Amino acid dipepetide frequency for Bat Hp-betacoronavirus/Zhejiang2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.694AlaAla: 6.694 ± 1.798
1.477AlaCys: 1.477 ± 0.354
3.839AlaAsp: 3.839 ± 0.856
2.756AlaGlu: 2.756 ± 0.484
3.544AlaPhe: 3.544 ± 0.351
3.741AlaGly: 3.741 ± 0.649
1.181AlaHis: 1.181 ± 0.335
4.528AlaIle: 4.528 ± 1.152
4.135AlaLys: 4.135 ± 0.567
6.005AlaLeu: 6.005 ± 0.765
2.363AlaMet: 2.363 ± 0.75
3.544AlaAsn: 3.544 ± 0.766
2.363AlaPro: 2.363 ± 0.788
2.855AlaGln: 2.855 ± 1.83
3.052AlaArg: 3.052 ± 0.476
3.249AlaSer: 3.249 ± 1.021
4.627AlaThr: 4.627 ± 0.928
6.891AlaVal: 6.891 ± 1.564
0.788AlaTrp: 0.788 ± 0.246
3.347AlaTyr: 3.347 ± 0.756
0.0AlaXaa: 0.0 ± 0.0
Cys
2.756CysAla: 2.756 ± 0.701
2.067CysCys: 2.067 ± 0.51
1.772CysAsp: 1.772 ± 0.606
1.181CysGlu: 1.181 ± 0.352
1.083CysPhe: 1.083 ± 0.294
1.969CysGly: 1.969 ± 0.464
0.886CysHis: 0.886 ± 0.254
2.166CysIle: 2.166 ± 0.501
2.067CysLys: 2.067 ± 0.774
1.772CysLeu: 1.772 ± 0.66
0.886CysMet: 0.886 ± 0.296
2.166CysAsn: 2.166 ± 0.704
1.181CysPro: 1.181 ± 0.331
0.886CysGln: 0.886 ± 0.254
1.575CysArg: 1.575 ± 0.386
2.756CysSer: 2.756 ± 0.631
2.363CysThr: 2.363 ± 0.757
2.461CysVal: 2.461 ± 0.617
0.394CysTrp: 0.394 ± 0.118
1.674CysTyr: 1.674 ± 0.435
0.0CysXaa: 0.0 ± 0.0
Asp
4.135AspAla: 4.135 ± 1.126
1.674AspCys: 1.674 ± 0.371
2.756AspAsp: 2.756 ± 0.798
2.264AspGlu: 2.264 ± 0.315
3.446AspPhe: 3.446 ± 1.028
3.544AspGly: 3.544 ± 1.017
1.083AspHis: 1.083 ± 0.305
3.446AspIle: 3.446 ± 1.028
2.56AspLys: 2.56 ± 0.593
4.725AspLeu: 4.725 ± 0.791
0.984AspMet: 0.984 ± 0.205
3.446AspAsn: 3.446 ± 0.685
1.674AspPro: 1.674 ± 1.164
1.28AspGln: 1.28 ± 0.558
1.28AspArg: 1.28 ± 0.307
4.036AspSer: 4.036 ± 0.476
3.347AspThr: 3.347 ± 0.58
4.528AspVal: 4.528 ± 0.699
0.492AspTrp: 0.492 ± 0.282
3.052AspTyr: 3.052 ± 0.471
0.0AspXaa: 0.0 ± 0.0
Glu
3.642GluAla: 3.642 ± 0.488
1.378GluCys: 1.378 ± 0.832
3.347GluAsp: 3.347 ± 0.691
2.56GluGlu: 2.56 ± 0.276
1.772GluPhe: 1.772 ± 0.373
1.969GluGly: 1.969 ± 0.331
0.984GluHis: 0.984 ± 0.332
1.772GluIle: 1.772 ± 0.367
3.15GluLys: 3.15 ± 0.955
4.036GluLeu: 4.036 ± 0.725
0.886GluMet: 0.886 ± 0.311
1.772GluAsn: 1.772 ± 0.251
1.969GluPro: 1.969 ± 0.392
1.772GluGln: 1.772 ± 0.468
1.772GluArg: 1.772 ± 0.528
1.378GluSer: 1.378 ± 0.337
2.461GluThr: 2.461 ± 0.304
3.642GluVal: 3.642 ± 0.917
0.492GluTrp: 0.492 ± 0.377
1.575GluTyr: 1.575 ± 0.507
0.0GluXaa: 0.0 ± 0.0
Phe
3.052PheAla: 3.052 ± 0.993
2.166PheCys: 2.166 ± 0.555
2.953PheAsp: 2.953 ± 0.453
1.674PheGlu: 1.674 ± 0.355
1.477PhePhe: 1.477 ± 0.236
2.953PheGly: 2.953 ± 0.248
0.984PheHis: 0.984 ± 0.231
2.756PheIle: 2.756 ± 0.508
3.938PheLys: 3.938 ± 0.535
4.036PheLeu: 4.036 ± 1.142
1.28PheMet: 1.28 ± 0.458
3.15PheAsn: 3.15 ± 1.242
1.378PhePro: 1.378 ± 0.45
1.969PheGln: 1.969 ± 0.926
1.181PheArg: 1.181 ± 0.273
3.544PheSer: 3.544 ± 0.701
2.953PheThr: 2.953 ± 0.838
4.824PheVal: 4.824 ± 0.875
0.492PheTrp: 0.492 ± 0.18
2.461PheTyr: 2.461 ± 0.789
0.0PheXaa: 0.0 ± 0.0
Gly
3.052GlyAla: 3.052 ± 0.545
1.969GlyCys: 1.969 ± 0.467
3.642GlyAsp: 3.642 ± 0.692
1.87GlyGlu: 1.87 ± 0.812
3.347GlyPhe: 3.347 ± 0.79
3.052GlyGly: 3.052 ± 1.176
1.083GlyHis: 1.083 ± 0.336
2.953GlyIle: 2.953 ± 0.322
2.56GlyLys: 2.56 ± 0.724
4.332GlyLeu: 4.332 ± 0.665
1.378GlyMet: 1.378 ± 0.248
3.15GlyAsn: 3.15 ± 0.471
1.87GlyPro: 1.87 ± 1.075
1.969GlyGln: 1.969 ± 0.576
1.378GlyArg: 1.378 ± 0.85
4.528GlySer: 4.528 ± 0.469
4.922GlyThr: 4.922 ± 0.981
6.104GlyVal: 6.104 ± 0.657
0.197GlyTrp: 0.197 ± 0.103
2.363GlyTyr: 2.363 ± 0.344
0.0GlyXaa: 0.0 ± 0.0
His
1.674HisAla: 1.674 ± 0.751
0.788HisCys: 0.788 ± 0.332
1.28HisAsp: 1.28 ± 0.363
1.083HisGlu: 1.083 ± 0.285
1.378HisPhe: 1.378 ± 0.41
1.378HisGly: 1.378 ± 0.843
0.295HisHis: 0.295 ± 0.155
1.378HisIle: 1.378 ± 0.713
1.181HisLys: 1.181 ± 0.366
1.28HisLeu: 1.28 ± 0.24
0.295HisMet: 0.295 ± 0.221
0.984HisAsn: 0.984 ± 0.646
0.492HisPro: 0.492 ± 0.18
0.591HisGln: 0.591 ± 0.272
0.591HisArg: 0.591 ± 0.486
1.378HisSer: 1.378 ± 0.41
1.575HisThr: 1.575 ± 0.253
2.461HisVal: 2.461 ± 0.44
0.197HisTrp: 0.197 ± 0.103
1.083HisTyr: 1.083 ± 0.371
0.0HisXaa: 0.0 ± 0.0
Ile
2.953IleAla: 2.953 ± 1.198
1.181IleCys: 1.181 ± 0.488
3.15IleAsp: 3.15 ± 0.279
2.363IleGlu: 2.363 ± 0.433
1.87IlePhe: 1.87 ± 0.457
2.855IleGly: 2.855 ± 0.406
0.591IleHis: 0.591 ± 0.309
1.378IleIle: 1.378 ± 0.355
2.953IleLys: 2.953 ± 0.679
4.725IleLeu: 4.725 ± 0.849
1.378IleMet: 1.378 ± 0.352
3.052IleAsn: 3.052 ± 1.133
2.461IlePro: 2.461 ± 0.648
0.984IleGln: 0.984 ± 0.281
2.067IleArg: 2.067 ± 0.655
2.658IleSer: 2.658 ± 0.736
5.021IleThr: 5.021 ± 1.44
5.611IleVal: 5.611 ± 1.28
0.492IleTrp: 0.492 ± 0.141
2.166IleTyr: 2.166 ± 0.911
0.0IleXaa: 0.0 ± 0.0
Lys
3.544LysAla: 3.544 ± 1.196
1.181LysCys: 1.181 ± 0.618
2.953LysAsp: 2.953 ± 0.645
1.969LysGlu: 1.969 ± 0.522
3.15LysPhe: 3.15 ± 1.18
3.249LysGly: 3.249 ± 0.992
2.166LysHis: 2.166 ± 0.814
2.067LysIle: 2.067 ± 0.407
2.067LysLys: 2.067 ± 0.497
5.218LysLeu: 5.218 ± 0.761
1.772LysMet: 1.772 ± 0.291
2.56LysAsn: 2.56 ± 0.725
4.528LysPro: 4.528 ± 0.96
2.461LysGln: 2.461 ± 0.628
2.264LysArg: 2.264 ± 0.527
3.15LysSer: 3.15 ± 0.641
2.953LysThr: 2.953 ± 0.933
4.036LysVal: 4.036 ± 0.498
0.788LysTrp: 0.788 ± 0.157
3.052LysTyr: 3.052 ± 0.537
0.0LysXaa: 0.0 ± 0.0
Leu
5.316LeuAla: 5.316 ± 1.072
3.544LeuCys: 3.544 ± 0.728
3.446LeuAsp: 3.446 ± 0.464
2.756LeuGlu: 2.756 ± 0.495
3.249LeuPhe: 3.249 ± 1.068
4.036LeuGly: 4.036 ± 1.198
1.181LeuHis: 1.181 ± 0.325
3.839LeuIle: 3.839 ± 1.173
5.119LeuLys: 5.119 ± 1.522
7.974LeuLeu: 7.974 ± 1.811
2.756LeuMet: 2.756 ± 0.546
4.922LeuAsn: 4.922 ± 0.313
4.332LeuPro: 4.332 ± 0.464
4.627LeuGln: 4.627 ± 0.893
3.15LeuArg: 3.15 ± 0.44
6.104LeuSer: 6.104 ± 1.398
7.088LeuThr: 7.088 ± 0.981
5.71LeuVal: 5.71 ± 0.83
0.788LeuTrp: 0.788 ± 0.307
4.135LeuTyr: 4.135 ± 1.391
0.0LeuXaa: 0.0 ± 0.0
Met
1.772MetAla: 1.772 ± 0.405
1.477MetCys: 1.477 ± 0.481
0.788MetAsp: 0.788 ± 0.329
0.788MetGlu: 0.788 ± 0.412
1.477MetPhe: 1.477 ± 0.227
1.28MetGly: 1.28 ± 0.231
1.28MetHis: 1.28 ± 0.271
0.689MetIle: 0.689 ± 0.259
0.591MetLys: 0.591 ± 0.176
2.56MetLeu: 2.56 ± 0.619
0.689MetMet: 0.689 ± 0.218
1.083MetAsn: 1.083 ± 0.285
1.378MetPro: 1.378 ± 0.309
0.492MetGln: 0.492 ± 0.244
0.886MetArg: 0.886 ± 0.362
2.166MetSer: 2.166 ± 0.455
1.674MetThr: 1.674 ± 0.371
1.772MetVal: 1.772 ± 0.524
0.492MetTrp: 0.492 ± 0.48
1.575MetTyr: 1.575 ± 0.373
0.0MetXaa: 0.0 ± 0.0
Asn
4.135AsnAla: 4.135 ± 0.421
2.56AsnCys: 2.56 ± 0.623
2.461AsnAsp: 2.461 ± 0.698
1.772AsnGlu: 1.772 ± 0.271
3.052AsnPhe: 3.052 ± 1.74
4.627AsnGly: 4.627 ± 0.94
1.28AsnHis: 1.28 ± 0.907
3.052AsnIle: 3.052 ± 0.595
2.658AsnLys: 2.658 ± 0.875
2.56AsnLeu: 2.56 ± 0.386
0.591AsnMet: 0.591 ± 0.309
3.347AsnAsn: 3.347 ± 1.478
2.067AsnPro: 2.067 ± 0.535
1.772AsnGln: 1.772 ± 0.968
1.87AsnArg: 1.87 ± 0.421
4.43AsnSer: 4.43 ± 0.694
4.036AsnThr: 4.036 ± 0.497
5.119AsnVal: 5.119 ± 0.894
0.197AsnTrp: 0.197 ± 0.103
3.15AsnTyr: 3.15 ± 1.439
0.0AsnXaa: 0.0 ± 0.0
Pro
2.953ProAla: 2.953 ± 0.726
1.575ProCys: 1.575 ± 0.871
1.772ProAsp: 1.772 ± 0.417
2.461ProGlu: 2.461 ± 0.463
1.969ProPhe: 1.969 ± 0.312
2.658ProGly: 2.658 ± 0.709
0.591ProHis: 0.591 ± 0.378
2.067ProIle: 2.067 ± 0.351
2.953ProLys: 2.953 ± 1.342
4.036ProLeu: 4.036 ± 0.517
0.984ProMet: 0.984 ± 0.483
1.674ProAsn: 1.674 ± 1.093
1.87ProPro: 1.87 ± 0.613
1.87ProGln: 1.87 ± 1.19
1.477ProArg: 1.477 ± 0.622
1.87ProSer: 1.87 ± 0.634
3.642ProThr: 3.642 ± 0.839
3.249ProVal: 3.249 ± 0.742
0.492ProTrp: 0.492 ± 0.244
1.969ProTyr: 1.969 ± 0.397
0.0ProXaa: 0.0 ± 0.0
Gln
2.067GlnAla: 2.067 ± 1.099
0.394GlnCys: 0.394 ± 0.118
1.575GlnAsp: 1.575 ± 0.414
2.56GlnGlu: 2.56 ± 1.243
1.378GlnPhe: 1.378 ± 0.296
2.56GlnGly: 2.56 ± 1.131
0.788GlnHis: 0.788 ± 0.389
1.378GlnIle: 1.378 ± 0.261
2.461GlnLys: 2.461 ± 1.607
3.347GlnLeu: 3.347 ± 0.761
0.788GlnMet: 0.788 ± 0.358
2.264GlnAsn: 2.264 ± 1.501
1.674GlnPro: 1.674 ± 0.249
1.575GlnGln: 1.575 ± 0.371
1.477GlnArg: 1.477 ± 0.353
2.855GlnSer: 2.855 ± 0.9
2.756GlnThr: 2.756 ± 0.41
2.363GlnVal: 2.363 ± 0.492
0.591GlnTrp: 0.591 ± 0.224
1.575GlnTyr: 1.575 ± 0.409
0.0GlnXaa: 0.0 ± 0.0
Arg
3.052ArgAla: 3.052 ± 0.62
1.575ArgCys: 1.575 ± 0.392
1.87ArgAsp: 1.87 ± 0.656
1.477ArgGlu: 1.477 ± 0.773
0.984ArgPhe: 0.984 ± 0.171
2.264ArgGly: 2.264 ± 0.79
1.181ArgHis: 1.181 ± 0.532
1.969ArgIle: 1.969 ± 0.471
1.969ArgLys: 1.969 ± 0.607
4.233ArgLeu: 4.233 ± 0.553
0.492ArgMet: 0.492 ± 0.141
2.166ArgAsn: 2.166 ± 0.518
1.28ArgPro: 1.28 ± 0.56
0.788ArgGln: 0.788 ± 0.288
2.067ArgArg: 2.067 ± 0.418
1.772ArgSer: 1.772 ± 0.974
2.264ArgThr: 2.264 ± 0.738
3.249ArgVal: 3.249 ± 1.031
0.492ArgTrp: 0.492 ± 0.206
1.772ArgTyr: 1.772 ± 0.441
0.0ArgXaa: 0.0 ± 0.0
Ser
5.218SerAla: 5.218 ± 1.016
2.067SerCys: 2.067 ± 0.643
2.953SerAsp: 2.953 ± 1.041
2.855SerGlu: 2.855 ± 0.798
4.43SerPhe: 4.43 ± 0.879
3.642SerGly: 3.642 ± 1.115
1.083SerHis: 1.083 ± 0.408
3.446SerIle: 3.446 ± 0.898
3.15SerLys: 3.15 ± 1.319
5.414SerLeu: 5.414 ± 0.987
1.674SerMet: 1.674 ± 0.383
2.756SerAsn: 2.756 ± 0.912
1.674SerPro: 1.674 ± 0.534
2.756SerGln: 2.756 ± 0.945
2.067SerArg: 2.067 ± 2.051
5.71SerSer: 5.71 ± 1.413
6.005SerThr: 6.005 ± 1.862
6.104SerVal: 6.104 ± 1.166
0.886SerTrp: 0.886 ± 0.327
1.772SerTyr: 1.772 ± 0.379
0.0SerXaa: 0.0 ± 0.0
Thr
4.627ThrAla: 4.627 ± 0.483
2.264ThrCys: 2.264 ± 0.71
3.446ThrAsp: 3.446 ± 0.341
3.642ThrGlu: 3.642 ± 0.533
3.938ThrPhe: 3.938 ± 0.785
4.036ThrGly: 4.036 ± 0.503
1.477ThrHis: 1.477 ± 1.03
4.922ThrIle: 4.922 ± 1.281
4.036ThrLys: 4.036 ± 1.043
5.808ThrLeu: 5.808 ± 0.867
2.658ThrMet: 2.658 ± 0.647
3.544ThrAsn: 3.544 ± 0.651
3.741ThrPro: 3.741 ± 0.666
3.249ThrGln: 3.249 ± 1.155
3.642ThrArg: 3.642 ± 0.532
4.627ThrSer: 4.627 ± 1.162
7.285ThrThr: 7.285 ± 4.419
7.088ThrVal: 7.088 ± 0.786
0.689ThrTrp: 0.689 ± 0.415
1.969ThrTyr: 1.969 ± 0.77
0.0ThrXaa: 0.0 ± 0.0
Val
7.777ValAla: 7.777 ± 1.139
2.56ValCys: 2.56 ± 0.447
6.005ValAsp: 6.005 ± 1.153
4.135ValGlu: 4.135 ± 1.296
4.233ValPhe: 4.233 ± 0.71
3.347ValGly: 3.347 ± 0.601
2.067ValHis: 2.067 ± 0.774
3.642ValIle: 3.642 ± 0.516
4.43ValLys: 4.43 ± 0.774
6.694ValLeu: 6.694 ± 1.333
1.575ValMet: 1.575 ± 0.507
5.021ValAsn: 5.021 ± 0.266
3.642ValPro: 3.642 ± 0.942
2.658ValGln: 2.658 ± 0.435
3.249ValArg: 3.249 ± 0.853
5.414ValSer: 5.414 ± 0.669
7.186ValThr: 7.186 ± 0.522
8.958ValVal: 8.958 ± 1.303
0.984ValTrp: 0.984 ± 0.515
4.922ValTyr: 4.922 ± 1.151
0.0ValXaa: 0.0 ± 0.0
Trp
0.197TrpAla: 0.197 ± 0.103
0.689TrpCys: 0.689 ± 0.361
1.083TrpAsp: 1.083 ± 0.243
0.591TrpGlu: 0.591 ± 0.162
0.591TrpPhe: 0.591 ± 0.225
0.197TrpGly: 0.197 ± 0.103
0.492TrpHis: 0.492 ± 0.596
0.492TrpIle: 0.492 ± 0.217
0.295TrpLys: 0.295 ± 0.115
1.575TrpLeu: 1.575 ± 0.409
0.197TrpMet: 0.197 ± 0.222
0.689TrpAsn: 0.689 ± 0.256
0.394TrpPro: 0.394 ± 0.419
0.197TrpGln: 0.197 ± 0.134
0.295TrpArg: 0.295 ± 0.271
1.083TrpSer: 1.083 ± 0.261
0.689TrpThr: 0.689 ± 0.369
0.591TrpVal: 0.591 ± 0.225
0.098TrpTrp: 0.098 ± 0.052
0.295TrpTyr: 0.295 ± 0.271
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.363TyrAla: 2.363 ± 0.491
1.477TyrCys: 1.477 ± 0.519
2.658TyrAsp: 2.658 ± 0.9
1.575TyrGlu: 1.575 ± 0.247
2.855TyrPhe: 2.855 ± 0.415
2.363TyrGly: 2.363 ± 0.532
0.689TyrHis: 0.689 ± 0.433
1.969TyrIle: 1.969 ± 0.47
2.855TyrLys: 2.855 ± 0.274
3.741TyrLeu: 3.741 ± 1.101
1.181TyrMet: 1.181 ± 0.352
3.446TyrAsn: 3.446 ± 0.51
2.166TyrPro: 2.166 ± 0.403
1.674TyrGln: 1.674 ± 0.457
1.575TyrArg: 1.575 ± 0.407
2.953TyrSer: 2.953 ± 0.564
3.839TyrThr: 3.839 ± 0.808
3.839TyrVal: 3.839 ± 0.634
0.689TyrTrp: 0.689 ± 0.301
2.855TyrTyr: 2.855 ± 0.416
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (10159 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski