Amino acid dipepetide frequency for Avian paramyxovirus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.989AlaAla: 8.989 ± 1.955
1.316AlaCys: 1.316 ± 0.317
3.947AlaAsp: 3.947 ± 0.968
3.508AlaGlu: 3.508 ± 0.719
2.193AlaPhe: 2.193 ± 0.718
4.166AlaGly: 4.166 ± 1.13
1.096AlaHis: 1.096 ± 0.491
5.481AlaIle: 5.481 ± 0.959
2.85AlaLys: 2.85 ± 1.284
8.551AlaLeu: 8.551 ± 0.713
2.193AlaMet: 2.193 ± 1.04
3.07AlaAsn: 3.07 ± 0.738
2.85AlaPro: 2.85 ± 0.7
3.289AlaGln: 3.289 ± 1.123
3.727AlaArg: 3.727 ± 0.639
3.727AlaSer: 3.727 ± 0.443
5.262AlaThr: 5.262 ± 1.523
3.07AlaVal: 3.07 ± 1.419
0.877AlaTrp: 0.877 ± 0.307
2.631AlaTyr: 2.631 ± 0.72
0.0AlaXaa: 0.0 ± 0.0
Cys
2.193CysAla: 2.193 ± 0.983
0.219CysCys: 0.219 ± 0.137
0.219CysAsp: 0.219 ± 0.137
0.439CysGlu: 0.439 ± 0.25
0.439CysPhe: 0.439 ± 0.228
0.658CysGly: 0.658 ± 0.29
0.439CysHis: 0.439 ± 0.25
0.658CysIle: 0.658 ± 0.411
0.439CysLys: 0.439 ± 0.39
3.07CysLeu: 3.07 ± 0.794
0.219CysMet: 0.219 ± 0.291
1.754CysAsn: 1.754 ± 0.377
0.877CysPro: 0.877 ± 0.714
0.658CysGln: 0.658 ± 0.277
0.877CysArg: 0.877 ± 0.266
1.535CysSer: 1.535 ± 0.482
0.877CysThr: 0.877 ± 0.266
1.535CysVal: 1.535 ± 0.746
0.0CysTrp: 0.0 ± 0.0
0.877CysTyr: 0.877 ± 0.456
0.0CysXaa: 0.0 ± 0.0
Asp
2.193AspAla: 2.193 ± 0.111
1.535AspCys: 1.535 ± 0.632
2.85AspAsp: 2.85 ± 0.56
1.754AspGlu: 1.754 ± 0.266
1.535AspPhe: 1.535 ± 0.536
2.412AspGly: 2.412 ± 0.336
3.07AspHis: 3.07 ± 1.063
3.289AspIle: 3.289 ± 0.49
1.754AspLys: 1.754 ± 0.762
3.07AspLeu: 3.07 ± 0.43
0.877AspMet: 0.877 ± 0.792
3.07AspAsn: 3.07 ± 0.784
5.262AspPro: 5.262 ± 0.956
2.412AspGln: 2.412 ± 0.638
1.973AspArg: 1.973 ± 0.765
5.262AspSer: 5.262 ± 1.078
4.604AspThr: 4.604 ± 1.245
2.193AspVal: 2.193 ± 1.371
0.219AspTrp: 0.219 ± 0.312
2.193AspTyr: 2.193 ± 0.517
0.0AspXaa: 0.0 ± 0.0
Glu
3.508GluAla: 3.508 ± 0.805
0.439GluCys: 0.439 ± 0.274
2.193GluAsp: 2.193 ± 1.11
1.535GluGlu: 1.535 ± 0.727
1.535GluPhe: 1.535 ± 0.96
4.385GluGly: 4.385 ± 0.46
0.658GluHis: 0.658 ± 0.29
2.193GluIle: 2.193 ± 0.742
2.193GluLys: 2.193 ± 0.779
6.578GluLeu: 6.578 ± 0.635
0.439GluMet: 0.439 ± 0.274
1.535GluAsn: 1.535 ± 0.746
1.316GluPro: 1.316 ± 0.552
2.193GluGln: 2.193 ± 0.379
3.07GluArg: 3.07 ± 0.714
3.727GluSer: 3.727 ± 0.494
2.193GluThr: 2.193 ± 0.743
3.508GluVal: 3.508 ± 0.966
0.219GluTrp: 0.219 ± 0.137
1.316GluTyr: 1.316 ± 0.537
0.0GluXaa: 0.0 ± 0.0
Phe
2.412PheAla: 2.412 ± 0.786
0.658PheCys: 0.658 ± 0.276
1.973PheAsp: 1.973 ± 0.765
1.754PheGlu: 1.754 ± 0.447
1.535PhePhe: 1.535 ± 0.746
1.535PheGly: 1.535 ± 0.864
0.439PheHis: 0.439 ± 0.274
1.754PheIle: 1.754 ± 0.491
1.754PheLys: 1.754 ± 0.544
3.947PheLeu: 3.947 ± 0.887
1.316PheMet: 1.316 ± 0.455
1.973PheAsn: 1.973 ± 0.444
1.535PhePro: 1.535 ± 0.721
0.219PheGln: 0.219 ± 0.137
0.439PheArg: 0.439 ± 0.275
3.289PheSer: 3.289 ± 0.926
3.07PheThr: 3.07 ± 0.575
2.193PheVal: 2.193 ± 0.717
0.0PheTrp: 0.0 ± 0.0
1.316PheTyr: 1.316 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
3.727GlyAla: 3.727 ± 1.083
1.973GlyCys: 1.973 ± 0.65
3.289GlyAsp: 3.289 ± 0.78
1.973GlyGlu: 1.973 ± 0.554
2.412GlyPhe: 2.412 ± 0.638
4.824GlyGly: 4.824 ± 0.405
1.316GlyHis: 1.316 ± 0.442
3.508GlyIle: 3.508 ± 0.367
1.973GlyLys: 1.973 ± 0.501
6.578GlyLeu: 6.578 ± 0.698
0.219GlyMet: 0.219 ± 0.137
2.85GlyAsn: 2.85 ± 1.579
2.412GlyPro: 2.412 ± 1.572
1.096GlyGln: 1.096 ± 0.37
2.85GlyArg: 2.85 ± 0.57
5.262GlySer: 5.262 ± 1.503
2.85GlyThr: 2.85 ± 1.053
4.166GlyVal: 4.166 ± 1.832
0.439GlyTrp: 0.439 ± 0.274
2.412GlyTyr: 2.412 ± 0.84
0.0GlyXaa: 0.0 ± 0.0
His
1.096HisAla: 1.096 ± 0.348
0.658HisCys: 0.658 ± 0.465
1.754HisAsp: 1.754 ± 0.458
0.877HisGlu: 0.877 ± 0.372
0.658HisPhe: 0.658 ± 0.56
1.535HisGly: 1.535 ± 0.521
0.658HisHis: 0.658 ± 0.411
1.535HisIle: 1.535 ± 0.327
0.658HisLys: 0.658 ± 0.277
2.193HisLeu: 2.193 ± 1.134
0.439HisMet: 0.439 ± 0.275
0.439HisAsn: 0.439 ± 0.228
1.316HisPro: 1.316 ± 0.51
1.535HisGln: 1.535 ± 0.563
0.658HisArg: 0.658 ± 0.301
1.754HisSer: 1.754 ± 0.422
1.316HisThr: 1.316 ± 0.822
1.316HisVal: 1.316 ± 0.612
0.219HisTrp: 0.219 ± 0.137
0.877HisTyr: 0.877 ± 0.548
0.0HisXaa: 0.0 ± 0.0
Ile
4.385IleAla: 4.385 ± 0.966
1.096IleCys: 1.096 ± 0.491
3.289IleAsp: 3.289 ± 0.365
3.947IleGlu: 3.947 ± 0.953
2.85IlePhe: 2.85 ± 0.288
2.412IleGly: 2.412 ± 0.987
1.316IleHis: 1.316 ± 0.394
5.043IleIle: 5.043 ± 0.993
1.535IleLys: 1.535 ± 0.224
5.92IleLeu: 5.92 ± 0.87
0.658IleMet: 0.658 ± 0.276
3.508IleAsn: 3.508 ± 0.274
3.289IlePro: 3.289 ± 0.731
5.701IleGln: 5.701 ± 0.768
2.85IleArg: 2.85 ± 0.78
4.385IleSer: 4.385 ± 0.742
2.85IleThr: 2.85 ± 0.542
3.07IleVal: 3.07 ± 1.156
1.096IleTrp: 1.096 ± 0.771
1.754IleTyr: 1.754 ± 0.581
0.0IleXaa: 0.0 ± 0.0
Lys
3.508LysAla: 3.508 ± 1.216
0.658LysCys: 0.658 ± 0.315
2.631LysAsp: 2.631 ± 0.765
3.07LysGlu: 3.07 ± 0.88
1.316LysPhe: 1.316 ± 0.611
1.316LysGly: 1.316 ± 0.859
1.535LysHis: 1.535 ± 0.96
1.535LysIle: 1.535 ± 0.728
2.85LysLys: 2.85 ± 1.118
4.166LysLeu: 4.166 ± 0.985
1.316LysMet: 1.316 ± 0.388
2.412LysAsn: 2.412 ± 0.199
1.316LysPro: 1.316 ± 0.63
1.316LysGln: 1.316 ± 0.544
2.412LysArg: 2.412 ± 0.816
2.631LysSer: 2.631 ± 0.311
2.412LysThr: 2.412 ± 0.521
2.85LysVal: 2.85 ± 0.586
0.877LysTrp: 0.877 ± 0.307
1.096LysTyr: 1.096 ± 0.566
0.219LysXaa: 0.219 ± 0.256
Leu
7.455LeuAla: 7.455 ± 0.982
1.535LeuCys: 1.535 ± 0.741
5.92LeuAsp: 5.92 ± 1.204
5.043LeuGlu: 5.043 ± 1.207
3.727LeuPhe: 3.727 ± 0.909
7.016LeuGly: 7.016 ± 1.145
2.412LeuHis: 2.412 ± 0.835
5.481LeuIle: 5.481 ± 0.857
5.481LeuLys: 5.481 ± 0.776
12.936LeuLeu: 12.936 ± 1.52
4.385LeuMet: 4.385 ± 0.379
6.358LeuAsn: 6.358 ± 1.013
3.727LeuPro: 3.727 ± 0.8
3.727LeuGln: 3.727 ± 0.52
5.262LeuArg: 5.262 ± 1.237
13.155LeuSer: 13.155 ± 1.738
7.455LeuThr: 7.455 ± 1.599
6.578LeuVal: 6.578 ± 0.994
1.096LeuTrp: 1.096 ± 0.685
3.07LeuTyr: 3.07 ± 0.495
0.0LeuXaa: 0.0 ± 0.0
Met
2.412MetAla: 2.412 ± 1.138
0.219MetCys: 0.219 ± 0.137
0.658MetAsp: 0.658 ± 0.37
1.535MetGlu: 1.535 ± 0.821
0.219MetPhe: 0.219 ± 0.137
1.316MetGly: 1.316 ± 0.256
0.658MetHis: 0.658 ± 0.301
0.877MetIle: 0.877 ± 0.36
0.439MetLys: 0.439 ± 0.582
1.754MetLeu: 1.754 ± 0.45
0.877MetMet: 0.877 ± 0.54
0.658MetAsn: 0.658 ± 0.441
1.535MetPro: 1.535 ± 0.492
1.096MetGln: 1.096 ± 0.275
1.535MetArg: 1.535 ± 0.563
2.193MetSer: 2.193 ± 0.546
2.412MetThr: 2.412 ± 0.199
1.316MetVal: 1.316 ± 0.529
0.219MetTrp: 0.219 ± 0.28
1.096MetTyr: 1.096 ± 0.273
0.0MetXaa: 0.0 ± 0.0
Asn
2.85AsnAla: 2.85 ± 0.464
0.439AsnCys: 0.439 ± 0.224
2.412AsnAsp: 2.412 ± 0.607
1.316AsnGlu: 1.316 ± 0.644
1.973AsnPhe: 1.973 ± 0.513
2.193AsnGly: 2.193 ± 0.773
0.658AsnHis: 0.658 ± 0.276
3.947AsnIle: 3.947 ± 0.791
1.754AsnLys: 1.754 ± 0.529
5.92AsnLeu: 5.92 ± 1.377
1.096AsnMet: 1.096 ± 0.551
1.096AsnAsn: 1.096 ± 0.612
4.824AsnPro: 4.824 ± 1.017
4.166AsnGln: 4.166 ± 0.575
2.193AsnArg: 2.193 ± 0.622
4.166AsnSer: 4.166 ± 0.743
2.85AsnThr: 2.85 ± 0.66
2.193AsnVal: 2.193 ± 0.542
1.096AsnTrp: 1.096 ± 0.468
1.096AsnTyr: 1.096 ± 0.339
0.0AsnXaa: 0.0 ± 0.0
Pro
3.289ProAla: 3.289 ± 0.626
0.658ProCys: 0.658 ± 0.29
3.07ProAsp: 3.07 ± 1.368
4.604ProGlu: 4.604 ± 0.802
2.412ProPhe: 2.412 ± 0.859
3.947ProGly: 3.947 ± 0.915
1.535ProHis: 1.535 ± 0.499
2.193ProIle: 2.193 ± 0.776
3.07ProLys: 3.07 ± 1.077
4.385ProLeu: 4.385 ± 0.593
0.877ProMet: 0.877 ± 0.393
1.535ProAsn: 1.535 ± 0.482
3.07ProPro: 3.07 ± 0.698
2.631ProGln: 2.631 ± 0.992
2.631ProArg: 2.631 ± 0.717
4.166ProSer: 4.166 ± 1.531
2.85ProThr: 2.85 ± 0.81
3.508ProVal: 3.508 ± 0.558
0.439ProTrp: 0.439 ± 0.249
1.316ProTyr: 1.316 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
3.289GlnAla: 3.289 ± 1.482
1.096GlnCys: 1.096 ± 0.294
2.412GlnAsp: 2.412 ± 0.752
1.973GlnGlu: 1.973 ± 0.552
0.877GlnPhe: 0.877 ± 0.549
2.412GlnGly: 2.412 ± 0.357
0.877GlnHis: 0.877 ± 0.618
3.07GlnIle: 3.07 ± 0.701
1.973GlnLys: 1.973 ± 0.556
7.674GlnLeu: 7.674 ± 1.001
0.658GlnMet: 0.658 ± 0.318
1.973GlnAsn: 1.973 ± 0.44
3.07GlnPro: 3.07 ± 1.521
1.973GlnGln: 1.973 ± 0.559
1.754GlnArg: 1.754 ± 0.553
5.481GlnSer: 5.481 ± 1.421
3.07GlnThr: 3.07 ± 0.34
5.262GlnVal: 5.262 ± 0.549
0.439GlnTrp: 0.439 ± 0.274
1.973GlnTyr: 1.973 ± 0.775
0.0GlnXaa: 0.0 ± 0.0
Arg
3.727ArgAla: 3.727 ± 0.589
1.535ArgCys: 1.535 ± 0.528
3.07ArgAsp: 3.07 ± 1.256
1.754ArgGlu: 1.754 ± 0.705
2.631ArgPhe: 2.631 ± 1.024
1.754ArgGly: 1.754 ± 0.266
0.877ArgHis: 0.877 ± 0.548
3.947ArgIle: 3.947 ± 1.206
3.07ArgLys: 3.07 ± 0.961
7.016ArgLeu: 7.016 ± 1.122
1.096ArgMet: 1.096 ± 0.294
2.631ArgAsn: 2.631 ± 0.974
2.412ArgPro: 2.412 ± 0.694
2.85ArgGln: 2.85 ± 0.717
2.85ArgArg: 2.85 ± 0.875
2.631ArgSer: 2.631 ± 0.512
3.508ArgThr: 3.508 ± 1.012
3.07ArgVal: 3.07 ± 0.654
0.877ArgTrp: 0.877 ± 0.379
1.316ArgTyr: 1.316 ± 0.467
0.0ArgXaa: 0.0 ± 0.0
Ser
7.235SerAla: 7.235 ± 1.995
1.096SerCys: 1.096 ± 0.434
4.604SerAsp: 4.604 ± 0.844
4.604SerGlu: 4.604 ± 0.952
1.535SerPhe: 1.535 ± 0.336
5.262SerGly: 5.262 ± 1.108
0.439SerHis: 0.439 ± 0.274
5.481SerIle: 5.481 ± 1.334
3.07SerLys: 3.07 ± 0.58
8.551SerLeu: 8.551 ± 0.776
2.193SerMet: 2.193 ± 1.073
3.289SerAsn: 3.289 ± 0.533
3.727SerPro: 3.727 ± 1.594
7.235SerGln: 7.235 ± 1.597
5.481SerArg: 5.481 ± 0.91
7.455SerSer: 7.455 ± 1.276
5.92SerThr: 5.92 ± 0.93
4.385SerVal: 4.385 ± 0.699
1.973SerTrp: 1.973 ± 0.53
2.412SerTyr: 2.412 ± 0.678
0.0SerXaa: 0.0 ± 0.0
Thr
3.947ThrAla: 3.947 ± 0.821
1.096ThrCys: 1.096 ± 0.434
2.85ThrAsp: 2.85 ± 0.746
1.754ThrGlu: 1.754 ± 0.644
1.535ThrPhe: 1.535 ± 0.566
4.385ThrGly: 4.385 ± 0.683
1.316ThrHis: 1.316 ± 0.394
3.289ThrIle: 3.289 ± 0.492
2.193ThrLys: 2.193 ± 0.448
7.674ThrLeu: 7.674 ± 0.876
1.754ThrMet: 1.754 ± 0.506
3.947ThrAsn: 3.947 ± 1.039
4.604ThrPro: 4.604 ± 1.204
3.508ThrGln: 3.508 ± 0.532
4.166ThrArg: 4.166 ± 1.041
3.727ThrSer: 3.727 ± 1.376
6.358ThrThr: 6.358 ± 1.2
5.481ThrVal: 5.481 ± 0.965
0.658ThrTrp: 0.658 ± 0.465
2.412ThrTyr: 2.412 ± 1.099
0.0ThrXaa: 0.0 ± 0.0
Val
3.727ValAla: 3.727 ± 0.829
0.877ValCys: 0.877 ± 0.378
2.85ValAsp: 2.85 ± 0.453
2.412ValGlu: 2.412 ± 0.73
1.973ValPhe: 1.973 ± 0.764
1.973ValGly: 1.973 ± 0.404
0.658ValHis: 0.658 ± 0.276
3.727ValIle: 3.727 ± 0.704
3.289ValLys: 3.289 ± 0.803
6.358ValLeu: 6.358 ± 0.685
1.535ValMet: 1.535 ± 0.525
3.947ValAsn: 3.947 ± 0.714
3.289ValPro: 3.289 ± 0.882
1.973ValGln: 1.973 ± 0.601
4.166ValArg: 4.166 ± 0.828
7.893ValSer: 7.893 ± 1.142
5.043ValThr: 5.043 ± 1.234
4.604ValVal: 4.604 ± 1.507
0.219ValTrp: 0.219 ± 0.28
1.535ValTyr: 1.535 ± 0.497
0.0ValXaa: 0.0 ± 0.0
Trp
1.096TrpAla: 1.096 ± 0.487
0.219TrpCys: 0.219 ± 0.256
0.439TrpAsp: 0.439 ± 0.228
0.219TrpGlu: 0.219 ± 0.291
0.439TrpPhe: 0.439 ± 0.249
0.877TrpGly: 0.877 ± 0.548
0.219TrpHis: 0.219 ± 0.137
0.877TrpIle: 0.877 ± 0.379
0.0TrpLys: 0.0 ± 0.0
0.658TrpLeu: 0.658 ± 0.411
0.0TrpMet: 0.0 ± 0.0
0.219TrpAsn: 0.219 ± 0.291
0.658TrpPro: 0.658 ± 0.465
0.658TrpGln: 0.658 ± 0.525
1.973TrpArg: 1.973 ± 1.006
0.658TrpSer: 0.658 ± 0.264
0.439TrpThr: 0.439 ± 0.275
0.658TrpVal: 0.658 ± 0.315
0.439TrpTrp: 0.439 ± 0.408
0.877TrpTyr: 0.877 ± 0.378
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.754TyrAla: 1.754 ± 1.114
0.658TyrCys: 0.658 ± 0.465
1.096TyrAsp: 1.096 ± 0.369
0.658TyrGlu: 0.658 ± 0.301
1.316TyrPhe: 1.316 ± 0.4
1.754TyrGly: 1.754 ± 0.417
1.316TyrHis: 1.316 ± 0.33
3.07TyrIle: 3.07 ± 0.41
1.096TyrLys: 1.096 ± 0.491
5.043TyrLeu: 5.043 ± 1.553
0.658TyrMet: 0.658 ± 0.301
1.973TyrAsn: 1.973 ± 0.863
1.096TyrPro: 1.096 ± 0.69
3.07TyrGln: 3.07 ± 0.557
1.754TyrArg: 1.754 ± 0.492
2.85TyrSer: 2.85 ± 0.659
1.316TyrThr: 1.316 ± 0.775
0.877TyrVal: 0.877 ± 0.243
0.219TyrTrp: 0.219 ± 0.137
2.631TyrTyr: 2.631 ± 1.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.219XaaVal: 0.219 ± 0.256
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (4562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski