Amino acid dipepetide frequency for Vagococcus fluvialis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.185AlaAla: 4.185 ± 0.096
0.506AlaCys: 0.506 ± 0.023
3.216AlaAsp: 3.216 ± 0.072
4.199AlaGlu: 4.199 ± 0.082
2.901AlaPhe: 2.901 ± 0.065
4.207AlaGly: 4.207 ± 0.093
1.062AlaHis: 1.062 ± 0.039
5.49AlaIle: 5.49 ± 0.098
4.769AlaLys: 4.769 ± 0.075
6.045AlaLeu: 6.045 ± 0.101
1.805AlaMet: 1.805 ± 0.052
2.83AlaAsn: 2.83 ± 0.059
1.813AlaPro: 1.813 ± 0.051
1.916AlaGln: 1.916 ± 0.051
1.965AlaArg: 1.965 ± 0.054
3.844AlaSer: 3.844 ± 0.071
3.724AlaThr: 3.724 ± 0.078
4.378AlaVal: 4.378 ± 0.069
0.504AlaTrp: 0.504 ± 0.029
2.16AlaTyr: 2.16 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.02
0.068CysCys: 0.068 ± 0.009
0.34CysAsp: 0.34 ± 0.019
0.355CysGlu: 0.355 ± 0.022
0.314CysPhe: 0.314 ± 0.019
0.577CysGly: 0.577 ± 0.028
0.186CysHis: 0.186 ± 0.015
0.412CysIle: 0.412 ± 0.026
0.249CysLys: 0.249 ± 0.018
0.726CysLeu: 0.726 ± 0.031
0.142CysMet: 0.142 ± 0.013
0.208CysAsn: 0.208 ± 0.015
0.24CysPro: 0.24 ± 0.017
0.266CysGln: 0.266 ± 0.021
0.211CysArg: 0.211 ± 0.017
0.38CysSer: 0.38 ± 0.025
0.264CysThr: 0.264 ± 0.019
0.403CysVal: 0.403 ± 0.023
0.05CysTrp: 0.05 ± 0.008
0.254CysTyr: 0.254 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.953AspAla: 2.953 ± 0.07
0.305AspCys: 0.305 ± 0.022
2.721AspAsp: 2.721 ± 0.066
4.609AspGlu: 4.609 ± 0.083
3.051AspPhe: 3.051 ± 0.059
3.303AspGly: 3.303 ± 0.071
0.806AspHis: 0.806 ± 0.032
4.629AspIle: 4.629 ± 0.079
4.032AspLys: 4.032 ± 0.072
5.403AspLeu: 5.403 ± 0.079
1.505AspMet: 1.505 ± 0.043
2.583AspAsn: 2.583 ± 0.055
1.542AspPro: 1.542 ± 0.045
1.573AspGln: 1.573 ± 0.045
1.633AspArg: 1.633 ± 0.047
3.131AspSer: 3.131 ± 0.069
2.85AspThr: 2.85 ± 0.064
4.003AspVal: 4.003 ± 0.072
0.541AspTrp: 0.541 ± 0.027
2.579AspTyr: 2.579 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
5.326GluAla: 5.326 ± 0.092
0.361GluCys: 0.361 ± 0.023
4.057GluAsp: 4.057 ± 0.081
7.63GluGlu: 7.63 ± 0.115
3.022GluPhe: 3.022 ± 0.065
4.006GluGly: 4.006 ± 0.076
1.127GluHis: 1.127 ± 0.034
6.447GluIle: 6.447 ± 0.107
7.843GluLys: 7.843 ± 0.126
8.05GluLeu: 8.05 ± 0.116
2.529GluMet: 2.529 ± 0.058
4.475GluAsn: 4.475 ± 0.082
1.803GluPro: 1.803 ± 0.06
2.668GluGln: 2.668 ± 0.063
2.731GluArg: 2.731 ± 0.068
4.103GluSer: 4.103 ± 0.079
4.723GluThr: 4.723 ± 0.085
5.558GluVal: 5.558 ± 0.092
0.737GluTrp: 0.737 ± 0.032
2.362GluTyr: 2.362 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
2.543PheAla: 2.543 ± 0.063
0.31PheCys: 0.31 ± 0.019
2.652PheAsp: 2.652 ± 0.054
3.305PheGlu: 3.305 ± 0.067
2.612PhePhe: 2.612 ± 0.075
3.12PheGly: 3.12 ± 0.068
0.763PheHis: 0.763 ± 0.029
4.097PheIle: 4.097 ± 0.083
3.128PheLys: 3.128 ± 0.067
4.747PheLeu: 4.747 ± 0.1
1.233PheMet: 1.233 ± 0.043
2.603PheAsn: 2.603 ± 0.061
1.518PhePro: 1.518 ± 0.045
1.287PheGln: 1.287 ± 0.04
1.312PheArg: 1.312 ± 0.042
3.714PheSer: 3.714 ± 0.072
2.536PheThr: 2.536 ± 0.07
3.188PheVal: 3.188 ± 0.07
0.402PheTrp: 0.402 ± 0.025
2.001PheTyr: 2.001 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.255GlyAla: 4.255 ± 0.092
0.448GlyCys: 0.448 ± 0.025
3.175GlyAsp: 3.175 ± 0.068
4.348GlyGlu: 4.348 ± 0.087
3.313GlyPhe: 3.313 ± 0.067
4.225GlyGly: 4.225 ± 0.087
1.129GlyHis: 1.129 ± 0.039
5.868GlyIle: 5.868 ± 0.103
4.797GlyLys: 4.797 ± 0.082
6.312GlyLeu: 6.312 ± 0.114
2.017GlyMet: 2.017 ± 0.062
2.879GlyAsn: 2.879 ± 0.068
1.426GlyPro: 1.426 ± 0.048
2.063GlyGln: 2.063 ± 0.051
2.084GlyArg: 2.084 ± 0.057
3.845GlySer: 3.845 ± 0.079
3.853GlyThr: 3.853 ± 0.071
4.777GlyVal: 4.777 ± 0.097
0.598GlyTrp: 0.598 ± 0.031
2.507GlyTyr: 2.507 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
0.958HisAla: 0.958 ± 0.033
0.129HisCys: 0.129 ± 0.014
0.909HisAsp: 0.909 ± 0.037
1.2HisGlu: 1.2 ± 0.046
0.991HisPhe: 0.991 ± 0.036
1.163HisGly: 1.163 ± 0.04
0.488HisHis: 0.488 ± 0.027
1.235HisIle: 1.235 ± 0.041
0.821HisLys: 0.821 ± 0.03
1.967HisLeu: 1.967 ± 0.05
0.458HisMet: 0.458 ± 0.024
0.684HisAsn: 0.684 ± 0.033
0.848HisPro: 0.848 ± 0.038
0.774HisGln: 0.774 ± 0.031
0.658HisArg: 0.658 ± 0.03
0.973HisSer: 0.973 ± 0.04
0.887HisThr: 0.887 ± 0.034
1.161HisVal: 1.161 ± 0.037
0.142HisTrp: 0.142 ± 0.013
0.79HisTyr: 0.79 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.492IleAla: 5.492 ± 0.101
0.596IleCys: 0.596 ± 0.031
4.772IleAsp: 4.772 ± 0.069
6.269IleGlu: 6.269 ± 0.102
3.71IlePhe: 3.71 ± 0.089
5.772IleGly: 5.772 ± 0.101
1.418IleHis: 1.418 ± 0.043
6.645IleIle: 6.645 ± 0.101
5.891IleLys: 5.891 ± 0.097
7.663IleLeu: 7.663 ± 0.132
1.979IleMet: 1.979 ± 0.054
4.351IleAsn: 4.351 ± 0.07
3.288IlePro: 3.288 ± 0.062
2.63IleGln: 2.63 ± 0.063
2.556IleArg: 2.556 ± 0.058
5.804IleSer: 5.804 ± 0.091
4.451IleThr: 4.451 ± 0.071
5.498IleVal: 5.498 ± 0.083
0.534IleTrp: 0.534 ± 0.029
2.75IleTyr: 2.75 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.435LysAla: 4.435 ± 0.084
0.268LysCys: 0.268 ± 0.02
4.507LysAsp: 4.507 ± 0.084
9.162LysGlu: 9.162 ± 0.146
2.224LysPhe: 2.224 ± 0.047
4.225LysGly: 4.225 ± 0.08
1.159LysHis: 1.159 ± 0.039
5.809LysIle: 5.809 ± 0.092
7.362LysLys: 7.362 ± 0.119
6.181LysLeu: 6.181 ± 0.094
2.533LysMet: 2.533 ± 0.064
4.585LysAsn: 4.585 ± 0.084
2.066LysPro: 2.066 ± 0.051
3.201LysGln: 3.201 ± 0.077
3.004LysArg: 3.004 ± 0.076
4.083LysSer: 4.083 ± 0.082
4.163LysThr: 4.163 ± 0.066
4.73LysVal: 4.73 ± 0.077
0.674LysTrp: 0.674 ± 0.032
2.444LysTyr: 2.444 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
6.833LeuAla: 6.833 ± 0.097
0.56LeuCys: 0.56 ± 0.027
5.413LeuAsp: 5.413 ± 0.088
7.206LeuGlu: 7.206 ± 0.127
4.885LeuPhe: 4.885 ± 0.113
6.405LeuGly: 6.405 ± 0.102
1.435LeuHis: 1.435 ± 0.043
7.996LeuIle: 7.996 ± 0.141
7.133LeuLys: 7.133 ± 0.104
9.869LeuLeu: 9.869 ± 0.151
2.596LeuMet: 2.596 ± 0.072
5.12LeuAsn: 5.12 ± 0.088
3.764LeuPro: 3.764 ± 0.07
2.73LeuGln: 2.73 ± 0.064
3.041LeuArg: 3.041 ± 0.071
7.176LeuSer: 7.176 ± 0.117
6.205LeuThr: 6.205 ± 0.102
6.893LeuVal: 6.893 ± 0.101
0.659LeuTrp: 0.659 ± 0.029
2.901LeuTyr: 2.901 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.85MetAla: 1.85 ± 0.058
0.146MetCys: 0.146 ± 0.012
1.398MetAsp: 1.398 ± 0.046
1.878MetGlu: 1.878 ± 0.049
1.107MetPhe: 1.107 ± 0.039
1.727MetGly: 1.727 ± 0.054
0.34MetHis: 0.34 ± 0.023
2.469MetIle: 2.469 ± 0.055
2.51MetLys: 2.51 ± 0.056
2.497MetLeu: 2.497 ± 0.056
0.931MetMet: 0.931 ± 0.038
1.692MetAsn: 1.692 ± 0.047
1.016MetPro: 1.016 ± 0.036
0.684MetGln: 0.684 ± 0.027
0.892MetArg: 0.892 ± 0.036
2.004MetSer: 2.004 ± 0.055
2.136MetThr: 2.136 ± 0.052
1.75MetVal: 1.75 ± 0.049
0.165MetTrp: 0.165 ± 0.014
0.776MetTyr: 0.776 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.571AsnAla: 2.571 ± 0.054
0.28AsnCys: 0.28 ± 0.019
2.456AsnAsp: 2.456 ± 0.05
4.064AsnGlu: 4.064 ± 0.079
2.293AsnPhe: 2.293 ± 0.054
3.257AsnGly: 3.257 ± 0.071
1.186AsnHis: 1.186 ± 0.04
3.963AsnIle: 3.963 ± 0.072
3.996AsnLys: 3.996 ± 0.08
4.795AsnLeu: 4.795 ± 0.086
1.454AsnMet: 1.454 ± 0.042
2.758AsnAsn: 2.758 ± 0.081
2.052AsnPro: 2.052 ± 0.043
2.799AsnGln: 2.799 ± 0.067
1.923AsnArg: 1.923 ± 0.05
2.801AsnSer: 2.801 ± 0.064
2.462AsnThr: 2.462 ± 0.059
3.093AsnVal: 3.093 ± 0.062
0.512AsnTrp: 0.512 ± 0.025
2.215AsnTyr: 2.215 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
1.717ProAla: 1.717 ± 0.051
0.153ProCys: 0.153 ± 0.013
1.772ProAsp: 1.772 ± 0.048
2.814ProGlu: 2.814 ± 0.063
1.766ProPhe: 1.766 ± 0.044
1.887ProGly: 1.887 ± 0.05
0.566ProHis: 0.566 ± 0.026
2.755ProIle: 2.755 ± 0.054
2.5ProLys: 2.5 ± 0.05
3.068ProLeu: 3.068 ± 0.059
0.822ProMet: 0.822 ± 0.032
1.794ProAsn: 1.794 ± 0.05
0.557ProPro: 0.557 ± 0.029
0.988ProGln: 0.988 ± 0.038
0.84ProArg: 0.84 ± 0.032
1.993ProSer: 1.993 ± 0.062
2.064ProThr: 2.064 ± 0.055
2.574ProVal: 2.574 ± 0.061
0.281ProTrp: 0.281 ± 0.018
1.309ProTyr: 1.309 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.259GlnAla: 2.259 ± 0.059
0.169GlnCys: 0.169 ± 0.014
1.564GlnAsp: 1.564 ± 0.045
2.89GlnGlu: 2.89 ± 0.069
1.448GlnPhe: 1.448 ± 0.049
1.981GlnGly: 1.981 ± 0.05
0.575GlnHis: 0.575 ± 0.027
2.653GlnIle: 2.653 ± 0.056
2.898GlnLys: 2.898 ± 0.071
3.82GlnLeu: 3.82 ± 0.077
1.057GlnMet: 1.057 ± 0.035
1.63GlnAsn: 1.63 ± 0.049
1.026GlnPro: 1.026 ± 0.039
1.42GlnGln: 1.42 ± 0.048
1.181GlnArg: 1.181 ± 0.037
1.978GlnSer: 1.978 ± 0.047
2.098GlnThr: 2.098 ± 0.055
2.555GlnVal: 2.555 ± 0.061
0.263GlnTrp: 0.263 ± 0.019
1.032GlnTyr: 1.032 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
1.695ArgAla: 1.695 ± 0.05
0.183ArgCys: 0.183 ± 0.015
1.739ArgAsp: 1.739 ± 0.049
2.852ArgGlu: 2.852 ± 0.057
1.627ArgPhe: 1.627 ± 0.049
1.953ArgGly: 1.953 ± 0.06
0.664ArgHis: 0.664 ± 0.028
2.661ArgIle: 2.661 ± 0.06
2.723ArgLys: 2.723 ± 0.067
3.276ArgLeu: 3.276 ± 0.067
1.011ArgMet: 1.011 ± 0.035
1.632ArgAsn: 1.632 ± 0.05
0.992ArgPro: 0.992 ± 0.039
1.349ArgGln: 1.349 ± 0.044
1.44ArgArg: 1.44 ± 0.045
1.704ArgSer: 1.704 ± 0.052
1.579ArgThr: 1.579 ± 0.054
2.379ArgVal: 2.379 ± 0.051
0.281ArgTrp: 0.281 ± 0.02
1.305ArgTyr: 1.305 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.406SerAla: 3.406 ± 0.063
0.333SerCys: 0.333 ± 0.021
3.341SerAsp: 3.341 ± 0.065
4.582SerGlu: 4.582 ± 0.088
3.492SerPhe: 3.492 ± 0.069
4.476SerGly: 4.476 ± 0.074
1.244SerHis: 1.244 ± 0.04
5.182SerIle: 5.182 ± 0.083
4.652SerLys: 4.652 ± 0.078
6.741SerLeu: 6.741 ± 0.111
1.615SerMet: 1.615 ± 0.046
2.921SerAsn: 2.921 ± 0.065
1.812SerPro: 1.812 ± 0.047
2.327SerGln: 2.327 ± 0.063
2.11SerArg: 2.11 ± 0.054
4.124SerSer: 4.124 ± 0.097
3.446SerThr: 3.446 ± 0.079
4.272SerVal: 4.272 ± 0.066
0.534SerTrp: 0.534 ± 0.027
2.557SerTyr: 2.557 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
3.408ThrAla: 3.408 ± 0.066
0.334ThrCys: 0.334 ± 0.021
3.1ThrAsp: 3.1 ± 0.069
3.946ThrGlu: 3.946 ± 0.085
2.77ThrPhe: 2.77 ± 0.06
4.149ThrGly: 4.149 ± 0.09
1.132ThrHis: 1.132 ± 0.039
4.993ThrIle: 4.993 ± 0.081
4.143ThrLys: 4.143 ± 0.078
5.759ThrLeu: 5.759 ± 0.101
1.37ThrMet: 1.37 ± 0.041
2.97ThrAsn: 2.97 ± 0.062
2.283ThrPro: 2.283 ± 0.057
1.75ThrGln: 1.75 ± 0.041
1.687ThrArg: 1.687 ± 0.045
3.787ThrSer: 3.787 ± 0.07
3.576ThrThr: 3.576 ± 0.079
3.931ThrVal: 3.931 ± 0.07
0.47ThrTrp: 0.47 ± 0.025
2.219ThrTyr: 2.219 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.909ValAla: 4.909 ± 0.089
0.495ValCys: 0.495 ± 0.027
3.931ValAsp: 3.931 ± 0.074
4.978ValGlu: 4.978 ± 0.085
3.099ValPhe: 3.099 ± 0.069
4.595ValGly: 4.595 ± 0.078
0.992ValHis: 0.992 ± 0.036
5.803ValIle: 5.803 ± 0.104
4.729ValLys: 4.729 ± 0.082
6.703ValLeu: 6.703 ± 0.102
1.853ValMet: 1.853 ± 0.045
3.105ValAsn: 3.105 ± 0.061
2.559ValPro: 2.559 ± 0.058
1.803ValGln: 1.803 ± 0.052
2.091ValArg: 2.091 ± 0.058
5.0ValSer: 5.0 ± 0.086
4.493ValThr: 4.493 ± 0.075
5.092ValVal: 5.092 ± 0.094
0.517ValTrp: 0.517 ± 0.026
2.273ValTyr: 2.273 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.403TrpAla: 0.403 ± 0.024
0.046TrpCys: 0.046 ± 0.007
0.472TrpAsp: 0.472 ± 0.024
0.576TrpGlu: 0.576 ± 0.03
0.409TrpPhe: 0.409 ± 0.03
0.521TrpGly: 0.521 ± 0.028
0.19TrpHis: 0.19 ± 0.017
0.604TrpIle: 0.604 ± 0.031
0.516TrpLys: 0.516 ± 0.026
1.075TrpLeu: 1.075 ± 0.034
0.24TrpMet: 0.24 ± 0.015
0.452TrpAsn: 0.452 ± 0.025
0.211TrpPro: 0.211 ± 0.016
0.446TrpGln: 0.446 ± 0.027
0.283TrpArg: 0.283 ± 0.017
0.507TrpSer: 0.507 ± 0.032
0.406TrpThr: 0.406 ± 0.024
0.497TrpVal: 0.497 ± 0.027
0.091TrpTrp: 0.091 ± 0.012
0.349TrpTyr: 0.349 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.998TyrAla: 1.998 ± 0.051
0.277TyrCys: 0.277 ± 0.02
2.215TyrAsp: 2.215 ± 0.06
2.695TyrGlu: 2.695 ± 0.056
2.04TyrPhe: 2.04 ± 0.047
2.37TyrGly: 2.37 ± 0.065
0.772TyrHis: 0.772 ± 0.034
2.357TyrIle: 2.357 ± 0.054
2.123TyrLys: 2.123 ± 0.052
4.121TyrLeu: 4.121 ± 0.073
0.817TyrMet: 0.817 ± 0.031
1.66TyrAsn: 1.66 ± 0.052
1.406TyrPro: 1.406 ± 0.042
1.822TyrGln: 1.822 ± 0.055
1.403TyrArg: 1.403 ± 0.044
2.216TyrSer: 2.216 ± 0.055
1.863TyrThr: 1.863 ± 0.051
2.287TyrVal: 2.287 ± 0.055
0.34TyrTrp: 0.34 ± 0.023
1.579TyrTyr: 1.579 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2526 proteins (783260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski