 ± 0.577
0.755ValTrp: 0.755 ± 0.272
2.34ValTyr: 2.34 ± 0.477
0.0ValXaa: 0.0 ± 0.0
Trp
1.057TrpAla: 1.057 ± 0.236
0.151TrpCys: 0.151 ± 0.099
0.604TrpAsp: 0.604 ± 0.232
0.528TrpGlu: 0.528 ± 0.182
0.679TrpPhe: 0.679 ± 0.193
1.283TrpGly: 1.283 ± 0.292
0.302TrpHis: 0.302 ± 0.185
0.981TrpIle: 0.981 ± 0.28
1.509TrpLys: 1.509 ± 0.356
1.509TrpLeu: 1.509 ± 0.426
0.528TrpMet: 0.528 ± 0.199
0.906TrpAsn: 0.906 ± 0.251
0.604TrpPro: 0.604 ± 0.277
0.679TrpGln: 0.679 ± 0.224
1.811TrpArg: 1.811 ± 0.381
1.283TrpSer: 1.283 ± 0.334
0.906TrpThr: 0.906 ± 0.257
0.981TrpVal: 0.981 ± 0.263
0.377TrpTrp: 0.377 ± 0.147
0.604TrpTyr: 0.604 ± 0.192
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.113TyrAla: 2.113 ± 0.474
0.377TyrCys: 0.377 ± 0.148
2.038TyrAsp: 2.038 ± 0.333
1.283TyrGlu: 1.283 ± 0.268
0.83TyrPhe: 0.83 ± 0.293
2.717TyrGly: 2.717 ± 0.401
0.528TyrHis: 0.528 ± 0.168
1.962TyrIle: 1.962 ± 0.363
1.736TyrLys: 1.736 ± 0.285
2.189TyrLeu: 2.189 ± 0.413
0.83TyrMet: 0.83 ± 0.253
1.057TyrAsn: 1.057 ± 0.239
1.208TyrPro: 1.208 ± 0.304
1.585TyrGln: 1.585 ± 0.234
2.415TyrArg: 2.415 ± 0.365
2.264TyrSer: 2.264 ± 0.351
1.962TyrThr: 1.962 ± 0.378
1.811TyrVal: 1.811 ± 0.406
0.226TyrTrp: 0.226 ± 0.117
0.755TyrTyr: 0.755 ± 0.198
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (13251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski