Amino acid dipepetide frequency for Sewage-associated circular DNA virus-24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.915AlaAla: 9.915 ± 1.543
1.416AlaCys: 1.416 ± 0.831
4.249AlaAsp: 4.249 ± 0.356
1.416AlaGlu: 1.416 ± 0.831
4.249AlaPhe: 4.249 ± 1.783
11.331AlaGly: 11.331 ± 2.375
1.416AlaHis: 1.416 ± 0.831
2.833AlaIle: 2.833 ± 2.614
1.416AlaLys: 1.416 ± 0.831
8.499AlaLeu: 8.499 ± 1.427
2.833AlaMet: 2.833 ± 1.663
1.416AlaAsn: 1.416 ± 0.831
1.416AlaPro: 1.416 ± 0.831
1.416AlaGln: 1.416 ± 0.831
5.666AlaArg: 5.666 ± 1.187
5.666AlaSer: 5.666 ± 3.326
4.249AlaThr: 4.249 ± 2.494
5.666AlaVal: 5.666 ± 3.326
1.416AlaTrp: 1.416 ± 0.831
1.416AlaTyr: 1.416 ± 1.307
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.416CysPhe: 1.416 ± 0.831
1.416CysGly: 1.416 ± 0.831
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
2.833CysLys: 2.833 ± 0.476
5.666CysLeu: 5.666 ± 1.187
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.416CysSer: 1.416 ± 0.831
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
1.416CysTyr: 1.416 ± 1.307
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
0.0AspCys: 0.0 ± 0.0
2.833AspAsp: 2.833 ± 2.614
2.833AspGlu: 2.833 ± 2.614
0.0AspPhe: 0.0 ± 0.0
1.416AspGly: 1.416 ± 1.307
1.416AspHis: 1.416 ± 0.831
4.249AspIle: 4.249 ± 1.783
1.416AspLys: 1.416 ± 0.831
5.666AspLeu: 5.666 ± 1.187
0.0AspMet: 0.0 ± 0.0
1.416AspAsn: 1.416 ± 1.307
0.0AspPro: 0.0 ± 0.0
1.416AspGln: 1.416 ± 1.307
2.833AspArg: 2.833 ± 0.476
1.416AspSer: 1.416 ± 0.831
2.833AspThr: 2.833 ± 1.663
7.082AspVal: 7.082 ± 0.12
2.833AspTrp: 2.833 ± 2.614
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
7.082GluAla: 7.082 ± 0.12
2.833GluCys: 2.833 ± 0.476
1.416GluAsp: 1.416 ± 1.307
8.499GluGlu: 8.499 ± 3.565
4.249GluPhe: 4.249 ± 1.783
7.082GluGly: 7.082 ± 0.12
0.0GluHis: 0.0 ± 0.0
0.0GluIle: 0.0 ± 0.0
1.416GluLys: 1.416 ± 1.307
2.833GluLeu: 2.833 ± 0.476
2.833GluMet: 2.833 ± 0.522
0.0GluAsn: 0.0 ± 0.0
1.416GluPro: 1.416 ± 1.307
1.416GluGln: 1.416 ± 1.307
4.249GluArg: 4.249 ± 1.783
0.0GluSer: 0.0 ± 0.0
4.249GluThr: 4.249 ± 1.783
2.833GluVal: 2.833 ± 0.476
1.416GluTrp: 1.416 ± 0.831
4.249GluTyr: 4.249 ± 0.356
0.0GluXaa: 0.0 ± 0.0
Phe
2.833PheAla: 2.833 ± 1.663
0.0PheCys: 0.0 ± 0.0
4.249PheAsp: 4.249 ± 0.356
7.082PheGlu: 7.082 ± 2.258
0.0PhePhe: 0.0 ± 0.0
1.416PheGly: 1.416 ± 1.307
0.0PheHis: 0.0 ± 0.0
1.416PheIle: 1.416 ± 0.831
0.0PheLys: 0.0 ± 0.0
1.416PheLeu: 1.416 ± 0.831
1.416PheMet: 1.416 ± 0.831
1.416PheAsn: 1.416 ± 0.831
1.416PhePro: 1.416 ± 1.307
2.833PheGln: 2.833 ± 0.476
2.833PheArg: 2.833 ± 0.476
4.249PheSer: 4.249 ± 1.783
4.249PheThr: 4.249 ± 2.494
4.249PheVal: 4.249 ± 2.494
4.249PheTrp: 4.249 ± 1.783
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
15.581GlyAla: 15.581 ± 4.869
0.0GlyCys: 0.0 ± 0.0
1.416GlyAsp: 1.416 ± 1.307
5.666GlyGlu: 5.666 ± 0.951
5.666GlyPhe: 5.666 ± 1.187
7.082GlyGly: 7.082 ± 2.258
2.833GlyHis: 2.833 ± 0.476
2.833GlyIle: 2.833 ± 0.476
4.249GlyLys: 4.249 ± 0.356
5.666GlyLeu: 5.666 ± 1.187
2.833GlyMet: 2.833 ± 0.476
2.833GlyAsn: 2.833 ± 0.476
0.0GlyPro: 0.0 ± 0.0
7.082GlyGln: 7.082 ± 0.12
0.0GlyArg: 0.0 ± 0.0
5.666GlySer: 5.666 ± 1.187
4.249GlyThr: 4.249 ± 1.783
7.082GlyVal: 7.082 ± 4.157
0.0GlyTrp: 0.0 ± 0.0
4.249GlyTyr: 4.249 ± 0.356
0.0GlyXaa: 0.0 ± 0.0
His
1.416HisAla: 1.416 ± 0.831
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.416HisGlu: 1.416 ± 0.831
1.416HisPhe: 1.416 ± 1.307
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.416HisIle: 1.416 ± 0.831
2.833HisLys: 2.833 ± 1.663
2.833HisLeu: 2.833 ± 0.476
0.0HisMet: 0.0 ± 0.0
2.833HisAsn: 2.833 ± 1.663
1.416HisPro: 1.416 ± 0.831
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
2.833HisTrp: 2.833 ± 2.614
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.249IleAla: 4.249 ± 2.494
1.416IleCys: 1.416 ± 0.831
4.249IleAsp: 4.249 ± 1.783
1.416IleGlu: 1.416 ± 1.307
0.0IlePhe: 0.0 ± 0.0
4.249IleGly: 4.249 ± 1.783
0.0IleHis: 0.0 ± 0.0
2.833IleIle: 2.833 ± 0.476
2.833IleLys: 2.833 ± 1.663
1.416IleLeu: 1.416 ± 0.831
0.0IleMet: 0.0 ± 0.0
2.833IleAsn: 2.833 ± 1.663
4.249IlePro: 4.249 ± 1.783
5.666IleGln: 5.666 ± 1.187
4.249IleArg: 4.249 ± 3.921
4.249IleSer: 4.249 ± 1.783
2.833IleThr: 2.833 ± 2.614
5.666IleVal: 5.666 ± 3.09
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
4.249LysAla: 4.249 ± 2.494
0.0LysCys: 0.0 ± 0.0
1.416LysAsp: 1.416 ± 1.307
4.249LysGlu: 4.249 ± 1.783
1.416LysPhe: 1.416 ± 0.831
9.915LysGly: 9.915 ± 3.682
1.416LysHis: 1.416 ± 0.831
1.416LysIle: 1.416 ± 0.831
7.082LysLys: 7.082 ± 2.258
1.416LysLeu: 1.416 ± 0.831
0.0LysMet: 0.0 ± 0.0
5.666LysAsn: 5.666 ± 0.951
1.416LysPro: 1.416 ± 0.831
0.0LysGln: 0.0 ± 0.0
5.666LysArg: 5.666 ± 1.187
1.416LysSer: 1.416 ± 1.307
4.249LysThr: 4.249 ± 0.356
7.082LysVal: 7.082 ± 0.12
2.833LysTrp: 2.833 ± 0.476
1.416LysTyr: 1.416 ± 0.831
0.0LysXaa: 0.0 ± 0.0
Leu
1.416LeuAla: 1.416 ± 0.831
2.833LeuCys: 2.833 ± 0.476
4.249LeuAsp: 4.249 ± 1.783
2.833LeuGlu: 2.833 ± 0.476
1.416LeuPhe: 1.416 ± 0.831
5.666LeuGly: 5.666 ± 1.187
1.416LeuHis: 1.416 ± 0.831
1.416LeuIle: 1.416 ± 0.831
1.416LeuLys: 1.416 ± 0.831
4.249LeuLeu: 4.249 ± 1.783
1.416LeuMet: 1.416 ± 1.307
5.666LeuAsn: 5.666 ± 3.326
1.416LeuPro: 1.416 ± 0.831
5.666LeuGln: 5.666 ± 3.09
4.249LeuArg: 4.249 ± 1.783
5.666LeuSer: 5.666 ± 1.187
11.331LeuThr: 11.331 ± 2.375
0.0LeuVal: 0.0 ± 0.0
2.833LeuTrp: 2.833 ± 0.476
1.416LeuTyr: 1.416 ± 1.307
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
2.833MetGlu: 2.833 ± 0.476
0.0MetPhe: 0.0 ± 0.0
1.416MetGly: 1.416 ± 0.831
0.0MetHis: 0.0 ± 0.0
1.416MetIle: 1.416 ± 0.831
1.416MetLys: 1.416 ± 0.831
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
4.249MetAsn: 4.249 ± 2.494
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.416MetArg: 1.416 ± 0.831
4.249MetSer: 4.249 ± 0.356
0.0MetThr: 0.0 ± 0.0
2.833MetVal: 2.833 ± 0.476
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
0.0AsnCys: 0.0 ± 0.0
1.416AsnAsp: 1.416 ± 0.831
0.0AsnGlu: 0.0 ± 0.0
4.249AsnPhe: 4.249 ± 2.494
2.833AsnGly: 2.833 ± 1.663
2.833AsnHis: 2.833 ± 1.663
4.249AsnIle: 4.249 ± 1.783
1.416AsnLys: 1.416 ± 0.831
5.666AsnLeu: 5.666 ± 1.187
0.0AsnMet: 0.0 ± 0.0
2.833AsnAsn: 2.833 ± 1.663
7.082AsnPro: 7.082 ± 0.12
1.416AsnGln: 1.416 ± 0.831
2.833AsnArg: 2.833 ± 1.663
9.915AsnSer: 9.915 ± 1.543
1.416AsnThr: 1.416 ± 0.831
2.833AsnVal: 2.833 ± 0.476
0.0AsnTrp: 0.0 ± 0.0
1.416AsnTyr: 1.416 ± 0.831
0.0AsnXaa: 0.0 ± 0.0
Pro
2.833ProAla: 2.833 ± 1.663
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
4.249ProGlu: 4.249 ± 3.921
2.833ProPhe: 2.833 ± 1.663
1.416ProGly: 1.416 ± 1.307
0.0ProHis: 0.0 ± 0.0
2.833ProIle: 2.833 ± 0.476
2.833ProLys: 2.833 ± 0.476
0.0ProLeu: 0.0 ± 0.0
1.416ProMet: 1.416 ± 0.831
1.416ProAsn: 1.416 ± 1.307
1.416ProPro: 1.416 ± 0.831
0.0ProGln: 0.0 ± 0.0
1.416ProArg: 1.416 ± 1.307
1.416ProSer: 1.416 ± 0.831
4.249ProThr: 4.249 ± 1.783
1.416ProVal: 1.416 ± 0.831
0.0ProTrp: 0.0 ± 0.0
1.416ProTyr: 1.416 ± 0.831
0.0ProXaa: 0.0 ± 0.0
Gln
7.082GlnAla: 7.082 ± 2.019
1.416GlnCys: 1.416 ± 0.831
0.0GlnAsp: 0.0 ± 0.0
1.416GlnGlu: 1.416 ± 0.831
4.249GlnPhe: 4.249 ± 0.356
2.833GlnGly: 2.833 ± 0.476
2.833GlnHis: 2.833 ± 2.614
0.0GlnIle: 0.0 ± 0.0
4.249GlnLys: 4.249 ± 1.783
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
1.416GlnAsn: 1.416 ± 0.831
0.0GlnPro: 0.0 ± 0.0
0.0GlnGln: 0.0 ± 0.0
0.0GlnArg: 0.0 ± 0.0
4.249GlnSer: 4.249 ± 0.356
4.249GlnThr: 4.249 ± 0.356
4.249GlnVal: 4.249 ± 1.783
0.0GlnTrp: 0.0 ± 0.0
5.666GlnTyr: 5.666 ± 0.951
0.0GlnXaa: 0.0 ± 0.0
Arg
1.416ArgAla: 1.416 ± 1.307
0.0ArgCys: 0.0 ± 0.0
0.0ArgAsp: 0.0 ± 0.0
2.833ArgGlu: 2.833 ± 0.476
1.416ArgPhe: 1.416 ± 1.307
7.082ArgGly: 7.082 ± 0.12
0.0ArgHis: 0.0 ± 0.0
2.833ArgIle: 2.833 ± 2.614
5.666ArgLys: 5.666 ± 3.326
8.499ArgLeu: 8.499 ± 1.427
1.416ArgMet: 1.416 ± 0.831
2.833ArgAsn: 2.833 ± 0.476
1.416ArgPro: 1.416 ± 1.307
1.416ArgGln: 1.416 ± 0.831
11.331ArgArg: 11.331 ± 6.179
7.082ArgSer: 7.082 ± 0.12
7.082ArgThr: 7.082 ± 2.258
0.0ArgVal: 0.0 ± 0.0
0.0ArgTrp: 0.0 ± 0.0
5.666ArgTyr: 5.666 ± 0.951
0.0ArgXaa: 0.0 ± 0.0
Ser
4.249SerAla: 4.249 ± 2.494
0.0SerCys: 0.0 ± 0.0
2.833SerAsp: 2.833 ± 0.476
2.833SerGlu: 2.833 ± 1.663
5.666SerPhe: 5.666 ± 1.187
5.666SerGly: 5.666 ± 3.326
0.0SerHis: 0.0 ± 0.0
4.249SerIle: 4.249 ± 0.356
4.249SerLys: 4.249 ± 1.783
1.416SerLeu: 1.416 ± 0.831
1.416SerMet: 1.416 ± 0.831
2.833SerAsn: 2.833 ± 0.476
5.666SerPro: 5.666 ± 1.187
2.833SerGln: 2.833 ± 2.614
9.915SerArg: 9.915 ± 2.734
4.249SerSer: 4.249 ± 2.494
2.833SerThr: 2.833 ± 1.663
1.416SerVal: 1.416 ± 1.307
1.416SerTrp: 1.416 ± 1.307
2.833SerTyr: 2.833 ± 1.663
0.0SerXaa: 0.0 ± 0.0
Thr
5.666ThrAla: 5.666 ± 1.187
2.833ThrCys: 2.833 ± 0.476
8.499ThrAsp: 8.499 ± 0.712
2.833ThrGlu: 2.833 ± 0.476
0.0ThrPhe: 0.0 ± 0.0
7.082ThrGly: 7.082 ± 0.12
1.416ThrHis: 1.416 ± 0.831
5.666ThrIle: 5.666 ± 1.187
4.249ThrLys: 4.249 ± 0.356
1.416ThrLeu: 1.416 ± 0.831
2.833ThrMet: 2.833 ± 1.663
4.249ThrAsn: 4.249 ± 2.494
1.416ThrPro: 1.416 ± 1.307
2.833ThrGln: 2.833 ± 0.476
1.416ThrArg: 1.416 ± 1.307
4.249ThrSer: 4.249 ± 1.783
7.082ThrThr: 7.082 ± 4.157
4.249ThrVal: 4.249 ± 2.494
1.416ThrTrp: 1.416 ± 1.307
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
7.082ValAla: 7.082 ± 2.258
1.416ValCys: 1.416 ± 0.831
0.0ValAsp: 0.0 ± 0.0
4.249ValGlu: 4.249 ± 0.356
4.249ValPhe: 4.249 ± 1.783
0.0ValGly: 0.0 ± 0.0
2.833ValHis: 2.833 ± 0.476
7.082ValIle: 7.082 ± 0.12
7.082ValLys: 7.082 ± 2.019
7.082ValLeu: 7.082 ± 0.12
0.0ValMet: 0.0 ± 0.649
4.249ValAsn: 4.249 ± 2.494
0.0ValPro: 0.0 ± 0.0
4.249ValGln: 4.249 ± 2.494
5.666ValArg: 5.666 ± 0.951
0.0ValSer: 0.0 ± 0.0
1.416ValThr: 1.416 ± 0.831
7.082ValVal: 7.082 ± 2.258
1.416ValTrp: 1.416 ± 1.307
1.416ValTyr: 1.416 ± 0.831
0.0ValXaa: 0.0 ± 0.0
Trp
1.416TrpAla: 1.416 ± 1.307
0.0TrpCys: 0.0 ± 0.0
2.833TrpAsp: 2.833 ± 0.476
1.416TrpGlu: 1.416 ± 1.307
0.0TrpPhe: 0.0 ± 0.0
1.416TrpGly: 1.416 ± 1.307
0.0TrpHis: 0.0 ± 0.0
4.249TrpIle: 4.249 ± 3.921
2.833TrpLys: 2.833 ± 0.476
1.416TrpLeu: 1.416 ± 1.307
0.0TrpMet: 0.0 ± 0.0
2.833TrpAsn: 2.833 ± 0.476
0.0TrpPro: 0.0 ± 0.0
1.416TrpGln: 1.416 ± 1.307
0.0TrpArg: 0.0 ± 0.0
1.416TrpSer: 1.416 ± 0.831
1.416TrpThr: 1.416 ± 0.831
0.0TrpVal: 0.0 ± 0.0
1.416TrpTrp: 1.416 ± 1.307
1.416TrpTyr: 1.416 ± 1.307
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.416TyrAla: 1.416 ± 1.307
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
2.833TyrPhe: 2.833 ± 0.476
5.666TyrGly: 5.666 ± 1.187
0.0TyrHis: 0.0 ± 0.0
1.416TyrIle: 1.416 ± 1.307
2.833TyrLys: 2.833 ± 0.476
1.416TyrLeu: 1.416 ± 1.307
0.0TyrMet: 0.0 ± 0.0
1.416TyrAsn: 1.416 ± 0.831
1.416TyrPro: 1.416 ± 1.307
4.249TyrGln: 4.249 ± 2.494
4.249TyrArg: 4.249 ± 2.494
0.0TyrSer: 0.0 ± 0.0
1.416TyrThr: 1.416 ± 0.831
4.249TyrVal: 4.249 ± 1.783
1.416TyrTrp: 1.416 ± 1.307
2.833TyrTyr: 2.833 ± 0.476
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski