Amino acid dipepetide frequency for Phytophthora infestans RNA virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.958AlaAla: 4.958 ± 0.136
2.479AlaCys: 2.479 ± 0.576
2.479AlaAsp: 2.479 ± 0.568
6.941AlaGlu: 6.941 ± 1.491
3.471AlaPhe: 3.471 ± 0.923
7.933AlaGly: 7.933 ± 2.261
0.0AlaHis: 0.0 ± 0.0
2.975AlaIle: 2.975 ± 1.719
2.479AlaLys: 2.479 ± 1.067
6.941AlaLeu: 6.941 ± 1.462
2.479AlaMet: 2.479 ± 1.067
3.471AlaAsn: 3.471 ± 1.468
1.983AlaPro: 1.983 ± 0.436
2.479AlaGln: 2.479 ± 2.861
5.454AlaArg: 5.454 ± 0.264
2.479AlaSer: 2.479 ± 0.568
1.983AlaThr: 1.983 ± 0.436
6.445AlaVal: 6.445 ± 2.516
0.496AlaTrp: 0.496 ± 0.399
1.487AlaTyr: 1.487 ± 1.034
0.0AlaXaa: 0.0 ± 0.0
Cys
1.983CysAla: 1.983 ± 0.436
0.496CysCys: 0.496 ± 0.399
0.992CysAsp: 0.992 ± 0.799
1.983CysGlu: 1.983 ± 0.436
2.479CysPhe: 2.479 ± 0.849
2.975CysGly: 2.975 ± 1.064
0.0CysHis: 0.0 ± 0.0
0.496CysIle: 0.496 ± 0.399
0.496CysLys: 0.496 ± 0.345
2.479CysLeu: 2.479 ± 1.616
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.992CysPro: 0.992 ± 0.955
0.496CysGln: 0.496 ± 0.992
1.983CysArg: 1.983 ± 0.436
1.487CysSer: 1.487 ± 0.781
0.0CysThr: 0.0 ± 0.0
1.487CysVal: 1.487 ± 0.781
0.496CysTrp: 0.496 ± 0.345
0.992CysTyr: 0.992 ± 0.799
0.0CysXaa: 0.0 ± 0.0
Asp
0.992AspAla: 0.992 ± 0.218
1.487AspCys: 1.487 ± 0.544
2.975AspAsp: 2.975 ± 1.406
1.983AspGlu: 1.983 ± 0.436
4.462AspPhe: 4.462 ± 1.237
2.975AspGly: 2.975 ± 0.661
0.992AspHis: 0.992 ± 0.218
2.975AspIle: 2.975 ± 2.069
2.479AspLys: 2.479 ± 0.726
4.462AspLeu: 4.462 ± 0.953
0.992AspMet: 0.992 ± 0.69
2.975AspAsn: 2.975 ± 0.833
0.992AspPro: 0.992 ± 0.218
1.487AspGln: 1.487 ± 0.544
3.966AspArg: 3.966 ± 0.586
2.975AspSer: 2.975 ± 0.654
0.0AspThr: 0.0 ± 0.0
3.966AspVal: 3.966 ± 0.873
0.496AspTrp: 0.496 ± 0.399
1.983AspTyr: 1.983 ± 0.792
0.0AspXaa: 0.0 ± 0.0
Glu
3.966GluAla: 3.966 ± 0.315
0.496GluCys: 0.496 ± 0.992
0.992GluAsp: 0.992 ± 0.69
5.949GluGlu: 5.949 ± 2.787
7.933GluPhe: 7.933 ± 0.893
2.975GluGly: 2.975 ± 0.654
0.992GluHis: 0.992 ± 0.218
5.454GluIle: 5.454 ± 1.685
2.975GluLys: 2.975 ± 0.833
6.445GluLeu: 6.445 ± 0.83
3.471GluMet: 3.471 ± 1.559
0.496GluAsn: 0.496 ± 0.345
0.992GluPro: 0.992 ± 0.69
1.487GluGln: 1.487 ± 1.034
2.975GluArg: 2.975 ± 1.719
3.966GluSer: 3.966 ± 1.633
4.958GluThr: 4.958 ± 1.091
3.966GluVal: 3.966 ± 1.885
1.487GluTrp: 1.487 ± 0.781
3.471GluTyr: 3.471 ± 2.413
0.0GluXaa: 0.0 ± 0.0
Phe
2.975PheAla: 2.975 ± 1.087
1.487PheCys: 1.487 ± 0.416
2.479PheAsp: 2.479 ± 1.067
7.437PheGlu: 7.437 ± 1.835
5.949PhePhe: 5.949 ± 0.957
6.941PheGly: 6.941 ± 1.847
0.992PheHis: 0.992 ± 0.218
3.966PheIle: 3.966 ± 1.465
3.471PheLys: 3.471 ± 0.754
6.941PheLeu: 6.941 ± 2.231
2.975PheMet: 2.975 ± 0.747
5.454PheAsn: 5.454 ± 1.159
3.471PhePro: 3.471 ± 1.468
0.992PheGln: 0.992 ± 0.799
3.966PheArg: 3.966 ± 0.315
4.462PheSer: 4.462 ± 0.536
1.487PheThr: 1.487 ± 0.416
5.949PheVal: 5.949 ± 0.663
0.0PheTrp: 0.0 ± 0.0
2.975PheTyr: 2.975 ± 0.833
0.0PheXaa: 0.0 ± 0.0
Gly
5.454GlyAla: 5.454 ± 1.805
1.487GlyCys: 1.487 ± 0.544
1.487GlyAsp: 1.487 ± 0.544
4.462GlyGlu: 4.462 ± 1.631
9.42GlyPhe: 9.42 ± 1.501
6.941GlyGly: 6.941 ± 2.937
1.983GlyHis: 1.983 ± 1.379
1.983GlyIle: 1.983 ± 0.436
2.975GlyLys: 2.975 ± 0.833
4.958GlyLeu: 4.958 ± 1.299
3.966GlyMet: 3.966 ± 1.885
0.992GlyAsn: 0.992 ± 0.799
0.496GlyPro: 0.496 ± 0.399
1.983GlyGln: 1.983 ± 0.436
4.958GlyArg: 4.958 ± 1.091
5.949GlySer: 5.949 ± 3.437
1.983GlyThr: 1.983 ± 0.436
11.899GlyVal: 11.899 ± 4.431
0.992GlyTrp: 0.992 ± 0.69
3.966GlyTyr: 3.966 ± 0.972
0.0GlyXaa: 0.0 ± 0.0
His
2.479HisAla: 2.479 ± 0.849
0.0HisCys: 0.0 ± 0.0
0.496HisAsp: 0.496 ± 0.345
1.487HisGlu: 1.487 ± 0.544
0.496HisPhe: 0.496 ± 0.345
0.992HisGly: 0.992 ± 0.218
0.496HisHis: 0.496 ± 0.345
0.992HisIle: 0.992 ± 0.69
0.496HisLys: 0.496 ± 0.345
1.487HisLeu: 1.487 ± 0.416
0.496HisMet: 0.496 ± 0.345
0.0HisAsn: 0.0 ± 0.0
0.496HisPro: 0.496 ± 0.345
0.0HisGln: 0.0 ± 0.0
2.479HisArg: 2.479 ± 0.576
1.487HisSer: 1.487 ± 0.544
0.0HisThr: 0.0 ± 0.0
1.983HisVal: 1.983 ± 0.733
0.0HisTrp: 0.0 ± 0.0
0.496HisTyr: 0.496 ± 0.345
0.0HisXaa: 0.0 ± 0.0
Ile
4.958IleAla: 4.958 ± 1.299
1.983IleCys: 1.983 ± 0.739
2.975IleAsp: 2.975 ± 0.654
4.462IleGlu: 4.462 ± 1.631
1.983IlePhe: 1.983 ± 0.733
3.471IleGly: 3.471 ± 1.521
0.992IleHis: 0.992 ± 0.218
3.966IleIle: 3.966 ± 1.263
0.992IleLys: 0.992 ± 0.69
3.966IleLeu: 3.966 ± 2.68
1.487IleMet: 1.487 ± 0.416
3.471IleAsn: 3.471 ± 1.335
1.487IlePro: 1.487 ± 1.034
0.496IleGln: 0.496 ± 0.345
1.983IleArg: 1.983 ± 0.436
2.975IleSer: 2.975 ± 1.741
2.479IleThr: 2.479 ± 0.726
4.958IleVal: 4.958 ± 1.443
0.0IleTrp: 0.0 ± 0.0
1.983IleTyr: 1.983 ± 0.436
0.0IleXaa: 0.0 ± 0.0
Lys
2.975LysAla: 2.975 ± 1.406
0.496LysCys: 0.496 ± 0.345
1.487LysAsp: 1.487 ± 0.416
3.471LysGlu: 3.471 ± 0.923
4.958LysPhe: 4.958 ± 1.553
3.471LysGly: 3.471 ± 1.468
0.992LysHis: 0.992 ± 0.218
3.966LysIle: 3.966 ± 0.873
0.992LysLys: 0.992 ± 0.69
3.471LysLeu: 3.471 ± 0.754
2.479LysMet: 2.479 ± 0.568
0.992LysAsn: 0.992 ± 0.218
1.983LysPro: 1.983 ± 1.379
0.496LysGln: 0.496 ± 0.345
4.958LysArg: 4.958 ± 0.844
3.471LysSer: 3.471 ± 0.754
0.992LysThr: 0.992 ± 0.69
2.975LysVal: 2.975 ± 0.833
0.0LysTrp: 0.0 ± 0.0
1.487LysTyr: 1.487 ± 0.544
0.0LysXaa: 0.0 ± 0.0
Leu
4.958LeuAla: 4.958 ± 2.53
3.471LeuCys: 3.471 ± 1.521
6.445LeuAsp: 6.445 ± 1.062
4.958LeuGlu: 4.958 ± 2.792
7.437LeuPhe: 7.437 ± 3.325
5.949LeuGly: 5.949 ± 0.663
2.479LeuHis: 2.479 ± 0.568
5.949LeuIle: 5.949 ± 2.788
3.966LeuLys: 3.966 ± 1.465
10.907LeuLeu: 10.907 ± 3.166
1.487LeuMet: 1.487 ± 1.039
5.454LeuAsn: 5.454 ± 1.159
2.479LeuPro: 2.479 ± 1.699
1.487LeuGln: 1.487 ± 0.416
6.445LeuArg: 6.445 ± 1.989
6.941LeuSer: 6.941 ± 0.378
2.479LeuThr: 2.479 ± 1.71
8.428LeuVal: 8.428 ± 2.297
0.496LeuTrp: 0.496 ± 0.399
4.958LeuTyr: 4.958 ± 1.553
0.0LeuXaa: 0.0 ± 0.0
Met
2.975MetAla: 2.975 ± 0.661
0.992MetCys: 0.992 ± 0.69
0.496MetAsp: 0.496 ± 0.399
0.992MetGlu: 0.992 ± 1.983
2.479MetPhe: 2.479 ± 1.724
0.992MetGly: 0.992 ± 0.955
0.992MetHis: 0.992 ± 0.69
0.992MetIle: 0.992 ± 0.69
2.975MetLys: 2.975 ± 2.069
3.471MetLeu: 3.471 ± 0.923
0.496MetMet: 0.496 ± 0.399
0.992MetAsn: 0.992 ± 0.69
0.992MetPro: 0.992 ± 0.69
0.496MetGln: 0.496 ± 0.345
2.479MetArg: 2.479 ± 1.699
3.471MetSer: 3.471 ± 1.747
2.975MetThr: 2.975 ± 0.661
0.992MetVal: 0.992 ± 0.955
0.496MetTrp: 0.496 ± 0.345
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.958AsnAla: 4.958 ± 1.451
0.0AsnCys: 0.0 ± 0.0
2.479AsnAsp: 2.479 ± 0.568
3.471AsnGlu: 3.471 ± 0.387
0.496AsnPhe: 0.496 ± 0.399
4.958AsnGly: 4.958 ± 1.091
0.0AsnHis: 0.0 ± 0.0
1.487AsnIle: 1.487 ± 0.544
0.496AsnLys: 0.496 ± 0.399
1.983AsnLeu: 1.983 ± 0.929
0.496AsnMet: 0.496 ± 0.399
0.496AsnAsn: 0.496 ± 0.345
2.975AsnPro: 2.975 ± 2.069
0.496AsnGln: 0.496 ± 0.399
2.975AsnArg: 2.975 ± 1.694
1.983AsnSer: 1.983 ± 0.792
1.487AsnThr: 1.487 ± 1.034
5.454AsnVal: 5.454 ± 1.383
0.496AsnTrp: 0.496 ± 0.345
2.975AsnTyr: 2.975 ± 0.654
0.0AsnXaa: 0.0 ± 0.0
Pro
1.983ProAla: 1.983 ± 0.792
0.0ProCys: 0.0 ± 0.0
1.983ProAsp: 1.983 ± 0.733
1.983ProGlu: 1.983 ± 1.379
1.487ProPhe: 1.487 ± 1.034
1.983ProGly: 1.983 ± 0.436
0.0ProHis: 0.0 ± 0.0
2.479ProIle: 2.479 ± 0.576
1.487ProLys: 1.487 ± 0.544
2.479ProLeu: 2.479 ± 0.568
0.496ProMet: 0.496 ± 0.345
1.487ProAsn: 1.487 ± 0.416
0.0ProPro: 0.0 ± 0.0
0.0ProGln: 0.0 ± 0.0
0.992ProArg: 0.992 ± 0.69
2.479ProSer: 2.479 ± 0.849
1.983ProThr: 1.983 ± 1.379
2.975ProVal: 2.975 ± 1.272
1.983ProTrp: 1.983 ± 0.739
0.992ProTyr: 0.992 ± 0.218
0.0ProXaa: 0.0 ± 0.0
Gln
0.992GlnAla: 0.992 ± 0.218
0.992GlnCys: 0.992 ± 0.218
0.0GlnAsp: 0.0 ± 0.0
0.992GlnGlu: 0.992 ± 0.955
0.992GlnPhe: 0.992 ± 0.218
0.0GlnGly: 0.0 ± 0.0
0.0GlnHis: 0.0 ± 0.0
1.983GlnIle: 1.983 ± 0.436
0.992GlnLys: 0.992 ± 0.69
3.471GlnLeu: 3.471 ± 1.481
0.992GlnMet: 0.992 ± 0.218
0.0GlnAsn: 0.0 ± 0.0
0.496GlnPro: 0.496 ± 0.399
0.0GlnGln: 0.0 ± 0.0
0.496GlnArg: 0.496 ± 0.345
0.992GlnSer: 0.992 ± 0.69
0.992GlnThr: 0.992 ± 0.218
0.992GlnVal: 0.992 ± 0.955
0.992GlnTrp: 0.992 ± 0.955
0.496GlnTyr: 0.496 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
7.437ArgAla: 7.437 ± 0.615
0.496ArgCys: 0.496 ± 0.399
4.462ArgAsp: 4.462 ± 0.536
2.975ArgGlu: 2.975 ± 1.734
4.958ArgPhe: 4.958 ± 2.645
5.454ArgGly: 5.454 ± 1.685
2.975ArgHis: 2.975 ± 1.694
0.992ArgIle: 0.992 ± 0.69
3.966ArgLys: 3.966 ± 0.873
7.437ArgLeu: 7.437 ± 2.546
1.487ArgMet: 1.487 ± 1.034
2.479ArgAsn: 2.479 ± 1.616
0.0ArgPro: 0.0 ± 0.0
1.487ArgGln: 1.487 ± 0.416
3.966ArgArg: 3.966 ± 1.885
4.958ArgSer: 4.958 ± 2.433
3.471ArgThr: 3.471 ± 0.675
2.975ArgVal: 2.975 ± 0.833
2.479ArgTrp: 2.479 ± 1.699
2.975ArgTyr: 2.975 ± 0.654
0.0ArgXaa: 0.0 ± 0.0
Ser
5.949SerAla: 5.949 ± 1.665
0.496SerCys: 0.496 ± 0.399
2.479SerAsp: 2.479 ± 0.726
3.471SerGlu: 3.471 ± 0.387
6.445SerPhe: 6.445 ± 1.848
3.966SerGly: 3.966 ± 0.873
0.992SerHis: 0.992 ± 0.218
1.983SerIle: 1.983 ± 0.739
3.471SerLys: 3.471 ± 0.754
5.949SerLeu: 5.949 ± 3.124
0.992SerMet: 0.992 ± 0.86
4.462SerAsn: 4.462 ± 0.536
2.975SerPro: 2.975 ± 0.661
1.487SerGln: 1.487 ± 0.416
4.462SerArg: 4.462 ± 0.536
4.958SerSer: 4.958 ± 1.451
3.471SerThr: 3.471 ± 1.61
8.924SerVal: 8.924 ± 1.151
1.983SerTrp: 1.983 ± 0.792
1.983SerTyr: 1.983 ± 0.436
0.0SerXaa: 0.0 ± 0.0
Thr
1.983ThrAla: 1.983 ± 0.436
0.992ThrCys: 0.992 ± 0.69
1.487ThrAsp: 1.487 ± 1.077
2.479ThrGlu: 2.479 ± 0.849
1.487ThrPhe: 1.487 ± 0.416
2.479ThrGly: 2.479 ± 0.726
1.487ThrHis: 1.487 ± 0.416
1.983ThrIle: 1.983 ± 0.792
3.471ThrLys: 3.471 ± 1.468
6.445ThrLeu: 6.445 ± 2.389
0.496ThrMet: 0.496 ± 0.399
0.496ThrAsn: 0.496 ± 0.399
0.496ThrPro: 0.496 ± 0.345
0.0ThrGln: 0.0 ± 0.0
3.966ThrArg: 3.966 ± 1.584
2.479ThrSer: 2.479 ± 0.726
1.487ThrThr: 1.487 ± 0.544
4.462ThrVal: 4.462 ± 1.264
0.496ThrTrp: 0.496 ± 0.399
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
4.462ValAla: 4.462 ± 0.249
3.471ValCys: 3.471 ± 1.521
4.958ValAsp: 4.958 ± 1.299
3.471ValGlu: 3.471 ± 1.747
5.454ValPhe: 5.454 ± 1.638
9.42ValGly: 9.42 ± 4.253
0.496ValHis: 0.496 ± 0.345
4.462ValIle: 4.462 ± 4.745
5.454ValLys: 5.454 ± 1.159
9.42ValLeu: 9.42 ± 0.205
2.479ValMet: 2.479 ± 0.576
3.966ValAsn: 3.966 ± 0.935
3.966ValPro: 3.966 ± 1.267
1.487ValGln: 1.487 ± 0.781
5.949ValArg: 5.949 ± 1.518
8.428ValSer: 8.428 ± 1.817
3.966ValThr: 3.966 ± 3.819
4.958ValVal: 4.958 ± 1.299
0.992ValTrp: 0.992 ± 0.218
1.487ValTyr: 1.487 ± 0.416
0.0ValXaa: 0.0 ± 0.0
Trp
0.496TrpAla: 0.496 ± 0.345
0.0TrpCys: 0.0 ± 0.0
0.496TrpAsp: 0.496 ± 0.345
0.992TrpGlu: 0.992 ± 0.799
0.0TrpPhe: 0.0 ± 0.0
0.496TrpGly: 0.496 ± 0.345
0.0TrpHis: 0.0 ± 0.0
0.992TrpIle: 0.992 ± 0.218
0.496TrpLys: 0.496 ± 0.992
1.487TrpLeu: 1.487 ± 1.077
1.487TrpMet: 1.487 ± 1.039
1.983TrpAsn: 1.983 ± 0.929
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.496TrpArg: 0.496 ± 0.345
1.487TrpSer: 1.487 ± 0.416
0.992TrpThr: 0.992 ± 0.218
1.983TrpVal: 1.983 ± 2.884
0.0TrpTrp: 0.0 ± 0.0
0.496TrpTyr: 0.496 ± 0.345
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.479TyrAla: 2.479 ± 0.726
0.992TyrCys: 0.992 ± 0.799
3.966TyrAsp: 3.966 ± 2.09
1.487TyrGlu: 1.487 ± 0.416
1.983TyrPhe: 1.983 ± 0.436
3.966TyrGly: 3.966 ± 0.972
0.0TyrHis: 0.0 ± 0.0
0.992TyrIle: 0.992 ± 0.218
1.983TyrLys: 1.983 ± 0.436
2.975TyrLeu: 2.975 ± 0.654
0.992TyrMet: 0.992 ± 0.69
0.496TyrAsn: 0.496 ± 0.345
1.983TyrPro: 1.983 ± 1.379
0.0TyrGln: 0.0 ± 0.0
2.479TyrArg: 2.479 ± 1.067
3.966TyrSer: 3.966 ± 0.315
1.487TyrThr: 1.487 ± 0.416
2.975TyrVal: 2.975 ± 0.654
0.0TyrTrp: 0.0 ± 0.0
0.992TyrTyr: 0.992 ± 0.799
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski