Amino acid dipepetide frequency for Streptococcus phage 11865

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.009AlaAla: 3.009 ± 0.83
0.502AlaCys: 0.502 ± 0.226
4.915AlaAsp: 4.915 ± 0.639
6.319AlaGlu: 6.319 ± 0.674
2.608AlaPhe: 2.608 ± 0.558
4.514AlaGly: 4.514 ± 0.659
0.401AlaHis: 0.401 ± 0.264
5.316AlaIle: 5.316 ± 1.069
5.316AlaLys: 5.316 ± 0.633
5.918AlaLeu: 5.918 ± 0.721
1.605AlaMet: 1.605 ± 0.354
3.711AlaAsn: 3.711 ± 0.807
1.304AlaPro: 1.304 ± 0.421
2.106AlaGln: 2.106 ± 0.308
2.608AlaArg: 2.608 ± 0.565
4.614AlaSer: 4.614 ± 0.63
3.711AlaThr: 3.711 ± 0.773
5.115AlaVal: 5.115 ± 0.817
1.906AlaTrp: 1.906 ± 0.659
1.805AlaTyr: 1.805 ± 0.418
0.0AlaXaa: 0.0 ± 0.0
Cys
0.1CysAla: 0.1 ± 0.115
0.201CysCys: 0.201 ± 0.125
0.301CysAsp: 0.301 ± 0.144
0.602CysGlu: 0.602 ± 0.188
0.201CysPhe: 0.201 ± 0.128
0.602CysGly: 0.602 ± 0.334
0.201CysHis: 0.201 ± 0.141
0.301CysIle: 0.301 ± 0.186
0.301CysLys: 0.301 ± 0.182
0.802CysLeu: 0.802 ± 0.299
0.1CysMet: 0.1 ± 0.101
0.301CysAsn: 0.301 ± 0.224
0.201CysPro: 0.201 ± 0.147
0.301CysGln: 0.301 ± 0.164
0.702CysArg: 0.702 ± 0.272
0.1CysSer: 0.1 ± 0.098
0.301CysThr: 0.301 ± 0.168
0.401CysVal: 0.401 ± 0.185
0.1CysTrp: 0.1 ± 0.101
0.401CysTyr: 0.401 ± 0.186
0.0CysXaa: 0.0 ± 0.0
Asp
3.811AspAla: 3.811 ± 0.72
0.502AspCys: 0.502 ± 0.223
3.711AspAsp: 3.711 ± 0.745
4.614AspGlu: 4.614 ± 0.8
3.109AspPhe: 3.109 ± 0.505
5.316AspGly: 5.316 ± 0.791
1.103AspHis: 1.103 ± 0.269
4.313AspIle: 4.313 ± 0.676
4.614AspLys: 4.614 ± 0.742
5.617AspLeu: 5.617 ± 0.721
1.204AspMet: 1.204 ± 0.277
3.009AspAsn: 3.009 ± 0.414
0.802AspPro: 0.802 ± 0.271
1.103AspGln: 1.103 ± 0.445
2.608AspArg: 2.608 ± 0.408
2.708AspSer: 2.708 ± 0.47
2.407AspThr: 2.407 ± 0.408
3.511AspVal: 3.511 ± 0.685
1.404AspTrp: 1.404 ± 0.338
3.511AspTyr: 3.511 ± 0.717
0.0AspXaa: 0.0 ± 0.0
Glu
6.319GluAla: 6.319 ± 0.992
0.401GluCys: 0.401 ± 0.19
4.213GluAsp: 4.213 ± 0.739
5.617GluGlu: 5.617 ± 0.992
2.909GluPhe: 2.909 ± 0.561
3.41GluGly: 3.41 ± 0.759
0.702GluHis: 0.702 ± 0.288
5.817GluIle: 5.817 ± 0.69
6.82GluLys: 6.82 ± 0.987
7.021GluLeu: 7.021 ± 1.05
2.006GluMet: 2.006 ± 0.509
5.216GluAsn: 5.216 ± 0.779
2.106GluPro: 2.106 ± 0.601
3.611GluGln: 3.611 ± 0.715
4.012GluArg: 4.012 ± 0.751
4.213GluSer: 4.213 ± 0.576
3.912GluThr: 3.912 ± 0.549
4.514GluVal: 4.514 ± 0.791
1.103GluTrp: 1.103 ± 0.287
2.407GluTyr: 2.407 ± 0.412
0.0GluXaa: 0.0 ± 0.0
Phe
3.21PheAla: 3.21 ± 0.582
0.1PheCys: 0.1 ± 0.101
4.112PheAsp: 4.112 ± 0.663
3.511PheGlu: 3.511 ± 0.54
2.407PhePhe: 2.407 ± 0.484
3.009PheGly: 3.009 ± 0.534
0.301PheHis: 0.301 ± 0.179
2.909PheIle: 2.909 ± 0.671
2.708PheLys: 2.708 ± 0.476
2.909PheLeu: 2.909 ± 0.745
1.404PheMet: 1.404 ± 0.326
2.407PheAsn: 2.407 ± 0.557
0.903PhePro: 0.903 ± 0.402
0.903PheGln: 0.903 ± 0.28
1.805PheArg: 1.805 ± 0.33
3.31PheSer: 3.31 ± 0.765
2.407PheThr: 2.407 ± 0.501
2.307PheVal: 2.307 ± 0.493
0.502PheTrp: 0.502 ± 0.195
2.006PheTyr: 2.006 ± 0.52
0.0PheXaa: 0.0 ± 0.0
Gly
4.213GlyAla: 4.213 ± 0.79
0.1GlyCys: 0.1 ± 0.099
3.009GlyAsp: 3.009 ± 0.66
4.112GlyGlu: 4.112 ± 0.517
3.811GlyPhe: 3.811 ± 0.675
5.717GlyGly: 5.717 ± 0.743
1.204GlyHis: 1.204 ± 0.383
5.617GlyIle: 5.617 ± 1.191
5.216GlyLys: 5.216 ± 0.607
7.121GlyLeu: 7.121 ± 1.133
2.508GlyMet: 2.508 ± 0.532
3.611GlyAsn: 3.611 ± 0.647
1.003GlyPro: 1.003 ± 0.303
3.511GlyGln: 3.511 ± 0.654
3.611GlyArg: 3.611 ± 0.633
4.012GlySer: 4.012 ± 0.833
3.109GlyThr: 3.109 ± 0.456
3.912GlyVal: 3.912 ± 0.799
1.103GlyTrp: 1.103 ± 0.29
4.514GlyTyr: 4.514 ± 0.68
0.0GlyXaa: 0.0 ± 0.0
His
0.802HisAla: 0.802 ± 0.295
0.502HisCys: 0.502 ± 0.25
0.702HisAsp: 0.702 ± 0.263
1.404HisGlu: 1.404 ± 0.426
0.602HisPhe: 0.602 ± 0.266
0.602HisGly: 0.602 ± 0.213
0.201HisHis: 0.201 ± 0.155
1.103HisIle: 1.103 ± 0.341
1.003HisLys: 1.003 ± 0.298
1.204HisLeu: 1.204 ± 0.364
0.1HisMet: 0.1 ± 0.097
1.003HisAsn: 1.003 ± 0.281
0.602HisPro: 0.602 ± 0.305
0.903HisGln: 0.903 ± 0.285
0.802HisArg: 0.802 ± 0.319
1.404HisSer: 1.404 ± 0.522
1.003HisThr: 1.003 ± 0.274
0.602HisVal: 0.602 ± 0.244
0.301HisTrp: 0.301 ± 0.195
0.401HisTyr: 0.401 ± 0.181
0.0HisXaa: 0.0 ± 0.0
Ile
5.817IleAla: 5.817 ± 0.974
0.502IleCys: 0.502 ± 0.23
4.012IleAsp: 4.012 ± 0.625
6.72IleGlu: 6.72 ± 0.772
2.808IlePhe: 2.808 ± 0.547
5.316IleGly: 5.316 ± 0.79
0.903IleHis: 0.903 ± 0.29
3.511IleIle: 3.511 ± 0.782
5.216IleLys: 5.216 ± 0.655
5.617IleLeu: 5.617 ± 0.971
1.204IleMet: 1.204 ± 0.403
3.31IleAsn: 3.31 ± 0.437
2.106IlePro: 2.106 ± 0.632
2.207IleGln: 2.207 ± 0.533
2.407IleArg: 2.407 ± 0.664
4.514IleSer: 4.514 ± 0.771
5.517IleThr: 5.517 ± 0.69
4.112IleVal: 4.112 ± 0.656
1.103IleTrp: 1.103 ± 0.71
2.307IleTyr: 2.307 ± 0.478
0.0IleXaa: 0.0 ± 0.0
Lys
5.817LysAla: 5.817 ± 0.795
0.401LysCys: 0.401 ± 0.184
5.115LysAsp: 5.115 ± 0.603
5.918LysGlu: 5.918 ± 0.693
2.407LysPhe: 2.407 ± 0.435
5.817LysGly: 5.817 ± 0.616
1.304LysHis: 1.304 ± 0.41
5.817LysIle: 5.817 ± 0.9
7.121LysLys: 7.121 ± 1.23
5.015LysLeu: 5.015 ± 0.63
2.207LysMet: 2.207 ± 0.424
4.915LysAsn: 4.915 ± 0.584
1.605LysPro: 1.605 ± 0.435
4.814LysGln: 4.814 ± 0.504
4.112LysArg: 4.112 ± 0.771
5.216LysSer: 5.216 ± 1.025
4.614LysThr: 4.614 ± 0.724
4.614LysVal: 4.614 ± 0.846
0.903LysTrp: 0.903 ± 0.35
3.21LysTyr: 3.21 ± 0.485
0.0LysXaa: 0.0 ± 0.0
Leu
6.018LeuAla: 6.018 ± 0.69
0.301LeuCys: 0.301 ± 0.217
5.316LeuAsp: 5.316 ± 0.496
5.918LeuGlu: 5.918 ± 0.807
3.611LeuPhe: 3.611 ± 0.678
6.72LeuGly: 6.72 ± 1.09
1.304LeuHis: 1.304 ± 0.353
4.915LeuIle: 4.915 ± 0.603
7.422LeuLys: 7.422 ± 0.795
6.319LeuLeu: 6.319 ± 0.989
1.805LeuMet: 1.805 ± 0.443
3.811LeuAsn: 3.811 ± 0.576
2.407LeuPro: 2.407 ± 0.666
2.808LeuGln: 2.808 ± 0.671
4.413LeuArg: 4.413 ± 0.932
6.72LeuSer: 6.72 ± 0.644
5.316LeuThr: 5.316 ± 0.738
4.112LeuVal: 4.112 ± 0.603
1.003LeuTrp: 1.003 ± 0.399
1.705LeuTyr: 1.705 ± 0.416
0.0LeuXaa: 0.0 ± 0.0
Met
1.705MetAla: 1.705 ± 0.46
0.301MetCys: 0.301 ± 0.148
1.003MetAsp: 1.003 ± 0.345
2.106MetGlu: 2.106 ± 0.483
0.702MetPhe: 0.702 ± 0.249
2.006MetGly: 2.006 ± 0.485
0.401MetHis: 0.401 ± 0.238
1.906MetIle: 1.906 ± 0.507
2.508MetLys: 2.508 ± 0.489
1.505MetLeu: 1.505 ± 0.405
0.602MetMet: 0.602 ± 0.251
1.805MetAsn: 1.805 ± 0.464
0.802MetPro: 0.802 ± 0.276
1.003MetGln: 1.003 ± 0.335
1.003MetArg: 1.003 ± 0.321
1.103MetSer: 1.103 ± 0.362
1.605MetThr: 1.605 ± 0.427
1.805MetVal: 1.805 ± 0.502
0.1MetTrp: 0.1 ± 0.101
0.702MetTyr: 0.702 ± 0.25
0.0MetXaa: 0.0 ± 0.0
Asn
3.21AsnAla: 3.21 ± 0.847
0.201AsnCys: 0.201 ± 0.123
2.708AsnAsp: 2.708 ± 0.543
3.31AsnGlu: 3.31 ± 0.556
2.207AsnPhe: 2.207 ± 0.42
5.015AsnGly: 5.015 ± 0.986
1.003AsnHis: 1.003 ± 0.389
3.912AsnIle: 3.912 ± 0.69
4.112AsnLys: 4.112 ± 0.663
4.915AsnLeu: 4.915 ± 0.761
1.304AsnMet: 1.304 ± 0.321
2.909AsnAsn: 2.909 ± 0.587
2.608AsnPro: 2.608 ± 0.51
3.41AsnGln: 3.41 ± 0.676
2.608AsnArg: 2.608 ± 0.506
3.41AsnSer: 3.41 ± 0.71
2.708AsnThr: 2.708 ± 0.55
3.511AsnVal: 3.511 ± 0.497
0.903AsnTrp: 0.903 ± 0.255
2.006AsnTyr: 2.006 ± 0.428
0.0AsnXaa: 0.0 ± 0.0
Pro
1.404ProAla: 1.404 ± 0.471
0.201ProCys: 0.201 ± 0.158
1.605ProAsp: 1.605 ± 0.424
1.906ProGlu: 1.906 ± 0.48
1.705ProPhe: 1.705 ± 0.446
0.903ProGly: 0.903 ± 0.309
0.702ProHis: 0.702 ± 0.325
1.705ProIle: 1.705 ± 0.402
3.109ProLys: 3.109 ± 0.535
2.407ProLeu: 2.407 ± 0.546
0.502ProMet: 0.502 ± 0.147
1.103ProAsn: 1.103 ± 0.306
0.702ProPro: 0.702 ± 0.311
1.404ProGln: 1.404 ± 0.467
1.605ProArg: 1.605 ± 0.375
2.006ProSer: 2.006 ± 0.479
1.605ProThr: 1.605 ± 0.439
1.705ProVal: 1.705 ± 0.565
0.1ProTrp: 0.1 ± 0.099
0.702ProTyr: 0.702 ± 0.319
0.0ProXaa: 0.0 ± 0.0
Gln
2.808GlnAla: 2.808 ± 0.539
0.201GlnCys: 0.201 ± 0.161
1.404GlnAsp: 1.404 ± 0.273
3.31GlnGlu: 3.31 ± 0.503
1.404GlnPhe: 1.404 ± 0.39
3.009GlnGly: 3.009 ± 0.64
0.702GlnHis: 0.702 ± 0.225
2.909GlnIle: 2.909 ± 0.578
3.811GlnLys: 3.811 ± 0.579
2.608GlnLeu: 2.608 ± 0.431
1.204GlnMet: 1.204 ± 0.406
2.307GlnAsn: 2.307 ± 0.411
1.705GlnPro: 1.705 ± 0.421
1.204GlnGln: 1.204 ± 0.315
2.106GlnArg: 2.106 ± 0.434
2.608GlnSer: 2.608 ± 0.499
1.805GlnThr: 1.805 ± 0.442
2.909GlnVal: 2.909 ± 0.55
0.401GlnTrp: 0.401 ± 0.179
1.204GlnTyr: 1.204 ± 0.408
0.0GlnXaa: 0.0 ± 0.0
Arg
2.909ArgAla: 2.909 ± 0.474
0.401ArgCys: 0.401 ± 0.209
2.407ArgAsp: 2.407 ± 0.528
3.912ArgGlu: 3.912 ± 0.774
1.805ArgPhe: 1.805 ± 0.506
2.006ArgGly: 2.006 ± 0.591
0.702ArgHis: 0.702 ± 0.249
3.41ArgIle: 3.41 ± 0.713
5.015ArgLys: 5.015 ± 0.69
4.313ArgLeu: 4.313 ± 0.7
1.103ArgMet: 1.103 ± 0.423
3.21ArgAsn: 3.21 ± 0.682
1.605ArgPro: 1.605 ± 0.458
1.705ArgGln: 1.705 ± 0.406
2.407ArgArg: 2.407 ± 0.665
1.505ArgSer: 1.505 ± 0.463
2.608ArgThr: 2.608 ± 0.592
2.307ArgVal: 2.307 ± 0.444
0.502ArgTrp: 0.502 ± 0.186
2.909ArgTyr: 2.909 ± 0.661
0.0ArgXaa: 0.0 ± 0.0
Ser
4.614SerAla: 4.614 ± 1.225
0.401SerCys: 0.401 ± 0.209
4.313SerAsp: 4.313 ± 0.591
4.614SerGlu: 4.614 ± 0.856
2.808SerPhe: 2.808 ± 0.371
4.714SerGly: 4.714 ± 0.79
1.204SerHis: 1.204 ± 0.421
3.912SerIle: 3.912 ± 0.69
4.614SerLys: 4.614 ± 0.849
5.115SerLeu: 5.115 ± 0.731
2.708SerMet: 2.708 ± 0.605
3.912SerAsn: 3.912 ± 0.695
1.705SerPro: 1.705 ± 0.399
1.705SerGln: 1.705 ± 0.31
2.106SerArg: 2.106 ± 0.435
4.213SerSer: 4.213 ± 0.953
4.112SerThr: 4.112 ± 0.53
3.41SerVal: 3.41 ± 0.794
1.103SerTrp: 1.103 ± 0.373
3.009SerTyr: 3.009 ± 0.532
0.0SerXaa: 0.0 ± 0.0
Thr
3.912ThrAla: 3.912 ± 0.855
0.502ThrCys: 0.502 ± 0.249
3.711ThrAsp: 3.711 ± 0.767
3.41ThrGlu: 3.41 ± 0.68
2.909ThrPhe: 2.909 ± 0.663
4.814ThrGly: 4.814 ± 0.767
1.003ThrHis: 1.003 ± 0.314
4.814ThrIle: 4.814 ± 0.635
3.109ThrLys: 3.109 ± 0.506
4.514ThrLeu: 4.514 ± 0.841
0.502ThrMet: 0.502 ± 0.189
2.608ThrAsn: 2.608 ± 0.466
1.404ThrPro: 1.404 ± 0.277
1.605ThrGln: 1.605 ± 0.387
2.207ThrArg: 2.207 ± 0.508
4.413ThrSer: 4.413 ± 0.664
4.112ThrThr: 4.112 ± 0.717
4.112ThrVal: 4.112 ± 0.588
0.702ThrTrp: 0.702 ± 0.265
1.906ThrTyr: 1.906 ± 0.45
0.0ThrXaa: 0.0 ± 0.0
Val
4.112ValAla: 4.112 ± 0.631
0.201ValCys: 0.201 ± 0.144
3.511ValAsp: 3.511 ± 0.558
4.814ValGlu: 4.814 ± 0.616
2.808ValPhe: 2.808 ± 0.587
4.112ValGly: 4.112 ± 0.804
0.802ValHis: 0.802 ± 0.299
3.41ValIle: 3.41 ± 0.513
5.015ValLys: 5.015 ± 0.698
4.614ValLeu: 4.614 ± 0.72
0.702ValMet: 0.702 ± 0.301
3.31ValAsn: 3.31 ± 0.653
2.407ValPro: 2.407 ± 0.514
2.508ValGln: 2.508 ± 0.506
2.708ValArg: 2.708 ± 0.518
4.413ValSer: 4.413 ± 0.693
3.41ValThr: 3.41 ± 0.753
4.112ValVal: 4.112 ± 0.598
0.903ValTrp: 0.903 ± 0.291
2.407ValTyr: 2.407 ± 0.483
0.0ValXaa: 0.0 ± 0.0
Trp
0.903TrpAla: 0.903 ± 0.327
0.201TrpCys: 0.201 ± 0.133
0.702TrpAsp: 0.702 ± 0.259
1.505TrpGlu: 1.505 ± 0.468
0.602TrpPhe: 0.602 ± 0.259
1.204TrpGly: 1.204 ± 0.326
0.1TrpHis: 0.1 ± 0.118
1.003TrpIle: 1.003 ± 0.298
0.903TrpLys: 0.903 ± 0.264
0.702TrpLeu: 0.702 ± 0.29
0.401TrpMet: 0.401 ± 0.184
1.304TrpAsn: 1.304 ± 0.406
0.201TrpPro: 0.201 ± 0.157
0.802TrpGln: 0.802 ± 0.235
0.802TrpArg: 0.802 ± 0.307
1.003TrpSer: 1.003 ± 0.371
0.401TrpThr: 0.401 ± 0.175
1.304TrpVal: 1.304 ± 0.274
0.201TrpTrp: 0.201 ± 0.133
0.702TrpTyr: 0.702 ± 0.336
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.608TyrAla: 2.608 ± 0.532
0.401TyrCys: 0.401 ± 0.185
2.207TyrAsp: 2.207 ± 0.518
2.708TyrGlu: 2.708 ± 0.548
1.705TyrPhe: 1.705 ± 0.38
2.207TyrGly: 2.207 ± 0.396
1.003TyrHis: 1.003 ± 0.29
2.608TyrIle: 2.608 ± 0.515
3.009TyrLys: 3.009 ± 0.589
3.711TyrLeu: 3.711 ± 0.554
1.404TyrMet: 1.404 ± 0.379
2.207TyrAsn: 2.207 ± 0.438
0.903TyrPro: 0.903 ± 0.344
2.006TyrGln: 2.006 ± 0.437
2.207TyrArg: 2.207 ± 0.412
2.808TyrSer: 2.808 ± 0.749
1.605TyrThr: 1.605 ± 0.344
1.906TyrVal: 1.906 ± 0.48
0.602TyrTrp: 0.602 ± 0.25
1.705TyrTyr: 1.705 ± 0.663
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (9971 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski