Amino acid dipepetide frequency for Roseovarius halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.399AlaAla: 16.399 ± 0.14	1.182AlaCys: 1.182 ± 0.038	6.818AlaAsp: 6.818 ± 0.092	7.89AlaGlu: 7.89 ± 0.092	4.296AlaPhe: 4.296 ± 0.071	10.833AlaGly: 10.833 ± 0.127	2.536AlaHis: 2.536 ± 0.052	5.961AlaIle: 5.961 ± 0.084	3.331AlaLys: 3.331 ± 0.06	14.09AlaLeu: 14.09 ± 0.141	4.001AlaMet: 4.001 ± 0.055	2.534AlaAsn: 2.534 ± 0.054	6.111AlaPro: 6.111 ± 0.101	4.421AlaGln: 4.421 ± 0.063	9.972AlaArg: 9.972 ± 0.122	5.571AlaSer: 5.571 ± 0.076	5.704AlaThr: 5.704 ± 0.082	7.917AlaVal: 7.917 ± 0.093	1.475AlaTrp: 1.475 ± 0.042	2.536AlaTyr: 2.536 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.156CysAla: 1.156 ± 0.037	0.117CysCys: 0.117 ± 0.01	0.661CysAsp: 0.661 ± 0.026	0.504CysGlu: 0.504 ± 0.023	0.369CysPhe: 0.369 ± 0.018	0.967CysGly: 0.967 ± 0.034	0.305CysHis: 0.305 ± 0.02	0.449CysIle: 0.449 ± 0.021	0.217CysLys: 0.217 ± 0.013	0.83CysLeu: 0.83 ± 0.028	0.196CysMet: 0.196 ± 0.013	0.228CysAsn: 0.228 ± 0.014	0.567CysPro: 0.567 ± 0.024	0.246CysGln: 0.246 ± 0.015	0.604CysArg: 0.604 ± 0.024	0.438CysSer: 0.438 ± 0.021	0.463CysThr: 0.463 ± 0.021	0.661CysVal: 0.661 ± 0.028	0.116CysTrp: 0.116 ± 0.011	0.227CysTyr: 0.227 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.442AspAla: 7.442 ± 0.097	0.572AspCys: 0.572 ± 0.025	3.688AspAsp: 3.688 ± 0.078	3.958AspGlu: 3.958 ± 0.07	2.241AspPhe: 2.241 ± 0.043	5.463AspGly: 5.463 ± 0.081	1.474AspHis: 1.474 ± 0.042	3.206AspIle: 3.206 ± 0.041	1.649AspLys: 1.649 ± 0.041	6.33AspLeu: 6.33 ± 0.083	1.893AspMet: 1.893 ± 0.042	1.289AspAsn: 1.289 ± 0.039	3.71AspPro: 3.71 ± 0.063	1.729AspGln: 1.729 ± 0.038	4.223AspArg: 4.223 ± 0.061	2.585AspSer: 2.585 ± 0.052	2.876AspThr: 2.876 ± 0.054	4.165AspVal: 4.165 ± 0.072	1.193AspTrp: 1.193 ± 0.032	1.517AspTyr: 1.517 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.228GluAla: 8.228 ± 0.115	0.406GluCys: 0.406 ± 0.02	3.506GluAsp: 3.506 ± 0.066	3.618GluGlu: 3.618 ± 0.078	1.757GluPhe: 1.757 ± 0.04	5.188GluGly: 5.188 ± 0.072	1.189GluHis: 1.189 ± 0.035	3.739GluIle: 3.739 ± 0.063	2.193GluLys: 2.193 ± 0.056	5.197GluLeu: 5.197 ± 0.082	1.932GluMet: 1.932 ± 0.04	1.767GluAsn: 1.767 ± 0.046	2.677GluPro: 2.677 ± 0.063	2.005GluGln: 2.005 ± 0.048	4.777GluArg: 4.777 ± 0.072	2.773GluSer: 2.773 ± 0.057	3.984GluThr: 3.984 ± 0.065	4.187GluVal: 4.187 ± 0.065	0.766GluTrp: 0.766 ± 0.028	1.086GluTyr: 1.086 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.332PheAla: 4.332 ± 0.069	0.442PheCys: 0.442 ± 0.021	2.807PheAsp: 2.807 ± 0.052	2.187PheGlu: 2.187 ± 0.042	1.412PhePhe: 1.412 ± 0.041	3.635PheGly: 3.635 ± 0.072	0.794PheHis: 0.794 ± 0.023	1.745PheIle: 1.745 ± 0.042	0.866PheLys: 0.866 ± 0.03	3.449PheLeu: 3.449 ± 0.068	0.932PheMet: 0.932 ± 0.031	0.986PheAsn: 0.986 ± 0.03	1.485PhePro: 1.485 ± 0.033	0.985PheGln: 0.985 ± 0.027	2.218PheArg: 2.218 ± 0.046	2.049PheSer: 2.049 ± 0.043	1.968PheThr: 1.968 ± 0.043	2.637PheVal: 2.637 ± 0.056	0.579PheTrp: 0.579 ± 0.026	0.935PheTyr: 0.935 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.399GlyAla: 10.399 ± 0.132	0.898GlyCys: 0.898 ± 0.029	5.004GlyAsp: 5.004 ± 0.09	5.074GlyGlu: 5.074 ± 0.074	3.776GlyPhe: 3.776 ± 0.059	7.504GlyGly: 7.504 ± 0.12	2.033GlyHis: 2.033 ± 0.05	4.548GlyIle: 4.548 ± 0.071	3.033GlyLys: 3.033 ± 0.061	9.445GlyLeu: 9.445 ± 0.098	2.755GlyMet: 2.755 ± 0.056	1.991GlyAsn: 1.991 ± 0.048	3.671GlyPro: 3.671 ± 0.064	3.145GlyGln: 3.145 ± 0.067	6.063GlyArg: 6.063 ± 0.079	4.145GlySer: 4.145 ± 0.066	4.453GlyThr: 4.453 ± 0.074	6.486GlyVal: 6.486 ± 0.083	1.511GlyTrp: 1.511 ± 0.038	2.323GlyTyr: 2.323 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.448HisAla: 2.448 ± 0.045	0.235HisCys: 0.235 ± 0.016	1.474HisAsp: 1.474 ± 0.042	1.238HisGlu: 1.238 ± 0.038	0.876HisPhe: 0.876 ± 0.026	1.994HisGly: 1.994 ± 0.042	0.602HisHis: 0.602 ± 0.035	0.945HisIle: 0.945 ± 0.031	0.501HisLys: 0.501 ± 0.021	2.141HisLeu: 2.141 ± 0.049	0.576HisMet: 0.576 ± 0.026	0.447HisAsn: 0.447 ± 0.02	1.404HisPro: 1.404 ± 0.034	0.59HisGln: 0.59 ± 0.024	1.386HisArg: 1.386 ± 0.035	0.978HisSer: 0.978 ± 0.03	0.75HisThr: 0.75 ± 0.026	1.682HisVal: 1.682 ± 0.039	0.379HisTrp: 0.379 ± 0.014	0.575HisTyr: 0.575 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.074IleAla: 7.074 ± 0.084	0.637IleCys: 0.637 ± 0.023	3.489IleAsp: 3.489 ± 0.055	3.791IleGlu: 3.791 ± 0.061	1.792IlePhe: 1.792 ± 0.042	4.942IleGly: 4.942 ± 0.077	0.928IleHis: 0.928 ± 0.03	2.186IleIle: 2.186 ± 0.049	1.367IleLys: 1.367 ± 0.033	4.962IleLeu: 4.962 ± 0.079	1.228IleMet: 1.228 ± 0.034	1.307IleAsn: 1.307 ± 0.037	2.315IlePro: 2.315 ± 0.048	1.099IleGln: 1.099 ± 0.034	3.365IleArg: 3.365 ± 0.06	2.909IleSer: 2.909 ± 0.048	2.788IleThr: 2.788 ± 0.052	3.748IleVal: 3.748 ± 0.069	0.731IleTrp: 0.731 ± 0.024	1.179IleTyr: 1.179 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.77LysAla: 3.77 ± 0.062	0.195LysCys: 0.195 ± 0.012	1.629LysAsp: 1.629 ± 0.041	1.46LysGlu: 1.46 ± 0.043	0.8LysPhe: 0.8 ± 0.026	2.624LysGly: 2.624 ± 0.057	0.6LysHis: 0.6 ± 0.023	1.49LysIle: 1.49 ± 0.044	1.078LysLys: 1.078 ± 0.042	2.785LysLeu: 2.785 ± 0.055	0.819LysMet: 0.819 ± 0.03	0.677LysAsn: 0.677 ± 0.026	1.764LysPro: 1.764 ± 0.038	0.867LysGln: 0.867 ± 0.033	2.307LysArg: 2.307 ± 0.044	1.723LysSer: 1.723 ± 0.04	1.813LysThr: 1.813 ± 0.041	2.146LysVal: 2.146 ± 0.05	0.357LysTrp: 0.357 ± 0.019	0.558LysTyr: 0.558 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.94LeuAla: 12.94 ± 0.122	0.99LeuCys: 0.99 ± 0.032	6.215LeuAsp: 6.215 ± 0.083	5.874LeuGlu: 5.874 ± 0.088	3.535LeuPhe: 3.535 ± 0.066	8.799LeuGly: 8.799 ± 0.104	1.95LeuHis: 1.95 ± 0.046	5.213LeuIle: 5.213 ± 0.076	3.075LeuLys: 3.075 ± 0.056	9.233LeuLeu: 9.233 ± 0.136	2.78LeuMet: 2.78 ± 0.049	2.6LeuAsn: 2.6 ± 0.045	5.445LeuPro: 5.445 ± 0.073	2.629LeuGln: 2.629 ± 0.043	7.428LeuArg: 7.428 ± 0.094	6.69LeuSer: 6.69 ± 0.081	5.535LeuThr: 5.535 ± 0.061	6.966LeuVal: 6.966 ± 0.089	1.338LeuTrp: 1.338 ± 0.036	1.979LeuTyr: 1.979 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.508MetAla: 3.508 ± 0.057	0.227MetCys: 0.227 ± 0.014	1.447MetAsp: 1.447 ± 0.036	1.437MetGlu: 1.437 ± 0.039	0.842MetPhe: 0.842 ± 0.031	2.401MetGly: 2.401 ± 0.046	0.494MetHis: 0.494 ± 0.022	1.624MetIle: 1.624 ± 0.038	1.106MetLys: 1.106 ± 0.029	2.768MetLeu: 2.768 ± 0.045	0.857MetMet: 0.857 ± 0.034	0.887MetAsn: 0.887 ± 0.029	1.594MetPro: 1.594 ± 0.037	1.056MetGln: 1.056 ± 0.03	2.109MetArg: 2.109 ± 0.05	1.913MetSer: 1.913 ± 0.046	2.117MetThr: 2.117 ± 0.04	1.926MetVal: 1.926 ± 0.038	0.265MetTrp: 0.265 ± 0.017	0.364MetTyr: 0.364 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.065AsnAla: 3.065 ± 0.053	0.239AsnCys: 0.239 ± 0.014	1.378AsnAsp: 1.378 ± 0.041	1.247AsnGlu: 1.247 ± 0.035	0.882AsnPhe: 0.882 ± 0.028	2.256AsnGly: 2.256 ± 0.056	0.509AsnHis: 0.509 ± 0.021	1.298AsnIle: 1.298 ± 0.034	0.611AsnLys: 0.611 ± 0.023	2.398AsnLeu: 2.398 ± 0.048	0.705AsnMet: 0.705 ± 0.024	0.625AsnAsn: 0.625 ± 0.027	1.785AsnPro: 1.785 ± 0.039	0.681AsnGln: 0.681 ± 0.028	1.76AsnArg: 1.76 ± 0.045	1.12AsnSer: 1.12 ± 0.035	1.245AsnThr: 1.245 ± 0.037	1.748AsnVal: 1.748 ± 0.041	0.392AsnTrp: 0.392 ± 0.019	0.572AsnTyr: 0.572 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.779ProAla: 5.779 ± 0.086	0.377ProCys: 0.377 ± 0.017	4.192ProAsp: 4.192 ± 0.077	4.502ProGlu: 4.502 ± 0.075	1.92ProPhe: 1.92 ± 0.045	4.891ProGly: 4.891 ± 0.071	1.098ProHis: 1.098 ± 0.032	2.092ProIle: 2.092 ± 0.043	1.413ProLys: 1.413 ± 0.038	4.708ProLeu: 4.708 ± 0.068	1.306ProMet: 1.306 ± 0.034	1.145ProAsn: 1.145 ± 0.032	2.357ProPro: 2.357 ± 0.058	1.537ProGln: 1.537 ± 0.033	3.056ProArg: 3.056 ± 0.056	2.328ProSer: 2.328 ± 0.046	2.24ProThr: 2.24 ± 0.04	4.371ProVal: 4.371 ± 0.066	0.66ProTrp: 0.66 ± 0.026	1.138ProTyr: 1.138 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.957GlnAla: 3.957 ± 0.067	0.207GlnCys: 0.207 ± 0.016	1.684GlnAsp: 1.684 ± 0.038	1.649GlnGlu: 1.649 ± 0.043	1.039GlnPhe: 1.039 ± 0.03	2.658GlnGly: 2.658 ± 0.055	0.57GlnHis: 0.57 ± 0.023	1.882GlnIle: 1.882 ± 0.043	1.037GlnLys: 1.037 ± 0.034	2.693GlnLeu: 2.693 ± 0.05	1.049GlnMet: 1.049 ± 0.031	0.845GlnAsn: 0.845 ± 0.03	1.595GlnPro: 1.595 ± 0.035	1.102GlnGln: 1.102 ± 0.038	2.205GlnArg: 2.205 ± 0.05	1.819GlnSer: 1.819 ± 0.049	1.631GlnThr: 1.631 ± 0.037	2.23GlnVal: 2.23 ± 0.046	0.413GlnTrp: 0.413 ± 0.019	0.573GlnTyr: 0.573 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.943ArgAla: 8.943 ± 0.115	0.542ArgCys: 0.542 ± 0.021	4.753ArgAsp: 4.753 ± 0.075	4.211ArgGlu: 4.211 ± 0.072	2.78ArgPhe: 2.78 ± 0.051	4.851ArgGly: 4.851 ± 0.062	1.722ArgHis: 1.722 ± 0.042	4.214ArgIle: 4.214 ± 0.064	2.351ArgLys: 2.351 ± 0.045	7.732ArgLeu: 7.732 ± 0.101	2.056ArgMet: 2.056 ± 0.046	1.895ArgAsn: 1.895 ± 0.048	3.444ArgPro: 3.444 ± 0.057	2.392ArgGln: 2.392 ± 0.051	5.588ArgArg: 5.588 ± 0.085	3.317ArgSer: 3.317 ± 0.059	2.911ArgThr: 2.911 ± 0.054	4.814ArgVal: 4.814 ± 0.072	0.928ArgTrp: 0.928 ± 0.03	1.584ArgTyr: 1.584 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.019SerAla: 6.019 ± 0.073	0.499SerCys: 0.499 ± 0.026	3.408SerAsp: 3.408 ± 0.056	3.114SerGlu: 3.114 ± 0.061	2.122SerPhe: 2.122 ± 0.047	5.464SerGly: 5.464 ± 0.072	1.087SerHis: 1.087 ± 0.032	2.455SerIle: 2.455 ± 0.048	1.375SerLys: 1.375 ± 0.037	5.091SerLeu: 5.091 ± 0.08	1.408SerMet: 1.408 ± 0.036	1.26SerAsn: 1.26 ± 0.035	2.562SerPro: 2.562 ± 0.047	1.633SerGln: 1.633 ± 0.041	3.368SerArg: 3.368 ± 0.059	2.488SerSer: 2.488 ± 0.055	2.346SerThr: 2.346 ± 0.047	3.733SerVal: 3.733 ± 0.065	0.698SerTrp: 0.698 ± 0.027	1.305SerTyr: 1.305 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.671ThrAla: 5.671 ± 0.066	0.508ThrCys: 0.508 ± 0.023	2.796ThrAsp: 2.796 ± 0.056	2.801ThrGlu: 2.801 ± 0.052	1.829ThrPhe: 1.829 ± 0.046	5.428ThrGly: 5.428 ± 0.077	1.07ThrHis: 1.07 ± 0.032	2.751ThrIle: 2.751 ± 0.05	1.248ThrLys: 1.248 ± 0.031	5.893ThrLeu: 5.893 ± 0.077	1.322ThrMet: 1.322 ± 0.037	1.184ThrAsn: 1.184 ± 0.034	3.305ThrPro: 3.305 ± 0.052	1.474ThrGln: 1.474 ± 0.035	3.668ThrArg: 3.668 ± 0.061	2.479ThrSer: 2.479 ± 0.052	2.582ThrThr: 2.582 ± 0.052	3.82ThrVal: 3.82 ± 0.065	0.686ThrTrp: 0.686 ± 0.025	1.179ThrTyr: 1.179 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.587ValAla: 8.587 ± 0.093	0.653ValCys: 0.653 ± 0.027	3.929ValAsp: 3.929 ± 0.064	4.408ValGlu: 4.408 ± 0.064	2.732ValPhe: 2.732 ± 0.054	5.212ValGly: 5.212 ± 0.078	1.351ValHis: 1.351 ± 0.036	4.385ValIle: 4.385 ± 0.065	2.029ValLys: 2.029 ± 0.049	7.567ValLeu: 7.567 ± 0.102	2.216ValMet: 2.216 ± 0.044	1.884ValAsn: 1.884 ± 0.041	3.49ValPro: 3.49 ± 0.058	1.982ValGln: 1.982 ± 0.04	4.155ValArg: 4.155 ± 0.07	4.184ValSer: 4.184 ± 0.071	4.52ValThr: 4.52 ± 0.067	5.428ValVal: 5.428 ± 0.088	0.909ValTrp: 0.909 ± 0.03	1.434ValTyr: 1.434 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.409TrpAla: 1.409 ± 0.037	0.143TrpCys: 0.143 ± 0.012	0.755TrpAsp: 0.755 ± 0.027	0.663TrpGlu: 0.663 ± 0.023	0.578TrpPhe: 0.578 ± 0.022	1.028TrpGly: 1.028 ± 0.032	0.36TrpHis: 0.36 ± 0.018	0.729TrpIle: 0.729 ± 0.026	0.451TrpLys: 0.451 ± 0.021	1.68TrpLeu: 1.68 ± 0.039	0.419TrpMet: 0.419 ± 0.017	0.418TrpAsn: 0.418 ± 0.019	0.741TrpPro: 0.741 ± 0.028	0.597TrpGln: 0.597 ± 0.025	1.128TrpArg: 1.128 ± 0.033	0.795TrpSer: 0.795 ± 0.025	0.693TrpThr: 0.693 ± 0.028	0.9TrpVal: 0.9 ± 0.03	0.224TrpTrp: 0.224 ± 0.015	0.258TrpTyr: 0.258 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.452TyrAla: 2.452 ± 0.048	0.255TyrCys: 0.255 ± 0.015	1.569TyrAsp: 1.569 ± 0.039	1.349TyrGlu: 1.349 ± 0.036	0.862TyrPhe: 0.862 ± 0.027	2.12TyrGly: 2.12 ± 0.046	0.549TyrHis: 0.549 ± 0.021	0.922TyrIle: 0.922 ± 0.031	0.532TyrLys: 0.532 ± 0.022	2.223TyrLeu: 2.223 ± 0.044	0.493TyrMet: 0.493 ± 0.022	0.547TyrAsn: 0.547 ± 0.023	1.088TyrPro: 1.088 ± 0.028	0.668TyrGln: 0.668 ± 0.025	1.648TyrArg: 1.648 ± 0.037	1.132TyrSer: 1.132 ± 0.032	1.074TyrThr: 1.074 ± 0.03	1.49TyrVal: 1.49 ± 0.037	0.351TyrTrp: 0.351 ± 0.019	0.583TyrTyr: 0.583 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3635 proteins (1122804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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