Amino acid dipepetide frequency for Corynebacterium phage LGCM-V4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.056AlaAla: 14.056 ± 2.435
0.643AlaCys: 0.643 ± 0.31
6.063AlaAsp: 6.063 ± 0.671
7.533AlaGlu: 7.533 ± 0.889
3.307AlaPhe: 3.307 ± 0.661
7.35AlaGly: 7.35 ± 1.227
2.113AlaHis: 2.113 ± 0.5
5.88AlaIle: 5.88 ± 0.677
5.604AlaLys: 5.604 ± 0.9
8.36AlaLeu: 8.36 ± 1.318
3.399AlaMet: 3.399 ± 0.476
2.94AlaAsn: 2.94 ± 0.491
3.491AlaPro: 3.491 ± 0.637
6.247AlaGln: 6.247 ± 1.188
5.42AlaArg: 5.42 ± 0.596
6.247AlaSer: 6.247 ± 0.7
6.615AlaThr: 6.615 ± 1.051
7.993AlaVal: 7.993 ± 0.991
1.929AlaTrp: 1.929 ± 0.387
2.021AlaTyr: 2.021 ± 0.36
0.0AlaXaa: 0.0 ± 0.0
Cys
0.551CysAla: 0.551 ± 0.209
0.184CysCys: 0.184 ± 0.115
0.459CysAsp: 0.459 ± 0.204
0.367CysGlu: 0.367 ± 0.198
0.092CysPhe: 0.092 ± 0.102
0.551CysGly: 0.551 ± 0.217
0.0CysHis: 0.0 ± 0.0
0.367CysIle: 0.367 ± 0.202
0.184CysLys: 0.184 ± 0.141
0.643CysLeu: 0.643 ± 0.251
0.276CysMet: 0.276 ± 0.161
0.367CysAsn: 0.367 ± 0.177
0.276CysPro: 0.276 ± 0.15
0.184CysGln: 0.184 ± 0.163
1.011CysArg: 1.011 ± 0.315
0.919CysSer: 0.919 ± 0.276
0.276CysThr: 0.276 ± 0.159
0.276CysVal: 0.276 ± 0.201
0.184CysTrp: 0.184 ± 0.11
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
7.166AspAla: 7.166 ± 0.605
0.184AspCys: 0.184 ± 0.112
3.399AspAsp: 3.399 ± 0.734
4.593AspGlu: 4.593 ± 0.688
3.032AspPhe: 3.032 ± 0.627
4.869AspGly: 4.869 ± 0.555
1.286AspHis: 1.286 ± 0.311
3.215AspIle: 3.215 ± 0.593
2.48AspLys: 2.48 ± 0.48
5.145AspLeu: 5.145 ± 1.015
1.286AspMet: 1.286 ± 0.315
2.572AspAsn: 2.572 ± 0.466
3.124AspPro: 3.124 ± 0.638
2.205AspGln: 2.205 ± 0.41
2.389AspArg: 2.389 ± 0.39
4.41AspSer: 4.41 ± 0.662
2.94AspThr: 2.94 ± 0.506
4.593AspVal: 4.593 ± 0.672
1.654AspTrp: 1.654 ± 0.388
1.378AspTyr: 1.378 ± 0.333
0.0AspXaa: 0.0 ± 0.0
Glu
5.696GluAla: 5.696 ± 1.083
0.551GluCys: 0.551 ± 0.212
3.215GluAsp: 3.215 ± 0.571
4.593GluGlu: 4.593 ± 0.579
1.929GluPhe: 1.929 ± 0.481
3.124GluGly: 3.124 ± 0.621
1.194GluHis: 1.194 ± 0.296
4.869GluIle: 4.869 ± 0.782
4.226GluLys: 4.226 ± 0.519
6.615GluLeu: 6.615 ± 0.752
1.286GluMet: 1.286 ± 0.308
2.94GluAsn: 2.94 ± 0.534
2.205GluPro: 2.205 ± 0.365
2.48GluGln: 2.48 ± 0.486
3.491GluArg: 3.491 ± 0.629
4.593GluSer: 4.593 ± 0.662
4.134GluThr: 4.134 ± 0.464
4.41GluVal: 4.41 ± 0.577
1.102GluTrp: 1.102 ± 0.342
0.919GluTyr: 0.919 ± 0.325
0.0GluXaa: 0.0 ± 0.0
Phe
2.572PheAla: 2.572 ± 0.586
0.276PheCys: 0.276 ± 0.16
2.848PheAsp: 2.848 ± 0.634
1.654PheGlu: 1.654 ± 0.296
0.827PhePhe: 0.827 ± 0.395
1.929PheGly: 1.929 ± 0.398
1.011PheHis: 1.011 ± 0.246
1.194PheIle: 1.194 ± 0.293
1.562PheLys: 1.562 ± 0.418
1.746PheLeu: 1.746 ± 0.508
0.551PheMet: 0.551 ± 0.269
1.286PheAsn: 1.286 ± 0.36
1.194PhePro: 1.194 ± 0.372
1.286PheGln: 1.286 ± 0.285
1.746PheArg: 1.746 ± 0.557
2.389PheSer: 2.389 ± 0.481
2.113PheThr: 2.113 ± 0.363
2.205PheVal: 2.205 ± 0.364
0.459PheTrp: 0.459 ± 0.212
0.735PheTyr: 0.735 ± 0.22
0.0PheXaa: 0.0 ± 0.0
Gly
7.901GlyAla: 7.901 ± 1.364
0.276GlyCys: 0.276 ± 0.177
4.134GlyAsp: 4.134 ± 0.586
2.848GlyGlu: 2.848 ± 0.466
2.664GlyPhe: 2.664 ± 0.575
6.063GlyGly: 6.063 ± 1.196
1.562GlyHis: 1.562 ± 0.291
5.88GlyIle: 5.88 ± 1.21
4.961GlyLys: 4.961 ± 0.741
7.258GlyLeu: 7.258 ± 1.174
1.102GlyMet: 1.102 ± 0.413
2.94GlyAsn: 2.94 ± 0.436
2.389GlyPro: 2.389 ± 0.519
2.848GlyGln: 2.848 ± 0.402
4.042GlyArg: 4.042 ± 0.679
4.134GlySer: 4.134 ± 0.471
4.41GlyThr: 4.41 ± 0.651
6.523GlyVal: 6.523 ± 0.764
1.47GlyTrp: 1.47 ± 0.536
1.746GlyTyr: 1.746 ± 0.385
0.0GlyXaa: 0.0 ± 0.0
His
1.286HisAla: 1.286 ± 0.345
0.367HisCys: 0.367 ± 0.184
1.286HisAsp: 1.286 ± 0.246
1.011HisGlu: 1.011 ± 0.28
0.459HisPhe: 0.459 ± 0.18
1.562HisGly: 1.562 ± 0.304
0.459HisHis: 0.459 ± 0.211
1.562HisIle: 1.562 ± 0.292
0.551HisLys: 0.551 ± 0.169
2.021HisLeu: 2.021 ± 0.483
0.551HisMet: 0.551 ± 0.183
0.643HisAsn: 0.643 ± 0.229
1.011HisPro: 1.011 ± 0.232
0.735HisGln: 0.735 ± 0.206
1.47HisArg: 1.47 ± 0.267
1.011HisSer: 1.011 ± 0.246
1.011HisThr: 1.011 ± 0.277
1.47HisVal: 1.47 ± 0.384
0.551HisTrp: 0.551 ± 0.19
0.367HisTyr: 0.367 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
7.993IleAla: 7.993 ± 0.783
0.184IleCys: 0.184 ± 0.127
3.675IleAsp: 3.675 ± 0.71
3.859IleGlu: 3.859 ± 0.625
1.102IlePhe: 1.102 ± 0.351
5.42IleGly: 5.42 ± 0.723
1.102IleHis: 1.102 ± 0.39
2.848IleIle: 2.848 ± 0.553
4.226IleLys: 4.226 ± 0.742
3.491IleLeu: 3.491 ± 0.476
1.102IleMet: 1.102 ± 0.336
3.215IleAsn: 3.215 ± 0.389
3.124IlePro: 3.124 ± 0.576
2.021IleGln: 2.021 ± 0.428
3.859IleArg: 3.859 ± 0.702
3.399IleSer: 3.399 ± 0.4
4.777IleThr: 4.777 ± 0.786
2.756IleVal: 2.756 ± 0.498
1.011IleTrp: 1.011 ± 0.315
0.919IleTyr: 0.919 ± 0.273
0.0IleXaa: 0.0 ± 0.0
Lys
7.35LysAla: 7.35 ± 1.296
0.092LysCys: 0.092 ± 0.102
3.124LysAsp: 3.124 ± 0.586
2.94LysGlu: 2.94 ± 0.408
0.919LysPhe: 0.919 ± 0.225
3.95LysGly: 3.95 ± 0.537
0.643LysHis: 0.643 ± 0.268
4.226LysIle: 4.226 ± 0.612
2.572LysLys: 2.572 ± 0.609
4.961LysLeu: 4.961 ± 0.609
0.827LysMet: 0.827 ± 0.31
2.205LysAsn: 2.205 ± 0.56
2.113LysPro: 2.113 ± 0.47
3.032LysGln: 3.032 ± 0.456
3.399LysArg: 3.399 ± 0.534
2.756LysSer: 2.756 ± 0.695
4.042LysThr: 4.042 ± 0.762
3.215LysVal: 3.215 ± 0.645
0.735LysTrp: 0.735 ± 0.213
1.194LysTyr: 1.194 ± 0.377
0.0LysXaa: 0.0 ± 0.0
Leu
8.636LeuAla: 8.636 ± 1.083
0.827LeuCys: 0.827 ± 0.245
5.88LeuAsp: 5.88 ± 0.984
6.706LeuGlu: 6.706 ± 0.766
2.205LeuPhe: 2.205 ± 0.401
7.074LeuGly: 7.074 ± 1.02
1.562LeuHis: 1.562 ± 0.375
3.767LeuIle: 3.767 ± 0.707
4.777LeuLys: 4.777 ± 0.578
8.268LeuLeu: 8.268 ± 1.058
2.572LeuMet: 2.572 ± 0.657
2.48LeuAsn: 2.48 ± 0.545
3.767LeuPro: 3.767 ± 0.477
2.297LeuGln: 2.297 ± 0.528
4.685LeuArg: 4.685 ± 0.876
6.431LeuSer: 6.431 ± 0.841
4.777LeuThr: 4.777 ± 0.599
4.777LeuVal: 4.777 ± 0.739
1.378LeuTrp: 1.378 ± 0.349
1.746LeuTyr: 1.746 ± 0.482
0.0LeuXaa: 0.0 ± 0.0
Met
1.837MetAla: 1.837 ± 0.336
0.0MetCys: 0.0 ± 0.0
1.286MetAsp: 1.286 ± 0.411
2.021MetGlu: 2.021 ± 0.444
0.551MetPhe: 0.551 ± 0.26
1.746MetGly: 1.746 ± 0.378
0.184MetHis: 0.184 ± 0.198
1.378MetIle: 1.378 ± 0.345
1.194MetLys: 1.194 ± 0.3
1.47MetLeu: 1.47 ± 0.606
0.0MetMet: 0.0 ± 0.0
1.47MetAsn: 1.47 ± 0.368
1.286MetPro: 1.286 ± 0.284
0.919MetGln: 0.919 ± 0.256
1.654MetArg: 1.654 ± 0.365
1.746MetSer: 1.746 ± 0.333
1.746MetThr: 1.746 ± 0.331
1.011MetVal: 1.011 ± 0.327
0.551MetTrp: 0.551 ± 0.214
0.551MetTyr: 0.551 ± 0.194
0.0MetXaa: 0.0 ± 0.0
Asn
3.859AsnAla: 3.859 ± 0.57
0.092AsnCys: 0.092 ± 0.102
2.021AsnAsp: 2.021 ± 0.406
2.389AsnGlu: 2.389 ± 0.424
0.919AsnPhe: 0.919 ± 0.303
2.94AsnGly: 2.94 ± 0.518
0.643AsnHis: 0.643 ± 0.25
1.929AsnIle: 1.929 ± 0.442
1.746AsnLys: 1.746 ± 0.398
3.859AsnLeu: 3.859 ± 0.591
0.643AsnMet: 0.643 ± 0.243
1.654AsnAsn: 1.654 ± 0.433
2.664AsnPro: 2.664 ± 0.51
1.102AsnGln: 1.102 ± 0.351
2.205AsnArg: 2.205 ± 0.533
2.297AsnSer: 2.297 ± 0.473
1.654AsnThr: 1.654 ± 0.369
2.48AsnVal: 2.48 ± 0.49
0.276AsnTrp: 0.276 ± 0.137
1.194AsnTyr: 1.194 ± 0.364
0.0AsnXaa: 0.0 ± 0.0
Pro
3.583ProAla: 3.583 ± 0.557
0.276ProCys: 0.276 ± 0.184
2.664ProAsp: 2.664 ± 0.563
3.399ProGlu: 3.399 ± 0.564
1.562ProPhe: 1.562 ± 0.334
3.583ProGly: 3.583 ± 0.531
1.102ProHis: 1.102 ± 0.339
2.94ProIle: 2.94 ± 0.635
1.929ProLys: 1.929 ± 0.373
4.41ProLeu: 4.41 ± 0.611
0.827ProMet: 0.827 ± 0.272
1.194ProAsn: 1.194 ± 0.288
2.664ProPro: 2.664 ± 0.599
2.48ProGln: 2.48 ± 0.465
1.837ProArg: 1.837 ± 0.456
2.572ProSer: 2.572 ± 0.72
2.756ProThr: 2.756 ± 0.687
3.399ProVal: 3.399 ± 0.618
0.643ProTrp: 0.643 ± 0.251
1.011ProTyr: 1.011 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
5.604GlnAla: 5.604 ± 0.769
0.643GlnCys: 0.643 ± 0.24
2.113GlnAsp: 2.113 ± 0.367
2.113GlnGlu: 2.113 ± 0.577
1.378GlnPhe: 1.378 ± 0.417
2.389GlnGly: 2.389 ± 0.612
0.735GlnHis: 0.735 ± 0.291
1.378GlnIle: 1.378 ± 0.332
2.205GlnLys: 2.205 ± 0.414
4.502GlnLeu: 4.502 ± 0.56
0.827GlnMet: 0.827 ± 0.221
0.643GlnAsn: 0.643 ± 0.218
1.654GlnPro: 1.654 ± 0.38
2.297GlnGln: 2.297 ± 0.508
2.756GlnArg: 2.756 ± 0.48
3.124GlnSer: 3.124 ± 0.457
1.929GlnThr: 1.929 ± 0.338
2.848GlnVal: 2.848 ± 0.497
1.654GlnTrp: 1.654 ± 0.37
0.827GlnTyr: 0.827 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
5.145ArgAla: 5.145 ± 0.675
0.459ArgCys: 0.459 ± 0.228
3.675ArgAsp: 3.675 ± 0.617
2.94ArgGlu: 2.94 ± 0.518
2.205ArgPhe: 2.205 ± 0.524
4.593ArgGly: 4.593 ± 0.562
1.194ArgHis: 1.194 ± 0.376
4.042ArgIle: 4.042 ± 0.637
3.859ArgLys: 3.859 ± 0.702
3.675ArgLeu: 3.675 ± 0.477
1.47ArgMet: 1.47 ± 0.35
2.113ArgAsn: 2.113 ± 0.338
3.307ArgPro: 3.307 ± 0.594
1.654ArgGln: 1.654 ± 0.292
5.42ArgArg: 5.42 ± 0.906
3.675ArgSer: 3.675 ± 0.546
1.837ArgThr: 1.837 ± 0.517
3.95ArgVal: 3.95 ± 0.793
1.102ArgTrp: 1.102 ± 0.431
1.011ArgTyr: 1.011 ± 0.251
0.0ArgXaa: 0.0 ± 0.0
Ser
7.166SerAla: 7.166 ± 0.952
0.643SerCys: 0.643 ± 0.253
3.767SerAsp: 3.767 ± 0.671
3.583SerGlu: 3.583 ± 0.638
2.389SerPhe: 2.389 ± 0.531
5.237SerGly: 5.237 ± 0.63
0.919SerHis: 0.919 ± 0.273
4.502SerIle: 4.502 ± 0.657
3.124SerLys: 3.124 ± 0.391
5.328SerLeu: 5.328 ± 0.84
2.205SerMet: 2.205 ± 0.513
2.205SerAsn: 2.205 ± 0.461
2.664SerPro: 2.664 ± 0.484
3.307SerGln: 3.307 ± 0.459
3.95SerArg: 3.95 ± 0.774
4.042SerSer: 4.042 ± 0.565
3.307SerThr: 3.307 ± 0.615
4.502SerVal: 4.502 ± 0.702
1.011SerTrp: 1.011 ± 0.252
1.286SerTyr: 1.286 ± 0.384
0.0SerXaa: 0.0 ± 0.0
Thr
6.615ThrAla: 6.615 ± 0.822
0.459ThrCys: 0.459 ± 0.211
2.756ThrAsp: 2.756 ± 0.488
3.032ThrGlu: 3.032 ± 0.511
1.746ThrPhe: 1.746 ± 0.35
4.502ThrGly: 4.502 ± 1.029
1.194ThrHis: 1.194 ± 0.273
4.318ThrIle: 4.318 ± 0.78
2.664ThrLys: 2.664 ± 0.635
4.685ThrLeu: 4.685 ± 0.631
1.562ThrMet: 1.562 ± 0.468
1.378ThrAsn: 1.378 ± 0.325
2.848ThrPro: 2.848 ± 0.506
2.94ThrGln: 2.94 ± 0.451
2.94ThrArg: 2.94 ± 0.546
4.502ThrSer: 4.502 ± 0.6
3.675ThrThr: 3.675 ± 0.503
4.685ThrVal: 4.685 ± 0.632
1.378ThrTrp: 1.378 ± 0.385
1.286ThrTyr: 1.286 ± 0.376
0.0ThrXaa: 0.0 ± 0.0
Val
6.431ValAla: 6.431 ± 0.718
0.643ValCys: 0.643 ± 0.348
5.328ValAsp: 5.328 ± 0.788
4.961ValGlu: 4.961 ± 0.665
1.286ValPhe: 1.286 ± 0.355
5.696ValGly: 5.696 ± 0.695
1.47ValHis: 1.47 ± 0.407
3.675ValIle: 3.675 ± 0.48
4.685ValLys: 4.685 ± 0.687
5.053ValLeu: 5.053 ± 0.658
1.102ValMet: 1.102 ± 0.3
3.124ValAsn: 3.124 ± 0.457
3.399ValPro: 3.399 ± 0.478
1.562ValGln: 1.562 ± 0.366
3.032ValArg: 3.032 ± 0.478
4.042ValSer: 4.042 ± 0.605
4.777ValThr: 4.777 ± 0.976
5.328ValVal: 5.328 ± 0.607
1.102ValTrp: 1.102 ± 0.316
2.48ValTyr: 2.48 ± 0.354
0.0ValXaa: 0.0 ± 0.0
Trp
1.746TrpAla: 1.746 ± 0.39
0.092TrpCys: 0.092 ± 0.085
1.654TrpAsp: 1.654 ± 0.388
1.378TrpGlu: 1.378 ± 0.328
0.276TrpPhe: 0.276 ± 0.116
1.011TrpGly: 1.011 ± 0.344
0.367TrpHis: 0.367 ± 0.194
1.286TrpIle: 1.286 ± 0.331
1.102TrpLys: 1.102 ± 0.261
1.837TrpLeu: 1.837 ± 0.383
0.551TrpMet: 0.551 ± 0.265
0.643TrpAsn: 0.643 ± 0.232
0.551TrpPro: 0.551 ± 0.299
1.102TrpGln: 1.102 ± 0.231
1.102TrpArg: 1.102 ± 0.306
0.827TrpSer: 0.827 ± 0.25
1.654TrpThr: 1.654 ± 0.399
1.011TrpVal: 1.011 ± 0.284
0.459TrpTrp: 0.459 ± 0.212
0.367TrpTyr: 0.367 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.021TyrAla: 2.021 ± 0.437
0.276TyrCys: 0.276 ± 0.139
2.572TyrAsp: 2.572 ± 0.414
1.654TyrGlu: 1.654 ± 0.322
0.735TyrPhe: 0.735 ± 0.321
1.562TyrGly: 1.562 ± 0.331
0.643TyrHis: 0.643 ± 0.271
0.827TyrIle: 0.827 ± 0.297
0.643TyrLys: 0.643 ± 0.27
1.286TyrLeu: 1.286 ± 0.405
0.367TyrMet: 0.367 ± 0.138
0.551TyrAsn: 0.551 ± 0.22
1.102TyrPro: 1.102 ± 0.319
0.919TyrGln: 0.919 ± 0.303
0.919TyrArg: 0.919 ± 0.267
2.113TyrSer: 2.113 ± 0.485
0.735TyrThr: 0.735 ± 0.202
1.746TyrVal: 1.746 ± 0.352
0.367TyrTrp: 0.367 ± 0.189
0.551TyrTyr: 0.551 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski