Amino acid dipepetide frequency for Edwardsiella phage pEt-SU

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.384AlaAla: 5.384 ± 0.46
0.46AlaCys: 0.46 ± 0.088
3.773AlaAsp: 3.773 ± 0.202
4.245AlaGlu: 4.245 ± 0.221
2.853AlaPhe: 2.853 ± 0.185
5.246AlaGly: 5.246 ± 0.375
0.943AlaHis: 0.943 ± 0.101
4.855AlaIle: 4.855 ± 0.263
4.406AlaLys: 4.406 ± 0.29
5.108AlaLeu: 5.108 ± 0.317
1.956AlaMet: 1.956 ± 0.19
3.704AlaAsn: 3.704 ± 0.213
2.611AlaPro: 2.611 ± 0.253
2.243AlaGln: 2.243 ± 0.146
2.703AlaArg: 2.703 ± 0.196
3.819AlaSer: 3.819 ± 0.273
4.187AlaThr: 4.187 ± 0.312
5.188AlaVal: 5.188 ± 0.283
0.633AlaTrp: 0.633 ± 0.083
2.128AlaTyr: 2.128 ± 0.141
0.0AlaXaa: 0.0 ± 0.0
Cys
0.644CysAla: 0.644 ± 0.107
0.092CysCys: 0.092 ± 0.035
0.575CysAsp: 0.575 ± 0.091
0.529CysGlu: 0.529 ± 0.083
0.345CysPhe: 0.345 ± 0.064
0.506CysGly: 0.506 ± 0.092
0.219CysHis: 0.219 ± 0.059
0.472CysIle: 0.472 ± 0.084
0.621CysLys: 0.621 ± 0.097
0.541CysLeu: 0.541 ± 0.102
0.23CysMet: 0.23 ± 0.051
0.38CysAsn: 0.38 ± 0.065
0.322CysPro: 0.322 ± 0.065
0.38CysGln: 0.38 ± 0.078
0.472CysArg: 0.472 ± 0.081
0.518CysSer: 0.518 ± 0.081
0.403CysThr: 0.403 ± 0.069
0.69CysVal: 0.69 ± 0.095
0.173CysTrp: 0.173 ± 0.049
0.414CysTyr: 0.414 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
3.819AspAla: 3.819 ± 0.271
0.414AspCys: 0.414 ± 0.082
3.497AspAsp: 3.497 ± 0.205
3.969AspGlu: 3.969 ± 0.248
3.359AspPhe: 3.359 ± 0.195
4.625AspGly: 4.625 ± 0.258
1.093AspHis: 1.093 ± 0.122
5.142AspIle: 5.142 ± 0.249
4.406AspLys: 4.406 ± 0.284
5.81AspLeu: 5.81 ± 0.229
1.852AspMet: 1.852 ± 0.16
2.934AspAsn: 2.934 ± 0.192
3.083AspPro: 3.083 ± 0.22
1.887AspGln: 1.887 ± 0.147
2.427AspArg: 2.427 ± 0.204
3.474AspSer: 3.474 ± 0.243
3.796AspThr: 3.796 ± 0.244
5.188AspVal: 5.188 ± 0.238
0.932AspTrp: 0.932 ± 0.093
2.795AspTyr: 2.795 ± 0.206
0.0AspXaa: 0.0 ± 0.0
Glu
3.716GluAla: 3.716 ± 0.29
0.656GluCys: 0.656 ± 0.101
3.509GluAsp: 3.509 ± 0.24
4.349GluGlu: 4.349 ± 0.355
3.003GluPhe: 3.003 ± 0.201
4.141GluGly: 4.141 ± 0.227
1.392GluHis: 1.392 ± 0.163
4.303GluIle: 4.303 ± 0.227
3.635GluLys: 3.635 ± 0.339
5.844GluLeu: 5.844 ± 0.374
2.117GluMet: 2.117 ± 0.214
2.934GluAsn: 2.934 ± 0.234
2.22GluPro: 2.22 ± 0.195
2.416GluGln: 2.416 ± 0.187
2.462GluArg: 2.462 ± 0.179
3.256GluSer: 3.256 ± 0.232
3.888GluThr: 3.888 ± 0.25
4.671GluVal: 4.671 ± 0.224
0.909GluTrp: 0.909 ± 0.112
2.577GluTyr: 2.577 ± 0.176
0.0GluXaa: 0.0 ± 0.0
Phe
2.473PheAla: 2.473 ± 0.185
0.506PheCys: 0.506 ± 0.093
3.428PheAsp: 3.428 ± 0.228
2.416PheGlu: 2.416 ± 0.141
1.852PhePhe: 1.852 ± 0.171
3.21PheGly: 3.21 ± 0.191
0.679PheHis: 0.679 ± 0.101
2.841PheIle: 2.841 ± 0.214
3.118PheLys: 3.118 ± 0.186
2.841PheLeu: 2.841 ± 0.229
1.415PheMet: 1.415 ± 0.139
3.394PheAsn: 3.394 ± 0.27
1.438PhePro: 1.438 ± 0.139
1.277PheGln: 1.277 ± 0.121
2.002PheArg: 2.002 ± 0.183
2.738PheSer: 2.738 ± 0.178
3.003PheThr: 3.003 ± 0.276
2.934PheVal: 2.934 ± 0.207
0.529PheTrp: 0.529 ± 0.076
1.795PheTyr: 1.795 ± 0.154
0.0PheXaa: 0.0 ± 0.0
Gly
3.957GlyAla: 3.957 ± 0.263
0.633GlyCys: 0.633 ± 0.114
4.613GlyAsp: 4.613 ± 0.26
4.118GlyGlu: 4.118 ± 0.217
3.072GlyPhe: 3.072 ± 0.223
4.981GlyGly: 4.981 ± 0.426
1.024GlyHis: 1.024 ± 0.106
4.406GlyIle: 4.406 ± 0.29
5.131GlyLys: 5.131 ± 0.313
5.372GlyLeu: 5.372 ± 0.242
2.059GlyMet: 2.059 ± 0.174
3.957GlyAsn: 3.957 ± 0.285
1.657GlyPro: 1.657 ± 0.159
2.232GlyGln: 2.232 ± 0.167
3.06GlyArg: 3.06 ± 0.204
4.475GlySer: 4.475 ± 0.307
4.82GlyThr: 4.82 ± 0.473
4.556GlyVal: 4.556 ± 0.32
0.955GlyTrp: 0.955 ± 0.117
2.841GlyTyr: 2.841 ± 0.178
0.0GlyXaa: 0.0 ± 0.0
His
1.254HisAla: 1.254 ± 0.118
0.23HisCys: 0.23 ± 0.05
1.058HisAsp: 1.058 ± 0.116
1.001HisGlu: 1.001 ± 0.131
0.966HisPhe: 0.966 ± 0.144
1.035HisGly: 1.035 ± 0.11
0.61HisHis: 0.61 ± 0.12
1.334HisIle: 1.334 ± 0.134
1.162HisLys: 1.162 ± 0.137
1.772HisLeu: 1.772 ± 0.183
0.414HisMet: 0.414 ± 0.068
0.863HisAsn: 0.863 ± 0.089
0.955HisPro: 0.955 ± 0.092
0.564HisGln: 0.564 ± 0.091
0.909HisArg: 0.909 ± 0.113
1.15HisSer: 1.15 ± 0.12
1.185HisThr: 1.185 ± 0.135
1.196HisVal: 1.196 ± 0.13
0.138HisTrp: 0.138 ± 0.039
0.978HisTyr: 0.978 ± 0.117
0.0HisXaa: 0.0 ± 0.0
Ile
4.268IleAla: 4.268 ± 0.218
0.679IleCys: 0.679 ± 0.097
4.947IleAsp: 4.947 ± 0.264
4.176IleGlu: 4.176 ± 0.224
2.278IlePhe: 2.278 ± 0.185
3.957IleGly: 3.957 ± 0.198
1.45IleHis: 1.45 ± 0.148
4.21IleIle: 4.21 ± 0.235
4.74IleLys: 4.74 ± 0.273
4.176IleLeu: 4.176 ± 0.231
1.611IleMet: 1.611 ± 0.149
4.498IleAsn: 4.498 ± 0.216
3.256IlePro: 3.256 ± 0.234
1.818IleGln: 1.818 ± 0.165
3.44IleArg: 3.44 ± 0.232
4.763IleSer: 4.763 ± 0.247
5.177IleThr: 5.177 ± 0.483
4.038IleVal: 4.038 ± 0.287
0.725IleTrp: 0.725 ± 0.101
2.312IleTyr: 2.312 ± 0.158
0.0IleXaa: 0.0 ± 0.0
Lys
5.165LysAla: 5.165 ± 0.356
0.552LysCys: 0.552 ± 0.09
4.786LysAsp: 4.786 ± 0.287
4.809LysGlu: 4.809 ± 0.342
2.761LysPhe: 2.761 ± 0.204
4.061LysGly: 4.061 ± 0.235
1.323LysHis: 1.323 ± 0.139
3.463LysIle: 3.463 ± 0.243
3.658LysLys: 3.658 ± 0.309
6.074LysLeu: 6.074 ± 0.322
1.875LysMet: 1.875 ± 0.175
3.026LysAsn: 3.026 ± 0.212
2.761LysPro: 2.761 ± 0.21
2.151LysGln: 2.151 ± 0.154
2.841LysArg: 2.841 ± 0.267
3.612LysSer: 3.612 ± 0.281
3.727LysThr: 3.727 ± 0.201
4.74LysVal: 4.74 ± 0.26
0.863LysTrp: 0.863 ± 0.089
2.761LysTyr: 2.761 ± 0.172
0.0LysXaa: 0.0 ± 0.0
Leu
5.384LeuAla: 5.384 ± 0.273
0.771LeuCys: 0.771 ± 0.111
6.005LeuAsp: 6.005 ± 0.261
4.993LeuGlu: 4.993 ± 0.245
3.359LeuPhe: 3.359 ± 0.232
4.705LeuGly: 4.705 ± 0.22
1.519LeuHis: 1.519 ± 0.165
4.613LeuIle: 4.613 ± 0.335
5.948LeuLys: 5.948 ± 0.281
5.994LeuLeu: 5.994 ± 0.369
2.312LeuMet: 2.312 ± 0.208
4.866LeuAsn: 4.866 ± 0.295
3.187LeuPro: 3.187 ± 0.18
2.761LeuGln: 2.761 ± 0.194
3.992LeuArg: 3.992 ± 0.245
5.292LeuSer: 5.292 ± 0.255
6.12LeuThr: 6.12 ± 0.371
5.936LeuVal: 5.936 ± 0.237
0.679LeuTrp: 0.679 ± 0.1
2.738LeuTyr: 2.738 ± 0.219
0.0LeuXaa: 0.0 ± 0.0
Met
1.921MetAla: 1.921 ± 0.148
0.299MetCys: 0.299 ± 0.063
1.875MetAsp: 1.875 ± 0.189
1.852MetGlu: 1.852 ± 0.171
1.484MetPhe: 1.484 ± 0.215
1.622MetGly: 1.622 ± 0.189
0.437MetHis: 0.437 ± 0.076
1.91MetIle: 1.91 ± 0.175
1.875MetLys: 1.875 ± 0.174
1.956MetLeu: 1.956 ± 0.129
0.886MetMet: 0.886 ± 0.185
1.599MetAsn: 1.599 ± 0.178
1.127MetPro: 1.127 ± 0.131
1.001MetGln: 1.001 ± 0.118
0.909MetArg: 0.909 ± 0.098
2.37MetSer: 2.37 ± 0.184
1.921MetThr: 1.921 ± 0.139
1.829MetVal: 1.829 ± 0.16
0.426MetTrp: 0.426 ± 0.07
1.104MetTyr: 1.104 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
4.084AsnAla: 4.084 ± 0.21
0.345AsnCys: 0.345 ± 0.067
3.451AsnAsp: 3.451 ± 0.235
3.451AsnGlu: 3.451 ± 0.217
2.439AsnPhe: 2.439 ± 0.212
4.291AsnGly: 4.291 ± 0.257
1.116AsnHis: 1.116 ± 0.143
3.854AsnIle: 3.854 ± 0.201
3.555AsnLys: 3.555 ± 0.247
4.51AsnLeu: 4.51 ± 0.286
1.357AsnMet: 1.357 ± 0.141
3.463AsnAsn: 3.463 ± 0.225
2.922AsnPro: 2.922 ± 0.156
2.071AsnGln: 2.071 ± 0.172
2.565AsnArg: 2.565 ± 0.14
3.29AsnSer: 3.29 ± 0.195
3.29AsnThr: 3.29 ± 0.218
3.394AsnVal: 3.394 ± 0.297
0.782AsnTrp: 0.782 ± 0.126
2.002AsnTyr: 2.002 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
3.175ProAla: 3.175 ± 0.234
0.161ProCys: 0.161 ± 0.047
2.577ProAsp: 2.577 ± 0.166
3.003ProGlu: 3.003 ± 0.217
1.864ProPhe: 1.864 ± 0.137
2.611ProGly: 2.611 ± 0.219
0.633ProHis: 0.633 ± 0.093
2.818ProIle: 2.818 ± 0.204
2.347ProLys: 2.347 ± 0.18
2.957ProLeu: 2.957 ± 0.208
1.139ProMet: 1.139 ± 0.105
2.404ProAsn: 2.404 ± 0.204
1.162ProPro: 1.162 ± 0.156
1.254ProGln: 1.254 ± 0.134
1.415ProArg: 1.415 ± 0.134
2.519ProSer: 2.519 ± 0.143
3.072ProThr: 3.072 ± 0.31
3.658ProVal: 3.658 ± 0.351
0.495ProTrp: 0.495 ± 0.087
1.242ProTyr: 1.242 ± 0.13
0.0ProXaa: 0.0 ± 0.0
Gln
2.554GlnAla: 2.554 ± 0.181
0.299GlnCys: 0.299 ± 0.057
1.852GlnAsp: 1.852 ± 0.131
1.829GlnGlu: 1.829 ± 0.146
1.806GlnPhe: 1.806 ± 0.157
1.956GlnGly: 1.956 ± 0.164
0.771GlnHis: 0.771 ± 0.099
2.232GlnIle: 2.232 ± 0.175
1.323GlnLys: 1.323 ± 0.122
3.244GlnLeu: 3.244 ± 0.198
1.058GlnMet: 1.058 ± 0.102
1.76GlnAsn: 1.76 ± 0.144
1.461GlnPro: 1.461 ± 0.121
1.53GlnGln: 1.53 ± 0.155
1.392GlnArg: 1.392 ± 0.142
2.048GlnSer: 2.048 ± 0.14
1.841GlnThr: 1.841 ± 0.195
2.519GlnVal: 2.519 ± 0.189
0.495GlnTrp: 0.495 ± 0.083
1.542GlnTyr: 1.542 ± 0.121
0.0GlnXaa: 0.0 ± 0.0
Arg
2.876ArgAla: 2.876 ± 0.221
0.414ArgCys: 0.414 ± 0.067
2.772ArgAsp: 2.772 ± 0.175
2.519ArgGlu: 2.519 ± 0.22
2.105ArgPhe: 2.105 ± 0.162
2.634ArgGly: 2.634 ± 0.193
0.955ArgHis: 0.955 ± 0.12
2.945ArgIle: 2.945 ± 0.202
2.692ArgLys: 2.692 ± 0.225
4.199ArgLeu: 4.199 ± 0.274
1.427ArgMet: 1.427 ± 0.151
2.301ArgAsn: 2.301 ± 0.195
1.484ArgPro: 1.484 ± 0.139
1.622ArgGln: 1.622 ± 0.139
2.013ArgArg: 2.013 ± 0.155
2.381ArgSer: 2.381 ± 0.185
2.439ArgThr: 2.439 ± 0.198
3.302ArgVal: 3.302 ± 0.194
0.437ArgTrp: 0.437 ± 0.075
2.048ArgTyr: 2.048 ± 0.183
0.0ArgXaa: 0.0 ± 0.0
Ser
4.268SerAla: 4.268 ± 0.34
0.483SerCys: 0.483 ± 0.07
3.67SerAsp: 3.67 ± 0.216
3.256SerGlu: 3.256 ± 0.243
2.749SerPhe: 2.749 ± 0.193
4.786SerGly: 4.786 ± 0.333
1.219SerHis: 1.219 ± 0.14
4.406SerIle: 4.406 ± 0.247
3.865SerLys: 3.865 ± 0.252
5.441SerLeu: 5.441 ± 0.246
1.91SerMet: 1.91 ± 0.15
3.532SerAsn: 3.532 ± 0.209
2.519SerPro: 2.519 ± 0.253
1.921SerGln: 1.921 ± 0.172
2.588SerArg: 2.588 ± 0.183
3.75SerSer: 3.75 ± 0.276
4.153SerThr: 4.153 ± 0.271
4.613SerVal: 4.613 ± 0.271
0.69SerTrp: 0.69 ± 0.101
2.312SerTyr: 2.312 ± 0.142
0.0SerXaa: 0.0 ± 0.0
Thr
4.199ThrAla: 4.199 ± 0.362
0.299ThrCys: 0.299 ± 0.062
3.67ThrAsp: 3.67 ± 0.239
3.946ThrGlu: 3.946 ± 0.224
3.014ThrPhe: 3.014 ± 0.279
5.338ThrGly: 5.338 ± 0.446
1.093ThrHis: 1.093 ± 0.117
4.372ThrIle: 4.372 ± 0.399
4.015ThrLys: 4.015 ± 0.235
5.718ThrLeu: 5.718 ± 0.456
1.392ThrMet: 1.392 ± 0.131
3.44ThrAsn: 3.44 ± 0.256
3.394ThrPro: 3.394 ± 0.256
2.22ThrGln: 2.22 ± 0.245
2.761ThrArg: 2.761 ± 0.151
4.107ThrSer: 4.107 ± 0.256
4.418ThrThr: 4.418 ± 0.421
5.579ThrVal: 5.579 ± 0.479
0.943ThrTrp: 0.943 ± 0.112
2.577ThrTyr: 2.577 ± 0.31
0.0ThrXaa: 0.0 ± 0.0
Val
4.59ValAla: 4.59 ± 0.316
0.725ValCys: 0.725 ± 0.096
4.832ValAsp: 4.832 ± 0.261
4.694ValGlu: 4.694 ± 0.241
2.519ValPhe: 2.519 ± 0.207
4.751ValGly: 4.751 ± 0.275
1.104ValHis: 1.104 ± 0.133
4.901ValIle: 4.901 ± 0.276
5.062ValLys: 5.062 ± 0.258
5.729ValLeu: 5.729 ± 0.212
1.944ValMet: 1.944 ± 0.13
4.072ValAsn: 4.072 ± 0.257
2.991ValPro: 2.991 ± 0.296
2.151ValGln: 2.151 ± 0.162
3.106ValArg: 3.106 ± 0.213
4.843ValSer: 4.843 ± 0.258
5.614ValThr: 5.614 ± 0.586
5.464ValVal: 5.464 ± 0.39
0.759ValTrp: 0.759 ± 0.104
2.899ValTyr: 2.899 ± 0.212
0.0ValXaa: 0.0 ± 0.0
Trp
0.506TrpAla: 0.506 ± 0.073
0.184TrpCys: 0.184 ± 0.048
0.932TrpAsp: 0.932 ± 0.127
0.736TrpGlu: 0.736 ± 0.086
0.541TrpPhe: 0.541 ± 0.078
0.679TrpGly: 0.679 ± 0.082
0.242TrpHis: 0.242 ± 0.056
1.07TrpIle: 1.07 ± 0.102
0.725TrpLys: 0.725 ± 0.086
0.897TrpLeu: 0.897 ± 0.11
0.345TrpMet: 0.345 ± 0.058
0.702TrpAsn: 0.702 ± 0.13
0.334TrpPro: 0.334 ± 0.067
0.368TrpGln: 0.368 ± 0.079
0.541TrpArg: 0.541 ± 0.075
0.966TrpSer: 0.966 ± 0.111
0.851TrpThr: 0.851 ± 0.135
1.047TrpVal: 1.047 ± 0.134
0.196TrpTrp: 0.196 ± 0.052
0.541TrpTyr: 0.541 ± 0.072
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.209TyrAla: 2.209 ± 0.193
0.322TyrCys: 0.322 ± 0.056
2.68TyrAsp: 2.68 ± 0.208
2.105TyrGlu: 2.105 ± 0.16
1.519TyrPhe: 1.519 ± 0.158
2.784TyrGly: 2.784 ± 0.146
0.955TyrHis: 0.955 ± 0.113
2.37TyrIle: 2.37 ± 0.164
2.738TyrLys: 2.738 ± 0.217
2.991TyrLeu: 2.991 ± 0.236
1.093TyrMet: 1.093 ± 0.119
2.404TyrAsn: 2.404 ± 0.164
1.622TyrPro: 1.622 ± 0.13
1.645TyrGln: 1.645 ± 0.115
1.967TyrArg: 1.967 ± 0.152
2.761TyrSer: 2.761 ± 0.191
2.588TyrThr: 2.588 ± 0.233
2.209TyrVal: 2.209 ± 0.176
0.644TyrTrp: 0.644 ± 0.099
1.645TyrTyr: 1.645 ± 0.141
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 284 proteins (86927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski