Amino acid dipepetide frequency for Streptomyces mangrovisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.611AlaAla: 22.611 ± 0.167	1.068AlaCys: 1.068 ± 0.023	8.845AlaAsp: 8.845 ± 0.071	8.749AlaGlu: 8.749 ± 0.094	3.562AlaPhe: 3.562 ± 0.036	13.35AlaGly: 13.35 ± 0.077	3.16AlaHis: 3.16 ± 0.044	3.351AlaIle: 3.351 ± 0.04	2.754AlaLys: 2.754 ± 0.044	14.962AlaLeu: 14.962 ± 0.106	2.387AlaMet: 2.387 ± 0.029	1.881AlaAsn: 1.881 ± 0.028	7.337AlaPro: 7.337 ± 0.067	3.824AlaGln: 3.824 ± 0.039	10.731AlaArg: 10.731 ± 0.087	6.147AlaSer: 6.147 ± 0.069	7.247AlaThr: 7.247 ± 0.06	12.712AlaVal: 12.712 ± 0.086	1.93AlaTrp: 1.93 ± 0.031	2.822AlaTyr: 2.822 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.105CysAla: 1.105 ± 0.019	0.095CysCys: 0.095 ± 0.007	0.451CysAsp: 0.451 ± 0.014	0.38CysGlu: 0.38 ± 0.014	0.221CysPhe: 0.221 ± 0.009	0.942CysGly: 0.942 ± 0.022	0.188CysHis: 0.188 ± 0.01	0.157CysIle: 0.157 ± 0.008	0.108CysLys: 0.108 ± 0.006	0.766CysLeu: 0.766 ± 0.02	0.104CysMet: 0.104 ± 0.007	0.13CysAsn: 0.13 ± 0.008	0.46CysPro: 0.46 ± 0.015	0.166CysGln: 0.166 ± 0.008	0.582CysArg: 0.582 ± 0.017	0.405CysSer: 0.405 ± 0.013	0.511CysThr: 0.511 ± 0.015	0.701CysVal: 0.701 ± 0.015	0.127CysTrp: 0.127 ± 0.008	0.149CysTyr: 0.149 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.068AspAla: 8.068 ± 0.069	0.416AspCys: 0.416 ± 0.015	3.788AspAsp: 3.788 ± 0.042	3.784AspGlu: 3.784 ± 0.042	1.697AspPhe: 1.697 ± 0.026	6.756AspGly: 6.756 ± 0.059	1.519AspHis: 1.519 ± 0.029	1.881AspIle: 1.881 ± 0.024	1.154AspLys: 1.154 ± 0.025	6.407AspLeu: 6.407 ± 0.056	0.818AspMet: 0.818 ± 0.017	0.937AspAsn: 0.937 ± 0.022	4.62AspPro: 4.62 ± 0.046	1.505AspGln: 1.505 ± 0.026	4.909AspArg: 4.909 ± 0.05	2.555AspSer: 2.555 ± 0.038	3.381AspThr: 3.381 ± 0.043	4.728AspVal: 4.728 ± 0.046	1.048AspTrp: 1.048 ± 0.022	1.132AspTyr: 1.132 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.237GluAla: 7.237 ± 0.073	0.345GluCys: 0.345 ± 0.012	2.793GluAsp: 2.793 ± 0.037	3.279GluGlu: 3.279 ± 0.045	1.439GluPhe: 1.439 ± 0.026	4.144GluGly: 4.144 ± 0.05	1.515GluHis: 1.515 ± 0.029	2.122GluIle: 2.122 ± 0.029	1.265GluLys: 1.265 ± 0.025	6.521GluLeu: 6.521 ± 0.065	0.827GluMet: 0.827 ± 0.021	0.959GluAsn: 0.959 ± 0.019	3.261GluPro: 3.261 ± 0.043	2.119GluGln: 2.119 ± 0.03	5.492GluArg: 5.492 ± 0.052	2.487GluSer: 2.487 ± 0.035	2.791GluThr: 2.791 ± 0.041	4.245GluVal: 4.245 ± 0.05	0.738GluTrp: 0.738 ± 0.017	1.039GluTyr: 1.039 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.733PheAla: 3.733 ± 0.038	0.261PheCys: 0.261 ± 0.009	1.934PheAsp: 1.934 ± 0.03	1.395PheGlu: 1.395 ± 0.025	0.836PhePhe: 0.836 ± 0.022	3.057PheGly: 3.057 ± 0.039	0.649PheHis: 0.649 ± 0.019	0.633PheIle: 0.633 ± 0.017	0.525PheLys: 0.525 ± 0.015	2.621PheLeu: 2.621 ± 0.034	0.39PheMet: 0.39 ± 0.013	0.533PheAsn: 0.533 ± 0.014	1.386PhePro: 1.386 ± 0.024	0.666PheGln: 0.666 ± 0.017	1.815PheArg: 1.815 ± 0.025	1.42PheSer: 1.42 ± 0.024	2.061PheThr: 2.061 ± 0.034	2.295PheVal: 2.295 ± 0.037	0.415PheTrp: 0.415 ± 0.013	0.594PheTyr: 0.594 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.577GlyAla: 11.577 ± 0.079	0.835GlyCys: 0.835 ± 0.021	5.322GlyAsp: 5.322 ± 0.055	4.873GlyGlu: 4.873 ± 0.056	2.914GlyPhe: 2.914 ± 0.038	9.06GlyGly: 9.06 ± 0.086	2.441GlyHis: 2.441 ± 0.036	3.273GlyIle: 3.273 ± 0.037	2.257GlyLys: 2.257 ± 0.039	9.524GlyLeu: 9.524 ± 0.066	1.928GlyMet: 1.928 ± 0.03	1.712GlyAsn: 1.712 ± 0.032	5.32GlyPro: 5.32 ± 0.054	2.627GlyGln: 2.627 ± 0.035	7.895GlyArg: 7.895 ± 0.063	5.577GlySer: 5.577 ± 0.054	6.654GlyThr: 6.654 ± 0.068	7.691GlyVal: 7.691 ± 0.063	1.77GlyTrp: 1.77 ± 0.03	2.33GlyTyr: 2.33 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.849HisAla: 2.849 ± 0.036	0.219HisCys: 0.219 ± 0.009	1.453HisAsp: 1.453 ± 0.026	1.231HisGlu: 1.231 ± 0.024	0.658HisPhe: 0.658 ± 0.02	2.591HisGly: 2.591 ± 0.037	0.73HisHis: 0.73 ± 0.018	0.662HisIle: 0.662 ± 0.016	0.347HisLys: 0.347 ± 0.012	2.435HisLeu: 2.435 ± 0.033	0.335HisMet: 0.335 ± 0.012	0.373HisAsn: 0.373 ± 0.011	1.901HisPro: 1.901 ± 0.029	0.673HisGln: 0.673 ± 0.016	2.125HisArg: 2.125 ± 0.029	1.004HisSer: 1.004 ± 0.021	1.394HisThr: 1.394 ± 0.025	1.776HisVal: 1.776 ± 0.03	0.392HisTrp: 0.392 ± 0.013	0.503HisTyr: 0.503 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.587IleAla: 4.587 ± 0.047	0.267IleCys: 0.267 ± 0.013	2.153IleAsp: 2.153 ± 0.031	1.847IleGlu: 1.847 ± 0.029	0.648IlePhe: 0.648 ± 0.018	3.491IleGly: 3.491 ± 0.038	0.603IleHis: 0.603 ± 0.018	0.765IleIle: 0.765 ± 0.018	0.678IleLys: 0.678 ± 0.021	2.281IleLeu: 2.281 ± 0.035	0.415IleMet: 0.415 ± 0.015	0.651IleAsn: 0.651 ± 0.018	1.616IlePro: 1.616 ± 0.026	0.699IleGln: 0.699 ± 0.018	2.094IleArg: 2.094 ± 0.03	1.574IleSer: 1.574 ± 0.025	2.11IleThr: 2.11 ± 0.03	2.73IleVal: 2.73 ± 0.034	0.356IleTrp: 0.356 ± 0.013	0.51IleTyr: 0.51 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.861LysAla: 2.861 ± 0.039	0.102LysCys: 0.102 ± 0.007	1.352LysAsp: 1.352 ± 0.027	1.098LysGlu: 1.098 ± 0.024	0.445LysPhe: 0.445 ± 0.017	1.772LysGly: 1.772 ± 0.033	0.397LysHis: 0.397 ± 0.013	0.827LysIle: 0.827 ± 0.022	0.834LysLys: 0.834 ± 0.029	1.856LysLeu: 1.856 ± 0.029	0.34LysMet: 0.34 ± 0.013	0.505LysAsn: 0.505 ± 0.017	1.19LysPro: 1.19 ± 0.023	0.66LysGln: 0.66 ± 0.018	1.31LysArg: 1.31 ± 0.025	1.147LysSer: 1.147 ± 0.021	1.229LysThr: 1.229 ± 0.027	1.866LysVal: 1.866 ± 0.033	0.272LysTrp: 0.272 ± 0.01	0.457LysTyr: 0.457 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.512LeuAla: 15.512 ± 0.107	0.846LeuCys: 0.846 ± 0.019	6.808LeuAsp: 6.808 ± 0.066	4.559LeuGlu: 4.559 ± 0.052	2.552LeuPhe: 2.552 ± 0.04	9.364LeuGly: 9.364 ± 0.067	2.392LeuHis: 2.392 ± 0.034	3.157LeuIle: 3.157 ± 0.042	1.99LeuLys: 1.99 ± 0.032	11.425LeuLeu: 11.425 ± 0.101	1.606LeuMet: 1.606 ± 0.029	1.602LeuAsn: 1.602 ± 0.029	6.475LeuPro: 6.475 ± 0.06	2.174LeuGln: 2.174 ± 0.033	8.696LeuArg: 8.696 ± 0.068	5.267LeuSer: 5.267 ± 0.052	7.062LeuThr: 7.062 ± 0.051	8.902LeuVal: 8.902 ± 0.07	1.321LeuTrp: 1.321 ± 0.022	1.911LeuTyr: 1.911 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.162MetAla: 2.162 ± 0.03	0.134MetCys: 0.134 ± 0.008	0.861MetAsp: 0.861 ± 0.021	0.731MetGlu: 0.731 ± 0.018	0.435MetPhe: 0.435 ± 0.015	1.247MetGly: 1.247 ± 0.028	0.362MetHis: 0.362 ± 0.013	0.611MetIle: 0.611 ± 0.017	0.392MetLys: 0.392 ± 0.014	1.58MetLeu: 1.58 ± 0.027	0.285MetMet: 0.285 ± 0.01	0.417MetAsn: 0.417 ± 0.013	1.061MetPro: 1.061 ± 0.021	0.422MetGln: 0.422 ± 0.013	1.337MetArg: 1.337 ± 0.022	1.243MetSer: 1.243 ± 0.022	1.537MetThr: 1.537 ± 0.023	1.227MetVal: 1.227 ± 0.024	0.209MetTrp: 0.209 ± 0.01	0.31MetTyr: 0.31 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.113AsnAla: 2.113 ± 0.029	0.161AsnCys: 0.161 ± 0.008	0.915AsnAsp: 0.915 ± 0.021	0.738AsnGlu: 0.738 ± 0.017	0.456AsnPhe: 0.456 ± 0.014	1.863AsnGly: 1.863 ± 0.032	0.382AsnHis: 0.382 ± 0.013	0.613AsnIle: 0.613 ± 0.017	0.383AsnLys: 0.383 ± 0.014	1.593AsnLeu: 1.593 ± 0.03	0.28AsnMet: 0.28 ± 0.012	0.408AsnAsn: 0.408 ± 0.014	1.287AsnPro: 1.287 ± 0.026	0.505AsnGln: 0.505 ± 0.017	1.171AsnArg: 1.171 ± 0.025	0.954AsnSer: 0.954 ± 0.024	1.138AsnThr: 1.138 ± 0.025	1.376AsnVal: 1.376 ± 0.022	0.292AsnTrp: 0.292 ± 0.011	0.4AsnTyr: 0.4 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.923ProAla: 8.923 ± 0.084	0.331ProCys: 0.331 ± 0.012	4.497ProAsp: 4.497 ± 0.049	4.16ProGlu: 4.16 ± 0.049	1.529ProPhe: 1.529 ± 0.025	6.638ProGly: 6.638 ± 0.059	1.429ProHis: 1.429 ± 0.026	1.178ProIle: 1.178 ± 0.022	1.107ProLys: 1.107 ± 0.024	5.38ProLeu: 5.38 ± 0.05	0.971ProMet: 0.971 ± 0.022	0.832ProAsn: 0.832 ± 0.018	3.391ProPro: 3.391 ± 0.056	1.745ProGln: 1.745 ± 0.032	3.984ProArg: 3.984 ± 0.045	3.139ProSer: 3.139 ± 0.045	3.097ProThr: 3.097 ± 0.034	5.535ProVal: 5.535 ± 0.049	0.903ProTrp: 0.903 ± 0.019	1.484ProTyr: 1.484 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.741GlnAla: 3.741 ± 0.045	0.162GlnCys: 0.162 ± 0.008	1.463GlnAsp: 1.463 ± 0.026	1.364GlnGlu: 1.364 ± 0.027	0.663GlnPhe: 0.663 ± 0.018	2.321GlnGly: 2.321 ± 0.034	0.643GlnHis: 0.643 ± 0.016	1.083GlnIle: 1.083 ± 0.021	0.608GlnLys: 0.608 ± 0.018	2.943GlnLeu: 2.943 ± 0.042	0.47GlnMet: 0.47 ± 0.014	0.523GlnAsn: 0.523 ± 0.018	1.622GlnPro: 1.622 ± 0.03	1.205GlnGln: 1.205 ± 0.029	2.232GlnArg: 2.232 ± 0.032	1.289GlnSer: 1.289 ± 0.029	1.367GlnThr: 1.367 ± 0.028	2.366GlnVal: 2.366 ± 0.029	0.461GlnTrp: 0.461 ± 0.014	0.613GlnTyr: 0.613 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.286ArgAla: 10.286 ± 0.092	0.576ArgCys: 0.576 ± 0.016	4.295ArgAsp: 4.295 ± 0.045	4.634ArgGlu: 4.634 ± 0.047	2.308ArgPhe: 2.308 ± 0.033	5.852ArgGly: 5.852 ± 0.053	2.183ArgHis: 2.183 ± 0.031	3.085ArgIle: 3.085 ± 0.036	1.47ArgLys: 1.47 ± 0.024	9.038ArgLeu: 9.038 ± 0.08	1.633ArgMet: 1.633 ± 0.027	1.248ArgAsn: 1.248 ± 0.025	5.073ArgPro: 5.073 ± 0.051	2.252ArgGln: 2.252 ± 0.03	7.868ArgArg: 7.868 ± 0.084	3.976ArgSer: 3.976 ± 0.043	5.42ArgThr: 5.42 ± 0.053	5.928ArgVal: 5.928 ± 0.055	1.38ArgTrp: 1.38 ± 0.024	1.754ArgTyr: 1.754 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.13SerAla: 7.13 ± 0.07	0.403SerCys: 0.403 ± 0.014	2.766SerAsp: 2.766 ± 0.036	2.24SerGlu: 2.24 ± 0.032	1.505SerPhe: 1.505 ± 0.027	6.114SerGly: 6.114 ± 0.069	0.998SerHis: 0.998 ± 0.02	1.324SerIle: 1.324 ± 0.026	1.015SerLys: 1.015 ± 0.024	4.766SerLeu: 4.766 ± 0.048	1.029SerMet: 1.029 ± 0.019	0.887SerAsn: 0.887 ± 0.021	3.038SerPro: 3.038 ± 0.046	1.231SerGln: 1.231 ± 0.023	3.576SerArg: 3.576 ± 0.041	2.904SerSer: 2.904 ± 0.048	3.136SerThr: 3.136 ± 0.047	4.327SerVal: 4.327 ± 0.046	0.922SerTrp: 0.922 ± 0.019	1.321SerTyr: 1.321 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.363ThrAla: 9.363 ± 0.069	0.433ThrCys: 0.433 ± 0.013	3.747ThrAsp: 3.747 ± 0.041	3.115ThrGlu: 3.115 ± 0.042	1.687ThrPhe: 1.687 ± 0.025	6.952ThrGly: 6.952 ± 0.065	1.218ThrHis: 1.218 ± 0.021	1.644ThrIle: 1.644 ± 0.022	1.161ThrLys: 1.161 ± 0.026	5.87ThrLeu: 5.87 ± 0.056	0.866ThrMet: 0.866 ± 0.018	0.953ThrAsn: 0.953 ± 0.022	4.118ThrPro: 4.118 ± 0.044	1.335ThrGln: 1.335 ± 0.026	3.919ThrArg: 3.919 ± 0.041	3.257ThrSer: 3.257 ± 0.044	4.072ThrThr: 4.072 ± 0.06	6.292ThrVal: 6.292 ± 0.055	0.936ThrTrp: 0.936 ± 0.018	1.375ThrTyr: 1.375 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.02ValAla: 11.02 ± 0.073	0.766ValCys: 0.766 ± 0.016	5.111ValAsp: 5.111 ± 0.046	4.547ValGlu: 4.547 ± 0.05	2.489ValPhe: 2.489 ± 0.037	6.604ValGly: 6.604 ± 0.061	2.049ValHis: 2.049 ± 0.03	2.674ValIle: 2.674 ± 0.035	1.703ValLys: 1.703 ± 0.032	9.72ValLeu: 9.72 ± 0.07	1.352ValMet: 1.352 ± 0.024	1.646ValAsn: 1.646 ± 0.031	5.273ValPro: 5.273 ± 0.05	2.118ValGln: 2.118 ± 0.03	7.377ValArg: 7.377 ± 0.062	4.361ValSer: 4.361 ± 0.044	5.788ValThr: 5.788 ± 0.054	8.289ValVal: 8.289 ± 0.088	1.186ValTrp: 1.186 ± 0.027	1.631ValTyr: 1.631 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.7TrpAla: 1.7 ± 0.034	0.149TrpCys: 0.149 ± 0.007	0.855TrpAsp: 0.855 ± 0.021	0.697TrpGlu: 0.697 ± 0.017	0.524TrpPhe: 0.524 ± 0.014	1.072TrpGly: 1.072 ± 0.022	0.377TrpHis: 0.377 ± 0.012	0.56TrpIle: 0.56 ± 0.015	0.361TrpLys: 0.361 ± 0.012	1.83TrpLeu: 1.83 ± 0.031	0.272TrpMet: 0.272 ± 0.011	0.426TrpAsn: 0.426 ± 0.015	0.783TrpPro: 0.783 ± 0.019	0.614TrpGln: 0.614 ± 0.017	1.382TrpArg: 1.382 ± 0.025	0.97TrpSer: 0.97 ± 0.02	1.079TrpThr: 1.079 ± 0.022	0.994TrpVal: 0.994 ± 0.019	0.348TrpTrp: 0.348 ± 0.014	0.375TrpTyr: 0.375 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.853TyrAla: 2.853 ± 0.037	0.18TyrCys: 0.18 ± 0.01	1.696TyrAsp: 1.696 ± 0.03	1.195TyrGlu: 1.195 ± 0.02	0.649TyrPhe: 0.649 ± 0.015	2.392TyrGly: 2.392 ± 0.034	0.419TyrHis: 0.419 ± 0.012	0.472TyrIle: 0.472 ± 0.013	0.409TyrLys: 0.409 ± 0.014	2.105TyrLeu: 2.105 ± 0.032	0.251TyrMet: 0.251 ± 0.012	0.402TyrAsn: 0.402 ± 0.013	1.043TyrPro: 1.043 ± 0.02	0.599TyrGln: 0.599 ± 0.018	1.764TyrArg: 1.764 ± 0.027	0.953TyrSer: 0.953 ± 0.023	1.24TyrThr: 1.24 ± 0.029	1.724TyrVal: 1.724 ± 0.028	0.362TyrTrp: 0.362 ± 0.014	0.473TyrTyr: 0.473 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7461 proteins (2489176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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