Amino acid dipepetide frequency for Emticicia sp. TH156

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.966AlaAla: 5.966 ± 0.084
0.734AlaCys: 0.734 ± 0.022
4.319AlaAsp: 4.319 ± 0.058
4.649AlaGlu: 4.649 ± 0.063
3.7AlaPhe: 3.7 ± 0.044
5.729AlaGly: 5.729 ± 0.071
1.284AlaHis: 1.284 ± 0.031
5.406AlaIle: 5.406 ± 0.065
4.461AlaLys: 4.461 ± 0.069
6.96AlaLeu: 6.96 ± 0.08
1.789AlaMet: 1.789 ± 0.029
3.719AlaAsn: 3.719 ± 0.052
2.406AlaPro: 2.406 ± 0.043
2.974AlaGln: 2.974 ± 0.046
3.231AlaArg: 3.231 ± 0.052
4.468AlaSer: 4.468 ± 0.064
4.059AlaThr: 4.059 ± 0.056
4.707AlaVal: 4.707 ± 0.058
0.833AlaTrp: 0.833 ± 0.024
2.961AlaTyr: 2.961 ± 0.043
0.001AlaXaa: 0.001 ± 0.001
Cys
0.477CysAla: 0.477 ± 0.02
0.131CysCys: 0.131 ± 0.01
0.378CysAsp: 0.378 ± 0.014
0.421CysGlu: 0.421 ± 0.016
0.436CysPhe: 0.436 ± 0.018
0.604CysGly: 0.604 ± 0.022
0.212CysHis: 0.212 ± 0.013
0.591CysIle: 0.591 ± 0.02
0.428CysLys: 0.428 ± 0.017
0.769CysLeu: 0.769 ± 0.023
0.189CysMet: 0.189 ± 0.011
0.352CysAsn: 0.352 ± 0.015
0.338CysPro: 0.338 ± 0.019
0.3CysGln: 0.3 ± 0.013
0.35CysArg: 0.35 ± 0.014
0.501CysSer: 0.501 ± 0.018
0.419CysThr: 0.419 ± 0.016
0.464CysVal: 0.464 ± 0.017
0.098CysTrp: 0.098 ± 0.008
0.291CysTyr: 0.291 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.89AspAla: 3.89 ± 0.053
0.389AspCys: 0.389 ± 0.016
2.328AspAsp: 2.328 ± 0.045
3.397AspGlu: 3.397 ± 0.052
3.315AspPhe: 3.315 ± 0.051
3.702AspGly: 3.702 ± 0.062
0.773AspHis: 0.773 ± 0.022
3.945AspIle: 3.945 ± 0.056
4.078AspLys: 4.078 ± 0.055
4.776AspLeu: 4.776 ± 0.059
1.138AspMet: 1.138 ± 0.031
2.773AspAsn: 2.773 ± 0.041
1.809AspPro: 1.809 ± 0.036
1.298AspGln: 1.298 ± 0.027
1.975AspArg: 1.975 ± 0.04
2.787AspSer: 2.787 ± 0.047
2.746AspThr: 2.746 ± 0.042
3.164AspVal: 3.164 ± 0.053
0.808AspTrp: 0.808 ± 0.024
2.453AspTyr: 2.453 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.711GluAla: 4.711 ± 0.072
0.333GluCys: 0.333 ± 0.016
2.774GluAsp: 2.774 ± 0.05
4.107GluGlu: 4.107 ± 0.07
2.529GluPhe: 2.529 ± 0.047
3.526GluGly: 3.526 ± 0.045
0.993GluHis: 0.993 ± 0.023
4.794GluIle: 4.794 ± 0.069
5.495GluLys: 5.495 ± 0.063
5.778GluLeu: 5.778 ± 0.081
1.61GluMet: 1.61 ± 0.033
3.603GluAsn: 3.603 ± 0.05
1.823GluPro: 1.823 ± 0.039
2.474GluGln: 2.474 ± 0.041
2.62GluArg: 2.62 ± 0.049
3.126GluSer: 3.126 ± 0.045
3.373GluThr: 3.373 ± 0.051
4.032GluVal: 4.032 ± 0.054
0.753GluTrp: 0.753 ± 0.021
2.317GluTyr: 2.317 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.476PheAla: 3.476 ± 0.05
0.456PheCys: 0.456 ± 0.018
2.983PheAsp: 2.983 ± 0.043
3.146PheGlu: 3.146 ± 0.04
2.743PhePhe: 2.743 ± 0.052
3.541PheGly: 3.541 ± 0.049
0.849PheHis: 0.849 ± 0.025
3.476PheIle: 3.476 ± 0.056
3.095PheLys: 3.095 ± 0.044
4.733PheLeu: 4.733 ± 0.067
1.167PheMet: 1.167 ± 0.027
2.85PheAsn: 2.85 ± 0.046
1.736PhePro: 1.736 ± 0.035
1.661PheGln: 1.661 ± 0.033
2.192PheArg: 2.192 ± 0.038
3.74PheSer: 3.74 ± 0.056
2.994PheThr: 2.994 ± 0.047
3.236PheVal: 3.236 ± 0.05
0.64PheTrp: 0.64 ± 0.025
2.176PheTyr: 2.176 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.492GlyAla: 4.492 ± 0.061
0.588GlyCys: 0.588 ± 0.02
3.134GlyAsp: 3.134 ± 0.048
3.507GlyGlu: 3.507 ± 0.052
3.766GlyPhe: 3.766 ± 0.049
4.908GlyGly: 4.908 ± 0.085
1.219GlyHis: 1.219 ± 0.032
5.562GlyIle: 5.562 ± 0.071
5.378GlyLys: 5.378 ± 0.064
6.275GlyLeu: 6.275 ± 0.067
1.767GlyMet: 1.767 ± 0.034
3.753GlyAsn: 3.753 ± 0.061
1.444GlyPro: 1.444 ± 0.035
2.282GlyGln: 2.282 ± 0.043
2.843GlyArg: 2.843 ± 0.046
4.147GlySer: 4.147 ± 0.063
3.942GlyThr: 3.942 ± 0.064
4.648GlyVal: 4.648 ± 0.067
0.953GlyTrp: 0.953 ± 0.024
3.027GlyTyr: 3.027 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.123HisAla: 1.123 ± 0.03
0.179HisCys: 0.179 ± 0.012
0.829HisAsp: 0.829 ± 0.023
1.058HisGlu: 1.058 ± 0.03
1.128HisPhe: 1.128 ± 0.029
1.154HisGly: 1.154 ± 0.028
0.499HisHis: 0.499 ± 0.02
1.264HisIle: 1.264 ± 0.031
1.035HisLys: 1.035 ± 0.028
1.891HisLeu: 1.891 ± 0.037
0.3HisMet: 0.3 ± 0.015
0.869HisAsn: 0.869 ± 0.028
0.931HisPro: 0.931 ± 0.027
0.782HisGln: 0.782 ± 0.024
0.776HisArg: 0.776 ± 0.024
1.049HisSer: 1.049 ± 0.026
1.06HisThr: 1.06 ± 0.026
0.901HisVal: 0.901 ± 0.029
0.262HisTrp: 0.262 ± 0.014
0.817HisTyr: 0.817 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.618IleAla: 5.618 ± 0.063
0.685IleCys: 0.685 ± 0.02
4.204IleAsp: 4.204 ± 0.058
4.972IleGlu: 4.972 ± 0.072
3.276IlePhe: 3.276 ± 0.053
5.005IleGly: 5.005 ± 0.065
1.295IleHis: 1.295 ± 0.036
5.008IleIle: 5.008 ± 0.071
4.879IleLys: 4.879 ± 0.067
6.278IleLeu: 6.278 ± 0.083
1.407IleMet: 1.407 ± 0.033
4.087IleAsn: 4.087 ± 0.057
3.171IlePro: 3.171 ± 0.041
2.449IleGln: 2.449 ± 0.044
3.14IleArg: 3.14 ± 0.05
4.902IleSer: 4.902 ± 0.068
4.179IleThr: 4.179 ± 0.059
4.364IleVal: 4.364 ± 0.062
0.734IleTrp: 0.734 ± 0.021
2.611IleTyr: 2.611 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
5.531LysAla: 5.531 ± 0.056
0.328LysCys: 0.328 ± 0.014
4.19LysAsp: 4.19 ± 0.054
4.99LysGlu: 4.99 ± 0.073
2.577LysPhe: 2.577 ± 0.041
4.61LysGly: 4.61 ± 0.058
1.192LysHis: 1.192 ± 0.028
5.313LysIle: 5.313 ± 0.062
5.705LysLys: 5.705 ± 0.076
6.083LysLeu: 6.083 ± 0.068
1.85LysMet: 1.85 ± 0.034
4.436LysAsn: 4.436 ± 0.054
3.032LysPro: 3.032 ± 0.052
2.677LysGln: 2.677 ± 0.048
2.8LysArg: 2.8 ± 0.047
3.917LysSer: 3.917 ± 0.052
4.374LysThr: 4.374 ± 0.057
4.619LysVal: 4.619 ± 0.052
0.821LysTrp: 0.821 ± 0.024
2.812LysTyr: 2.812 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
7.301LeuAla: 7.301 ± 0.083
0.757LeuCys: 0.757 ± 0.022
4.542LeuAsp: 4.542 ± 0.058
5.112LeuGlu: 5.112 ± 0.081
4.659LeuPhe: 4.659 ± 0.067
6.115LeuGly: 6.115 ± 0.071
1.625LeuHis: 1.625 ± 0.037
6.56LeuIle: 6.56 ± 0.081
7.577LeuLys: 7.577 ± 0.084
9.542LeuLeu: 9.542 ± 0.112
2.389LeuMet: 2.389 ± 0.043
5.4LeuAsn: 5.4 ± 0.07
4.249LeuPro: 4.249 ± 0.056
3.524LeuGln: 3.524 ± 0.049
3.777LeuArg: 3.777 ± 0.061
6.595LeuSer: 6.595 ± 0.081
5.369LeuThr: 5.369 ± 0.061
5.729LeuVal: 5.729 ± 0.071
1.017LeuTrp: 1.017 ± 0.028
3.237LeuTyr: 3.237 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.052MetAla: 2.052 ± 0.037
0.154MetCys: 0.154 ± 0.01
1.015MetAsp: 1.015 ± 0.028
1.292MetGlu: 1.292 ± 0.031
0.843MetPhe: 0.843 ± 0.027
1.606MetGly: 1.606 ± 0.038
0.402MetHis: 0.402 ± 0.016
1.473MetIle: 1.473 ± 0.033
2.235MetLys: 2.235 ± 0.043
2.269MetLeu: 2.269 ± 0.039
0.612MetMet: 0.612 ± 0.021
1.369MetAsn: 1.369 ± 0.026
1.167MetPro: 1.167 ± 0.031
0.982MetGln: 0.982 ± 0.026
0.996MetArg: 0.996 ± 0.023
1.373MetSer: 1.373 ± 0.029
1.226MetThr: 1.226 ± 0.027
1.46MetVal: 1.46 ± 0.031
0.211MetTrp: 0.211 ± 0.011
0.646MetTyr: 0.646 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.922AsnAla: 3.922 ± 0.048
0.383AsnCys: 0.383 ± 0.016
2.593AsnAsp: 2.593 ± 0.051
3.174AsnGlu: 3.174 ± 0.052
2.762AsnPhe: 2.762 ± 0.041
3.817AsnGly: 3.817 ± 0.061
1.064AsnHis: 1.064 ± 0.029
3.856AsnIle: 3.856 ± 0.06
3.554AsnLys: 3.554 ± 0.047
5.292AsnLeu: 5.292 ± 0.061
1.205AsnMet: 1.205 ± 0.029
3.181AsnAsn: 3.181 ± 0.054
2.868AsnPro: 2.868 ± 0.043
2.284AsnGln: 2.284 ± 0.039
2.511AsnArg: 2.511 ± 0.044
3.065AsnSer: 3.065 ± 0.051
3.144AsnThr: 3.144 ± 0.05
3.056AsnVal: 3.056 ± 0.044
0.767AsnTrp: 0.767 ± 0.021
2.604AsnTyr: 2.604 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.268ProAla: 3.268 ± 0.058
0.212ProCys: 0.212 ± 0.012
2.639ProAsp: 2.639 ± 0.047
3.011ProGlu: 3.011 ± 0.045
1.959ProPhe: 1.959 ± 0.036
2.413ProGly: 2.413 ± 0.045
0.725ProHis: 0.725 ± 0.023
2.396ProIle: 2.396 ± 0.045
2.425ProLys: 2.425 ± 0.048
3.393ProLeu: 3.393 ± 0.041
0.898ProMet: 0.898 ± 0.023
2.006ProAsn: 2.006 ± 0.038
1.175ProPro: 1.175 ± 0.033
1.433ProGln: 1.433 ± 0.029
1.221ProArg: 1.221 ± 0.031
2.167ProSer: 2.167 ± 0.038
2.141ProThr: 2.141 ± 0.037
3.219ProVal: 3.219 ± 0.053
0.392ProTrp: 0.392 ± 0.016
1.567ProTyr: 1.567 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.727GlnAla: 2.727 ± 0.047
0.202GlnCys: 0.202 ± 0.011
1.577GlnAsp: 1.577 ± 0.028
2.18GlnGlu: 2.18 ± 0.043
1.752GlnPhe: 1.752 ± 0.035
2.009GlnGly: 2.009 ± 0.038
0.687GlnHis: 0.687 ± 0.022
2.624GlnIle: 2.624 ± 0.038
3.045GlnLys: 3.045 ± 0.047
3.809GlnLeu: 3.809 ± 0.062
0.945GlnMet: 0.945 ± 0.022
2.164GlnAsn: 2.164 ± 0.043
1.498GlnPro: 1.498 ± 0.031
1.791GlnGln: 1.791 ± 0.044
1.518GlnArg: 1.518 ± 0.036
2.245GlnSer: 2.245 ± 0.042
2.277GlnThr: 2.277 ± 0.039
2.29GlnVal: 2.29 ± 0.035
0.464GlnTrp: 0.464 ± 0.015
1.458GlnTyr: 1.458 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.538ArgAla: 2.538 ± 0.045
0.262ArgCys: 0.262 ± 0.013
1.871ArgAsp: 1.871 ± 0.035
2.431ArgGlu: 2.431 ± 0.042
2.336ArgPhe: 2.336 ± 0.046
2.31ArgGly: 2.31 ± 0.049
0.769ArgHis: 0.769 ± 0.028
3.357ArgIle: 3.357 ± 0.052
3.254ArgLys: 3.254 ± 0.052
4.179ArgLeu: 4.179 ± 0.056
1.138ArgMet: 1.138 ± 0.03
2.536ArgAsn: 2.536 ± 0.043
1.531ArgPro: 1.531 ± 0.031
1.763ArgGln: 1.763 ± 0.034
1.852ArgArg: 1.852 ± 0.036
2.164ArgSer: 2.164 ± 0.041
2.215ArgThr: 2.215 ± 0.041
2.58ArgVal: 2.58 ± 0.041
0.555ArgTrp: 0.555 ± 0.02
1.847ArgTyr: 1.847 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.506SerAla: 4.506 ± 0.059
0.535SerCys: 0.535 ± 0.019
2.961SerAsp: 2.961 ± 0.045
3.312SerGlu: 3.312 ± 0.052
3.651SerPhe: 3.651 ± 0.048
4.652SerGly: 4.652 ± 0.064
1.073SerHis: 1.073 ± 0.028
4.542SerIle: 4.542 ± 0.065
4.028SerLys: 4.028 ± 0.052
6.101SerLeu: 6.101 ± 0.064
1.337SerMet: 1.337 ± 0.026
2.916SerAsn: 2.916 ± 0.051
2.359SerPro: 2.359 ± 0.042
2.12SerGln: 2.12 ± 0.036
2.428SerArg: 2.428 ± 0.037
3.656SerSer: 3.656 ± 0.059
3.405SerThr: 3.405 ± 0.051
4.184SerVal: 4.184 ± 0.049
0.762SerTrp: 0.762 ± 0.024
2.549SerTyr: 2.549 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.316ThrAla: 4.316 ± 0.066
0.369ThrCys: 0.369 ± 0.016
3.361ThrAsp: 3.361 ± 0.05
3.29ThrGlu: 3.29 ± 0.047
2.901ThrPhe: 2.901 ± 0.048
4.399ThrGly: 4.399 ± 0.061
1.088ThrHis: 1.088 ± 0.028
4.28ThrIle: 4.28 ± 0.057
3.267ThrLys: 3.267 ± 0.05
5.489ThrLeu: 5.489 ± 0.054
1.013ThrMet: 1.013 ± 0.028
2.768ThrAsn: 2.768 ± 0.046
2.633ThrPro: 2.633 ± 0.041
1.978ThrGln: 1.978 ± 0.039
2.248ThrArg: 2.248 ± 0.036
3.354ThrSer: 3.354 ± 0.049
3.314ThrThr: 3.314 ± 0.063
3.543ThrVal: 3.543 ± 0.049
0.656ThrTrp: 0.656 ± 0.021
2.287ThrTyr: 2.287 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
4.8ValAla: 4.8 ± 0.062
0.606ValCys: 0.606 ± 0.021
3.051ValAsp: 3.051 ± 0.048
3.71ValGlu: 3.71 ± 0.049
3.537ValPhe: 3.537 ± 0.056
4.017ValGly: 4.017 ± 0.055
1.036ValHis: 1.036 ± 0.024
4.586ValIle: 4.586 ± 0.054
4.446ValLys: 4.446 ± 0.056
6.113ValLeu: 6.113 ± 0.072
1.52ValMet: 1.52 ± 0.027
3.417ValAsn: 3.417 ± 0.053
2.538ValPro: 2.538 ± 0.043
2.062ValGln: 2.062 ± 0.039
2.502ValArg: 2.502 ± 0.045
4.615ValSer: 4.615 ± 0.053
3.479ValThr: 3.479 ± 0.052
4.499ValVal: 4.499 ± 0.068
0.773ValTrp: 0.773 ± 0.024
2.463ValTyr: 2.463 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.881TrpAla: 0.881 ± 0.027
0.11TrpCys: 0.11 ± 0.008
0.605TrpAsp: 0.605 ± 0.021
0.689TrpGlu: 0.689 ± 0.022
0.656TrpPhe: 0.656 ± 0.022
0.891TrpGly: 0.891 ± 0.031
0.282TrpHis: 0.282 ± 0.015
0.76TrpIle: 0.76 ± 0.021
0.886TrpLys: 0.886 ± 0.026
1.307TrpLeu: 1.307 ± 0.034
0.315TrpMet: 0.315 ± 0.013
0.643TrpAsn: 0.643 ± 0.02
0.261TrpPro: 0.261 ± 0.014
0.648TrpGln: 0.648 ± 0.022
0.547TrpArg: 0.547 ± 0.019
0.691TrpSer: 0.691 ± 0.023
0.601TrpThr: 0.601 ± 0.021
0.81TrpVal: 0.81 ± 0.022
0.201TrpTrp: 0.201 ± 0.011
0.46TrpTyr: 0.46 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.759TyrAla: 2.759 ± 0.047
0.337TyrCys: 0.337 ± 0.014
2.194TyrAsp: 2.194 ± 0.042
2.323TyrGlu: 2.323 ± 0.037
2.361TyrPhe: 2.361 ± 0.043
2.628TyrGly: 2.628 ± 0.05
0.84TyrHis: 0.84 ± 0.023
2.472TyrIle: 2.472 ± 0.046
2.586TyrLys: 2.586 ± 0.051
4.038TyrLeu: 4.038 ± 0.047
0.796TyrMet: 0.796 ± 0.023
2.259TyrAsn: 2.259 ± 0.04
1.691TyrPro: 1.691 ± 0.031
1.779TyrGln: 1.779 ± 0.038
1.96TyrArg: 1.96 ± 0.034
2.513TyrSer: 2.513 ± 0.039
2.235TyrThr: 2.235 ± 0.047
2.265TyrVal: 2.265 ± 0.047
0.546TyrTrp: 0.546 ± 0.019
1.83TyrTyr: 1.83 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 4502 proteins (1548216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski