Amino acid dipepetide frequency for Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.097AlaAla: 5.097 ± 0.886
0.91AlaCys: 0.91 ± 0.266
2.367AlaAsp: 2.367 ± 0.776
4.369AlaGlu: 4.369 ± 0.988
4.551AlaPhe: 4.551 ± 1.209
3.823AlaGly: 3.823 ± 1.565
0.728AlaHis: 0.728 ± 0.293
3.095AlaIle: 3.095 ± 0.662
3.823AlaLys: 3.823 ± 0.521
4.733AlaLeu: 4.733 ± 1.037
1.274AlaMet: 1.274 ± 0.514
1.092AlaAsn: 1.092 ± 0.318
3.277AlaPro: 3.277 ± 1.071
1.456AlaGln: 1.456 ± 0.557
3.277AlaArg: 3.277 ± 0.871
5.826AlaSer: 5.826 ± 0.718
6.918AlaThr: 6.918 ± 1.647
3.823AlaVal: 3.823 ± 0.703
0.728AlaTrp: 0.728 ± 0.279
0.546AlaTyr: 0.546 ± 0.232
0.0AlaXaa: 0.0 ± 0.0
Cys
1.274CysAla: 1.274 ± 0.604
0.364CysCys: 0.364 ± 0.191
0.91CysAsp: 0.91 ± 0.322
1.092CysGlu: 1.092 ± 0.496
0.182CysPhe: 0.182 ± 0.113
0.91CysGly: 0.91 ± 0.3
0.364CysHis: 0.364 ± 0.292
0.546CysIle: 0.546 ± 0.374
1.456CysLys: 1.456 ± 0.425
1.456CysLeu: 1.456 ± 0.487
0.182CysMet: 0.182 ± 0.113
1.274CysAsn: 1.274 ± 0.386
0.728CysPro: 0.728 ± 0.333
0.546CysGln: 0.546 ± 0.232
1.82CysArg: 1.82 ± 0.724
0.728CysSer: 0.728 ± 0.333
0.728CysThr: 0.728 ± 0.345
0.546CysVal: 0.546 ± 0.23
0.182CysTrp: 0.182 ± 0.113
1.092CysTyr: 1.092 ± 0.343
0.0CysXaa: 0.0 ± 0.0
Asp
2.367AspAla: 2.367 ± 0.638
0.91AspCys: 0.91 ± 0.327
4.187AspAsp: 4.187 ± 2.338
2.913AspGlu: 2.913 ± 0.813
3.277AspPhe: 3.277 ± 0.753
3.641AspGly: 3.641 ± 0.724
2.549AspHis: 2.549 ± 0.699
2.549AspIle: 2.549 ± 1.001
2.003AspLys: 2.003 ± 0.912
4.369AspLeu: 4.369 ± 1.278
0.546AspMet: 0.546 ± 0.236
3.459AspAsn: 3.459 ± 0.681
3.095AspPro: 3.095 ± 0.42
2.185AspGln: 2.185 ± 0.503
3.095AspArg: 3.095 ± 0.689
3.823AspSer: 3.823 ± 0.797
2.367AspThr: 2.367 ± 0.987
2.003AspVal: 2.003 ± 0.562
0.546AspTrp: 0.546 ± 0.287
1.456AspTyr: 1.456 ± 0.587
0.0AspXaa: 0.0 ± 0.0
Glu
5.097GluAla: 5.097 ± 1.184
0.546GluCys: 0.546 ± 0.364
2.367GluAsp: 2.367 ± 0.308
3.459GluGlu: 3.459 ± 1.819
1.82GluPhe: 1.82 ± 0.627
5.097GluGly: 5.097 ± 1.011
1.092GluHis: 1.092 ± 0.377
3.641GluIle: 3.641 ± 0.734
2.731GluLys: 2.731 ± 0.881
3.459GluLeu: 3.459 ± 0.565
1.092GluMet: 1.092 ± 0.342
3.095GluAsn: 3.095 ± 0.625
2.549GluPro: 2.549 ± 0.664
3.095GluGln: 3.095 ± 0.578
2.003GluArg: 2.003 ± 0.754
4.005GluSer: 4.005 ± 0.888
4.369GluThr: 4.369 ± 0.741
2.185GluVal: 2.185 ± 0.314
1.456GluTrp: 1.456 ± 0.604
2.185GluTyr: 2.185 ± 0.601
0.0GluXaa: 0.0 ± 0.0
Phe
2.185PheAla: 2.185 ± 0.798
0.728PheCys: 0.728 ± 0.301
2.185PheAsp: 2.185 ± 0.686
2.185PheGlu: 2.185 ± 0.43
3.095PhePhe: 3.095 ± 0.84
2.185PheGly: 2.185 ± 0.469
2.185PheHis: 2.185 ± 0.25
1.456PheIle: 1.456 ± 0.536
2.913PheLys: 2.913 ± 0.765
8.92PheLeu: 8.92 ± 0.876
0.546PheMet: 0.546 ± 0.194
1.274PheAsn: 1.274 ± 0.492
2.185PhePro: 2.185 ± 0.383
2.913PheGln: 2.913 ± 0.515
1.274PheArg: 1.274 ± 0.337
4.005PheSer: 4.005 ± 0.628
1.82PheThr: 1.82 ± 0.399
2.003PheVal: 2.003 ± 0.605
1.092PheTrp: 1.092 ± 0.29
0.728PheTyr: 0.728 ± 0.293
0.0PheXaa: 0.0 ± 0.0
Gly
2.549GlyAla: 2.549 ± 0.437
0.0GlyCys: 0.0 ± 0.0
2.731GlyAsp: 2.731 ± 0.465
2.913GlyGlu: 2.913 ± 0.72
3.641GlyPhe: 3.641 ± 0.75
2.185GlyGly: 2.185 ± 0.54
2.185GlyHis: 2.185 ± 0.738
3.459GlyIle: 3.459 ± 0.885
4.187GlyLys: 4.187 ± 1.164
6.19GlyLeu: 6.19 ± 0.878
0.91GlyMet: 0.91 ± 0.327
2.367GlyAsn: 2.367 ± 0.69
3.641GlyPro: 3.641 ± 1.047
2.185GlyGln: 2.185 ± 0.537
2.367GlyArg: 2.367 ± 0.577
3.277GlySer: 3.277 ± 0.517
4.551GlyThr: 4.551 ± 0.805
5.097GlyVal: 5.097 ± 2.127
0.91GlyTrp: 0.91 ± 0.456
1.456GlyTyr: 1.456 ± 0.424
0.0GlyXaa: 0.0 ± 0.0
His
2.003HisAla: 2.003 ± 0.51
0.182HisCys: 0.182 ± 0.113
1.456HisAsp: 1.456 ± 0.374
0.364HisGlu: 0.364 ± 0.224
1.092HisPhe: 1.092 ± 0.469
0.91HisGly: 0.91 ± 0.728
1.638HisHis: 1.638 ± 0.472
2.367HisIle: 2.367 ± 0.627
2.367HisLys: 2.367 ± 0.855
2.913HisLeu: 2.913 ± 0.929
0.728HisMet: 0.728 ± 0.53
2.003HisAsn: 2.003 ± 0.578
1.638HisPro: 1.638 ± 0.441
2.185HisGln: 2.185 ± 0.541
1.82HisArg: 1.82 ± 0.663
2.003HisSer: 2.003 ± 0.472
1.638HisThr: 1.638 ± 0.394
0.728HisVal: 0.728 ± 0.311
0.364HisTrp: 0.364 ± 0.195
1.092HisTyr: 1.092 ± 0.354
0.0HisXaa: 0.0 ± 0.0
Ile
2.185IleAla: 2.185 ± 0.628
1.092IleCys: 1.092 ± 0.674
2.731IleAsp: 2.731 ± 0.552
4.551IleGlu: 4.551 ± 1.093
1.82IlePhe: 1.82 ± 0.631
2.731IleGly: 2.731 ± 0.633
1.638IleHis: 1.638 ± 0.706
3.641IleIle: 3.641 ± 0.644
3.095IleLys: 3.095 ± 0.821
6.736IleLeu: 6.736 ± 0.792
2.003IleMet: 2.003 ± 0.814
1.456IleAsn: 1.456 ± 0.49
3.459IlePro: 3.459 ± 0.797
2.731IleGln: 2.731 ± 0.625
3.277IleArg: 3.277 ± 0.626
5.097IleSer: 5.097 ± 1.128
4.733IleThr: 4.733 ± 0.917
3.459IleVal: 3.459 ± 1.418
0.91IleTrp: 0.91 ± 0.466
2.185IleTyr: 2.185 ± 0.6
0.0IleXaa: 0.0 ± 0.0
Lys
2.003LysAla: 2.003 ± 0.515
0.91LysCys: 0.91 ± 0.3
2.367LysAsp: 2.367 ± 0.713
2.731LysGlu: 2.731 ± 0.526
2.549LysPhe: 2.549 ± 0.55
2.185LysGly: 2.185 ± 0.553
1.456LysHis: 1.456 ± 0.721
4.551LysIle: 4.551 ± 0.631
4.551LysLys: 4.551 ± 1.224
6.372LysLeu: 6.372 ± 0.653
0.546LysMet: 0.546 ± 0.297
2.549LysAsn: 2.549 ± 0.78
3.459LysPro: 3.459 ± 0.646
1.092LysGln: 1.092 ± 0.39
3.823LysArg: 3.823 ± 0.739
1.638LysSer: 1.638 ± 0.576
3.641LysThr: 3.641 ± 0.91
3.459LysVal: 3.459 ± 0.838
0.182LysTrp: 0.182 ± 0.113
2.185LysTyr: 2.185 ± 0.808
0.0LysXaa: 0.0 ± 0.0
Leu
7.282LeuAla: 7.282 ± 1.109
2.003LeuCys: 2.003 ± 0.615
3.823LeuAsp: 3.823 ± 0.763
6.918LeuGlu: 6.918 ± 0.935
4.369LeuPhe: 4.369 ± 0.662
4.551LeuGly: 4.551 ± 0.472
2.549LeuHis: 2.549 ± 0.766
7.828LeuIle: 7.828 ± 1.17
4.733LeuLys: 4.733 ± 1.597
7.1LeuLeu: 7.1 ± 1.222
1.274LeuMet: 1.274 ± 0.539
4.733LeuAsn: 4.733 ± 0.834
7.464LeuPro: 7.464 ± 1.585
5.644LeuGln: 5.644 ± 1.186
6.736LeuArg: 6.736 ± 0.79
7.1LeuSer: 7.1 ± 1.67
8.01LeuThr: 8.01 ± 1.178
4.005LeuVal: 4.005 ± 0.495
2.003LeuTrp: 2.003 ± 0.482
2.731LeuTyr: 2.731 ± 0.654
0.0LeuXaa: 0.0 ± 0.0
Met
1.638MetAla: 1.638 ± 0.421
0.182MetCys: 0.182 ± 0.113
0.91MetAsp: 0.91 ± 0.339
0.364MetGlu: 0.364 ± 0.319
0.364MetPhe: 0.364 ± 0.195
1.274MetGly: 1.274 ± 0.37
1.092MetHis: 1.092 ± 0.354
0.546MetIle: 0.546 ± 0.339
0.546MetLys: 0.546 ± 0.35
1.456MetLeu: 1.456 ± 0.405
0.546MetMet: 0.546 ± 0.298
0.91MetAsn: 0.91 ± 0.689
0.546MetPro: 0.546 ± 0.232
0.91MetGln: 0.91 ± 0.312
0.728MetArg: 0.728 ± 0.307
1.092MetSer: 1.092 ± 0.677
1.638MetThr: 1.638 ± 0.593
1.638MetVal: 1.638 ± 0.587
0.0MetTrp: 0.0 ± 0.0
0.364MetTyr: 0.364 ± 0.289
0.0MetXaa: 0.0 ± 0.0
Asn
1.82AsnAla: 1.82 ± 0.438
1.274AsnCys: 1.274 ± 0.345
2.185AsnAsp: 2.185 ± 0.446
2.913AsnGlu: 2.913 ± 0.921
2.185AsnPhe: 2.185 ± 0.675
2.367AsnGly: 2.367 ± 0.693
1.274AsnHis: 1.274 ± 0.414
2.549AsnIle: 2.549 ± 0.418
0.91AsnLys: 0.91 ± 0.303
4.915AsnLeu: 4.915 ± 0.784
0.546AsnMet: 0.546 ± 0.42
2.185AsnAsn: 2.185 ± 0.504
4.369AsnPro: 4.369 ± 0.618
1.638AsnGln: 1.638 ± 0.298
2.913AsnArg: 2.913 ± 0.607
4.551AsnSer: 4.551 ± 0.586
3.823AsnThr: 3.823 ± 1.112
2.185AsnVal: 2.185 ± 0.849
0.364AsnTrp: 0.364 ± 0.191
1.092AsnTyr: 1.092 ± 0.404
0.0AsnXaa: 0.0 ± 0.0
Pro
3.095ProAla: 3.095 ± 1.107
1.092ProCys: 1.092 ± 0.297
3.459ProAsp: 3.459 ± 1.03
2.367ProGlu: 2.367 ± 0.874
1.638ProPhe: 1.638 ± 0.611
3.459ProGly: 3.459 ± 1.146
2.549ProHis: 2.549 ± 0.924
2.913ProIle: 2.913 ± 1.146
4.005ProLys: 4.005 ± 0.911
5.826ProLeu: 5.826 ± 1.058
0.364ProMet: 0.364 ± 0.193
1.456ProAsn: 1.456 ± 0.26
3.459ProPro: 3.459 ± 0.893
4.187ProGln: 4.187 ± 0.5
2.003ProArg: 2.003 ± 0.692
4.005ProSer: 4.005 ± 0.488
2.731ProThr: 2.731 ± 1.067
5.097ProVal: 5.097 ± 0.952
0.182ProTrp: 0.182 ± 0.169
0.91ProTyr: 0.91 ± 0.424
0.0ProXaa: 0.0 ± 0.0
Gln
3.459GlnAla: 3.459 ± 0.51
1.274GlnCys: 1.274 ± 0.49
4.005GlnAsp: 4.005 ± 1.081
2.367GlnGlu: 2.367 ± 0.617
1.638GlnPhe: 1.638 ± 0.286
3.459GlnGly: 3.459 ± 0.723
1.092GlnHis: 1.092 ± 0.318
2.731GlnIle: 2.731 ± 0.949
2.731GlnLys: 2.731 ± 0.699
7.1GlnLeu: 7.1 ± 1.63
1.092GlnMet: 1.092 ± 0.354
1.456GlnAsn: 1.456 ± 0.404
1.092GlnPro: 1.092 ± 0.468
3.459GlnGln: 3.459 ± 1.334
2.367GlnArg: 2.367 ± 0.33
3.459GlnSer: 3.459 ± 0.722
2.549GlnThr: 2.549 ± 0.956
2.367GlnVal: 2.367 ± 0.443
0.546GlnTrp: 0.546 ± 0.356
2.185GlnTyr: 2.185 ± 0.739
0.0GlnXaa: 0.0 ± 0.0
Arg
2.185ArgAla: 2.185 ± 0.661
0.91ArgCys: 0.91 ± 0.274
2.913ArgAsp: 2.913 ± 0.566
3.641ArgGlu: 3.641 ± 0.541
2.913ArgPhe: 2.913 ± 0.504
3.823ArgGly: 3.823 ± 0.879
0.728ArgHis: 0.728 ± 0.293
1.638ArgIle: 1.638 ± 0.541
1.638ArgLys: 1.638 ± 0.431
5.279ArgLeu: 5.279 ± 1.084
1.638ArgMet: 1.638 ± 0.496
2.549ArgAsn: 2.549 ± 0.728
1.638ArgPro: 1.638 ± 0.761
2.549ArgGln: 2.549 ± 0.783
1.638ArgArg: 1.638 ± 0.495
5.279ArgSer: 5.279 ± 0.551
5.826ArgThr: 5.826 ± 0.722
2.367ArgVal: 2.367 ± 0.759
0.91ArgTrp: 0.91 ± 0.407
2.003ArgTyr: 2.003 ± 0.57
0.0ArgXaa: 0.0 ± 0.0
Ser
5.461SerAla: 5.461 ± 0.489
0.546SerCys: 0.546 ± 0.274
5.461SerAsp: 5.461 ± 0.855
3.095SerGlu: 3.095 ± 0.853
4.733SerPhe: 4.733 ± 0.583
6.372SerGly: 6.372 ± 0.971
1.638SerHis: 1.638 ± 0.361
3.641SerIle: 3.641 ± 1.411
2.185SerLys: 2.185 ± 0.747
7.282SerLeu: 7.282 ± 1.759
0.728SerMet: 0.728 ± 0.373
4.005SerAsn: 4.005 ± 0.781
2.367SerPro: 2.367 ± 0.742
3.095SerGln: 3.095 ± 0.505
4.187SerArg: 4.187 ± 0.832
7.646SerSer: 7.646 ± 0.86
7.1SerThr: 7.1 ± 1.114
4.005SerVal: 4.005 ± 0.62
1.092SerTrp: 1.092 ± 0.432
2.003SerTyr: 2.003 ± 0.618
0.0SerXaa: 0.0 ± 0.0
Thr
5.644ThrAla: 5.644 ± 0.974
1.456ThrCys: 1.456 ± 0.434
2.913ThrAsp: 2.913 ± 0.491
4.915ThrGlu: 4.915 ± 0.792
2.367ThrPhe: 2.367 ± 0.579
4.915ThrGly: 4.915 ± 1.729
1.456ThrHis: 1.456 ± 0.429
5.644ThrIle: 5.644 ± 0.93
3.823ThrLys: 3.823 ± 0.917
7.1ThrLeu: 7.1 ± 1.266
0.546ThrMet: 0.546 ± 0.282
4.005ThrAsn: 4.005 ± 1.08
3.641ThrPro: 3.641 ± 0.751
4.733ThrGln: 4.733 ± 0.579
3.823ThrArg: 3.823 ± 1.198
5.826ThrSer: 5.826 ± 0.95
7.464ThrThr: 7.464 ± 2.447
3.095ThrVal: 3.095 ± 0.558
0.91ThrTrp: 0.91 ± 0.45
1.82ThrTyr: 1.82 ± 0.306
0.0ThrXaa: 0.0 ± 0.0
Val
3.277ValAla: 3.277 ± 0.8
1.456ValCys: 1.456 ± 0.47
2.185ValAsp: 2.185 ± 0.632
1.638ValGlu: 1.638 ± 0.542
2.185ValPhe: 2.185 ± 0.633
1.456ValGly: 1.456 ± 0.468
2.003ValHis: 2.003 ± 0.289
4.733ValIle: 4.733 ± 1.298
2.731ValLys: 2.731 ± 0.761
4.551ValLeu: 4.551 ± 1.566
1.274ValMet: 1.274 ± 0.342
4.005ValAsn: 4.005 ± 1.133
4.187ValPro: 4.187 ± 0.839
2.913ValGln: 2.913 ± 0.534
2.185ValArg: 2.185 ± 0.83
4.369ValSer: 4.369 ± 0.55
3.277ValThr: 3.277 ± 0.616
3.641ValVal: 3.641 ± 1.264
0.0ValTrp: 0.0 ± 0.0
1.82ValTyr: 1.82 ± 0.31
0.0ValXaa: 0.0 ± 0.0
Trp
2.003TrpAla: 2.003 ± 0.851
0.0TrpCys: 0.0 ± 0.0
0.364TrpAsp: 0.364 ± 0.195
1.092TrpGlu: 1.092 ± 0.29
0.728TrpPhe: 0.728 ± 0.345
0.91TrpGly: 0.91 ± 0.407
0.182TrpHis: 0.182 ± 0.113
0.91TrpIle: 0.91 ± 0.406
0.91TrpLys: 0.91 ± 0.363
1.456TrpLeu: 1.456 ± 0.381
0.364TrpMet: 0.364 ± 0.149
0.0TrpAsn: 0.0 ± 0.0
0.364TrpPro: 0.364 ± 0.149
0.546TrpGln: 0.546 ± 0.24
0.364TrpArg: 0.364 ± 0.191
0.546TrpSer: 0.546 ± 0.282
1.092TrpThr: 1.092 ± 0.55
0.91TrpVal: 0.91 ± 0.397
0.182TrpTrp: 0.182 ± 0.199
0.728TrpTyr: 0.728 ± 0.451
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.092TyrAla: 1.092 ± 0.324
0.546TyrCys: 0.546 ± 0.339
1.82TyrAsp: 1.82 ± 0.653
1.456TyrGlu: 1.456 ± 0.331
0.728TyrPhe: 0.728 ± 0.273
0.546TyrGly: 0.546 ± 0.204
1.274TyrHis: 1.274 ± 0.492
1.092TyrIle: 1.092 ± 0.406
0.91TyrLys: 0.91 ± 0.266
3.641TyrLeu: 3.641 ± 1.499
0.364TyrMet: 0.364 ± 0.238
2.185TyrAsn: 2.185 ± 0.684
1.638TyrPro: 1.638 ± 0.516
2.367TyrGln: 2.367 ± 0.631
2.367TyrArg: 2.367 ± 0.427
2.367TyrSer: 2.367 ± 0.57
1.82TyrThr: 1.82 ± 0.306
1.274TyrVal: 1.274 ± 0.659
1.092TyrTrp: 1.092 ± 0.266
1.456TyrTyr: 1.456 ± 0.268
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski